CONCLUSION: Jejunal leiomyoma should be considered in a child with neurofibromatosis presenting with gastro-intestinal bleeding. [ncbi.nlm.nih.gov]

Conclusion Jejunal leiomyoma should be considered in a child with neurofibromatosis presenting with gastro-intestinal bleeding. [link.springer.com]

Wu TI, Yen TC, Lai CH (2011) Clinical presentation and diagnosis of uterine sarcoma, including imaging. Best Pract Res Clin Obstet Gynaecol 25:681-689. [omicsonline.org]

• Pain

  Seite 428 - Practice guidelines for acute pain management in the perioperative setting: A report by the American Society of Anesthesiologists Task Force on Pain Management, Acute Pain Section. ‎ [books.google.de]

  T. (28), Freiburg (Germany) During a routine examination my doctor established that I had fibroids measuring 3 cm x 3 cm, which explained why I had such painful and strong menstruation. [bruno-groening.org]

  Surgery is the definitive treatment, especially for complications such as bleeding or pain, and when there's a suspicion for malignancy. [medical-dictionary.thefreedictionary.com]

  Possible signs and symptoms are as follows [2, 3, 4, 5] : Abdominal pain - This is generally nonspecific, dull, and epigastric in location; pain is more commonly associated with larger lesions, which may cause symptoms of intermittent bowel obstruction [emedicine.medscape.com]

  She reports irregular spotting between periods and pain with intercourse. Physical exam reveals a mobile, asymmetric, nontender uterus with multiple nodular abnormalities. A Transvaginal ultrasound shows hyperchoic masses within the uterine wall. [step2.medbullets.com]

• Asymptomatic

  Benign tumours Most benign tumours are relatively asymptomatic and are undiagnosed until autopsy. [surgwiki.com]

  […] well-circumscribed round masses STUDIES Labs β-hCG to rule out pregnancy Histology whorled pattern of smooth muscle bundles Differential Diagnosis Leiomyosarcoma Adenomyosis Endometrial polyp Pregnancy Diagnosis Confirmed with sonogram Treatment If asymptomatic [step2.medbullets.com]

  [Uterine multiple node fibromyomatosis associated with an asymptomatic leiomyoma of the small intestine]. Guzzetti A, Sacchi F, Conturso R. Guzzetti A, et al. Chir Ital. 1985 Apr;37(2):183-8. Chir Ital. 1985. PMID: 4017143 Italian. [pubmed.ncbi.nlm.nih.gov]

  These lesions usually remain asymptomatic and are often found incidentally; however, they can become symptomatic if obstruction occurs or the tumor outgrows its blood supply resulting mucosa. [academic.oup.com]

  Most women have small, asymptomatic fibroids. [amboss.com]

• Pathologist

  If it is indeed a polyp, a distinct appearance is noted by the pathologist. [dovemed.com]

• Melena

  Abstract A 41-year-old woman visited a local doctor with the chief complaint of massive melena. Upper and lower gastrointestinal endoscopy as well as abdominal computed tomography failed to reveal the source of the bleeding. [jstage.jst.go.jp]

  In the case of leiomyoma of the jejunum with massive enterorrhagia and melena reported below, the preoperative diagnosis was bleeding duodenal ulcer.Leiomyoma of the small intestine is rare. [nejm.org]

  Their clinical manifestations can include abdominal pain, diarrhea, melena, a palpable abdominal mass and weight loss. [academic.oup.com]

  […] jejunum, 010813, 漿膜, ｼｮｳﾏｸ, serosa, 011358, 再建術, ｻｲｹﾝｼﾞｭﾂ, reconstructive surgery, 059071, 症例報告, ｼｮｳﾚｲﾎｳｺｸ, case report, 054676, 男性, ﾀﾞﾝｾｲ(ｵﾄｺ), man, 017125, ﾀﾞﾝｾｲ, 成人, ｾｲｼﾞﾝ, adult(person), 017082, adult, ヒト, ﾋﾄ, human(primates), 012150, human, 下血, ｹﾞｹﾂ, melena [togodb.biosciencedbc.jp]

  Case 1 was a 74-year-old female, who had a history of receiving multiple blood transfusions because of recurrent melena for several years. [iss.ndl.go.jp]

• Vomiting

  […] cw 十二指腸腫瘍, ｼﾞｭｳﾆｼﾁｮｳｼｭﾖｳ, duodenal neoplasm, 055456, *, 平滑筋腫, ﾍｲｶﾂｷﾝｼｭ, leiomyoma, 039763, 嘔吐, ｵｳﾄ, vomiting, 010556, 内視鏡検査, ﾅｲｼｷｮｳｹﾝｻ, endoscopy, 056141, 開腹術, ｶｲﾌｸｼﾞｭﾂ, laparotomy, 054756, 腸切除, ﾁｮｳｾﾂｼﾞｮ, enterectomy, 059500, 空腸, ｸｳﾁｮｳ, jejunum, 010813 [togodb.biosciencedbc.jp]

