2110 Classification level: Disorder Synonym(s): Kleiner-Holmes syndrome Prevalence: <1 / 1 000 000 Inheritance: - Age of onset: Neonatal ICD-10: Q74.2 OMIM: 234280 UMLS: C1856197 MeSH: - GARD: 3118 MedDRA: - The documents contained in this web site are presented [orpha.net]

Conclusions: We have presented a novel surgical technique for the reconstruction of MTPP presenting with a cosmetic lateral hallux, involving an amalgamating osteotomy without extensive soft tissue reconstruction. [ingentaconnect.com]

At the time of presentation the child was 1 year 3 months but unable to walk. [jocr.co.in]

Co-authored by Adrienne O'Neill, DPM Polydactyly is characterized by the presentation of one or more supernumerary digits on the hands and/or feet. [podiatrytoday.com]

We present a novel surgical technique for the treatment of children with MTPP presenting with a cosmetic lateral hallux, involving an amalgamating osteotomy that permits retention of the stable medial metatarsotarsal joint while avoiding the complication [bioportfolio.com]

• Broad Great Toe

  One brother had duplication-triplication of the great toes and the other had unusually broad great toes with incomplete duplication of the phalanges. The parents were not related and showed no skeletal abnormality. [accessanesthesiology.mhmedical.com]

  Clinical aspects: In 1980, Kleiner and Holmes described two brothers with bilateral hallux varus, One brother had duplication-triplication of the great toes and the other bad unusually broad great toes with Incomplete duplication of the phalanges. [checkorphan.org]

  […] deviated, broad great toes; Cutaneous syndactyly of second and third toes; Short, broad metatarsal; Tarsonavicular and calcaneonavicular fusion]; #123500:Crouzon syndrome [Craniosynostosis; Brachycephaly; Frontal bossing; Maxillary hypoplasia; Mandibular [panelapp.genomicsengland.co.uk]

• Toe Pain

  Except perhaps if differential growth in length of the toes causes joint flexion of the longer toe and painful callus formation over the dorsum of the flexed IP joint(s) b. Complex i. Pain that is directly related to the bony syndactyly. [doctorlib.info]

• Restless Legs Syndrome

  The editors and contributing authors are internationally recognized authorities who cover everything from sleep and ADHD, headaches, restless leg syndrome, parasomnias, hypersomnias, autism, brain tumors, epilepsy, traumatic brain injury, and other primary [books.google.de]

  Syndrome Renal Nutcracker Syndrome restless legs syndrome + Retinal Dysplasia + Retinal Dystrophy, Iris Coloboma, and Comedogenic Acne Syndrome Retinal Dystrophy, Juvenile Cataracts, and Short Stature Syndrome Retinitis Pigmentosa, Deafness, Mental Retardation [rgd.mcw.edu]

• Large Feet

  valgus Talipes equinovarus HP:0001762 - 26.1.9 Club foot, varus Talipes equinovarus HP:0001762 - 26.1.10 Prominent heels - - - 26.1.11 Large feet Large feet HP:0001833 - 26.1.12 Long feet - - - 26.1.13 Narrow feet - - - 26.1.14 Oedema of feet - - - [compbio.charite.de]

• Absent Hallux

  […] mapping known disease genes to disease phenotypes from the HPO Gene-Disease Associations dataset. absent hallux Gene Set From MPO Gene-Phenotype Associations gene mutations causing the absent hallux phenotype in transgenic mice from the MPO Gene-Phenotype [amp.pharm.mssm.edu]

• Long Toes

  (not 2-3) Syndactyly HP:0001159 - 26.5.11 Wide-spaced toes - - - 26.5.12 Long toes - - - 26.5.13 Camptodactyly/hammer toes Hammer toes HP:0001765 - 26.5.14 Pre-axial polydactyly of toes - - - 26.5.15 Meso-axial polydactyly of toes - - - 26.5.16 Mirror [compbio.charite.de]

• Narrow Feet

  valgus Talipes equinovarus HP:0001762 - 26.1.9 Club foot, varus Talipes equinovarus HP:0001762 - 26.1.10 Prominent heels - - - 26.1.11 Large feet Large feet HP:0001833 - 26.1.12 Long feet - - - 26.1.13 Narrow feet - - - 26.1.14 Oedema of feet - - - [compbio.charite.de]

• Vaginal Bleeding

  bleeding had only a borderline effect. [eurekamag.com]

Further medical workup may be necessary prior to surgical reconstruction if the patient’s polydactyly is felt to be part of an inherited syndrome. [musculoskeletalkey.com]

Find diagnostic and treatment information quickly and easily thanks to a highly illustrated, easy-to-read format that highlights key details. [books.google.de]

The material is in no way intended to replace professional medical care by a qualified specialist and should not be used as a basis for diagnosis or treatment. [orpha.net]

