Presentation
The present study retrospectively analysed the infection trends, resistance patterns, and clonal relationships between isolates of Klebsiella spp. from a tertiary care hospital. [ncbi.nlm.nih.gov]
We present a comprehensive and clinically relevant study of the diversity of O- and K-antigen biosynthesis gene clusters across a global collection of over 500 K. pneumoniae whole-genome sequences and the seroepidemiology of human isolates from different [mgen.microbiologyresearch.org]
He had moved to the United States 25 years before presentation. His last visit to Asia was a trip to Vietnam 5 years before presentation. He worked in a restaurant before he became ill. [academic.oup.com]
Patients demonstrate a wide range of presentations with pyelonephritis, ranging from a mild illness to sepsis. Patients usually present with fever, flank or back pain, shaking chills, and irritation related to bladder voiding. [clinicaladvisor.com]
Respiratoric
- Pleuritic Pain
Clinically, the pneumonia has a sudden onset, characterized by fever, pleuritic pain, cough, and thick mucoid sputum when infection is severe these symptoms progress to shortness of breath, cyanosis, and death in 2 to 3 days. [histopathology-india.net]
Gastrointestinal
- Hemorrhagic Diarrhea
Essential features Gram negative, rod shaped, facultatively anaerobic Lactose fermenting, indole positive Many anatomic and environmental sources Opportunistic pathogenic, multiple sites Antibiotic associated hemorrhagic diarrhea Cytotoxin Frequently [pathologyoutlines.com]
Skin
- Ecthyma
Ecthyma gangrenosum caused by Klebsiella pneumoniae. [jaad.org]
Treatment
Treatment of Klebsiella pneumonia has discrepant results. [emedicine.medscape.com]
MALDI-TOF mass spectrometry Treatment Likely to harbor multidrug resistance mechanisms (example: extended spectrum beta lactamase [ESBL]) Carbapenems are typically treatment of choice when ESBL suspected in significantly ill patients Empiric treatment [pathologyoutlines.com]
Biofield treatment strategy Treatment groups of each strain, in sealed pack were handed over to Mr. Trivedi for biofield treatment under laboratory conditions. Mr. [trivedieffect.com]
Respiratory infections have been shown to be associated with high rates of treatment failure. However, combination therapy is recommended for the treatment of KPC. [adeniumbiotech.com]
Prognosis
When doctors identify K. pneumoniae in samples quickly and prescribe the appropriate antibiotics right away, the prognosis improves. However, delays in diagnosis and testing are common, and this can lead to a less favorable prognosis. [medicalnewstoday.com]
Recovery can take several months, but early treatment will improve your prognosis. [healthline.com]
Etiology
Species include K. pneumo´niae (also called K. friedlän´deri ), the etiologic agent of Friedländer's pneumonia ; K. pneumo´niae ozae´nae, which occurs in ozena and other respiratory diseases; and K. rhinosclero´matis, a species isolated from patients [medical-dictionary.thefreedictionary.com]
A small percentage of pneumonias have as their etiologic agent Klebsiella pneumoniae, an organism belonging to the Friedländer group. Bullowa reports this organism as the causative agent in 1.1 per cent of 4,416 cases of pneumonia. [jamanetwork.com]
Etiology: Klebsiella pneumoniae is a Gram-negative facultatively anaerobic non spore-forming rod. K. pneumoniae has not been recognized as a primary pathogen. Incidence: The incidence of infection is rare. [dora.missouri.edu]
A recent publication by Elikwu et al., (2017) on etiology and antimicrobial susceptibility patterns from urinary tract infections in Nigeria described that of all bacteria isolated from urine samples only 4% were caused by ESBL. [ncbi.nlm.nih.gov]
Epidemiology
The two isolates were identical as determined by ribotyping and pulsed-field gel electrophoresis, and they differed from 10 epidemiologically unrelated strains. [ncbi.nlm.nih.gov]
Its polysaccharide capsule is a major virulence determinant and epidemiological marker. However, little is known about capsule epidemiology since serological typing is not widely accessible and many isolates are serologically non-typeable. [mgen.microbiologyresearch.org]
DISCUSSION Epidemiology The genus Klebsiella is a member of the Enterobacteriaceae family. [nature.com]
The relative importance of plasmid transmission in the overall epidemiology of antimicrobial resistance is not known. [jamanetwork.com]
Pathophysiology
Lactose fermenting, indole positive Many anatomic and environmental sources Opportunistic pathogenic, multiple sites Antibiotic associated hemorrhagic diarrhea Cytotoxin Frequently antibiotic resistant, including extended spectrum beta lactamases (ESBLs) Pathophysiology [pathologyoutlines.com]
The development of new therapeutic strategies requires a better understanding of K. pneumoniae pathophysiology in the context of the complex interactions between the microbe and our body. [healio.com]
[…] of the pathophysiology of Klebsiella pneumonia we see neutrophil myeloperoxidase defense against K P. [en.wikipedia.org]
Prevention
Prevention To prevent spreading the infections between patients, healthcare personnel must follow specific infection control precautions. [solutionsdesignedforhealthcare.com]
Preventing Klebsiella from spreading To prevent spreading Klebsiella infections between patients, healthcare personnel must follow specific infection control precautions (see: Guideline for Isolation Precautions: Preventing Transmission of Infectious [cdc.gov]