In this report, a late onset depression was the initial presentation of SREAT in a middle aged patient, something rarely described before, indicating the need to suspect SREAT as a possible etiology for depression in this age group. [ncbi.nlm.nih.gov]

• Fatigue

  Energy Normal energy level, but reduced activity due to poor initiation related to fatigue. Executive. Subacute decrease in energy and increased complaints of fatigue. [moodclinic.com.au]

  The Genetic and Environmental Structure of the Covariation Among the Symptoms of Insomnia, Fatigue, and Depression in Adult Females. Twin Res Hum Genet. 2012; 15 (6):1-7 19. Nakao M, Yano E. [medsci.org]

  Although not as severe as those of major depression, symptoms of persistent depressive disorder also include the presence of two (or more) of the following: Feelings of hopelessness Low self-esteem Low energy or fatigue Poor appetite or overeating Difficulty [my.clevelandclinic.org]

  Decreased ability to care for self Physical symptoms: Significant change in appetite or weight Psychomotor retardation Physical pains without any discernable reason Gastrointestinal symptoms Headaches Multiple diffuse symptoms Insomnia or hypersomnia Fatigue [valleybehavioral.com]

  Fatigue, lack of energy. Poor self-esteem. Difficulty with concentration or decision making. Feeling hopeless. C. A person has not been free of the symptoms during the two-year time period (one-year for children and adolescents). D. [allaboutdepression.com]

• Weight Loss

  loss and a suppressed appetite (P less than .007), fewer feelings of worthlessness (P .01), less diminished concentration (P .04), and fewer thoughts of death (P less than .001). [mdedge.com]

  loss or weight gain Decrease in sexual urge Behavioral Symptoms: Becoming withdrawn socially; avoiding social interactions Becoming slow in movements Losing interest in maintaining personal hygiene or grooming Decrease in the abilities to function in [sen.ust.hk]

  Longer duration of symptoms, a personal history of depressive episodes, a serious suicide attempt, childhood events, a family history of depression, and high neuroticism are more often present in EOD, whereas decreased appetite/weight loss is more prominent [jmedsoc.org]

  Megestrol acetate and mirtazapine for the treatment of unplanned weight loss in the elderly. Pharmacotherapy. 2009;29(4):383–397. 74. Jung Y, Jun T, Kim K, Bahk W. [dovepress.com]

  Anxiety and depressive ideation as well as retardation and weight loss are significantly associated with impairment in instrumental activities of daily living. [ncbi.nlm.nih.gov]

• Weight Gain

  The authors found, using a continuous age of onset indicator ranging from 4 to 64 years and adjusting for socio-demographic factors, late onset depression was associated with less sadness (P less than .001), less weight gain and fewer increases in appetite [mdedge.com]

  Side effects include weight gain and sedation due to histamine receptor effects. [statpearls.com]

  gain Decrease in sexual urge Behavioral Symptoms: Becoming withdrawn socially; avoiding social interactions Becoming slow in movements Losing interest in maintaining personal hygiene or grooming Decrease in the abilities to function in their academic [sen.ust.hk]

• Malaise

  Parental characteristics included mother's internalizing symptoms, which were assessed with the Rutter Malaise Inventory34 when the study members were ages 5, 7, and 9 years. [jamanetwork.com]

• Pulmonary Disorder

  disorder; interleukin 10; late onset depression; polymerase chain reaction; single nucleotide polymorphism [ncbi.nlm.nih.gov]

• Increased Appetite

  The most important symptoms elevating the risk of late-onset depression in a multivariate model were lack of joy and interest, poor concentration, increased appetite, lack of energy and joint pain. [ncbi.nlm.nih.gov]

  Common side effects include sedation, increased appetite causing weight gain, dry mouth, and constipation. Noradrenergic effects are more pronounced over the anti-histaminergic effects at higher dosages and thus lower sedative effects. [statpearls.com]

• Loss of Appetite

  Loss of appetite: This symptom is also difficult to assess, especially in individuals living in circumstances whereby the quality of food may be low. On the other hand, true loss of appetite may mistakenly be attributed to low quality of food. [ncbi.nlm.nih.gov]

  - Loss of appetite : This symptom is also difficult to assess, especially in individuals living in circumstances whereby the quality of food may be low. [annals-general-psychiatry.biomedcentral.com]

