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Late-onset Depression

Depression Senile


Presentation

  • In this report, a late onset depression was the initial presentation of SREAT in a middle aged patient, something rarely described before, indicating the need to suspect SREAT as a possible etiology for depression in this age group.[ncbi.nlm.nih.gov]
Progressive Dementia
  • CONCLUSIONS: Primary progressive dementia and early-onset depression represent clinical entities with distinct inheritance.[ncbi.nlm.nih.gov]
Coronary Atherosclerosis
  • In both patients and controls, WML volume was associated with carotid but not with coronary atherosclerosis.[ncbi.nlm.nih.gov]
Pulmonary Disorder
  • disorder; interleukin 10; late onset depression; polymerase chain reaction; single nucleotide polymorphism[ncbi.nlm.nih.gov]
Motor Symptoms
  • PURPOSE: Lewy body disease (LBD) is comprised of a spectrum of diseases that includes Parkinson's disease (PD), PD dementia (PDD) and dementia with LBD (DLBD), an array of dementia, and motor symptoms.[ncbi.nlm.nih.gov]
  • The frequency and severity of each NMS was evaluated by Non-Motor Symptom Scale (NMSS), which consists of 9 subdomains.[pubfacts.com]
  • She had a long history of epilepsy and headache, epilepsy consisting of both partial and generalized seizures, simple partial seizures presenting with motor symptoms and causing jerking movements of the foot, face, arm and complex partial seizures showing[dovepress.com]
Akinesia
  • When both groups were matched for duration of the disease, the early-onset group still showed a significantly higher frequency of depression, whereas tremor, akinesia, and rigidity were significantly more severe in the late-onset group.[neurology.org]
  • Changes are characterized by indifference, apathy, reduced sexuality, akinesia, loss of initiative and crying.[dovepress.com]

Workup

Hypercholesterolemia
  • Smoking and hypercholesterolemia was positively associated with the BDNF (t 2.36, P 0.023) and VEGF levels (t 2.28, P 0.028), respectively.[ncbi.nlm.nih.gov]
White Matter Lesions
  • Therefore, we wished to investigate the relationship between age of first depression onset and hippocampal volume, with adjustment for subcortical white matter lesions.[ncbi.nlm.nih.gov]
  • Some white matter lesions may be vascular in origin.[research.manchester.ac.uk]
Gliosis
  • Neuropathological evaluation included bilateral semi-quantitative assessment of lacunes, deep white matter and periventricular demyelination, cortical microinfarcts and both focal and diffuse gliosis.[ncbi.nlm.nih.gov]

Treatment

  • NIRS is a simple technique that can be used before treatment to evaluate the social functioning levels of patients with LOD, and predict social functioning improvement after treatment. Copyright 2015 Elsevier Ltd. All rights reserved.[ncbi.nlm.nih.gov]

Prognosis

  • Further research is warranted to ascertain the link between late-onset depression, neuropsychological deficits and prognosis. Copyright 2010 John Wiley & Sons, Ltd.[ncbi.nlm.nih.gov]
  • This will give us a better understanding of the connection between brain changes, neuropsychology and depression prognosis, which is decisive for accurate diagnostics, effective treatment and targeted prevention of the disease in the long run.[clinicaltrials.gov]
  • In fact for every medical illness studied, e.g. heart disease, diabetes, cancer, individuals who are depressed have a worse prognosis.[books.google.com]
  • Millard proposed the 'rule of thirds' concerning the prognosis of geriatric depression [ 114 ].[annals-general-psychiatry.biomedcentral.com]
  • ., Peters, K. et al ( 1993 ) Prognosis of depression in the elderly. A comparison with younger patients. British Journal of Psychiatry, 163, 589 – 596. Brodaty, H., Luscombe, G., Gordon, P. et al ( 2001 ) Early and late onset depression in old age.[apt.rcpsych.org]

Etiology

  • In this report, a late onset depression was the initial presentation of SREAT in a middle aged patient, something rarely described before, indicating the need to suspect SREAT as a possible etiology for depression in this age group.[ncbi.nlm.nih.gov]
  • These data suggest that depression in patients with early-onset PD may have a different etiology than in patients with late-onset PD. 1989 by the American Academy of Neurology AAN Members: Sign in with your AAN member credentials (e-mail or 6-digit Member[neurology.org]
  • Etiology Early onset and late onset depression (EOD and LOD) are similar phenotypically, but differ etiologically. [11] Various factors have been proposed as explanations for the onset of depression in early or later life.[jmedsoc.org]
  • A. ( 1994 ) Clinical and etiological heterogeneity of mood disorders in elderly patients. In Diagnosis and Treatment of Depression in Late Life: Results of the NIH Consensus Development Conference (eds Lon, S., Schneider, M. D., Reynolds, C.[apt.rcpsych.org]

Epidemiology

  • OBJECTIVES: In this paper we review clinical, epidemiological, structural neuroimaging and genetic investigations of late life depression that have been performed over the past two decades and offer evidence that LOD is often a prodromal disorder for[ncbi.nlm.nih.gov]
  • This is the first volume devoted to the epidemiology, phenomenology, psychobiology, treatment and consequences of late-life depression.[books.google.com]
  • Patients who scored 16 on the Center for Epidemiologic Studies Depression Scale (CES-D) and/or were currently taking antidepressant medication specifically for the treatment of depression were considered to have depressive symptoms.[psychiatryadvisor.com]
  • This review attempts to summarize the current status of evidence regarding epidemiology, etiology, clinical features, and treatment options available for late-onset depression.[jmhhb.org]
  • PubMed Google Scholar Moscicki EK: Epidemiology of Suicide-North American Perspectives. International Psychogeriatrics. 1995, 7: 137-148.[annals-general-psychiatry.biomedcentral.com]
Sex distribution
Age distribution

Pathophysiology

  • CONCLUSIONS: Our findings suggest that loss of white matter integrity in parahippocampal gyrus may be associated with the pathophysiology of LOD, and thus highlight the limbic contribution to the pathophysiology of LOD. Copyright 2014 Elsevier B.V.[ncbi.nlm.nih.gov]

Prevention

  • These differential findings are important factors to keep in mind for diagnostics, treatment, and prevention. Copyright 2012 Elsevier B.V. All rights reserved.[ncbi.nlm.nih.gov]

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