Presenting Author: Dr. Saudamini Jadhav 2nd year resident, MVPS Dr.Vasantrao Pawar Medical College, Nashik Guide: Dr. Mrunal Patil Professor & Dean, MVPS Dr.Vasantrao Pawar Medical College, Nashik Co-Author: Dr. [slideshare.net]

This patient presented with corneal steepening on topography consistent with keratoglobus, as well as large areas of irregular polymorphous changes of the corneal endothelium on specular microscopy consistent with PPMD. [ncbi.nlm.nih.gov]

This case is presented to highlight the need for close follow-up and early intervention in keratoglobus to prevent sight-threatening complications. [ijoreports.in]

Vernal keratoconjunctivitis was present in one pediatric patient. Choroidal osteoma, retinitis pigmentosa, and retinal detachment were present in adults. [doaj.org]

• Surgical Procedure

  To describe the outcomes of femtosecond laser-assisted tuck-in penetrating keratoplasty as a single-step surgical procedure for visual and anatomical rehabilitation of patients with severe keratoglobus (KTG) and endothelial damage. [ncbi.nlm.nih.gov]

  Surgical procedures to treat keratoglobus included large-diameter lamellar and penetrating keratoplasty, and limbus-to-limbus epikeratoplasty. © Lippincott-Raven Publishers. Related Articles [journals.lww.com]

  […] reconstructive surgical procedures. [books.google.ro]

• Swelling

  Swelling of the eyeball. A congenital disorder of the eye in which the whole cornea bulges forward in a regular curve. A globular protrusion and enlargement of the cornea, seen in congenital glaucoma. [healthbenefitstimes.com]

  However, the problem of cross-linking thin corneas in keratoconus has been tackled in a number of ways: artificially swelling the cornea with hypotonic riboflavin before cross-linking to make it thick enough to safely cross-link;4 placing a riboflavin-soaked [elza-institute.com]

  […] keratoglobus, and pellucid marginal corneal degeneration—and is due to a break in Descemet membrane that allows fluid to enter the cornea. 2-4 Patients present to the eye care specialist with a sudden reduction in vision associated with a focal area of corneal swelling [crstoday.com]

  Smith et al16 showed that 2.4% to 3.5% of corneal swelling is induced during the day with rigid GP scleral lens after 3 hours of wear. [docksci.com]

  In many cases, hypoosmoloaric riboflavin is used to swell the stroma. [journals.healio.com]

• Weakness

  The patient is at risk for globe perforation because the thinned out cornea is extremely weak. [ipfs.io]

  The patient is at risk for globe perforation because the thinned out cornea is extremely weak. Surgical treatment Further progression of the disease usually leads to a need for surgery because of extreme thinning of the cornea. [wikidoc.org]

  The mechanism of production of this globular corneal contour is not totally clear, but wound weakness in the area of the grafthost junction could be a possible cause. [ncbi.nlm.nih.gov]

• Collapse

  The globe collapses immediately and the sclerocorneal graft is applied to the surface of the recipient eye,” Prof. Busin said. [healio.com]

  A paracentesis was made, and aqueous was aspirated until the anterior chamber had collapsed enough to take up a more physiologic shape. The donor corneoscleral graft was sutured into the prefashioned scleral bed with long, interrupted sutures. [ncbi.nlm.nih.gov]

• Fatigue

  We ask about general symptoms (anxious mood, depressed mood, fatigue, pain, and stress) regardless of condition. Last updated: January 31, 2019 [patientslikeme.com]

  Most patients report increased eye fatigue and the appearance of headaches with prolonged visual load. Keratoglobus can develop as an isolated disease or occur against the background of Van der Hoove syndrome or Leber congenital amaurosis. [medic-journal.com]

• Hypertension

  Hypertensive Retinopathy Iris and Ciliary Body Lacrimal System Lens Lids Neuro-Ophthalmology Optic Nerve Orbit Retina Sclera Strabismus, Ocular Motility Disorders Systemic Diseases Vitreous Z Videos Z-iPodcasts Z_Op-Videos Endorsed by iPod Podcasting [atlasophthalmology.net]

  One eye developed mild postoperative ocular hypertension. No intraoperative or other postoperative complications were observed. Corrected distance visual acuity was 20/50 in both eyes, with complete functional rehabilitation of the patient. [ncbi.nlm.nih.gov]

• Strabismus

  New Fifth Edition chapters cover Neonatal Ophthalmology, Surgical Management of Strabismus, Medicolegal Issues, and Evolution of Strabismus Surgery. [books.google.ro]

