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Ketoconazole


Presentation

  • AIMS: To report the adult height of a MAS boy with PPP who was treated with ketoconazole - cyproterone acetate - leuprolide depot and to describe some atypical aspects of MAS presentation and course in this boy.[ncbi.nlm.nih.gov]
  • Although this infection often heals spontaneously, we present a case of a nonhealing ulcer following surgical drainage of cellulitis.[ncbi.nlm.nih.gov]
  • The present study was conducted in 150 men presenting with telogen effluvium related to androgenic alopecia associated with dandruff.[ncbi.nlm.nih.gov]
  • Of these metabolites, six were present in rat ocular S9 whereas eight were present in rabbit and human ocular matrices.[ncbi.nlm.nih.gov]
  • A case of tinea nigra that responded to treatment with topical ketoconazole is presented.[ncbi.nlm.nih.gov]
Virilization
  • Common clinical signs include virilization, Cushing's syndrome, feminization and hypertension, either isolated or in association.[ncbi.nlm.nih.gov]
Advanced Bone Age
  • As an alternative treatment, we successfully used ketoconazole 200 mg t.i.d. orally in two girls with MAS, GIPP and advanced bone age Ketoconazole led to rapid control of GIPP with cessation of menses and regression of pubertal signs in both patients.[ncbi.nlm.nih.gov]
Tremor
  • A 77-y-old patient developed weakness of extremities, legs paralysis, dysarthria and tremor 1 h after ingestion of 200 mg ketoconazole for the first time in his life. All complaints faded away within 24 h.[ncbi.nlm.nih.gov]
Dysarthria
  • A 77-y-old patient developed weakness of extremities, legs paralysis, dysarthria and tremor 1 h after ingestion of 200 mg ketoconazole for the first time in his life. All complaints faded away within 24 h.[ncbi.nlm.nih.gov]

Workup

Torsades De Pointes
  • We report a woman with coronary artery disease who developed a markedly prolonged QT interval and torsades de pointes (TdP) after taking ketoconazole for treatment of fungal infection.[ncbi.nlm.nih.gov]
  • Ketoconazole is listed among drugs that prolong QT interval and may increase the risk of torsade de pointes, a severe ventricular arrhythmia. This compound has recently been approved for treatment of Cushing's syndrome, a severe endocrine disorder.[ncbi.nlm.nih.gov]
  • […] sometimes resulting in life-threatening ventricular dysrhythmias (eg, torsades de pointes) Concurrent therapy with cisapride, ergot derivatives, or triazolam (fatal cardiac arrhythmias may occur) Acute or chronic liver disease CYP3A4 metabolized HMG-CoA[reference.medscape.com]
  • Ketoconazole can cause elevated plasma concentrations of these drugs and may prolong QT intervals, sometimes resulting in life-threatening ventricular dysrhythmias such as torsades de pointes.[rxlist.com]
Left Ventricular Hypertrophy
  • These patients harbour several risk factors for prolonged QT interval, for example hypokalaemia and left ventricular hypertrophy, but no study has evaluated whether administration of ketoconazole affects their QT interval.[ncbi.nlm.nih.gov]
Ventricular Hypertrophy
  • These patients harbour several risk factors for prolonged QT interval, for example hypokalaemia and left ventricular hypertrophy, but no study has evaluated whether administration of ketoconazole affects their QT interval.[ncbi.nlm.nih.gov]

Treatment

  • […] nearly so throughout the treatment period.[doi.org]
  • […] or choosing an appropriate alternative treatment.[ema.europa.eu]
  • This drug caused a dramatic decrease in UFC excretion, although not normalization; in all patients, escape from treatment occurred. Combined treatment was carried out for 10-180 days.[ncbi.nlm.nih.gov]
  • This compound has recently been approved for treatment of Cushing's syndrome, a severe endocrine disorder.[ncbi.nlm.nih.gov]

Etiology

  • Dysfunction of TRP channels has been linked to the etiology of several diseases, such as polycystic kidney disease, diabetes, and cardiac conductivity disorders.[doi.org]

Epidemiology

  • Ketoconazole has been given a teratogenic classification of C by the US Food and Drug Administration, but human controlled epidemiological studies of the treatment's effects have not been reported.[ncbi.nlm.nih.gov]
  • […] review by the Committee for Medicinal Products for Human Use ( CHMP ), which looked at available data on the benefits of oral ketoconazole and the risk of hepatotoxicity from preclinical and clinical studies, post-marketing spontaneous case reports, epidemiological[ema.europa.eu]
Sex distribution
Age distribution

Pathophysiology

  • The entire pathophysiologic spectrum is now called acute lung injury (ALI), whereas ARDS refers to the more severe end of that spectrum. 4 The degree of impairment of oxygenation of arterial blood is used to distinguish patients with ARDS from those with[jamanetwork.com]

Prevention

  • We present a case occurring in a 48-year-old woman where improvement in the ichthyosiform dermatosis, stabilization of her ocular disease, and apparent partial prevention of further cutaneous malignancies occurred in association with ketoconazole therapy[ncbi.nlm.nih.gov]
  • Since the medications were effective in reducing the T. cruzi parasitaemia in both patients, they probably helped prevent the severe morbidity sometimes associated with Chagas disease, although the HIV infections still proved fatal in both cases.[ncbi.nlm.nih.gov]
  • Current methods available to prevent painful postoperative erections are inadequate.[doi.org]
  • We conclude that ketoconazole effectively prevents painful postoperative erections with minimal side effects.[ncbi.nlm.nih.gov]
  • Monitoring of liver function and addition of dexamethasone are recommended to prevent the possibility of reversible adverse effects such as severe hepatic injury and adrenal insufficiency or even crisis.[ncbi.nlm.nih.gov]

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