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Klebsiella Pneumoniae

Bacillus Pneumoniae


Presentation

  • Thus, physicians should carefully consider the underlying cause in elderly patients who present with rhabdomyolysis, as they may lack symptoms of a primary infection.[ncbi.nlm.nih.gov]
  • We present the first case of this syndrome in a patient of middle-eastern descent. We also present pictorial evidence of the microbe's unique viscous, muculent texture grown on agar. The Author 2016.[ncbi.nlm.nih.gov]
  • In the present study, we investigate K. pneumoniae outbreak causing bacteraemia amongst neonates over a span of 2 months.[ncbi.nlm.nih.gov]
  • : K. pneumoniae pyogenic liver abscess with metastatic endophthalmitis is a relatively new syndrome that should be considered in patients presenting with acute vision loss who appear septic, with or without abdominal complaints.[ncbi.nlm.nih.gov]
  • We present a case of an 83-year-old man who was examined in the Medicine Department of San Camillo Hospital in Treviso for dehydration in gastroenteritis.[ncbi.nlm.nih.gov]
Fever
  • A 56-year-old male who presented with intermittent headache and low fever was admitted, he had transsphenoidal surgery for pituitary adenoma 3 years ago.[ncbi.nlm.nih.gov]
  • A 62-year-old man presented with fever, abdominal pain, and malaise 13 months after emergency endovascular aortic repair. Computed tomographic angiograms showed a periprosthetic fluid and gas collection, so infection was diagnosed.[ncbi.nlm.nih.gov]
  • A 14-year-old otherwise healthy boy presented with right-sided back pain following high fever. Abdominal computed tomography scan showed a large liver abscess.[ncbi.nlm.nih.gov]
  • We describe an 84-year-old man who presented to the emergency department with fever, orbital cellulitis, and bilateral visual loss. Although the patient had no overt abdominal symptoms, computed tomography scan revealed a pyogenic liver abscess.[ncbi.nlm.nih.gov]
  • IE must remain high on the differential diagnosis in every patient with fever of unknown origin.[journalmc.org]
Chills
  • Bloodstream infections (bacteremia and sepsis ) from Klebsiella cause fever, chills, rash, light-headedness, and altered mental states.[everydayhealth.com]
  • Typical symptoms might include fever, chills, cough, and chest pain. Often the cough is productive and blood tinged, and described as currant jelly sputum.[patientslikeme.com]
  • Symptoms of pneumonia include: fever chills coughing yellow or bloody mucus shortness of breath chest pain Urinary tract infection If K. pneumoniae gets in your urinary tract, it can cause a urinary tract infection (UTI).[healthline.com]
  • Pneumonia is an infection of the lungs which results in fever, chills, shortness of breath, fatigue and more. Typically, Klebsiella pneumonia is rare except among members of the community with alcohol dependence.[verywellhealth.com]
  • - Symptoms of pneumonia are shortness of breath, chest pain, coughing, shallow, and fever and chills. How is pneumonia diagnosed? - The diagnosis of pneumonia is usually made from a medical history, a physical examination, and a chest X-ray.[respiratory-lung.health-cares.net]
Rigor
  • Inference of most likely transmission route Next, we sought to extract insights from the genetic data more rigorously and to reconstruct a putative transmission map.[stm.sciencemag.org]
  • In addition, during this period, even though our ICU had agreed-upon protocols that were well-known by the unit’s staff, we were unable to rigorously analyse compliance with the various strategies in place to help prevent patient colonisation.[aricjournal.biomedcentral.com]
  • With a low diversity of resistance phenotypes, we were unable to rigorously test the agreement of susceptibility testing between colonizing isolates and subsequent infecting isolates in the same patient.[msphere.asm.org]
  • Methods A systematic review A systematic literature review was rigorously performed and published by ECDC, to identify the best available evidence on the effective infection prevention and control measures to prevent the transmission of CPE into healthcare[aricjournal.biomedcentral.com]
High Fever
  • A 14-year-old otherwise healthy boy presented with right-sided back pain following high fever. Abdominal computed tomography scan showed a large liver abscess.[ncbi.nlm.nih.gov]
  • Generally, meningitis causes a sudden onset of: high fever headache stiff neck Other symptoms may include: nausea vomiting sensitivity to light ( photophobia ) confusion Endophthalmitis If K. pneumoniae is in the blood, it can spread to the eye and cause[healthline.com]
  • "The symptoms of infection can vary depending on the organs (like the lungs or bladder) that are involved, but they usually include a high fever and chills," Palisano told Live Science. Most CRE infections occur in health-care settings, said Mary B.[livescience.com]
  • Part of urinary tract affected Signs and symptoms Kidneys (acute pyelonephritis) Upper back and side (flank) pain High fever Shaking and chills Nausea Vomiting Bladder (cystitis) Pelvic pressure Lower abdomen discomfort Frequent, painful urination Blood[mayoclinic.org]
