Left ventricular hypertrophy (LVH) is essentially an increase in myocardial mass. The most common cause is hypertension. Current evidence indicates that if untreated, LVH has high morbidity and mortality from heart disease and stroke.
Presentation
Most patients with mild or moderate LVH have no symptoms. However, if the LVH is severe there may present with:
The symptoms usually occur after chronic LVH has developed. In many cases, the symptoms may be of the primary disorder that has caused the LVH.
Entire Body System
- Coarctation of the Aorta
The work-up of a previously asymptomatic 72-year-old man presenting with sudden cardiac death revealed a coarctation of the aorta as the cause of arterial hypertension, severe left ventricular hypertrophy, in combination with coronary artery disease with [ncbi.nlm.nih.gov]
[…] of the aorta Hypertrophic cardiomyopathy Handy Tips Voltage criteria alone are not diagnostic of LVH ECG changes are an insensitive means of detecting LVH (patients with clinically significant left ventricular hypertrophy seen on echocardiography may [lifeinthefastlane.com]
Left ventricular hypertrophy (LVH) The most common causes of left ventricular hypertrophy are aortic stenosis, aortic regurgitation (insufficiency), hypertension, cardiomyopathy and coarctation of the aorta. [ecgwaves.com]
- Abdominal Obesity
Rodilla E, Costa JA, Martín J, González C, Pascual JM, et al. (2014) Impact of abdominal obesity and ambulatory blood pressure in the diagnosis of left ventricular hypertrophy in never treated hypertensives. Med Clin (Barc) 142: 235-242. [omicsgroup.org]
- Coronary Atherosclerosis
Second, hypertension promotes the development of coronary artery atherosclerosis, which increases the risk for an acute myocardial infarction, with subsequent systolic dysfunction and congestive heart failure. [heart.bmj.com]
Respiratoric
- Dyspnea
And this result could explain that the patients with exertional dyspnea are more common in LVH group. [ncbi.nlm.nih.gov]
Cardiovascular
- Heart Disease
[…] that reversing LVH also leads to improved survival or decreased risk of heart disease. [symptoma.com]
A definite pattern even when unassociated with coronary heart disease, congestive heart failure, or rheumatic heart disease resulted in mortality of 59% within 12 years. [annals.org]
- Cardiomegaly
[…] factors for LVH and cardiomegaly; 3) develop prediction models and/or screening algorithms; and 4) validate the models and/or screening algorithms. [hsph.harvard.edu]
[…] of left ventricle, Cardiomegaly of left ventricle (disorder), VENTRICULAR HYPERTROPHY, LEFT, LEFT VENTRICULAR HYPERTROPHY, LV hypertrophy, LVH - Left ventricular hypertrophy, Left ventricular hypertrophy, LV+ - Left ventricular hypertrophy, Left ventricular [fpnotebook.com]
2015 ICD-9-CM Diagnosis Code 429.3 Cardiomegaly 2015 Billable Thru Sept 30/2015 Non-Billable On/After Oct 1/2015 ICD-9-CM 429.3 is a billable medical code that can be used to indicate a diagnosis on a reimbursement claim, however, 429.3 should only be [icd9data.com]
Cardiomegaly Ventricular hypertrophy Primary hyperparathyroidism [en.wikipedia.org]
- Left Ventricular Dysfunction
Tako-tsubo-like cardiomyopathy is a newly-recognized enigmatic disease characterized by transient left ventricular dysfunction of a broad area of the apex with a hyperkinetic area around the cardiac base. [ncbi.nlm.nih.gov]
Ventricular Dysfunction (SOLVD) investigators suggests that black patients with left ventricular dysfunction do not respond well to ACE inhibitors, especially if they have a past history of hypertension. 17 Limited data on LVH regression and other hypertensive [circ.ahajournals.org]
Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction: results of the survival and ventricular enlargement trial. [books.google.it]
