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Korsakoff Syndrome

Presentation

Nutr Rev 61:320–323 CrossRef PubMed Google Scholar Subramanian R, Khadori R (2000) Severe hypophosphatemia: pathophysiologic implications, clinical presentations, and treatment. [link.springer.com]

If significant heterogeneity had been noted, a random‐effects model would have been presented. [cochranelibrary.com]

Entire Body System

  • Unconsciousness

    This includes anyone showing evidence of ophthalmoplegia, ataxia, acute confusion, memory disturbance, unexplained hypotension, hypothermia, coma or unconsciousness (Cook 2000). [cochranelibrary.com]

  • Anorexia

    Medicine 79:1–8 CrossRef PubMed CAS Google Scholar Kohn MR, Golden NH, Shenker IR (1998) Cardiac arrest and delirium: presentations of the refeeding syndrome in severly malnourished adolescents with anorexia nervosa. [link.springer.com]

Gastrointestinal

  • Loss of Appetite

    […] past year, reduced body mass index (BMI), loss of appetite, nausea and vomiting), acute illness or alcohol‐related co‐morbidity requiring hospitalisation (NCGCACC 2010). [cochranelibrary.com]

Cardiovascular

  • Hypotension

    This includes anyone showing evidence of ophthalmoplegia, ataxia, acute confusion, memory disturbance, unexplained hypotension, hypothermia, coma or unconsciousness (Cook 2000). [cochranelibrary.com]

Neurologic

  • Confusion

    Types of outcome measures The primary outcome measures of interest included the following: Efficacy as measured by change in any of five key domains: Global 'confusion' or delirium (e.g. presence or absence of delirium using the Confusion Assessment Method [cochranelibrary.com]

  • Polyneuropathy

    The symptoms that Wernicke recorded included disturbances of eye movement, ataxia of gait, polyneuropathy and mental changes including apathy, decreased attention span and disorientation in time and space. [cochranelibrary.com]

Treatment

Other interventions or no treatment. [cochranelibrary.com]

Arch Neurol Psychiatry 46:569–596 Google Scholar Cleckley HM, Sydenstricker VP, Geeslin LE (1939) Nicotinic acid in the treatment of atypical psychotic states. [link.springer.com]

Etiology

Presse Med 25:115–118 Google Scholar Bowman KM, Goodhart R, Jolliffe N (1939) Observation on the role of vitamin B1 in the etiology and treatment of Korsakoff psychosis. [link.springer.com]

Pathophysiology

Nutr Rev 61:320–323 CrossRef PubMed Google Scholar Subramanian R, Khadori R (2000) Severe hypophosphatemia: pathophysiologic implications, clinical presentations, and treatment. [link.springer.com]

Prevention

However, the article does not report the number of participants in each group, thus preventing quantitative analysis. The review was limited by inability to contact the authors to discuss this further. [cochranelibrary.com]

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