Three cases of Larsen's syndrome in siblings are presented to illustrate a paradigm for the age-related treatment of deformity. Each child presented at a different age, with differing degrees of deformity and growth disturbance. [ncbi.nlm.nih.gov]

• Periodontitis

  We report here advanced periodontitis with severe gingival inflammation in a 29-year-old Larsen's syndrome patient. Bacterial culture of subgingival plaque identified the periodontal pathogens that were present in numbers above the normal range. [ncbi.nlm.nih.gov]

• Short Nails

  […] distal phalanx of finger Short outermost finger bone 0009882 Short nail Short nails 0001799 30%-79% of people have these symptoms Accessory carpal bones 0004232 5%-29% of people have these symptoms Abnormality of epiphysis morphology Abnormal shape of [rarediseases.info.nih.gov]

  […] of spinal segmentation 29. short terminal phalanges 30. abnormal vertebrae 31. acid reflux 32. gastorial reflux 33. burr holes 34. stomach problems 35. intestinal problems 36. learning disabilities (ADHD, Dyslexia) 37. short nails 38. multiple carpal [tawnymullins77.blogspot.com]

  […] metacarpals cylindric fingers supernumerary carpal bones Skin Nails Hair Nails: short nails Growth Height: short stature (final adult height less than 152cm) Head And Neck Nose: depressed nasal bridge Chest External Features: pectus carinatum pectus [malacards.org]

  nails – – – – – – – Airway abnormality – – – – – – – Cardiac defect – – – – – – – Cryptorchidism – – NA – – NA – Spinal cord compression – – – – – – – Skeletal phenotype Short stature – – – – + + – Joint laxity + + + + + + + Cylindrical fingers – + + [bmcmedgenet.biomedcentral.com]

Special features in the radiologic workup should be sought after so as to plan staged surgical procedures. Conventional principles of planning of fusion levels are inadequate. Early treatment is advocated, as the neurologic compromise is reversible. [ncbi.nlm.nih.gov]

Neither the natural history nor the optimal treatment of cervical spine anomalies in Larsen's syndrome has been clearly defined. [ncbi.nlm.nih.gov]

Make informed clinical choices for each patient, from diagnosis and treatment selection through post-treatment strategies and management of complications, with new evidence-based criteria throughout. [books.google.com]

Prognosis LS does not affect life-expectancy. The documents contained in this web site are presented for information purposes only. [orpha.net]

Prognosis The effects of the syndrome vary markedly from person to person. Therefore, prognosis is based on the findings in a given individual. [encyclopedia.com]

The prognosis of children who have LS is variable and most affected persons have moderate symptoms that can be treated, allowing for a relatively normal life span. In severe forms of LS the prognosis can be poor. [jcnonweb.com]

What is the general prognosis for Larsen Syndrome? If Larsen Syndrome is caught early, most individuals can lead healthy lives with normal lifespans. [checkorphan.org]

[ edit ] While Larsen syndrome can be lethal if untreated, the prognosis is relatively good if individuals are treated with orthopedic surgery, physical therapy, and other procedures used to treat the symptoms linked with Larsen syndrome. [7] See also [en.wikipedia.org]

These novel congenital anomalies further support the etiology of Larsen's syndrome as a generalized mesenchymal disorder, since they arise from a defective process of embryonal induction involving mesenchymal tissue. [ncbi.nlm.nih.gov]

Their etiology is not precisely century with the first clinical recognition of known, so we have included chapters that dis symptoms and patterns for diagnosis of car cuss many aspects of congenital cardiac mal diovascular diseases. [books.google.com]

Etiology LS is due to missense mutations or small in-frame deletions in the FLNB gene (localized to 3p14.3) that encodes cytoskeletal protein filamin B. [orpha.net]

Its Etiology and Natural History’, Journal of Bone & Joint Surgery, December 1978, vol. 60, no. 8, p. 1113-1116. [physio-pedia.com]

M92.61 - Juvenile osteochondrosis of tarsus, right ankle M92.62 - Juvenile osteochondrosis of tarsus, left ankle Sindig-Larsen-Johansson Disease ICD-9 732.4 (juvenile osteochondrosis of the lower extemity, exlcuding foot) Sindig-Larsen-Johansson Disease Etiology [eorif.com]

Summary Epidemiology The birth prevalence of Larsen syndrome in Europe is 1/250,000 live births. [orpha.net]

Juvenile osteochondrosis of tarsus, right ankle M92.62 - Juvenile osteochondrosis of tarsus, left ankle Sindig-Larsen-Johansson Disease ICD-9 732.4 (juvenile osteochondrosis of the lower extemity, exlcuding foot) Sindig-Larsen-Johansson Disease Etiology / Epidemiology [eorif.com]

[…] anterior knee pain at the inferior pole of patella at the proximal patella tendon attachment similar to Osgood-Schlatter's disease which is at the distal attachment of the patella tendon differnt from Jumper's Knee which is tendonitis of the patella tendon Epidemiology [orthobullets.com]

Epidemiology Larsen's syndrome with the same frequency develops both in men and in women. By very rough estimates, this disease occurs in a newborn of a hundred thousand. This, fortunately, is a rarity. [acikgunluk.net]

Epidemiology Frequency United States The incidence is not known. International The prevalence is estimated to be 0.4 cases per 100,000 people in Sweden. [19] The prevalence elsewhere is not known. [emedicine.medscape.com]

[…] which is at the distal attachment of the patella tendon differnt from Jumper's Knee which is tendonitis of the patella tendon Epidemiology demographics more common in adolescence Location patellar tendon insertion at the inferior pole of the patella Pathophysiology [orthobullets.com]

Pathophysiology Osteochondroses all involve a defect in ossification. [patient.info]

Tracheomalacia and bronchomalacia in children: Pathophysiology, assessment, treatment and anaesthesia management. Paediatr Anaesth 2003;13:3-11. 6. Saricaoglu F, Dal D. Cardiac arrest in a patient with Larsen syndrome under sevoflurane anesthesia. [joacp.org]

The ichthyosis (usually evident at birth) may be seen in some patients after the first year of life. [1] Pathophysiology Sjögren-Larsson syndrome (SLS) is due to deficient activity of fatty aldehyde dehydrogenase (FALDH), an enzyme required to oxidize [emedicine.medscape.com]

The surgeon who undertakes the correction or prevention of these deformities must face the problem of and, it is hoped, use, growth potential from open physes and the progressive loss of remodeling capacity with advancing age. [ncbi.nlm.nih.gov]

How Can You Prevent SLJ Syndrome? The most important thing you can do to prevent getting SLJ is to stop doing an activity that causes pain in your knee at the first signs of irritation. Then, try to limit your activity until the pain goes away. [kidshealth.org]

Learn more about how to prevent ACL injuries with our ACL Injury Prevention Program A discoid meniscus is an abnormality of the structure of the meniscus. [childrensortho.com]