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Kidney Neoplasm

Kidney Neoplasms


Presentation

  • Histology of the non-neoplastic kidney showed mild parenchymal scarring with some glomerulitis and transplant glomerulopathy present. Moderate transplant arteriopathy and hyaline arteriosclerosis were also present.[jkcvhl.com]
  • Acquired cystic kidney disease-associated renal cell carcinoma is frequently asymptomatic (86%), but may be associated with bleeding, abrupt changes in hematocrit, fever, and flank pain or rarely with hypoglycemia, hypercalcemia, or metastases at presentation[ncbi.nlm.nih.gov]
  • Indeed, in the series we are presenting, one of the cases was diagnosed 12 months after the implant.[revistanefrologia.com]
  • Entire specimen Weight (g) Size in three dimensions (mm) Kidney, in three dimensions Ureter (posterior) , length Renal artery (middle) , length Renal vein (anterior) , length Adrenal (if present), in three dimensions Gerota’s fascia Absent Present Other[rcpa.edu.au]
  • The TNM staging classification in its most recently revised form is described, with discussion of the challenges this presents to cross-sectional imaging.[birpublications.org]
Fatigue
  • Malignant kidney neoplasia also do not usually have noticeable symptoms, but occasionally may cause weight loss, blood in the urine, a nagging pain in the back or side, fatigue or a fever.[wisegeek.com]
  • Fatigue Having a tumor in your kidney may cause you to feel fatigued. One reason may be anemia caused by the cancer. Your fatigue could also be a result of the cancer cells competing with your healthy cells for nutrients.[healthline.com]
  • Many people with cancer say fatigue is one of the most difficult symptoms to manage. Fatigue from cancer is different than just feeling tired from lack of sleep. Cancer-related fatigue is persistent and interferes with daily activities.[healthline.com]
  • Side effects can include fatigue, hair loss, appetite loss, nausea, mouth sores and infection. Radiation —uses high-energy light particles, such as X-rays or gamma rays, to destroy the cancer.[stjude.org]
  • Physical therapy can also be used to combat fatigue, which is not only a common symptom of renal cancer but it can be a side effect of treatment (e.g. chemotherapy) [13].[physio-pedia.com]
Overeating
  • […] evolved from choreoathetoid to dystonic over the course of her hospitalization.[jamanetwork.com]
  • In VHL, a person with kidney involvement typically has a series of tumors on both kidneys which develop over the course of several decades.[vhl.org]
  • You should be able to go home as soon as the test is over. MRI scan An MRI scan uses magnetism to build up a detailed picture of areas of your body.[macmillan.org.uk]
  • Like many other cancers, the growth begins small and grows larger over time. RCC typically grows as a single mass. However, there are cases where a kidney may contain more than one tumor, or tumors are found in both kidneys at the same time.[urology.ucla.edu]
  • She has over 15 years of extensive cancer research and management experience in industry and academia covering wide range of medical areas, including basic, translational, and clinical research.[cancergenetics.com]
Abdominal Mass
  • Some of the common symptoms include: Abdominal mass Blood in urine Persistent pain in the back or loin Recurrent fever and malaise Persistent fever, anorexia or weight loss Smoking is strong risk factor for most transitional cell carcinomas and at least[news-medical.net]
  • Presentation [ edit ] Kidney tumours may be discovered on medical imaging incidentally (i.e. an incidentaloma ), or may be present in patients as an abdominal mass or kidney cyst, hematuria, abdominal pain, or manifest first in a paraneoplastic syndrome[en.wikipedia.org]
  • About 45 percent of people with RCC have an abdominal mass. But kidney lumps are hard to feel, especially in the early stages. That’s because the kidneys sit deep in the abdomen. You may not even see or feel the lump as the tumor grows.[healthline.com]
  • Other signs may include flank pain and an abdominal mass that can be felt by the examining doctor. Other symptoms of renal cell carcinoma may include high blood pressure (hypertension), anemia, abnormal liver function and fever.[rarediseases.org]
  • See separate articles Abdominal Masses , Loin Pain and Haematuria which discuss the various causes. Investigations Urinalysis, cytology, culture and sensitivity should be performed to exclude urinary tract infection.[patient.info]
Heart Failure
  • Failure and Transplantation Cardiology Nita Ahuja MD, MBA Gastrointestinal Surgical Oncology, General Surgery, Minimally Invasive Surgery, Sarcoma and Connective Tissue Surgical Oncology Paul Aiello MD Radiology, Diagnostic Radiology Joseph Akar MD,[yalemedicine.org]
  • Gerstein HC, Mann JF, Yi Q et al: Albuminuria and risk of cardiovascular events, death, and heart failure in diabetic and nondiabetic individuals. Jama 2001; 286 : 421.[auanet.org]