  Diseases (see also separate chapter Systemic Diseases) Trauma, Toxic Keratopathies, Radiation Tumors Glaucomas Hypertensive Retinopathy iPod Beiträge Iris and Ciliary Body Lacrimal System Lens Lids Neuro-Ophthalmology Optic Nerve Orbit Retina Sclera Strabismus [atlasophthalmology.net]

• Lacrimation

  Cataract Cases: A Multi-Disciplinary Approach 2019 (CME) Author/Presenter: Retina Update: Controversies in Retina 2018 :Debates & Discussion (CME) Author/Presenter: Anterior Segment Surgery Update (CME) Author/Presenter: Oculoplastics Update: Eyelid and Lacrimal [willseyeonline.org]

  Keratitis, Infectious/ Non-Infectious Medication Postoperative Cases Systemic Diseases (see also separate chapter Systemic Diseases) Trauma, Toxic Keratopathies, Radiation Tumors Glaucomas Hypertensive Retinopathy iPod Beiträge Iris and Ciliary Body Lacrimal [atlasophthalmology.net]

• Hypertensive Retinopathy

  Retinopathy iPod Beiträge Iris and Ciliary Body Lacrimal System Lens Lids Neuro-Ophthalmology Optic Nerve Orbit Retina Sclera Strabismus Systemerkrankungen Vitreous Z Op-Videos Z Videos Endorsed by iPod Podcasting Keratoglobus Diagnosis: Keratoglobus [atlasophthalmology.net]

• Iridodonesis

  Iridodonesis was noted in left eye. Retinal evaluation of LE revealed retinal detachment (RD) with posterior staphyloma due to high myopia, hereas RE was within normal limits. Intraocular pressure was normal in both eyes. [mendeley.com]

  Associated findings include anterior megalophthalmos, enlarged ciliary ring with zonular stretching (leading to phacodonesis), ectopia lentis, iridodonesis, iris stromal hypoplasia, posterior embryotoxon, transillumination defects, Krukenberg spindles [medical-dictionary.thefreedictionary.com]

  Other ocular abnormalities associated with megalophthalmos anterior include iridodonesis, iris stromal hypoplasia, phacodonesis, ectopia lentis, cataracts, and pigmentary glaucoma with Krukenberg spindles (Vail, 1931; Neumann, 1984; Javadi, 2000; Chien-Kuang [webeye.ophth.uiowa.edu]

• Corneal Infiltrate

  Laibson PR., Dhiri S, Oconer J: Corneal infiltrates in epidemic keratoconjunctivitis. Response to double-blind corticosteroid therapy. Arch Ophthalmol 84:36, 1970. 95. [oculist.net]

• Suggestibility

  The similarities in immunohistochemical labeling between keratoglobus and keratoconus suggest that these entities may share common mechanisms that are involved in stromal thinning. [ncbi.nlm.nih.gov]

  His complaints of chest and back pain suggested coronary ischemia due to the PAA pressure. Medical treatment is recommended to improve clinical symptoms and findings of PAAs. [tgkdc.dergisi.org]

  The correspondent therapy was applied and several therapeutic options were suggested. [medigraphic.com]

  Corneal topography suggested that in the second patient, PMCD may have preceded the development of keratoglobus. [scienceopen.com]

• Irritability

  Inflammation is the first response of the immune system to infection or irritation and may be referred to as the Innate immune system and as healthy nor unhealthy on its own: Inflammation helps fight disease, but it comes at the cost of suspending the [indiahospitaltour.com]

  Health News and Articles Comprehensive information about Diabetes, depression, weight management, osteoarthritis and more from MerckSource.com Health Resource Library - Information about Irritable Bowel Syndrome (IBS), high blood pressure, osteoporosis [web.archive.org]

  Lubricants reduce the redness and provide relief from the chronic irritation. [patient.info]

  Corneal irritation is not accompanied by activation of the corneal reflex. In the later stages, the friction of eyelashes on the cornea leads to increased lacrimation. [medic-journal.com]

  Ten days later, the patient complained of pain, irritation, and tearing. Vision decreased to 20/200 with no pinhole improvement. Conjunctival injection with corneal bullae was noted. [hindawi.com]

• Stroke

  Click on the brush button to enter characters just by drawing them with the correct stroke order. Stroke order animation. Sample. [yellowbridge.com]

Bilateral cases are often associated with systemic disorders and warrant a complete genetic workup. [entokey.com]