Acute myocardial infarction can cause left ventricular dysfunction, which can cause backup pressure to the left atrium. [ecgguru.com]
McKelvie RS et al (1999) Comparison of candesartan, enalapril, and their combination in congestive heart failure: randomized evaluation of strategies for left ventricular dysfunction (RESOLVD) pilot study. The RESOLVD Pilot Study Investigators. [doi.org]
Urogenital
- Renal Insufficiency
Causes: Renal insufficiency Medication Blood transfusion, Massive hemolysis Addison's disease congenital adrenal hyperplasia Burns,necrosis,tumor lysis syndrome Potassium containg dietary supplements 17. [slideshare.net]
Garg AX, Clark WF, Haynes RB, House AA: Moderate renal insufficiency and the risk of cardiovascular mortality: results from the NHANES I. Kidney Int 2002;61:1486-1494. [karger.com]
Cardiovascular Disease in Chronic Renal Insufficiency. Am J Kidney Dis 2000; 36:24-30. 17. Dikow R, Adamczak M, Henriquez E, Ritz E. Strategies to decrease cardiovascular mortality in patients with end-stage renal disease. [bjn.org.br]
- Kidney Failure
Failure, Chronic/blood Kidney Failure, Chronic/therapy* Male Middle Aged Mitochondrial Proteins/blood* Muscle Proteins/blood* Natriuretic Peptide, Brain/blood Peptide Fragments/blood Renal Dialysis/adverse effects* Risk Factors Substances Biomarkers [ncbi.nlm.nih.gov]
Am J Kidney Dis 2001; 38:1271-6. 22. Perianayagam MC, Murray SL, Balakrishnan VS et al. Serum soluble Fas (CD95) and Fas ligand profiles in chronic kidney failure. J Lab Clin Med 2000; 136:320-7. 23. Berl T, Henrich W. [bjn.org.br]
Neurologic
- Confusion
One of the most confusing ST-elevation mimics for paramedics is the “strain pattern†(or repolarization abnormality) occasionally found with left ventricular hypertrophy. [ems12lead.com]
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At present, 37 different ECG criteria have been endorsed by the American Heart Association, a figure that suggests lack of consensus and often leads to confusion among clinicians (3,4). [onlinejacc.org]
As depicted above, each regression equation was derived based on a specific border limits convention, an issue that is source of great confusion when interpreting different studies [ 20 ]. [cardiovascularultrasound.biomedcentral.com]
Workup
The diagnosis of LVH is usually initially based on the ECG and the following criteria have been established.
Cornell product:
- S in V3 and R in aVL >24 mm (men) and 20 mm (women)
Sokolow Lyon voltage:
- S in V1 and R in V5 or V6 = or > 35 mm
- R in AVL = or > to 11 mm
There may be repolarization changes such as QRS prolongation, left axis deviation and left ventricular strain and left atrial enlargement. LVH based on ECG is often underdiagnosed in patients with obesity, pectus deformity and chronic obstructive pulmonary disease (COPD). It is important to note that there is very poor correlation between ECG and left ventricular mass. However ECG is inexpensive, accessible and is ideal for high risk patients with ischemic heart disease and hypertension. The technique can also assess for presence of Q waves, arrhythmias, and left bundle branch block.
Echocardiography is the procedure of choice to asses left ventricular mass. In addition the technique can also assess for systolic and diastolic dysfunction, left atrial size, function of valves, presence of blood clots and ejection fraction.
The gold standard test to examine left ventricle mass is the cardiac MRI [8]. It does not require any contrast and does not use radiation. The technique can also assess left atrium size, function of valves and ventricular function and it can determine other causes of left ventricular hypertrophy and provide prognostic information [9] [10]. Downside of cardiac MRI is expense and lack of availability.