Treatment - Kleiner Holmes syndrome Not supplied. Resources - Kleiner Holmes syndrome Not supplied. [checkorphan.org]

Surgical treatment consists of excision of the duplicated digit and reconstruction of any associated abnormalities in the remaining rays (eg, longitudinal epiphyseal bracket). [4, 11, 12, 13] A thorough preoperative examination should be undertaken, including [emedicine.medscape.com]

Treatment of this anomaly is complex because it has both functional and a esthetic implications. [6], [7] McCarthy et al. and Galois et al. stated that the surgical treatment of preaxial polydactyly is complex with poor long term result. [3], [4] Most [ijoonline.com]

Prognosis - Kleiner Holmes syndrome Not supplied. Treatment - Kleiner Holmes syndrome Not supplied. Resources - Kleiner Holmes syndrome Not supplied. [checkorphan.org]

Subsequently, he was diagnosed with CATBP, a disorder with a good prognosis that is not known to present with any CNS malformations. [jmedicalcasereports.biomedcentral.com]

[…] the upper extremity 485 357 Fractures of the upper extremities 494 358 Tumors of the upper extremities 522 41 Traumatology basic principles 532 413 Diagnosis 533 414 Special injuries 536 415 Therapeutic principles 540 416 Followup management 543 418 Prognosis [books.google.es]

Prognosis [ edit ] The prognosis for children with LKS varies. Some affected children may have a permanent severe language disorder, while others may regain much of their language abilities (although it may take months or years). [en.wikipedia.org]

Based on our experience, two main factors are noticed in the etiology of congenital hallux varus deformity: inadequacy of the adductor hallucis and tightening of the fibrous band pulling the big toe into the varus. ©1987American Society of Plastic Surgeons [journals.lww.com]

They are organised into groups, and further divided into clinical, etiological or histopathological sub-types. [orpha.net]

Metatarsalgia: Distal Metatarsal Osteotomies, Metatarsalgia: Proximal Metatarsal Osteotomies, Crossover and Valgus Toe Deformity, Revision Lesser Toe Surgery, Freiberg's Infraction, Fifth Toe Deformities, Congenital Toe Deformities, Bunionette Deformity - Etiology [books.google.es]

[…] frequently in the hands than the feet. 1,4 The condition occurs throughout the world with the highest incidence among Asian people. 2 Researchers have not identified a gender predilection with males and females affected equally. 2 The inheritance pattern and etiology [podiatrytoday.com]

The anomalies are organized by anatomical system and presented in a consistent manner, including details of the clinical presentation, epidemiology, embryology, treatment and prevention for each anomaly. [books.google.es]

The aim of this work was to test whether thumb and hallux duplication also had different clinical and epidemiological characteristics, depending on limb involvement. [eurekamag.com]

In the Figures related to the epidemiological features of apathetic strain the lord it over spot is patent post-stroke depression are highly uncertain, because apathy and inattention. [gravesen.com]

The epidemiology of nonalcoholic fatty liver disease: a global perspective. Semin Liver Dis 2008;28:339-350. 18956290. 2. Vernon G, Baranova A, Younossi ZM. [e-cmh.org]

Epidemiology of idiopathic cardiomyopathy in japan: Results from a nationwide survey. Heart. 2002; 87 :126–130. [ PMC free article ] [ PubMed ] [ Google Scholar ] 10. Amoah AG, Kallen C. [ncbi.nlm.nih.gov]

Conclusion Chorea can be due to a multitude of disorders with a wide variety of pathophysiologies. [movementdisorders.org]

Insulin sensitizing agents Insulin resistance is a key pathophysiological factor in the development of NASH. [digestive-diseases.imedpub.com]

The pathophysiology of cyclic Cushing's is unknown. [frontiersin.org]

Prevention - Kleiner Holmes syndrome Not supplied. Diagnosis - Kleiner Holmes syndrome Not supplied. Prognosis - Kleiner Holmes syndrome Not supplied. Treatment - Kleiner Holmes syndrome Not supplied. Resources - Kleiner Holmes syndrome Not supplied. [checkorphan.org]

The anomalies are organized by anatomical system and presented in a consistent manner, including details of the clinical presentation, epidemiology, embryology, treatment and prevention for each anomaly. [books.google.es]

Venkata Department More information Prevention Diagnosis Prevention and Management of Positional Skull Deformities in Infants John Persing, MD, Hector James, MD, Jack Swanson, MD, John Kattwinkel, MD, Committee on Practice and Ambulatory Medicine, Section [healthdocbox.com]

The remaining great toe should have a careful repair of the capsule if necessary to prevent residual hallux varus; Kirschner wire fixation is used for 4 to 6 weeks. The technique for postaxial polydactyly is described later. [orthopedia.co]

Correction of an associated longitudinal bracket epiphysis helps to prevent the development of hallux varus and an excessive short first metatarsal. The capsule is repaired as accurately as possible. [emedicine.medscape.com]