Presentation
The five cases presented in this study demonstrate keratosis pilaris as a condition in which the onset or severity of the dermatosis may be linked to the hormonal changes of pregnancy. [ncbi.nlm.nih.gov]
Musculoskeletal
- Short Arm
Our data suggest that the short arm of chromosome 18 is a candidate region for a gene causing keratosis pilaris. [ncbi.nlm.nih.gov]
(The authors present a keratosis pilaris patient with partial monosomy, where a portion of the short arm of chromosome 18 has only one copy, caused by de novo translocation t[Y;18]. [clinicaladvisor.com]
- Myopathy
Keratosis pilaris subtypes are occasionally part of genetically inherited syndromes associated with intellectual disability, neuro-cardio-facial-cutaneous syndromes, RASopathies, ectodermal dysplasias, and certain myopathies. [en.wikipedia.org]
Expression of the collagen VI alpha5 and alpha6 Chains in normal human skin and in skin of patients with collagen VI-related myopathies. J Investig Dermatol. 2011;131(1):99–107. PubMed Google Scholar 211. [doi.org]
Skin
- Dry Skin
Dermatologists' top 10 tips for relieving dry skin. American Academy of Dermatology. https://www.aad.org/dermatology-a-to-z/health-and-beauty/general-skin-care/dry-skin-tips. Accessed Nov. 4, 2015. Retin-A. U.S. [mayoclinic.org]
What Causes Dry Skin? When Skin Becomes Too Dry Treatment Dry skin and keratosis pilaris are common. Dry skin can occur at any age and for many reasons. [wederm.com]
People with very dry skin should consider moisturizing several times a day, including any time the skin feels dry or itchy. [medicalnewstoday.com]
Body skin is generally much tougher than facial skin, so you can exfoliate everyday if you want. I actually dry skin brush twice a day to keep my KP at bay. [skinacea.com]
skin conditions, such as ichthyosis vulgaris, dry skin and atopic dermatitis, including those of asthma and allergies.Keratosis pilaris does not bear any known, long-term health implications, nor is it associated with increased mortality or morbidity [en.wikipedia.org]
- Follicular Plugging
Erythromelanosis follicularis faciei et colli (EFF) is an unusual condition characterized by the triad of hyperpigmentation, follicular plugging and erythema of face and neck. This is less common in women and familial case reports are few. [ncbi.nlm.nih.gov]
- Koilonychia
We describe a family with keratosis pilaris and hereditary koilonychia, with an autosomal dominant pattern of inheritance. These two findings have only been previously found in the context of monilethrix. [ncbi.nlm.nih.gov]
- Chronic Urticaria
Eczema and keratosis pilaris are two more chronic dermatologic conditions besides chronic urticaria and prurigo nodularis that respond extremely well to treatment with dextroamphetamine sulfate. [ncbi.nlm.nih.gov]
Psychiatrical
- Suggestibility
The coexistence of the two disorders suggests a close association of their genetic pathogenesis. [ncbi.nlm.nih.gov]
We suggest using the MSM Soothing Cream while the skin is still moist, and at least one application before sleep. [moogoo.com.au]
Neurologic
- Hyperalgesia
Case 1 was a patient with chronic eczema of 30 years duration was started on treatment for other conditions related to the sympathetic neural hyperalgesia edema syndrome, i.e., migraine headaches and chronic fatigue syndrome. [ncbi.nlm.nih.gov]
Workup
Microbiology
- Candida
These include Tinea (or Athletes Foot), Candida, Ringworm and Intertrigo which refers to skin problems in the folds of the skin. [moogoo.com.au]
I had a very high candida yeast count. After 4 months I have attained excellent health and my skin has healed from bumps and redness. I saw a naturopathic doctor who did a vega test for the foods. [longnaturalhealth.com]
Treatment
Treatment of post-inflammatory hyperpigmentation using a 1064-nm Q-switched Nd:YAG laser with low fluence is reported. [ncbi.nlm.nih.gov]
Topical creams and lotions are currently the most commonly used treatment for keratosis pilaris, specifically those consisting of moisturizing or keratolytic treatments, including urea, lactic acid, glycolic acid, salicylic acid, vitamin D, or topical [en.wikipedia.org]
Prognosis
The overall prognosis for patients is very good. Keratosis pilaris tends to improve over time, though it can persist with a waxing and waning course in some. Keratosis pilaris does not tend to leave scars. [emedicine.medscape.com]
Etiology
Data, and critical analysis of existing data, are lacking, so the etiologies, pathogeneses, disease associations, and treatments of these clinical entities are poorly understood. [ncbi.nlm.nih.gov]
Etiology The etiology of keratosis pilaris is not completely known. Keratosis pilaris may be due to a disorder of corneocyte adhesion that prevents normal desquamation in the area around the hair follicle. [emedicine.medscape.com]
Epidemiology
Histopathologic, genomic, and epidemiologic evidence points to keratosis pilaris as a primary disorder of the pilosebaceous unit as a result of inherited mutations or acquired disruptions in various biomolecular pathways. [ncbi.nlm.nih.gov]
Epidemiology It affects nearly 50-80% of all adolescents and approximately 40% of adults. [ 1 ] Most people with KP are otherwise asymptomatic and are often unaware of the condition. [patient.info]
[…] with interstitial deletion of 12q21-q22. [6] Keratosis pilaris–like eruptions have been described in patients receiving targeted cancer therapies such as RAF inhibitors (ie, vemurafenib) and the Bcr-Abl tyrosine kinase inhibitor nilotinib. [7, 8, 9] Epidemiology [emedicine.medscape.com]
Pathophysiology
Recent data highlight aberrant Ras signaling as an important contributor to the pathophysiology of keratosis pilaris and its subtypes. [ncbi.nlm.nih.gov]
Pathophysiology Keratosis pilaris is theorized to result from defective keratinization of the follicular epithelium, resulting in the lack of proper desquamation of keratinocytes and the formation of a keratotic plug at the follicular orifice. [emedicine.medscape.com]
Prevention
Creams to prevent plugged follicles. Creams derived from vitamin A (topical retinoids) work by promoting cell turnover and preventing plugged hair follicles. [mayoclinic.org]
Sunscreen While sunscreen won’t prevent the condition from forming, it can make a significant difference in preventing red bumps from worsening and looking more obvious. The sun’s damaging rays are known to aggravate keratosis pilaris. [onegoodthingbyjillee.com]
Keratin is a protective substance that prevents harmful bacteria from entering skin. [victoriahealth.com]
[…] from vitamin A, that may help to prevent the hair follicle from becoming plugged. [livestrong.com]
Learn how to treat and prevent keratosis pilaris and "chicken skin" | Keratosis pilaris (KP) is a condition that makes you look like you have “chicken skin." [skinacea.com]