In general the following patients should have an echocardiography or cardiac MRI:
- Symptomatic patients
- Signs of CHF
- Presence of hypertension
- Concern for congenital hypertrophic cardiomyopathy
- Presence of other risk factors for LVH
- ECG evidence of LVH
Axis
- Left Axis Deviation
Left axis deviation 2 points QRS duration 0.09 sec 1 point Delayed intrinsicoid deflection in V5 or V6 (>0.05 sec) 1 point CORNELL Voltage Criteria for LVH (sensitivity = 22%, specificity = 95%) S in V3 + R in aVL > 24 mm (men) S in V3 + R in aVL > 20 [ecg.utah.edu]
Left axis deviation. Severe LVH such as this appears almost identical to left bundle branch block — the main clue to the presence of LVH is the excessively high LV voltages. [lifeinthefastlane.com]
P mitrale – Left atrial enlargement ( P mitrale ) may develop because LVH affects the hemodynamics of the left atrium. Left axis deviation – is common in LVH. QT prolongation – A slight prolongation of the QT (QTc) interval is frequently seen. [ecgwaves.com]
PR Interval
- Prolonged PR Interval
There is also first-degree AV block, with a prolonged PR interval of 228 ms. The criteria for diagnosis of left BBB are: wide QRS, supraventricular rhythm, and a negatively-deflected QRS in V1 with a positive QRS in Leads I and V6. [ecgguru.com]
T Wave
- T Wave Inversion
R-wave peak time > 50 ms in V5-6 with associated QRS broadening. LV strain pattern with ST depression and T-wave inversions in I, aVL and V5-6. ST elevation in V1-3. Prominent U waves in V1-3. Left axis deviation. [lifeinthefastlane.com]
Furthermore, delayed repolarization as a result of ventricular hypertrophy generally produces ST depression and T wave inversion in the same leads. [meds.queensu.ca]
With left ventricular hypertrophy, the deeper the QRS complex, the higher the ST segment and more pronounced the T wave abnormality. This is also true of the ST segment depression and T wave inversion typically found in the lateral leads. [ems12lead.com]
An electrocardiogram showed atrial fibrillation, with inferolateral T wave inversion, and left ventricular hypertrophy. A chest X-ray showed features consistent with pulmonary edema. [ncbi.nlm.nih.gov]
P Wave
- P Mitrale
P mitrale – Left atrial enlargement ( P mitrale ) may develop because LVH affects the hemodynamics of the left atrium. Left axis deviation – is common in LVH. QT prolongation – A slight prolongation of the QT (QTc) interval is frequently seen. [ecgwaves.com]
The wide p waves in Lead II and the biphasic p waves in V1 may also indicate left atrial strain, a common finding with LVH, called " P mitrale ". [ecgguru.com]
Other Pathologies
- Myocardial Fibrosis
BACKGROUND: Myocardial fibrosis quantified by myocardial extracellular volume fraction (ECV) and left ventricular mass (LVM) index (LVMI) measured by cardiovascular magnetic resonance might represent independent and opposing contributors to ECG voltage [ncbi.nlm.nih.gov]
The development of myocardial fibrosis appears to be pathophysiologically linked to the renin-angiotensin-aldosterone system. [mdedge.com]
Hypertrophy
- Left Ventricular Hypertrophy
hypertrophy of left ventricle (diagnosis), left ventricular hypertrophy, LVH (left ventricular hypertrophy), Hypertrophy, Left Ventricular [Disease/Finding], lvh, Hypertrophy;ventricular;left, hypertrophy left ventricular, lv hypertrophy, Ventricular [fpnotebook.com]
Right and Left Ventricular Hypertrophy Look for signs of right and left ventricular hypertrophy in the right chest leads (V1 and V2) and left chest leads (V5 and V6). [medicine-on-line.com]
The following echocardiogram parameters are the gold standard for diagnosing left ventricular hypertrophy: left ventricular mass index ≥134 g.m-2, relative wall thickness ≥0.42 mm, left ventricular diastolic diameter index ≥32 mm.m-2, septum wall thickness [ncbi.nlm.nih.gov]
Treatment
Once LVH has been diagnosed, the primary condition that is causing it needs to be treated. Many studies have shown that regression of LVH can occur but this can take several months or even years. For people with hypertension, many types of antihypertensive are used to treat the disorder [11]. But when it comes to LV mass regression, the drugs of choice are calcium channel blockers or ACE inhibitors. Several studies have shown the use of ACE Inhibitors can result in improvement in diastolic function after a year. However, the reduction in stroke risk just based on LV mass reduction is not clear cut. Many of these patients have other risk factors like diabetes mellitus, hyperlipidemia, smoking and obesity. There is insufficient data to recommend treatment only for the reduction of LV mass a treatment goal.
- In patients with diabetes mellitus with LVH, some studies have shown that the lowering of blood pressure can result in regression of LVH and may even reduce the incidence of new onset atrial fibrillation.
- In addition, patients should have a low salt diet and undergo weight loss if obese. This can further help reversing LVH.
- Majority of patients with chronic hypertension will need more than one anti-hypertensive medication. It is important for healthcare providers to understand that lowering the blood pressure to a selected target is far more important than selecting the type of antihypertensive agent.
