Presentation
Of the 19 subjects, an "abnormal" LBT pre-probiotic was present in ten subjects and during the probiotic, 13 were abnormal. [ncbi.nlm.nih.gov]
In the present study we have compared the colonic metabolism of the two sugars using an in vitro faecal incubation system. [doi.org]
Entire Body System
- Swelling
Lactulose Solution Consumer Information Get emergency medical help if you have any of these signs of an allergic reaction : hives; difficult breathing; swelling of your face, lips, tongue, or throat. [rxlist.com]
Tell the doctor about the allergy and what signs your child had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs. [mskcc.org]
Tell your doctor about the allergy and what signs you had, like rash; hives ; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs. If you are on a low-galactose or lactose-free diet. [drugs.com]
Although uncommon, if you should experience any signs of an allergic reaction like hives, difficulty breathing, swelling of your face, lips, tongue or throat seek emergency medical help. [he123.liverfoundation.org]
- Weakness
Gas amounts produced during LBT were not associated with IBS symptoms, except a weak correlation between total gas amounts and a few IBS symptoms such as bloating (r = 0.324, P = 0.039), flatulence (r = 0.314, P = 0.046) and abdominal pain (r = 0.364, [ncbi.nlm.nih.gov]
The sugar is broken down into weak acids in the large colon. These acids attract water into the intestine, which softens the stools. [enkivillage.com]
Lactulose Overdose Symptoms of an overdose include the following: Thirst Increased urination Irregular heart beat Muscle weakness If you suspect an overdose, you should contact a poison control center or emergency room immediately. [everydayhealth.com]
Vol. 7, Pg. 3517, 1973. rabbit LDLo oral 24gm/kg (24000mg/kg) BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: MUSCLE WEAKNESS Kiso to Rinsho. Clinical Report. [chem.nlm.nih.gov]
Overdose symptoms may include confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, and muscle weakness or limp feeling. What should I avoid while taking lactulose? Avoid using antacids without your doctor's advice. [rxlist.com]
- Fever
CONCLUSIONS: Enteropathy (high L:M) is associated with younger age, undernutrition, low vitamin A and iron status, and infection particularly diarrhea and fever. [ncbi.nlm.nih.gov]
Signs and symptoms: This medication should not be used in the presence of abdominal pain, nausea, fever, or vomiting. Pregnancy: This medication should not be used during pregnancy unless the benefits outweigh the risks. [medbroadcast.com]
- Fatigue
Jasmohan S Bajaj, Muhammad Hafeezullah, Yelena Zadvornova, Eric Martin, Christine M Schubert, Douglas P Gibson, Raymond G Hoffmann, Arun J Sanyal, Douglas M Heuman, Thomas A Hammeke and Kia Saeian, The Effect of Fatigue on Driving Skills in Patients With [doi.org]
Respiratoric
- Dyspnea
Vol. 7, Pg. 3517, 1973. mouse LD50 intraperitoneal 15800mg/kg (15800mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA Kiso to Rinsho. Clinical Report. [chem.nlm.nih.gov]
Gastrointestinal
- Diarrhea
Adverse reactions GI: nausea, vomiting, diarrhea, intestinal cramps, abdominal distention, flatulence Metabolic: hyperglycemia (in diabetic patients), hypokalemia, hypernatremia Interactions Drug-drug. [medical-dictionary.thefreedictionary.com]
At too strong a dose, it may cause diarrhea. Lactulose is generally sold in the form of drinkable solutions. [health.ccm.net]
[…] difficile (5), chronic diarrhea and malnutrition (6), and infectious diarrhea (7). [scielo.br]
You have to find out how the Lactulose works best for you to get good results and to avoid diarrhea. For me it's 33ml once or twice a day. Sometimes I find I need to go a few days without taking it to avoid diarrhea. [ibstales.com]
Severe diarrhea may lead to hypovolemia, hypokalemia, and hypernatremia, especially in elderly or acutely ill patients. If diarrhea develops, the dosage should be reduced. [drugs.com]
- Vomiting
Frequency of nausea and vomiting between lactulose and non-lactulose groups [ Time Frame: First 5 days post-Caesarean ] Frequency of nausea and vomiting between lactulose and non-lactulose groups post Caesarean Section. [clinicaltrials.gov]
Contra Indications Lactulose is contraindicated in Galactosaemia, undiagnosed abdominal pain or vomiting, organic constipation like intestinal obstruction, stricture, malignancy or hypercalcaemia. [webhealthcentre.com]
