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Leiomyosarcoma of the Small Intestine

Intestine Small Leiomyosarcoma


Presentation

  • Thus, this patient presents evidence that beta-HCG may be produced by sarcoma cells and, therefore, that beta-HCG may be used as a tumor marker in some sarcoma patients.[ncbi.nlm.nih.gov]
  • We present a challenging case of differential diagnosis of leiomyosarcoma of the small intestine in a patient presented with a pelvic mass. This 43-year-old Japanese woman complained of hypermenorrhea and was diagnosed as myoma uteri.[ncbi.nlm.nih.gov]
  • Three cases of small-intestinal leiomyosarcoma are presented. The neoplasms were located within 50 cm from the ligament of Treitz and the only symptoms was severe recurrent gastrointestinal bleeding.[ncbi.nlm.nih.gov]
  • Four patients with leiomyosarcoma of the small intestine who presented with a pelvic mass are reviewed. The tumors had clinical and radiographic features resembling ovarian neoplasms.[ncbi.nlm.nih.gov]
  • ORPHA:104076 Synonym(s): - Prevalence: - Inheritance: - Age of onset: - ICD-10: C17.0 C17.1 C17.2 C17.3 C17.8 OMIM: - UMLS: C0920305 MeSH: - GARD: - MedDRA: - The documents contained in this web site are presented for information purposes only.[orpha.net]
Antipsychotic Agent
  • Agents Phase 3 25 Autonomic Agents Phase 3 26 Antineoplastic Agents, Hormonal Phase 3,Phase 2 27 Psychotropic Drugs Phase 3 28 glucocorticoids Phase 3 29 Hormones Phase 3,Not Applicable 30 BB 1101 Phase 3,Phase 2 31 HIV Protease Inhibitors Phase 3 32[malacards.org]
Inguinal Hernia
  • Abstract Inguinal hernias and intra-abdominal malignancy are both common phenomena and their co-existence cannot be rare.[ncbi.nlm.nih.gov]
Falling
  • While I was in the hospital my Mother passed away and a crazy women who thought we going to get married decided to move into my other house near Niagara Falls.[cancerguide.org]
Pelvic Mass
  • Although such leiomyosarcomas are rare, they can appear as pelvic masses and must be differentiated from gynecologic disease. Preoperative CT and MRI of the abdomen were useful in obtaining the diagnosis.[ncbi.nlm.nih.gov]
  • Four patients with leiomyosarcoma of the small intestine who presented with a pelvic mass are reviewed. The tumors had clinical and radiographic features resembling ovarian neoplasms.[ncbi.nlm.nih.gov]
  • For both leiomyomas and sarcoma, the primary presenting symptoms are abnormal uterine bleeding, pelvic pain or pressure, or a pelvic mass, making the difference between leiomyoma and sarcoma difficult [ 9 - 11 ].[omicsonline.org]
  • Local and regional spread may result in an abdominal or pelvic mass and gastrointestinal or urinary tract symptoms. The usual destination of haematogenous dissemination are the lungs. Leiomyosarcoma is the most common pure uterine sarcoma.[codes.iarc.fr]
  • The findings of atypical degeneration with irregular contours should bring LMS into the differential when evaluating leiomyomas (or other pelvic masses). 19-21 One study looked at patients (including nine patients with pathologically proven LMS and three[sarcomahelp.org]
Intestinal Disease
  • Homepage Rare diseases Search Search for a rare disease Leiomyosarcoma of small intestine Disease definition Small bowel leiomyosarcoma is a rare type of small bowel malignancy, originating in the smooth muscle cells within the muscularis propria or the[orpha.net]
  • disease (IPSID, Mediterranean lymphoma or diffuse small intestinal lymphoma ) Various genetic disorders are also associated with an increased incidence of small bowel tumors 1,2 : Peutz-Jeghers syndrome : hamartomatous polyps Gardner's syndrome : adenoma[radiopaedia.org]
  • The typical subtype is non-Hodgkin's lymphoma; more specifically MALT lymphomas, large B cell lymphoma, immunoproliferative small intestinal disease, and Burkitt’s lymphoma.[oncolink.org]
Rectal Bleeding
  • Clinical findings included abdominal pain in 17 (85%), rectal bleeding in 8 (40%), anemia in 7 (35%), intraperitoneal perforation in 6 (30%), and abdominal mass in 4 (20%).[ncbi.nlm.nih.gov]
Withdrawn
  • Patients With Abdominal or Non-Small Cell Lung Cancer Terminated NCT00087191 Not Applicable EF5;motexafin lutetium 29 Heparin or M-EDTA in Preventing Catheter-Related Infections and Blockages in Patients at High Risk for a Catheter-Related Infection Withdrawn[malacards.org]