  • Patients typically present with an acute onset of high fever and chills; flulike symptoms; and productive cough with an abundant, thick, tenacious, and blood-tinged sputum sometimes called currant jelly sputum.[emedicine.medscape.com]
Malaise
  • A 62-year-old man presented with fever, abdominal pain, and malaise 13 months after emergency endovascular aortic repair. Computed tomographic angiograms showed a periprosthetic fluid and gas collection, so infection was diagnosed.[ncbi.nlm.nih.gov]
  • Here, we present a case of a 64-year-old male who presented with a progressive visual disturbance with general malaise. A K. pneumoniae -induced endogenous endophthalmitis was suspected.[mdpi.com]
  • Snapshot A 56-year-old man presents to the emergency department for a severe headache, generalized malaise, and fatigue. Her symptoms are associated with neck stiffness and nausea.[medbullets.com]
Cough
  • Typical symptoms might include fever, chills, cough, and chest pain. Often the cough is productive and blood tinged, and described as currant jelly sputum.[patientslikeme.com]
  • Abstract A 53-year-old man presented with fevers, productive cough and decreased appetite. He emigrated from Iraq 4 years ago. Chest x-ray revealed a left lung consolidation.[ncbi.nlm.nih.gov]
  • For example, if the bacteria gives you pneumonia, you may have: Fever Cough Chest pain Trouble breathing More mucus, which may be thick and bloody Klebsiella pneumoniae can hit other parts of your body, too.[webmd.com]
Productive Cough
  • Abstract A 53-year-old man presented with fevers, productive cough and decreased appetite. He emigrated from Iraq 4 years ago. Chest x-ray revealed a left lung consolidation.[ncbi.nlm.nih.gov]
  • Review Topic QID: 106715 M1 Select Answer to see Preferred Response PREFERRED RESPONSE 2 (M1.MC.74) An 84-year-old female presents to the emergency department from her nursing home with complaints of fever and a productive cough with rust-colored sputum[medbullets.com]
  • Patients typically present with an acute onset of high fever and chills; flulike symptoms; and productive cough with an abundant, thick, tenacious, and blood-tinged sputum sometimes called currant jelly sputum.[emedicine.medscape.com]
Rales
  • The heart sounds were normal and a 2/6 Levine murmur was audible on the right sternal border; the breath sounds were diminished bilaterally and rales were audible in both lung bases, the peripheral oxygen saturation was 72%.[imedpub.com]
  • […] knees while the patient is supine Kernig sign extension of the knee while the hips are flexed at 90 causes pain/discomfort otitis media fever irritability ear-tugging/rubbing pneumonia decreased breath sounds increased fremitus dullness to percussion rales[medbullets.com]
Dyspnea
  • About ten days after transplant he developed acute dyspnea at rest, with fever, cough and chest pain. On physical examination the heart rate was 130 beats/min and the blood pressure was 140/80 mmHg.[imedpub.com]
Dyspnea at Rest
  • About ten days after transplant he developed acute dyspnea at rest, with fever, cough and chest pain. On physical examination the heart rate was 130 beats/min and the blood pressure was 140/80 mmHg.[imedpub.com]
Tachycardia
  • ECG showed synusal tachycardia, and new onset of negative T waves in a VL, V1 and V2.[imedpub.com]
  • Individuals with Klebsiella pneumonia tend to cough up a characteristic sputum, as well as having fever, nausea, tachycardia and vomiting. Klebsiella pneumonia tends to affect people with underlying conditions, such as alcoholism.[en.wikipedia.org]
  • Signs may include tachycardia, tachypnoea, decreased breath sounds and dullness to percussion over areas of consolidation, pleural friction rub. Severe infection may lead to hypoxia and septic shock.[patient.info]
Withdrawn
  • All infected patients were cured or improved with fosfomycin and/or carbapenem-containing combination therapy, except one case in whom treatment was withdrawn.[ncbi.nlm.nih.gov]
Altered Mental Status
  • He developed high-grade fever and altered mental status on postoperative day 2. NDM-1-producing K. pneumoniae was identified in the cerebrospinal fluid, establishing the diagnosis of meningitis.[ncbi.nlm.nih.gov]
  • Blood 2017 130:2906; doi: A 24-year-old man presented to the emergency room with respiratory distress and altered mental status. He had a past medical history of pyruvate kinase deficiency with status postsplenectomy at 6 years of age.[bloodjournal.org]
  • GR is a 44 yo M with a PMH of atrial fibrillation, diabetes mellitus, and seizure disorder admitted for altered mental status likely secondary to pyelonephritis.[accessmedicinenetwork.com]
Intracranial Hemorrhage
  • A patient was admitted to the emergency department with intracranial hemorrhage and ventriculitis due to traumatic injury. A ventriculostomy and, subsequently, a ventriculoperitoneal (VP) shunt were placed.[ncbi.nlm.nih.gov]