Workup

  • […] incidentaloma ), or may be present in patients as an abdominal mass or kidney cyst, hematuria, abdominal pain, or manifest first in a paraneoplastic syndrome that seems unrelated to the kidney. [1] Diagnosis [ edit ] A CT scan is the first choice modality for workup[en.wikipedia.org]
  • Laboratory studies in the evaluation of renal cell carcinoma should include a workup for paraneoplastic syndromes.[slideshare.net]
  • Clinical Testing and Workup A skin biopsy, which is the surgical removal and microscopic study of a small sample of skin tissue, is necessary in order to confirm the presence of leiomyomas.[rarediseases.org]
  • Much of the testing performed in the workup of RCC is in an effort to determine the stage of disease which impacts treatment decisions and determines prognosis.[renalandurologynews.com]
  • […] aminotransferase [AST] and alanine aminotransferase [ALT]) Serum calcium Imaging studies used to evaluate and stage renal masses may include the following: Excretory urography CT scanning PET scanning Ultrasonography Arteriography Venography MRI See Workup[emedicine.medscape.com]

Treatment

  • INTRODUCTION Kidney transplant is the treatment of choice for end-stage chronic kidney disease as well as the only alternative to renal replacement treatment with dialysis.[revistanefrologia.com]
  • Treatment depends on the stage of the disease and the general health state of the patient, although surgery is the most common treatment and within it, there are several options: partial, radical or bilateral nephrectomy depending on whether part of the[ugr.es]
  • Treatment depends on your age, your overall health and how advanced the cancer is. It might include surgery, chemotherapy, or radiation, biologic, or targeted therapies. Biologic therapy boosts your body's own ability to fight cancer.[icdlist.com]
  • Treatment for a malignant kidney neoplasm depends on the size of the tumor, the symptoms the patient is experiencing, other diseases the patient has and the patient’s health and family history.[wisegeek.com]
  • DeKernion JB, Berry D: The diagnosis and treatment of renal cell carcinoma. Cancer 45 :1947–1956, 1980 PubMed Google Scholar 4. Clayman RV, Williams RD, Farley EE: The pursuit of the renal mass.[link.springer.com]

Prognosis

  • The diagnosed patients followed a tumour extension study, physical examination and the function of the graft’s prognosis was individually analysed. Case 1. A 56-year-old male.[revistanefrologia.com]
  • ; 1 or 2 factors are considered intermediate prognosis, and 3 or more of these factors are considered to have a poor prognosis and may be less likely to benefit from certain treatments.[cancer.org]
  • Metastatic renal cell carcinoma has a poor prognosis with a median overall survival rate of approximately 2 years.[infona.pl]
  • Prognosis for kidney cancer It is not possible for a doctor to predict the exact course of a disease, as it will depend on each person's individual circumstances.[cancer.org.au]