Side effects of Lactulose solution include: diarrhea, nausea, vomiting, bloating, gas, belching, and stomach pain or discomfort. [rxlist.com]
A questionnaire was administered regarding digestive symptoms (abdominal pain, bloating, vomiting, and bowel-movement disorders). [ncbi.nlm.nih.gov]
Feeling sick and vomiting. This can usually be avoided by taking the lactulose with water, fruit juice or a meal. Abdominal cramps and diarrhoea. These usually only occur if the dose is too high. [netdoctor.co.uk]
- Nausea
Frequency of nausea and vomiting between lactulose and non-lactulose groups [ Time Frame: First 5 days post-Caesarean ] Frequency of nausea and vomiting between lactulose and non-lactulose groups post Caesarean Section. [clinicaltrials.gov]
Side effects of Lactulose solution include: diarrhea, nausea, vomiting, bloating, gas, belching, and stomach pain or discomfort. [rxlist.com]
The most common subjective symptom after the medication was nausea, especially after lactulose. [ncbi.nlm.nih.gov]
Tell your doctor if any of these symptoms are severe or do not go away: diarrhea gas nausea If you have any of the following symptoms, stop taking lactulose and call your doctor immediately: stomach pain or cramps vomiting If you experience a serious [web.archive.org]
Nausea and vomiting have been reported. Safety and effectiveness in pediatric patients have not been established. REFERENCES: 1. Barish CF, Kaelin B. [kristalose.com]
- Rectal Bleeding
People who also have symptoms such as severe abdominal pain, feeling sick and vomiting, or rectal bleeding where you don't know the cause, as this could indicate that you have a more serious condition that needs investigating. [netdoctor.co.uk]
- Dyspepsia
GI symptoms, such as dyspepsia, bloating, abdominal pain/discomfort, and epigastric pain on an eleven-point scale were also analyzed and correlate with the results of those tests. [ncbi.nlm.nih.gov]
Skin
- Flushing
Signs of high blood sugar like confusion, feeling sleepy, more thirst, more hungry, passing urine more often, flushing, fast breathing, or breath that smells like fruit. Diarrhea. [mskcc.org]
However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. [nlm.nih.gov]
- Urticaria
Pagina 226 - Mechanisms by Which Carbohydrates Regulate Expression of Genes for Glycolytic and Lipogenic Enzymes, Pagina 220 - Paganelli R, Fagiolo U, Cancian M, Scala E: Intestinal permeability in patients with chronic urticaria-angioedema with and [books.google.it]
Musculoskeletal
- Muscle Weakness
Lactulose Overdose Symptoms of an overdose include the following: Thirst Increased urination Irregular heart beat Muscle weakness If you suspect an overdose, you should contact a poison control center or emergency room immediately. [everydayhealth.com]
Vol. 7, Pg. 3517, 1973. rabbit LDLo oral 24gm/kg (24000mg/kg) BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: MUSCLE WEAKNESS Kiso to Rinsho. Clinical Report. [chem.nlm.nih.gov]
Overdose symptoms may include confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, and muscle weakness or limp feeling. What should I avoid while taking lactulose? Avoid using antacids without your doctor's advice. [rxlist.com]
- Muscle Cramp
If you experience any of the following symptoms, stop taking the medicine and call your doctor immediately: Abdominal pain Muscle cramps Dizziness Weakness Emergency medical help is required if you have any of the signs of an allergic reaction, such as [enkivillage.com]
Contact your doctor right away if you develop any of the following symptoms of dehydration : muscle weakness, muscle cramps, dizziness. [webmd.com]
If you have stomach pain, vomiting, muscle cramps, dizziness or weakness, stop taking the lactulose and call your doctor right away. [he123.liverfoundation.org]
Neurologic
- Encephalopathy
These effects reduce blood ammonia level in portal-system encephalopathy. [medical-dictionary.thefreedictionary.com]
Comparative modes of action of lactitol and lactulose in the treatment of hepatic encephalopathy. [doi.org]
As lactitol and lactulose have similar effects within the colon, lactitol would appear to have a role in the treatment of hepatic encephalopathy. [ncbi.nlm.nih.gov]
- Confusion
Some symptoms include poor memory, confusion, sleepiness, being awake during the night and sleeping during the day, irritability and tremor. Encephalopathy is most commonly a complication of cirrhosis but can also occur in some other conditions. [gitract.mngastro.com]