Workup

  • Workup showed macrocytic anemia, leukocytosis, and slight neutrophilia, with elevated lactate, prothrombin time, and activated partial thromboplastin time, mixed respiratory and metabolic acidosis, and hypoxemia.[bloodjournal.org]
  • Urine collected from an indwelling catheter as part of a rule-out sepsis workup grew 10 4 colonies/ml of a carbapenemase-producing K. pneumoniae that was negative for ESBL production and bla KPC by PCR.[doi.org]
Air Bronchogram
  • Often there can be extensive lobar opacification with air bronchograms.[radiopaedia.org]
Pulmonary Infiltrate
Blood Culture Positive
  • Sonography of his abdomen revealed a large liver abscess with two blood cultures positive for Klebsiella pneumoniae. He made a complete recovery following aspiration of the abscess and treatment with intravenously administered ceftriaxone.[ncbi.nlm.nih.gov]

Treatment

  • Our data showed that (1) carbapenem treatment led to the emergence of CRKP in the gastrointestinal (GI) tract of the patient, which subsequently caused infections at other body sites as well as septicemia; (2) treatment with tigecycline led to the emergence[ncbi.nlm.nih.gov]
  • A patient with carbapenem-resistant Klebsiella pneumoniae infection is described, and treatment options are discussed.[ncbi.nlm.nih.gov]
  • CONCLUSIONS: In this small outbreak, antibiotic treatment seemed to be the predominant risk factor for monoclonal transmission of bla OXA-48 positive CKP.[ncbi.nlm.nih.gov]
  • Despite improved treatment outcomes compared to those achieved with aminoglycoside- and colistin-based regimens, the rapid evolution of CAZ-AVI resistance during treatment has previously been reported in Klebsiella pneumoniae sequence type 258 (ST258)[ncbi.nlm.nih.gov]
  • One daily intraperitoneal injection of Klebsiella bacteriophage for 15-20 days proved to be the optimum scheme of treatment.[ncbi.nlm.nih.gov]

Prognosis

  • Ocular signs regressed and prognosis was excellent with 20/20 of final BCVA. KPEE is a rare but severe condition with a typically poor ocular prognosis.[ncbi.nlm.nih.gov]
  • Community-acquired bacterial meningitis due to Klebsiella pneumoniae has mainly been described in Southeast Asia and has a poor prognosis.[ncbi.nlm.nih.gov]
  • Herein, we analyzed risk factors and prognosis in invasive infections caused by KP versus EC, in an area with low antimicrobial resistance.[ncbi.nlm.nih.gov]
  • Early recognition and careful consideration of the underlying cause of rhabdomyolysis are critical to improving the patient's prognosis.[ncbi.nlm.nih.gov]
  • Recovery can take several months, but early treatment will improve your prognosis.[healthline.com]