Etiology

  • Subheadings: analysis anatomy and histology blood blood supply chemically induced chemistry classification complications congenital cytology diagnosis diagnostic imaging diet therapy drug therapy economics embryology enzymology epidemiology ethnology etiology[ncbi.nlm.nih.gov]
  • “It is conceivable that the two malignancies share some etiologic factors,” the authors of the Italian study wrote. “Asbestos is the most likely candidate.[asbestos.com]
  • Most common benign renal parenchymal tumor.Discovered occasionaly at postmortem or incidentally during radiological imaging .Asymptomatic .Despite the classification of adenoma as a benign tumor, difficult to differentiate from renal carcinoma.Unknown etiology[slideshare.net]
  • Etiology A specific factor in the etiology of RCC is not known at the moment, although a number of dietary, environmental factors, hormonal, celllular and genetic factors associated with increased risk.[atlasgeneticsoncology.org]
  • The large geographic variation in renal cell cancer rates suggests that westernization may contribute to its etiology.[care.diabetesjournals.org]

Epidemiology

  • […] search builder options Subheadings: analysis anatomy and histology blood blood supply chemically induced chemistry classification complications congenital cytology diagnosis diagnostic imaging diet therapy drug therapy economics embryology enzymology epidemiology[ncbi.nlm.nih.gov]
  • Middleton Memorial Veterans Administration Hospital, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, for helping conceptualize this research; and Sujata Patil, PhD, Department of Epidemiology and Biostatistics, Memorial[annals.org]
  • The epidemiology, presentation and relevance of the various surgical options will be reviewed. The imaging modalities applied to staging will be discussed, with an emphasis on multidetector CT.[birpublications.org]
  • […] malignant potential from cystic renal cell carcinomas which have some overlapping morphologic features Use of "multilocular cystic renal cell carcinoma" is considered obsolete (WHO 2016); some literature references in this topic use the older terminology Epidemiology[pathologyoutlines.com]
  • In the case of kidney neoplasms, they represent aproximately 3% of all adult neoplasms 4, with an incidence rate of 10.02 cases in every 100,000 people per year (0.01%) according to data from the epidemiological study carried out by the Spanish Association[revistanefrologia.com]
Sex distribution
Age distribution

Pathophysiology

  • […] are being investigated. [6] Some studies have linked regular use of NSAIDs such as ibuprofen and naproxen to increases of kidney cancer risk by up to 51%, [7] but other research shows no such connection at least with regards to renal cell cancers. [8] Pathophysiology[en.wikipedia.org]
  • All these conditions are the components of metabolic syndrome, and insulin resistance is underlying pathophysiology ( 20 ).[care.diabetesjournals.org]
  • Pathophysiology The tissue of origin for renal cell carcinoma (RCC) is the proximal renal tubular epithelium.[emedicine.medscape.com]
  • Jacobson HR: Chronic renal failure: pathophysiology. Lancet 1991; 338 : 419. Nagata M, Kriz W: Glomerular damage after uninephrectomy in young rats. II. Mechanical stress on podocytes as a pathway to sclerosis. Kidney Int 1992; 42 : 148.[auanet.org]

Prevention

  • […] imaging diet therapy drug therapy economics embryology enzymology epidemiology ethnology etiology genetics history immunology metabolism microbiology mortality nursing organization and administration parasitology pathology physiology physiopathology prevention[ncbi.nlm.nih.gov]
  • […] and early detection of cervical cancer: American Cancer Society, American Society for Colposcopy and Cervical Pathology, and American Society for Clinical Pathology screening guidelines for the prevention and early detection of cervical cancer.[nccn.org]
  • Causes, Risk Factors, and Prevention Learn about the causes, risk factors, and prevention of kidney cancer and what you might be able to do to help lower your risk from the American Cancer Society.[cancer.org]
  • Return to top How can I prevent kidney cancer? It is not always possible to prevent kidney cancer, but you can take these steps to lower your chances of getting it: Do not smoke or use tobacco. If you smoke, quit now. Keep a healthy weight.[kidneyfund.org]
  • Prevention Taking steps to improve your health may help reduce your risk of kidney cancer. To reduce your risk, try to: Quit smoking. If you smoke, quit.[mayoclinic.org]

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