• Suicidal Ideation

  We used PHQ-9 item #9 as our measure of suicidal ideation. [tandfonline.com]

  The researchers also examined suicidal ideation in the mood disorder patients at baseline. Just one patient experienced suicidal ideation, and that patient didn’t have any worsening of suicidal ideation throughout the course of the study. [mdmag.com]

  Here it is imperative to inquire about any homicidal or suicidal ideations/plans. The clinician should always ask the patient about access to firearms. Conduct neuropsychological testing if needed. [statpearls.com]

  Firstly, treatment outcome and suicidal ideations assessed in previous studies relate to the index episode and not exclusively to the first episode as in the present study. [ncbi.nlm.nih.gov]

• Psychomotor Retardation

  Measures of depression severity, psychomotor retardation, verbal and visual memory and vascular and specific genetic risk factors were collected. [ncbi.nlm.nih.gov]

  CONCLUSION: We concluded that early onset depression patients have more severe psychomotor retardation and general somatic symptoms than late onset depression patients in Korea. [koreamed.org]

  retardation, poor executive function on cognitive testing, less depressive thinking (such as guilt or unworthiness), and a late age at onset. [jmedsoc.org]

  retardation Physical pains without any discernable reason Gastrointestinal symptoms Headaches Multiple diffuse symptoms Insomnia or hypersomnia Fatigue or reduction in energy Changes in the structure and functioning of the brain Cognitive symptoms: Thoughts [valleybehavioral.com]

• Feeling of Worthlessness

  RESULTS AND CONCLUSION: Low spirits and feelings of worthlessness were more frequently found in EOD, they were sufficient discriminators to distinguish elderly subjects with EOD and LOD. [ncbi.nlm.nih.gov]

  […] of worthlessness (P .01), less diminished concentration (P .04), and fewer thoughts of death (P less than .001). [mdedge.com]

  The questions are designed to test the mood, energy level, loss of interest in pleasurable activities, guilt feelings, hopelessness, worthlessness, and suicidal ideations. Each question gets a score of 0 or 1 points. [statpearls.com]

  […] of worthlessness or inappropriate guilt; and recurrent thoughts of death or suicidal ideation. [dovepress.com]

• Sleep Disturbance

  disturbance Decrease or increase in appetite Unusual weight loss or weight gain Decrease in sexual urge Behavioral Symptoms: Becoming withdrawn socially; avoiding social interactions Becoming slow in movements Losing interest in maintaining personal [sen.ust.hk]

  Symptoms such as psychosis, sleep disturbance, and aggressiveness can be confused with dementia or depressive disorder, according to an article in Primary Psychiatry. [healthline.com]

  The common side effects include gastrointestinal distress (nausea, diarrhea), anxiety, and sleep disturbance.[17] Serotonin-norepinephrine reuptake inhibitors (SNRI): These are considered as the second-line treatment and include venlafaxine, desvenlafaxine [statpearls.com]

  disturbance (increased or decreased sleep) Appetite disturbance (increased or decreased appetite) typically with weight change Energy disturbance (increased or decreased energy/activity level), usually fatigue Poor memory or concentration Feelings of [en.wikipedia.org]

  Both smoking and alcohol use are the risk factors of LLD.18 In addition, the use of sleep medication has been linked to LLD, but sleep disturbance in general is a risk factor for LLD.35 Screening In the following text, we only discuss screening tools [dovepress.com]

• Difficulty Concentrating

  Depression can result in irritation, withdrawal, social isolation, feelings of guilt, difficulty concentrating, a lack of energy and self-harm. [senexpertsolicitors.co.uk]

  concentrating or remembering changing habits thinking of or attempting suicide If you think someone is at immediate risk of self-harm or hurting another person: Call 911 or your local emergency number. [healthline.com]

  Symptoms can include feelings of despair or guilt, sadness, fatigue, difficulty concentrating, changes in appetite, and thoughts of suicide or of harming the baby. [nysenate.gov]

• Motor Symptoms

  PURPOSE: Lewy body disease (LBD) is comprised of a spectrum of diseases that includes Parkinson's disease (PD), PD dementia (PDD) and dementia with LBD (DLBD), an array of dementia, and motor symptoms. [ncbi.nlm.nih.gov]

