Presentation
We present a case of a boy aged 2.5 years with noma where klebsiella was grown and was the initial cause of failure of empiric therapy. [ncbi.nlm.nih.gov]
Patients demonstrate a wide range of presentations with pyelonephritis, ranging from a mild illness to sepsis. Patients usually present with fever, flank or back pain, shaking chills, and irritation related to bladder voiding. [clinicaladvisor.com]
We present a comprehensive and clinically relevant study of the diversity of O- and K-antigen biosynthesis gene clusters across a global collection of over 500 K. pneumoniae whole-genome sequences and the seroepidemiology of human isolates from different [mgen.microbiologyresearch.org]
Jaw & Teeth
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Poor Oral Hygiene
It mainly affects malnourished children with poor oral hygiene and concurrent debilitating systemic illnesses. It is a polymicrobial infection and borrelia vincentii and fusobacterium are the most important pathogens known. [ncbi.nlm.nih.gov]
Skin
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Skin Lesion
In experimentally induced skin lesions in mice, Klebsiella strains of serotypes K1, K2, K4, and K5 were more virulent than were those expressing other capsule types ( 220 ). [doi.org]
Workup
Serum
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Iron Increased
Availability of iron increases host susceptibility to K pneumoniae infection. [emedicine.com]
Microbiology
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Gram Negative Rods in Blood Culture
Appelbaum, PC, Schick, SF, Kellogg, JA : Evaluation of the four-hour Micro-ID technique for direct identification of oxidase-negative, gram-negative rods from blood cultures. J Clin Microbiol 1980 ; 12 : 533 – 537. 20. [doi.org]
Treatment
Treatment of Klebsiella pneumonia has discrepant results. [emedicine.medscape.com]
Biofield treatment strategy Treatment groups of each strain, in sealed pack were handed over to Mr. Trivedi for biofield treatment under laboratory conditions. Mr. [trivedieffect.com]
Respiratory infections have been shown to be associated with high rates of treatment failure. However, combination therapy is recommended for the treatment of KPC. [adeniumbiotech.com]
Prognosis
When doctors identify K. pneumoniae in samples quickly and prescribe the appropriate antibiotics right away, the prognosis improves. However, delays in diagnosis and testing are common, and this can lead to a less favorable prognosis. [medicalnewstoday.com]
Recovery can take several months, but early treatment will improve your prognosis. [healthline.com]
Etiology
Species include K. pneumo niae (also called K. friedlän deri ), the etiologic agent of Friedländer's pneumonia ; K. pneumo niae ozae nae, which occurs in ozena and other respiratory diseases; and K. rhinosclero matis, a species isolated from patients [medical-dictionary.thefreedictionary.com]
A small percentage of pneumonias have as their etiologic agent Klebsiella pneumoniae, an organism belonging to the Friedländer group. Bullowa reports this organism as the causative agent in 1.1 per cent of 4,416 cases of pneumonia. [jamanetwork.com]
Etiology: Klebsiella pneumoniae is a Gram-negative facultatively anaerobic non spore-forming rod. K. pneumoniae has not been recognized as a primary pathogen. Incidence: The incidence of infection is rare. [dora.missouri.edu]
Background: Klebsiella pneumoniae liver abscess is the most common etiology of liver abscess in Singapore and much of Asia, and its incidence is increasing. [clinicaltrials.gov]
Epidemiology
Klebsiella spp. is a common cause of bovine mastitis, but information regarding its molecular epidemiology is lacking from many parts of the world. [ncbi.nlm.nih.gov]
Its polysaccharide capsule is a major virulence determinant and epidemiological marker. However, little is known about capsule epidemiology since serological typing is not widely accessible and many isolates are serologically non-typeable. [mgen.microbiologyresearch.org]
Carbapenem-resistant Enterobacteriaceae: epidemiology and prevention. Clin Infect Dis. 2011 Jul 1. 53(1):60-7. [Medline]. van Duin D, Bonomo RA. [emedicine.com]
DISCUSSION Epidemiology The genus Klebsiella is a member of the Enterobacteriaceae family. [nature.com]
Pathophysiology
Lactose fermenting, indole positive Many anatomic and environmental sources Opportunistic pathogenic, multiple sites Antibiotic associated hemorrhagic diarrhea Cytotoxin Frequently antibiotic resistant, including extended spectrum beta lactamases (ESBLs) Pathophysiology [pathologyoutlines.com]
The development of new therapeutic strategies requires a better understanding of K. pneumoniae pathophysiology in the context of the complex interactions between the microbe and our body. [healio.com]
Pathophysiology Host protection from bacterial invasion mainly depends on two things: polymorphonuclear granulocytes, which phagocytose the bacteria and serum complement proteins, which are bactericidal. [ncbi.nlm.nih.gov]
Pathophysiology Host defense against bacterial invasion depends on phagocytosis by polymorphonuclear granulocytes and the bactericidal effect of serum, mediated in large part by complement proteins. [emedicine.com]
Prevention
Prevention To prevent spreading the infections between patients, healthcare personnel must follow specific infection control precautions. [solutionsdesignedforhealthcare.com]
Preventing Klebsiella from spreading To prevent spreading Klebsiella infections between patients, healthcare personnel must follow specific infection control precautions (see: Guideline for Isolation Precautions: Preventing Transmission of Infectious [cdc.gov]