We do not endorse non-Cleveland Clinic products or services Policy This video presents a rare case of a 14-year-old, gravida-0 female with a 9 cm intramural fibroid. [consultqd.clevelandclinic.org]

A rich vascular component is also present. [ajnr.org]

Renal tumors (mean age of presentation: 44) are less commonly seen in this syndrome (10-16% of cases) and may present with back pain, although some may be asymptomatic. [orpha.net]

This tumor presents as painful or asymptomatic solitary red-brown nodules and the predominant location is on the extremities. It has been more frequently observed in men. [escholarship.org]

Rarely they are present at birth and have slight female predominance. [6] Our patient had presented with 2 cm small solitary nodule on his left arm. [ccij-online.org]

Workup for polycythemia vera was negative [serum erythropoietin: 24.6 mIU/mL (normal, 3.7 mIU/L to 31.5 mIU/L); vitamin B12: 654 pg/mL (normal, 211 pg/mL-911 pg/mL); JAK2 mutation analysis negative]. [healio.com]

Uterine Artery Embolization for Uterine Leiomyoma: Role of Uterine Artery Doppler in the Pre-Interventional, Interventional and Post-interventional Patient Workup. Ultrasound Obstet Gynecol. 2011 Dec 16. [Medline]. Virchow R. [emedicine.medscape.com]

Clinical Testing and Workup A skin biopsy, which is the surgical removal and microscopic study of a small sample of skin tissue, is necessary in order to confirm the presence of leiomyomas. [rarediseases.org]

Given the utility of imaging in the workup of uterine masses, particularly fibroids, radiologists should be aware of leiomyoma variants and their associated clinical, imaging, and pathologic issues. [ajronline.org]

These medical treatments are summarized in Table 1. [arcfertility.com]

Additional recommended knowledge Contents 1 Etymology 2 Uterine leiomyomata 3 Esophageal 4 Leiomyoma of Jejunum 5 Treatment 5.1 Medical Treatment: 5.2 Surgical Treatment: 6 Outcomes 7 References 8 See also Etymology Greek: leios smooth muV (myo) mouse [bionity.com]

The patient’s age and reproductive goals direct the modality and goals of treatment. Treatment options include both medical and surgical intervention [1]. [ncbi.nlm.nih.gov]

Back to Top Non-surgical treatment for fibroids Focused Ultrasound Treatment MRI-guided focused ultrasound surgery (FUS) is a noninvasive treatment option for uterine fibroids that preserves your uterus. [fibroids.net]

Presentation and treatment of uterine leiomyoma in adolescence: a systematic review. [bmcwomenshealth.biomedcentral.com]

Prognosis The prognosis of HLRCC is poor but treatments with new molecular targets may improve survival in the future. The documents contained in this web site are presented for information purposes only. [orpha.net]

Prognosis The prognosis of uterine fibroids varies extensively for individual patients. Many patients have an excellent prognosis and remain asymptomatic for many years or indefinitely. [ncbi.nlm.nih.gov]

The 2017 AHRQ meta-analysis provided additional information regarding prognosis. [m.acog.org]

[…] adenomatoid tumour Gross well-circumscribed, whorled appearance, firm Site skin, uterus, others Syndromes hereditary leiomyomatosis and renal cell cancer (cutaneous & uterine leiomyomas) Symptoms skin: pain, uterus: bulky Prevalence very common - esp. uterine Prognosis [librepathology.org]

Prognosis The prognosis for a solitary lesion is excellent, especially if it is surgically excised. Multiple piloleiomyomas gradually increase in size and number. [emedicine.medscape.com]

Etiology, symptomatology, and diagnosis of uterine myomas. Fertil Steril. 2007 Apr;87(4):725 – 36 9 Walker CL. Uterine fibroids: the elephant in the room. Science. 2005 Jun 10;308(5728):1589 – 92 10 Lethaby A, Vollenhoven B, Sowter M. [arcfertility.com]