Workup

  • With MRI spatial resolution less than that achieved with conventional enteroclysis or CT, therefore it is less useful for evaluation of lesions Endoscopic ultrasonography (EUS) is very sensitive and effective for the workup of neoplasms in the ampullary[radiopaedia.org]

Treatment

  • The material is in no way intended to replace professional medical care by a qualified specialist and should not be used as a basis for diagnosis or treatment.[orpha.net]
  • Complementary treatments (particularly polychemotherapy) are not yet able to modify survival. The authors report a case of leiomyosarcoma of the preterminal small intestine. The patient was female and presented vague, aspecific symptoms.[minervamedica.it]
  • Hopefully in the meantime new treatments would unfold. The goal was set to live to see my daughter get on a school bus. I had the surgery in April 1997.[cancerguide.org]
  • When clinical trials show that a new treatment is better than the standard treatment, the new treatment may become the standard treatment. Patients may want to think about taking part in a clinical trial.[medstarsouthernmaryland.org]
  • Open Esophageal Close Esophageal Risks, Symptoms, Diagnosis, Treatment Prevention GI Expert Care Team Clinical Trials Other Resources GIST Open GIST Close GIST Risks, Symptoms, Diagnosis, Treatment Prevention GI Expert Care Team Clinical Trials Other[ruesch.georgetown.edu]

Prognosis

  • The prognosis for disseminated intestinal leiomyosarcoma in childhood appears to be poor.[ncbi.nlm.nih.gov]
  • The prognosis for disseminated intestinal leiomyosarcoma in childhood appears to be poor. This is a preview of subscription content, log in to check access. Preview Unable to display preview. Download preview PDF. References 1.[link.springer.com]
  • Metastatis to small bowel is rare, treatment is chemotherapy and the prognosis is poor.[omicsonline.org]
  • Although cancer took his life, he outlived his prognosis by a great deal and in the process helped many people. I hope his story is still doing that, and that it will stand as a monument to “where cancer cannot go.”[cancerguide.org]
  • The prognosis is poor 16 Tavassoli FA, Devilee P (Eds.) World Health Organization Classification of Tumours.[codes.iarc.fr]

Epidemiology

  • Epidemiology Leiomyosarcoma accounts for 7 to 11 percent of all soft tissue sarcomas among adults and children.[curesarcoma.org]
  • World J Gastroenterology 16(12):1527–1532 CrossRef Google Scholar Hatzaras I, Palesty JA, Abir F et al (2007) Small-bowel tumors: epidemiologic and clinical characteristics of 1260 cases from the connecticut tumor registry.[link.springer.com]
  • "Surveillance, Epidemiology, and End Results (SEER) Program Stat Database: Incidence—SEER 18 Regs Research Data Hurricane Katrina Impacted Louisiana Cases, Nov 2016 Sub 2000-2014 Katrina/Rita Population Adjustment—Linked To County Attributes - Total U.S[en.wikipedia.org]
  • Brooks SE, Zhan M, Cote T, Baquet CR (2004) Surveillance, epidemiology, and end results analysis of 2677 cases of uterine sarcoma 1989-1999. Gynecol Oncol 93:204.[omicsonline.org]
  • Small bowel adenocarcinoma: epidemiology, risk factors, diagnosis and treatment. Digestive and Liver Disease, 46 (2), 97-104. Bülow, S., Christensen, I. J., Højen, H., Björk, J., Elmberg, M., Järvinen, H., ... & Vasen, H. (2012).[oncolink.org]
Sex distribution
Age distribution

Prevention

  • Vomiting in Patients Receiving Radiation Therapy to the Upper Abdomen Completed NCT00016380 Phase 3 dexamethasone;ondansetron 4 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3 cyproheptadine[malacards.org]
  • Open Esophageal Close Esophageal Risks, Symptoms, Diagnosis, Treatment Prevention GI Expert Care Team Clinical Trials Other Resources GIST Open GIST Close GIST Risks, Symptoms, Diagnosis, Treatment Prevention GI Expert Care Team Clinical Trials Other[ruesch.georgetown.edu]
  • Statistics BC Canada Can I help to prevent it? Eating healthy, nutritious foods can reduce your cancer risk.[bccancer.bc.ca]
  • Radiation therapy works to destroy cancer cells by depositing energy that damages their genetic material, preventing or slowing their growth and replication.[rarediseases.org]

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