Etiology

  • Four years later Weichselbaum 2 demonstrated that Diplococcus pneumoniae was the more frequent etiologic agent.[jamanetwork.com]
  • In some cases a firm etiological diagnosis cannot be established -such lesions being classified as cryptogenic abscesses or abscesses of obscure origin.[scielo.isciii.es]
  • Also, it is known as Friedlander's bacillum in honor of Carl Friedländer, a German pathologist, who proposed that this bacterium was the etiological factor for the pneumonia seen especially in immunocompromised individuals such as people with chronic[en.wikipedia.org]
  • Applicable To Bronchopneumonia due to S. pneumoniae Code First Code First Help Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology.[icd10data.com]
  • However, bacterial correlation in these groups will provide new insights into etiology of tracheomalacia and pneumonia infected with different bacterial pathogens.[jtd.amegroups.com]

Epidemiology

  • However, it is uncertain how the data produced by WGS can be best integrated into epidemiologic investigations.[ncbi.nlm.nih.gov]
  • Epidemiological analysis of recent clinical isolates in China warns the global dissemination of hypervirulent K. pneumoniae strains with extensive antibiotic resistance in the near future.[ncbi.nlm.nih.gov]
  • There was limited data in pediatric populations, thus this study aimed to investigate molecular epidemiology and drug resistant mechanism of CR-KP strains from pediatric patients in Shanghai, China.[ncbi.nlm.nih.gov]
  • In Sri Lanka, further studies are necessary to understand the epidemiology and modes of spread. Furthermore, a high index of suspicion is essential as early detection is the key to successful treatment and prevention of complications.[ncbi.nlm.nih.gov]
  • Ljubljana , Slovenia. 2 b Institute of Microbiology and Immunology, Faculty of Medicine , University of Ljubljana , Ljubljana , Slovenia. 3 c Faculty of Pharmacy , University of Ljubljana , Ljubljana , Slovenia. 4 d Department of Infectious Diseases and Epidemiology[ncbi.nlm.nih.gov]
Sex distribution
Age distribution

Pathophysiology

  • In this article, the authors review those reported cases, and also the literature regarding the pathophysiology of this intriguing syndrome. Published by Elsevier Inc.[ncbi.nlm.nih.gov]
  • Mikulicz cells observed during Klebsiella rhinoscleromatis infection However, despite their clinical importance, many facets of the pathophysiology of Klebsiella pneumoniae remain unknown.[research.pasteur.fr]
  • Klebsiella pneumonia usually hits the right upper lung lobe and results in cavitation and pyogenic (aka pus-producing) tissue death (aka necrosis); this distinct pathophysiology is evident on chest x-ray.[verywellhealth.com]
  • It is typically due to aspiration and alcoholism may be a risk factor, though it is also commonly implicated in hospital-acquired urinary tract infections, and COPD (chronic obstructive pulmonary disease) individualsIn terms of the pathophysiology of[en.wikipedia.org]
  • Pathophysiology Host defense against bacterial invasion depends on phagocytosis by polymorphonuclear granulocytes and the bactericidal effect of serum, mediated in large part by complement proteins.[emedicine.medscape.com]

Prevention

  • Preventing Klebsiella from spreading To prevent spreading Klebsiella infections between patients, healthcare personnel must follow specific infection control precautions (see: Guideline for Isolation Precautions: Preventing Transmission of Infectious[cdc.gov]
  • Infection prevention control measures available at the time contained the initial outbreak, but had no effect on the spread of CRKP later.[ncbi.nlm.nih.gov]
  • The objective of these studies was to identify the concentrations of both agents associated with the selection or prevention of single-step mutations leading to reduced sensitivity to the combination and to characterize the selected mutations.[ncbi.nlm.nih.gov]
  • Moreover, this provides further insight into not only detecting these highly resistant organisms but also preventing their spread.[ncbi.nlm.nih.gov]
  • Our control measures successfully prevented further outbreak and inhibited the recurrence.[ncbi.nlm.nih.gov]

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