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Klebsiella

Klebsiella (organism)


Presentation

  • We present a case of a boy aged 2.5 years with noma where klebsiella was grown and was the initial cause of failure of empiric therapy.[ncbi.nlm.nih.gov]
  • The present study retrospectively analysed the infection trends, resistance patterns, and clonal relationships between isolates of Klebsiella spp. from a tertiary care hospital.[ncbi.nlm.nih.gov]
  • Patients demonstrate a wide range of presentations with pyelonephritis, ranging from a mild illness to sepsis. Patients usually present with fever, flank or back pain, shaking chills, and irritation related to bladder voiding.[clinicaladvisor.com]
  • We present a comprehensive and clinically relevant study of the diversity of O- and K-antigen biosynthesis gene clusters across a global collection of over 500 K. pneumoniae whole-genome sequences and the seroepidemiology of human isolates from different[mgen.microbiologyresearch.org]
  • Ten months later the patient presented a new liver abscess caused by the same microorganism in the same location, and which was likewise subjected to conservative management.[scielo.isciii.es]
Poor Oral Hygiene
  • It mainly affects malnourished children with poor oral hygiene and concurrent debilitating systemic illnesses. It is a polymicrobial infection and borrelia vincentii and fusobacterium are the most important pathogens known.[ncbi.nlm.nih.gov]
Skin Lesion
  • In experimentally induced skin lesions in mice, Klebsiella strains of serotypes K1, K2, K4, and K5 were more virulent than were those expressing other capsule types ( 220 ).[doi.org]

Treatment

  • Treatment of Klebsiella pneumonia has discrepant results.[emedicine.medscape.com]
  • Biofield treatment strategy Treatment groups of each strain, in sealed pack were handed over to Mr. Trivedi for biofield treatment under laboratory conditions. Mr.[trivedieffect.com]
  • Respiratory infections have been shown to be associated with high rates of treatment failure. However, combination therapy is recommended for the treatment of KPC.[adeniumbiotech.com]
  • Some UTIs with mild symptoms may respond to natural treatments and home remedies.[medicalnewstoday.com]
  • Treatment Klebsiella infections can be dangerous, so doctors start treatment with antibiotics right away. Examples include cephalosporins ( cefotaxime and ceftriaxone) and carbapenems ( imipenem or cilastatin).[webmd.com]

Prognosis

  • Recovery can take several months, but early treatment will improve your prognosis.[healthline.com]
  • J Immunol May 1, 2016, 196 (1 Supplement) 143.12; Abstract Acute infection in a cancer-bearing organ has been associated with improved prognosis and enhanced survival, although the anti-cancer immune mechanisms remained undefined.[jimmunol.org]
  • Herein, we analyzed risk factors and prognosis in invasive infections caused by KP versus EC, in an area with low antimicrobial resistance.[journals.plos.org]
  • It was also noted that bacteraemic community-associated pneumonia mediated by K. pneumoniae had a poorer prognosis than Streptococcus pneumoniae mediated bactereamia [ 88 ].[intechopen.com]

Etiology

  • A small percentage of pneumonias have as their etiologic agent Klebsiella pneumoniae, an organism belonging to the Friedländer group. Bullowa reports this organism as the causative agent in 1.1 per cent of 4,416 cases of pneumonia.[jamanetwork.com]
  • Species include K. pneumo niae (also called K. friedlän deri ), the etiologic agent of Friedländer's pneumonia ; K. pneumo niae ozae nae, which occurs in ozena and other respiratory diseases; and K. rhinosclero matis, a species isolated from patients[medical-dictionary.thefreedictionary.com]
  • Background: Klebsiella pneumoniae liver abscess is the most common etiology of liver abscess in Singapore and much of Asia, and its incidence is increasing.[clinicaltrials.gov]
  • In some cases a firm etiological diagnosis cannot be established -such lesions being classified as cryptogenic abscesses or abscesses of obscure origin.[scielo.isciii.es]

Epidemiology

  • Klebsiella spp. is a common cause of bovine mastitis, but information regarding its molecular epidemiology is lacking from many parts of the world.[ncbi.nlm.nih.gov]
  • The two isolates were identical as determined by ribotyping and pulsed-field gel electrophoresis, and they differed from 10 epidemiologically unrelated strains.[ncbi.nlm.nih.gov]
  • DISCUSSION Epidemiology The genus Klebsiella is a member of the Enterobacteriaceae family.[nature.com]
  • Carbapenem-resistant Enterobacteriaceae: epidemiology and prevention. Clin Infect Dis. 2011 Jul 1. 53(1):60-7. [Medline]. van Duin D, Bonomo RA.[emedicine.com]
  • Epidemiology and resistance phenotypes of carbapenemase-producing Klebsiella pneumoniae in Greece, 2014 to 2016. Euro Surveill. 2018;23(31):pii 1700775.[eurosurveillance.org]
Sex distribution
Age distribution

Pathophysiology

  • Klebsiella pneumonia usually hits the right upper lung lobe and results in cavitation and pyogenic (aka pus-producing) tissue death (aka necrosis); this distinct pathophysiology is evident on chest x-ray.[verywellhealth.com]
  • Lactose fermenting, indole positive Many anatomic and environmental sources Opportunistic pathogenic, multiple sites Antibiotic associated hemorrhagic diarrhea Cytotoxin Frequently antibiotic resistant, including extended spectrum beta lactamases (ESBLs) Pathophysiology[pathologyoutlines.com]
  • Pathophysiology Host defense against bacterial invasion depends on phagocytosis by polymorphonuclear granulocytes and the bactericidal effect of serum, mediated in large part by complement proteins.[emedicine.com]

Prevention

  • Preventing Klebsiella from spreading To prevent spreading Klebsiella infections between patients, healthcare personnel must follow specific infection control precautions (see: Guideline for Isolation Precautions: Preventing Transmission of Infectious[cdc.gov]
  • Prevention To prevent spreading the infections between patients, healthcare personnel must follow specific infection control precautions.[solutionsdesignedforhealthcare.com]
  • Centers for Disease Control and Prevention K. pneumoniae Overview and Lab Testing.[lgcstandards-atcc.org]

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