NOTE: Children should be referred for an extensive developmental workup Differential Diagnosis Simple megalocornea Megalophthalmos anterior Congenital glaucoma Keratoglobus High myopia References Basti S and Koch DD. [webeye.ophth.uiowa.edu]

Intracameral injection of C(3)F(8) may possibly be a viable treatment option for acute hydrops in a case of corneal ectasia. [ncbi.nlm.nih.gov]

Our current treatment method for patients who present with acute corneal hydrops can be seen in the sidebar, Acute Corneal Hydrops Treatment. [crstoday.com]

Nonetheless, there is no clear consensus on the surgical treatment for a PAA. [tgkdc.dergisi.org]

Treatment Treatment Options: Treatment beyond corneal repair is limited. References [disorders.eyes.arizona.edu]

Prognosis: The prognosis for penetrating keratoplasty in treating kerato-conus is good because the cornea is avascular in keratoconus. [brainkart.com]

Prognosis and prevention Specific measures for the prevention of keratoglobus have not been developed, since in most cases this pathology is congenital. [medic-journal.com]

Prognosis often depends on the extent of opacity and disorganization of the anterior segment. Corneal transplantation has been performed for these disorders with variable success. [content.iospress.com]

Prognosis Keratoglobus continues to be a somewhat mysterious disease, but it can be successfully managed with a variety of clinical and surgical techniques. [ipfs.io]

The etiology and pathogenesis of these disorders are unknown but may be associated with a variety of factors, including contact lens wear, eye rubbing, Down's syndrome, atopic disease, connective tissue disease, tapetoretinal degeneration and inheritance [scholars.northwestern.edu]

We aimed to discuss the etiology and the association of keratoglobus with some systemic abnormalities caused by collogen tissue disturbance, and make a brief review about the recent literature concerning the management of keratoglobus patients. [ncbi.nlm.nih.gov]

The etiology is unknown. [eyewiki.aao.org]

Beginning with basic science, examination techniques and epidemiology, the following chapters discuss the diagnosis and the medical and surgical treatment of numerous different conditions and diseases that may affect the cornea. [books.google.ro]

Epidemiology: Keratoconus is the mostfrequently encountereddeformationof the cornea. Occurrence is familial, although women are more likely to be affected than men. Etiology: Keratoconus is probably a genetic disorder. [brainkart.com]

Epidemiology It is a much rarer condition than keratoconus, which is the most common dystrophy of the cornea. [4] Similar to keratoconus it is typically diagnosed in the patient's adolescent years and attains its most severe state in the twenties and [ipfs.io]

Epidemiology It is a much rarer condition than keratoconus, which is the most common dystrophy of the cornea. [2] Similar to keratoconus it is typically diagnosed in the patient's adolescent years and attains its most severe state in the twenties and [wikidoc.org]

Epidemiology[edit] It is a much rarer condition than keratoconus, which is the most common dystrophy of the cornea.[4] Similar to keratoconus it is typically diagnosed in the patient's adolescent years and attains its most severe state in the twenties [en.wikipedia.org]

It is sometimes equated with "megalocornea". [1] Pathophysiology Keratoglobus is a little-understood disease with an uncertain cause, and its progression following diagnosis is unpredictable. [ipfs.io]

Pathophysiology Keratoglobus is a little-understood disease with an uncertain cause, and its progression following diagnosis is unpredictable. [wikidoc.org]

It is sometimes equated with "megalocornea".[1] Pathophysiology[edit] Keratoglobus is a little-understood disease with an uncertain cause, and its progression following diagnosis is unpredictable. [en.wikipedia.org]

Pathophysiology The pathophysiologic mechanism is unknown. Primary prevention An effective means of prevention has not been discovered. [eyewiki.aao.org]

To report a case of corneal hydrops in a patient with keratoglobus that was managed with endothelial keratoplasty to achieve corneal stability and prevent a limbus-to-limbus tear in Descemet membrane. [ncbi.nlm.nih.gov]

Preventing progression of a central Descemet tear is essential to bypass the need for a large-diameter penetrating keratoplasty graft and its complications in a young patient with a history of bilateral corneal hydrops. [eye.hms.harvard.edu]

Complete removal of the epithelium is important to prevent cystic formations or even melting of the donor lamella, Prof. Busin said. [healio.com]

Prognosis and prevention Specific measures for the prevention of keratoglobus have not been developed, since in most cases this pathology is congenital. [medic-journal.com]

Primary prevention An effective means of prevention has not been discovered. Diagnosis History Patients usually present with a stable or worsening bilateral visual impairment that cannot be properly corrected with spectacles or contact lenses. [eyewiki.aao.org]