- The clinician should select antihypertensives based on presence or absence of other comorbidities, their effectiveness and adverse effects.
- The drugs of choice to reverse LVH include ACE inhibitors and calcium channel blockers.
- Beta blockers may be useful in patients with coronary artery disease, angina pectoris and in individuals with other comorbid conditions like portal hypertension, atrial fibrillation, thyrotoxicosis, esophageal varices and benign essential tremor. in addition, patients with systolic dysfunction or CHF may benefit from beta blockers like bisoprolol, carvediol or metoprolol.
Prognosis
If the left ventricular hypertrophy is treated, it can be reversed in most cases leading to a decrease in morbidity. However, if the LVH is not treated it can result in several complications including the following:
- Congestive heart failure in the presence of normal systolic function
- Congestive heart failure in the presence of impaired systolic function
- Diastolic dysfunction is more common in elderly females with normal ejection fraction and presence of heart failure
- Atrial arrhythmias
- Ventricular arrhythmias [7]
- Sudden cardiac death
- Coronary artery disease with myocardial infarction
- Stroke
There are no long term studies indicating that reversing LVH also leads to improved survival or decreased risk of heart disease. The reason for this is that there are other risk factors for heart disease and stroke that also need to be treated at the same time. Just treating LVH alone for decreasing morbidity is not recommended clinical practice.
Etiology
There are many causes of LVH which include the following:
- Hypertension is the most common. Patients with chronic untreated hypertension may have severe LVH but treatment can reverse the condition.
- Diabetics are also known to develop LVH in the absence of hypertension or coronary artery disease.
- Obese individuals also develop LVH but the exact cause is not known. Some studies indicate that a combination of weight, hypertension or sleep apnea may be contributing factors.
- Older people generally tend to have LVH, but it mild in nature.
- Obstructive sleep apnea patients are known to have LVH. If left untreated it can lead to congestive heart failure (CHF), myocardial infarction (MI), cerebrovascular accident (CVA), arrhythmias, pulmonary hypertension and hypertension. There continues to be debate on obstructive sleep apnea and LVH. There is a belief that the cause of LVH may not be directly related to sleep apnea but to the existing hypertension
- Aortic stenosis is the most common valvular heart disorder causing LVH [5].
- Aortic regurgitation
- Athletes usually have varying degrees of LVH.
- Congenital hypertrophic cardiomyopathy
- Amyloidosis
- Sarcoidosis
- Chronic renal failure [6]
Epidemiology
There are no solid data on prevalence of LVH. There is no study that has reported LVH incidence based solely on ECG or echocardiogram. However, the conditions that cause LVH like hypertension, aortic stenosis or diabetes mellitus are very common and it is assumed that LVH is also a frequent occurrence. Since LVH always occurs in association with other traditional cardiac risk factors, it is usually mentioned. The chief reason is that the ECG is not very sensitive for detecting LVH and echocardiogram is not normally used to screen patients with LVH. LVH has been reported in both genders and in people of all ages. No race is immune from development of LVH. The exact number of hypertensive and diabetics patients who have LVH has never been reported but the numbers are not miniscule. Autopsy data show that LVH is a frequent finding in patients with aortic stenosis and hypertension.
Pathophysiology
When the left ventricle encounters increased afterload or elevated systolic or diastolic pressure, it adapts by increasing its muscle mass. Histological studies reveal that there is an increase in the size of myofibrils and fibrosis. If the increased pressure or volume overload is not reversed, then the increased hypertrophy continues resulting in abnormalities of the intramyocardial coronary vessels. Histological studies showed that in patients with severe left ventricular hypertrophy there is medial hypertrophy with perivascular fibrosis. In addition, the mechanical stress on the left ventricular wall from the increased pressure results in generation of growth factors, neurohormones and cytokines like insulin and angiotensin ll. LVH is most common with pressure overload and the hypertrophy is more concentric. When the left ventricle is faced with an increased volume overload as in aortic or mitral regurgitations, the hypertrophy is more eccentric.
