Presentation
An understanding of the presentation and clinical course of ketoprofen-induced photosensitivity is necessary to correctly diagnose and manage this condition. [ncbi.nlm.nih.gov]
Entire Body System
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Amyloidosis
There are no therapeutic strategies for the treatment or prevention of islet amyloidosis. [ncbi.nlm.nih.gov]
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Pathologist
Standing Advisory Committee for Haematology of the Royal College of Pathologists. Drug interaction with coumarin derivative anticoagulants. BMJ. 1982; 285:274-5. 30. Brogden RN, Speight TM, Avery GS. [drugs.com]
Musculoskeletal
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Heel Pain
Sever disease is the most common cause of heel pain in athletic children. The purpose of this case report is to describe the addition of ketoprofen gel to the physical therapy intervention of a child with Sever disease. [ncbi.nlm.nih.gov]
Urogenital
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Uterine Cramps
For postpartum pain, we planned to include studies if the pain investigated was due to episiotomy or Caesarean section irrespective of the presence of uterine cramps, but to exclude studies investigating pain due to uterine cramps alone. [doi.org]
Neurologic
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Hyperalgesia
Additionally, when ketoprofen is administered in conjunction with an opioid during pain management, it prevents the development of opioid-induced hyperalgesia. The main limitation for racemic ketoprofen IV administration is venous irritation. [ncbi.nlm.nih.gov]
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Mild Cognitive Impairment
Nine subjects (four healthy subjects, two Pittsburgh compound-B (PiB)-positive patients with mild cognitive impairment (MCI), and three PiB-positive AD patients) underwent a dynamic brain PET scan for 70min after injection. [ncbi.nlm.nih.gov]
Workup
Serum
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Liver Function Tests Abnormal
eosinophilia, rash) occur or if liver function test abnormalities persist or worsen. 1 209 210 Anemia reported rarely. 1 141 Determine hemoglobin concentration or hematocrit in patients receiving long-term therapy if signs or symptoms of anemia occur [drugs.com]
Gastroscopy
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Gastric Lesion
Since the management of NSAIDs gastrotoxicity still represents a major limitation in prolonged therapies, mainly when gastric lesions are present, this study investigated the gastro-protective activity of L-lysine by using a well-established model of [ncbi.nlm.nih.gov]
Treatment
To evaluate the efficacy and tolerability of ketoprofen patch in the treatment of tendinitis. [ncbi.nlm.nih.gov]
Epidemiology
Article date: October 2007 Although epidemiological studies have suggested that piroxicam is associated with a higher gastrointestinal risk than most non-steroidal anti-inflammatory drugs (NSAIDs), these studies have also raised concern about the relative [gov.uk]
An epidemiology of disability among adults in the United States. Milbank Memorial Fund Quarterly: Health and Society, 54, 439 -467. Nierop, A., Bratsikas, A., Zimmermann, R., Ehlert, U. ( 2006 ). [doi.org]
PubMed Citation (Review of estimated frequency of drug induced liver injury due to NSAIDs from large published epidemiological studies; no discussion of ketoprofen). Reuben A, Koch DG, Lee WM; Acute Liver Failure Study Group. [livertox.nih.gov]
Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer’s disease: a review of 17 epidemiologic studies. Neurology. 1996; 47:425-32. 278. Beard CM, Waring SC, O’sBrien PC et al. [drugs.com]
Pathophysiology
Fever: pathogenesis, pathophysiology, and purpose. Ann Intern Med. 1979; 91:261-70. 22. Wilkens RF. The use of nonsteroidal anti-inflammatory agents. JAMA. 1978; 240:1632-5. 23. Capetola RJ, Rosenthale ME, Dubinsky B et al. [drugs.com]
Prevention
Prophylaxis with omeprazole is effective for the prevention of gastroduodenal ulcers, maintenance of remission and alleviation of dyspeptic symptoms in NSAID recipients. [ncbi.nlm.nih.gov]
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor A compound or agent that combines with cyclooxygenases (EC 1.14.99.1) and thereby prevents its substrate-enzyme combination with arachidonic acid and the formation of icosanoids, prostaglandins [ebi.ac.uk]