  She has been feeling generally well but notes some morning nausea and vomiting. [step2.medbullets.com]

  The clinical manifestations are nonspecific and can include: nausea and vomiting abdominal pain melena Tumor-related obstructions do not produce symptoms until a late stage, due to the fluid contents of the small intestine. [radiopaedia.org]

  […] nonspecific, dull, and epigastric in location; pain is more commonly associated with larger lesions, which may cause symptoms of intermittent bowel obstruction Constipation Melena Perforation Nausea Diarrhea Gastrointestinal (GI) hemorrhage Volvulus Vomiting [emedicine.medscape.com]

  There was no vomiting or constipation. However, he was lethargic and had headache. His rectal bleeding persisted for 2 days and necessitated blood transfusion. There was no history of drug intake. [saudijgastro.com]

• Intestinal Disease

  […] grêle Intestin pathologie Léiomyome Observation Tumeur Tunisie Afrique Keyword (en) Digestive diseases Human Hemorrhage Small intestine Intestinal disease Leiomyoma Observation Tumor Tunisia Africa Keyword (es) Aparato digestivo patologia Hombre Hemorragia [pascal-francis.inist.fr]

  054590, *, 腸疾患, ﾁｮｳｼｯｶﾝ, intestinal disease, 054586, 胃腸疾患, ｲﾁｮｳｼｯｶﾝ, gastrointestinal disease, 054588, 消化器疾患, ｼｮｳｶｷｼｯｶﾝ, digestive system disease, 012793, 病気, ﾋﾞｮｳｷ, disease, 017213, 腸腫瘍, ﾁｮｳｼｭﾖｳ, intestinal tumor, 054236, 消化器腫瘍, ｼｮｳｶｷｼｭﾖｳ, digestive [togodb.biosciencedbc.jp]

  Some inflammatory disorders predispose to malignancy 1,2 : celiac disease : lymphoma Crohn's disease : adenocarcinoma, 5-20 x increased risk immunoproliferative small intestinal disease (IPSID, Mediterranean lymphoma or diffuse small intestinal lymphoma [radiopaedia.org]

  Following resectable nodal metastases, median survival is 15 years.With non-resectable intestinal disease or liver metastases, survivals are 5 and 3 years, respectively. [surgwiki.com]

• Osteoporosis

  […] planned surgery (decreases leiomyoma size and vascularization and overall uterine size) Before interventional therapy or additional pharmacotherapy Until menopause Not suitable as long-term therapy because of the risk of hypoestrogenic effects (e.g., osteoporosis [amboss.com]

• Confusion

  Figure 10 KIT-positive Cajal may colonize gastrointestinal leiomyomas, and this should not lead into confusion with a GIST. Muscularis mucosae leiomyomas usually occur in the colon and rectum, where these tumors are far more common than GISTs. [nature.com]

With MRI spatial resolution less than that achieved with conventional enteroclysis or CT, therefore it is less useful for evaluation of lesions Endoscopic ultrasonography (EUS) is very sensitive and effective for the workup of neoplasms in the ampullary [radiopaedia.org]

[4][6] Ultrasound pelvis (transvaginal, transabdominal) Most appropriate initial test for all patients with a suspected uterine leiomyoma [7] Supportive findings [8] Neither plain radiography nor CT is recommended in the workup of leiomyomas because of [amboss.com]

• Hypophosphatemia

  Hypercalcaemia, hypophosphatemia, hyperchloremia, elevated chloride/phosphorus ratio, increased urinary cyclic AMP, and blood levels of immunoreactive parathormone were present. Electron microscopy showed dense round granules in the tumour cells. [cris.tau.ac.il]

• Taenia Solium

  solium, Hymenolepis nana) Hookworm (e.g. [en.wikipedia.org]

• Polyps

  If it is indeed a polyp, a distinct appearance is noted by the pathologist. [dovemed.com]

  Leiomyoma of small intestine Leiomyoma, small intestine Polyp in small intestine Polyp of duodenum Polyp of small intestine Polyp, small intestine 211.2 Excludes [icd9data.com]

  These are a group of disorders characterized by the presence of multiple polyps affecting all or parts of the gastrointestinal tract. They are distinguished by the way they can be inherited but also by the microscopic appearance of the polyps. [ddc.musc.edu]

  A polyp was found at the recto-sigmoid junction that was removed by snare polypectomy and sent for histopathology. [ispub.com]

  The types of tumors include the following: Hyperplastic polyps Adenomas Gut stromal tumors Lipomas Hemangiomas Peutz-Jeghers syndrome Hyperplastic polyps Hyperplastic polyps are benign mucosal growths frequently observed in the duodenum and proximal ileum [emedicine.medscape.com]

Metastatis to small bowel is rare, treatment is chemotherapy and the prognosis is poor. [omicsonline.org]