Prevention
Based on existing data it is suggested that patients with hypertension have a yearly ECG to look for LVH as part of standard evaluation. This should be followed by an echocardiogram. However the role of echocardiography as a screening tool for LVH is not established. Only patients with other risk factors for heart disease and those with symptoms should undergo echocardiography. Nonetheless some experts indicate that the low cost examination may be cost effective, especially if it can lead to a decrease in risk of heart disease. Since LVH is a marker for severe disease, its presence should suggest more aggressive management by the healthcare provider. Further, these patients will need serial ECGs and echocardiograms to determine if the LVH is decreasing after treatment. Since the most common cause of LVH is hypertension, it is imperative that the condition be adequately treated. Measurement of blood pressure regularly is a key to preventing LVH.
To prevent worsening of LVH, patient should be asked to reduce salt intake and control body weight. Most patients with hypertension and LVH may require more than one antihypertensive agent. However, clinicians should remember that reaching the target blood pressure is more important that the type of agent used. While beta blockers do not induce regression of LVH they do have a role in the treatment of hypertension. The beta blockers may have a role in management of patients with angina pectoris, atrial fibrillation for rate control, and in patients with systolic dysfunction with heart failure (carvediol, bisoprolol, metoprolol). At the same time, it is vital to treat risk factors for ischemic heart disease like diabetes mellitus, discontinuation of smoking, encourage exercise and lower levels of lipids.
Summary
Left ventricular hypertrophy (LVH) is essentially an increase in left ventricular mass and is also a form of myocardial remodeling. Left ventricular hypertrophy is considered to be a normal adaptive mechanism caused by an increased workload of the heart, of which the most common cause is hypertension [1]. However, there are many other causes of LVH including aortic stenosis, coarctation of aorta, thyrotoxicosis, obstructive sleep apnea and diabetes mellitus [2]. In the short term, an increase in left ventricular mass may be of some benefit to the individual as it permits the myocardium to compensate for any increase in wall stress. The adaptation can also help overcome any acute hemodynamic compromise. However, in the long run, left ventricular hypertrophy is harmful. Chronic LVH has been recognized as a risk factor for cardiovascular events, stoke and premature death [3]. When it comes to diagnosis, one needs to be aware that the ECG is relatively insensitive for detecting prognostically significant LVH [4].
Despite extensive data linking ECG and echocardiographic evidence of ventricular hypertrophy to a higher risk of cardiovascular disease, LVH alone is not thought to be as a classic or standard risk factor for heart disease. The other reason is that left ventricular mass is often difficult to quantify with transthoracic echocardiogram. In addition, there are only sparse data showing that reversing LVH improves outcomes. On the other hand, there is ample medical literature showing that lowering of blood cholesterol, blood pressure, discontinuation of tobacco and exercise have important clinical benefits. Finally, although echocardiography is more sensitive than ECG in detecting left ventricular mass, its routine use in patients with hypertension is still being debated.
Even mild cases of hypertension are associated with an increase in left ventricular mass. The important thing is that the left ventricular hypertrophy associated with hypertension is reversible and longtime blood pressure therapy does have benefits. Data show that use of angiotensin converting enzyme (ACE) inhibitors or calcium channel blockers are more effective at reducing left ventricular mass than other antihypertensive drugs.
Patient Information
Left ventricular hypertrophy (LVH) is basically an increase in the size of the left ventricle. The most common cause of LVH is high blood pressure, especially when it is not treated. Other causes of LVH include diabetes mellitus, aortic valve disease, narrowing of the aorta and systemic disorders like hyperactive thyroid gland. Most patients have no symptoms initially but if the LVH is untreated, it can present with heart failure, stroke or a heart attack. The diagnosis of LVH is initially made by an ECG and can be confirmed by an echocardiogram. The treatment of LVH requires treating the condition causing it and in most cases this means treating the high blood pressure. If treated, the LVH can reverse and this decreases the risk of stroke and heart disease.
References
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- Fattal J, Henry MA, Ou S, Bradette S, Papas K, Marcotte F, Garceau P, Pressacco J. magnetic resonance imaging of hypertrophic cardiomyopathy: beyond left ventricular wall thickness. Can Assoc Radiol J. 2015 Feb;66(1):71-8
- Charytan D. Is left ventricular hypertrophy a modifiable risk factor in end-stage renal disease. Curr Opin Nephrol Hypertens. 2014 Nov;23(6):578-85.