  The frequency and severity of each NMS was evaluated by Non-Motor Symptom Scale (NMSS), which consists of 9 subdomains. [pubfacts.com]

  She had a long history of epilepsy and headache, epilepsy consisting of both partial and generalized seizures, simple partial seizures presenting with motor symptoms and causing jerking movements of the foot, face, arm and complex partial seizures showing [dovepress.com]

• Akinesia

  When both groups were matched for duration of the disease, the early-onset group still showed a significantly higher frequency of depression, whereas tremor, akinesia, and rigidity were significantly more severe in the late-onset group. [neurology.org]

  Changes are characterized by indifference, apathy, reduced sexuality, akinesia, loss of initiative and crying. [dovepress.com]

Physical examination to rule out any medical or neurological disorder should be part of the total workup. [statpearls.com]

• White Matter Lesions

  Therefore, we wished to investigate the relationship between age of first depression onset and hippocampal volume, with adjustment for subcortical white matter lesions. [ncbi.nlm.nih.gov]

  Some white matter lesions may be vascular in origin. [research.manchester.ac.uk]

• Gliosis

  Neuropathological evaluation included bilateral semi-quantitative assessment of lacunes, deep white matter and periventricular demyelination, cortical microinfarcts and both focal and diffuse gliosis. [ncbi.nlm.nih.gov]

Multivariate analysis showed that treatment with tricyclic or tetracyclic antidepressants, atypical antipsychotics were associated with prolonged LOHS. [ncbi.nlm.nih.gov]

Further research is warranted to ascertain the link between late-onset depression, neuropsychological deficits and prognosis. Copyright 2010 John Wiley & Sons, Ltd. [ncbi.nlm.nih.gov]

This will give us a better understanding of the connection between brain changes, neuropsychology and depression prognosis, which is decisive for accurate diagnostics, effective treatment and targeted prevention of the disease in the long run. [clinicaltrials.gov]

In fact for every medical illness studied, e.g. heart disease, diabetes, cancer, individuals who are depressed have a worse prognosis. [books.google.com]

Millard proposed the 'rule of thirds' concerning the prognosis of geriatric depression [ 114 ]. [annals-general-psychiatry.biomedcentral.com]

In this report, a late onset depression was the initial presentation of SREAT in a middle aged patient, something rarely described before, indicating the need to suspect SREAT as a possible etiology for depression in this age group. [ncbi.nlm.nih.gov]

Various theories have been postulated to elucidate the etiology of late onset depression, but a unifying hypothesis is lacking. [go.gale.com]

These data suggest that depression in patients with early-onset PD may have a different etiology than in patients with late-onset PD. 1989 by the American Academy of Neurology AAN Members: Sign in with your AAN member credentials (e-mail or 6-digit Member [neurology.org]

Emerging data suggest that late-onset depression is a distinct entity with a pathophysiology, etiology, trajectory and treatment response different from adult MDD. [isctm.org]

OBJECTIVES: In this paper we review clinical, epidemiological, structural neuroimaging and genetic investigations of late life depression that have been performed over the past two decades and offer evidence that LOD is often a prodromal disorder for [ncbi.nlm.nih.gov]

[sup][2] The prevalence of either a major depressive episode or dysthymia in the epidemiologic catchment area survey was 2.5% in the geriatric age group. [go.gale.com]

This is the first volume devoted to the epidemiology, phenomenology, psychobiology, treatment and consequences of late-life depression. [books.google.com]

Patients who scored 16 on the Center for Epidemiologic Studies Depression Scale (CES-D) and/or were currently taking antidepressant medication specifically for the treatment of depression were considered to have depressive symptoms. [psychiatryadvisor.com]

CONCLUSIONS: Our findings suggest that loss of white matter integrity in parahippocampal gyrus may be associated with the pathophysiology of LOD, and thus highlight the limbic contribution to the pathophysiology of LOD. Copyright 2014 Elsevier B.V. [ncbi.nlm.nih.gov]

These differential findings are important factors to keep in mind for diagnostics, treatment, and prevention. Copyright 2012 Elsevier B.V. All rights reserved. [ncbi.nlm.nih.gov]