Overdose symptoms may include confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, and muscle weakness or limp feeling. What should I avoid while taking lactulose? Avoid using antacids without your doctor's advice. [uofmhealth.org]
Grade 3 disease was present in 33% of patients (gross disorientation, confusion, bizarre behavior, asterixis usually absent, somnolence or stupor), and 48% had grade 4 disease (coma). [dynamed.com]
- Tremor
Some symptoms include poor memory, confusion, sleepiness, being awake during the night and sleeping during the day, irritability and tremor. Encephalopathy is most commonly a complication of cirrhosis but can also occur in some other conditions. [gitract.mngastro.com]
Lactulose is sometimes used to treat or prevent certain conditions of the brain that are caused by liver failure, which can lead to confusion, problems with memory or thinking, behavior changes, tremors, feeling irritable, sleep problems, loss of coordination [uofmhealth.org]
- Ataxia
In this study, two trehalase analogs, lactulose and melibiose, were examined for their potentials in spinocerebellar ataxia treatment. [ncbi.nlm.nih.gov]
Vol. 7, Pg. 3517, 1973. rabbit LDLo oral 24gm/kg (24000mg/kg) BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: MUSCLE WEAKNESS Kiso to Rinsho. Clinical Report. [chem.nlm.nih.gov]
- Asthenia
Random, 95% CI) 2.20 [1.06, 4.54] 4.4 Nausea 4 104 Risk Ratio (IV, Random, 95% CI) 3.20 [0.76, 13.43] 4.5 Hyponatraemia 1 25 Risk Ratio (IV, Random, 95% CI) 3.23 [0.14, 72.46] 4.6 Abdominal pain 3 91 Risk Ratio (IV, Random, 95% CI) 0.95 [0.47, 1.91] 4.7 Asthenia [doi.org]
Treatment
In accordance with previous studies, a low encopresis frequency and a short period of treatment before enrolment were associated with successful treatment outcome. 18 A longer period of treatment suggests an early age of onset of constipation, indicating [doi.org]
Prognosis
BACKGROUND & AIMS: Minimal hepatic encephalopathy is associated with poor prognosis and mortality in patients with cirrhosis. [ncbi.nlm.nih.gov]
MHE can also lead to the development of more severe HE, and can be associated with a poor prognosis. Led by Radha K. [news-medical.net]
Etiology
Demographics: Age 40.4 years, male sex 75% Etiology of liver disease: Alcohol 63.4%, HBV 15.9%, HCV 4.8%, other 15.9% Baseline laboratory data: Hgb 8.1 g/dL, platelets 83,560, bilirubin 4.9 mg/dL, albumin 2.5 g/dL, AST 62.9 IU/L, ALT 68.1 IU/L, alk phos [wikijournalclub.org]
Altered mental status in cirrhosis: etiologies and outcomes. J Investig Med. 2013;61(4):695-700. PubMed Google Scholar 13. Colli A, Fraquelli M, Andreoletti M, Marino B, Zuccoli E, Conte D. [jamanetwork.com]
Epidemiology
Gastroenterology. 1990 Feb;98(2):353-60. [ PubMed:2295390 ] Goto K, Chew F, Torun B, Peerson JM, Brown KH: Epidemiology of altered intestinal permeability to lactulose and mannitol in Guatemalan infants. [hmdb.ca]
Spiegel, Questioning the Bacterial Overgrowth Hypothesis of Irritable Bowel Syndrome: An Epidemiologic and Evolutionary Perspective, Clinical Gastroenterology and Hepatology, 9, 6, (461), (2011). [doi.org]
Epidemiology of altered intestinal permeability to lactulose and mannitol in Guatemalan infants. Journal of Pediatric Gastroenterology and Nutrition, 28: 282-290. [ Links ] Correspondence and Footnotes Address for correspondence: A.A.M. [scielo.br]
Pathophysiology
Abstract It has been known that the pathophysiology of carbon monoxide (CO) poisoning is related to hypoxia, the increased production of reactive oxygen species (ROS) and oxidative stress. [ncbi.nlm.nih.gov]
Liver Pathophysiology, 10.1016/B978-0-12-804274-8.00053-9, (743-759), (2017). [doi.org]
Prevention
Lactulose versus lactitol for the prevention and treatment of hepatic encephalopathy in people with cirrhosis Lactulose versus lactitol for the prevention and treatment of hepatic encephalopathy in people with cirrhosis Population: prevention and treatment [doi.org]
Lactulose is effective for prevention of recurrence of HE in patients with cirrhosis. [ncbi.nlm.nih.gov]
Dosage Professional Interactions Pregnancy More Introduction A synthetic derivative of lactose; an ammonia detoxicant and laxative. 1 2 Uses for Lactulose Portal-Systemic Encephalopathy Used as an adjunct to protein restriction and supportive therapy for prevention [drugs.com]
Constulose, Enulose, Generlac, Kristalose Introduction A synthetic derivative of lactose; an ammonia detoxicant and laxative. 1 2 Uses for Lactulose Portal-Systemic Encephalopathy Used as an adjunct to protein restriction and supportive therapy for prevention [web.archive.org]