Etiology Leiomyomas are comprised of monoclonal cells arising from the myometrium [5]. Continued research to determine the etiology of leiomyomas is ongoing. Several studies have identified specific gene mutations associated with fibroids [2]. [ncbi.nlm.nih.gov]

Etiology HLRCC is caused by a mutation in the FH gene (1q42.1),which is thought to act as a tumor suppressor gene, encoding the enzyme fumarate hydratase (FH) that metabolizes the fumarate produced during the purine nucleotide cycle and arginine synthesis [orpha.net]

Etiology Description A benign, hormone -sensitive smooth muscle tumor of the uterus Can be submucosal, intramural, or subserosal Arises from a single myometrial cell (monoclonal growth) and causes: Upregulation of hormone receptors, particularly estrogen [amboss.com]

[…] fibromyoma, leiomyofibroma, fibroma, myoma Epidemiology Present in 25% of women during reproductive years More common in blacks than whites; usually multiple in blacks Clinically apparent lesions are more common in nulliparous, postmenopausal women Etiology [pathologyoutlines.com]

Summary Epidemiology The prevalence is unknown. Over 200 families with HLRCC have been reported. Clinical description Disease onset can occur at any age, but is more common in young adults and elderly patients. [orpha.net]

Definition / general Extremely common tumor At autopsy, present in uterus in 77% of females; 84% of tumors are multicentric Terminology Also called fibroid, myofibroma, fibromyoma, leiomyofibroma, fibroma, myoma Epidemiology Present in 25% of women during [pathologyoutlines.com]

An estimate may be drawn from an epidemiologic survey involving 21,479 women in 8 countries, which were evaluated through an online questionnaire. [bmcwomenshealth.biomedcentral.com]

Epidemiology. 2013 May. 24(3):447-53. [Medline]. Kerins MJ1, Vashisht AA2, Liang BX1, Duckworth SJ1, Praslicka BJ1, Wohlschlegel JA2, et al. [emedicine.medscape.com]

Epidemiology Although uterine leiomyomas are common, leiomyosarcoma is rare, with an estimated incidence of 0.36 per 100,000 woman-years ( 12 ). [m.acog.org]

This article presents the general approach to diagnosis, pathophysiology, histology, and treatment of leiomyomas. Etiology Leiomyomas are comprised of monoclonal cells arising from the myometrium [5]. [ncbi.nlm.nih.gov]

[…] modulators in the regulation of uterine leiomyoma growth. 9 38 Yoshida S...Maruo T 20414849 2010 3 Changes related to phosphatidylinositol 3-kinase/Akt signaling in leiomyomas: possible involvement of glycogen synthase kinase 3alpha and cyclin D2 in the pathophysiology [malacards.org]

Biological studies should be performed in order to determine whether are differences among its pathophysiology. [bmcwomenshealth.biomedcentral.com]

Pathophysiology Three fairly distinct types of cutaneous leiomyomas exist: piloleiomyomas, angioleiomyomas, and genital leiomyomas with distinct clinical and histological characteristics. [emedicine.medscape.com]

Pathophysiology Extensive work has been performed to characterize cellular mechanisms of myometrial tissue and neoplasmic growth leiomyoma. [healthcare-communications.imedpub.com]

Prevention Although researchers continue to study the causes of fibroid tumors, little scientific evidence is available on how to prevent them. [mayoclinic.org]

Next Benignes, pulmonal metastasierendes Leiomyom des Uterus Surgical resection and hormonal therapy help prevent progression of this disease and provide an avenue for a cure. [vanity1.campuslabs.com]

To expand our knowledge of leiomyomas, we need further research to identify predisposing genetic factors for potential use to better target preventive care. [ncbi.nlm.nih.gov]

Preventive Services Task Force Recommendation Statement. U.S. Preventive Services Task Force. JAMA 2018;320:674–86. Diagnosis of abnormal uterine bleeding in reproductive-aged women. Practice Bulletin No. 128. [m.acog.org]

However, it is possible that leiomyomas can cause infertility or pregnancy loss or prevention of implantation and growth of an embryo. [breast-cancer.ca]