Pathophysiology is emphasized throughout, providing a sound basis for discussions of the diagnosis, treatment, and prognosis that follow. [books.google.com]

The patient’s age and reproductive goals direct the modality and goals of treatment. Treatment options include both medical and surgical intervention [1]. [ncbi.nlm.nih.gov]

Uterine Fibroids: Diagnosis and Treatment. Am Fam Physician. 2017; 95 (2): p.100-107. Al-Hendy A, Lukes AS, Poindexter AN, et al. Treatment of Uterine Fibroid Symptoms with Relugolix Combination Therapy. [amboss.com]

Small noncancerous growths may be destroyed by treatments applied through a flexible viewing tube (endoscope—see Endoscopy ) inserted into the intestine. [merckmanuals.com]

Metastatis to small bowel is rare, treatment is chemotherapy and the prognosis is poor. [omicsonline.org]

Pathophysiology is emphasized throughout, providing a sound basis for discussions of the diagnosis, treatment, and prognosis that follow. [books.google.com]

Prognosis The prognosis of uterine fibroids varies extensively for individual patients. Many patients have an excellent prognosis and remain asymptomatic for many years or indefinitely. [ncbi.nlm.nih.gov]

Outcome Prognosis depends on the stage of the disease and histological grade. Histological grade is determined by cellularity, nuclear atypia and number of mitoses. [surgwiki.com]

Etiology Leiomyomas are comprised of monoclonal cells arising from the myometrium [5]. Continued research to determine the etiology of leiomyomas is ongoing. Several studies have identified specific gene mutations associated with fibroids [2]. [ncbi.nlm.nih.gov]

Etiology Predisposing factors [1][2] Nulliparity Early menarche (< 10 years of age) Age: 25–45 years Fibroids are largely found in women of reproductive age. [amboss.com]

(Etiology) The exact cause of Leiomyoma of Colon is unknown. Researchers have documented certain genetic changes within the tumor. However, cases where these specific genetic mutations have been observed are rare. [dovemed.com]

While duodenal ulcers and diverticulosis are certainly more common than symptomatic neoplasms of the small intestine, it is important to have a higher index of suspicion for additional etiologies, especially when irregularities of imaging studies are [academic.oup.com]

Pathophysiology Leiomyomas have a clonal origin Several alterations identified (Table 1) (Clin Obstet Gynecol 2016;59:25) Risk decreased by oral contraceptives May occur in hereditary leiomyomatosis and renal cancer syndrome (HLRCC) and Alport syndrome Etiology [pathologyoutlines.com]

Uterine sarcoma: Classification, epidemiology, clinical manifestations, and diagnosis. In: Post TW, ed. UpToDate. [amboss.com]

[…] undergo a hysterectomy because she does not want any more children. summary Otherwise known as fibroids Leiomyomas are smooth muscle growths of the uterine myometrium can be intramural submucosal subserosal Often present with multiple discrete tumors Epidemiology [step2.medbullets.com]

Brooks SE, Zhan M, Cote T, Baquet CR (2004) Surveillance, epidemiology, and end results analysis of 2677 cases of uterine sarcoma 1989-1999. Gynecol Oncol 93:204. [omicsonline.org]

These results suggest that mutations affecting the regulators of circadian rhythm can be frequently found in cancer, and therefore could help to understand the well-known linkage from epidemiologic studies between disrupted circadian rhythm and cancer [helda.helsinki.fi]

Epidemiology Leiomyomas are diagnosed in close to 70% of white women and more than 80% of black women by age 50, but the incidence of clinical symptoms in blacks is double that found in whites [2]. [ncbi.nlm.nih.gov]

Pathophysiology is emphasized throughout, providing a sound basis for discussions of the diagnosis, treatment, and prognosis that follow. [books.google.com]

The literature is revised emphasizing issues of pathophysiology, specific characteristics and the treatment of this tumour. [jsurgacad.com]

Describe the hormone responsiveness of tumors in the pathophysiology of leiomyomas. Explain the FIGO classification in the evaluation of leiomyomas. [ncbi.nlm.nih.gov]

[…] fumarate hydratase deficient leiomyoma More common (up to 80%) in African American women References: Best Pract Res Clin Obstet Gynaecol 2008;22:571, BJOG 2017;124:1501 Sites Uterine corpus Less common in vulva, vagina, cervix, broad ligament, ovary Pathophysiology [pathologyoutlines.com]

Hence, a complete removal of the tumor is recommended How can Leiomyoma of Colon be Prevented? Currently, no known preventive methods exist for Leiomyoma of Colon. [dovemed.com]

With advanced disease, debulking or palliative resection is performed to prevent complications of bleeding or perforation, provided excessive removal of normal small bowel is avoided. [surgwiki.com]

To expand our knowledge of leiomyomas, we need further research to identify predisposing genetic factors for potential use to better target preventive care. [ncbi.nlm.nih.gov]