(Focused case presentation of LS with guidelines and procedures that help in getting to a diagnosis of a disorder with variable presentations.) Limongelli, G, Pacileo, G, Marino, B, Digilio, MC, Sarkozy, A, Elliott, P. [dermatologyadvisor.com]

Cardiac conduction defects, pulmonic stenosis, and hypertrophic cardiomyopathy are often (85%) present. Cognitive defects are present in 30% of patients and some individuals have been described as mentally retarded. [disorders.eyes.arizona.edu]

If no lentigo is present, findings from at least three categories must be present and a first-degree relative of the patient must have lentigines. [4] Further, lentigines which give a clue to diagnosis may occur at any age as in our case. [ijpd.in]

Clinically, they present as irregularly shaped, faint-to-dark brown macules. [medicaljournals.se]

From the age of 6 years hyperchromic spots with similar characteristics appeared on his palms and on the soles of his feet, where they were present on the areas of the toes, the metatarsi, and the heels (Fig. 2). [revistagastroenterologiamexico.org]

• Disability

  Please enable JS and disable any ad blocker [aocd.org]

  ND is rarely accompanied by other abnormalities, but there have been reports of associated seizures, intellectual disability, unilateral limb hypertrophy, atopic dermatitis, and abnormal systemic features.6 Furthermore, a few cases of lentigines within [journals.lww.com]

  Other signs and symptoms of Noonan syndrome with multiple lentigines include hearing loss caused by abnormalities in the inner ear (sensorineural deafness), mild intellectual disability, and extra folds of skin on the back of the neck. [ghr.nlm.nih.gov]

• Fishing

  (a) Hyphal pattern, (b) overlapping vessels, (c) parallel lines, (d) fish-scale-like pattern. PPV: Positive predictive value, NPV: Negative predictive value. [dermsinica.org]

  And what’s this about fish the look like aliens. September’s Words in the News explain all. Read more Scrabble score for 'lentigines': 11 [collinsdictionary.com]

• Pathologist

  This is where a piece of skin is removed under local anaesthesic and sent for analysis by a pathologist. Treatments for lentigines Most lentigines are left alone, unless there is uncertainty around the diagnosis or an unusual appearance. [myskindoctor.co.uk]

  […] cardiologists, specialists who diagnose and treat skeletal disorders (orthopedists), physicians who specialize in diagnosing and treating disorders of the glands (endocrinologists), specialists who assess and treat hearing problems (audiologists), speech pathologists [rarediseases.org]

• Freckles

  Your Brown Spots Are Likely Freckles If… Freckles arise as a result of increased sun exposure and melanin production. [halecosmeceuticals.com]

  What are freckles? Freckles are small brown spots usually found on the face and arms. Freckles are extremely common and are not a health threat. [my.clevelandclinic.org]

  Salicylic acid as a peeling agent has a number of indications, including acne vulgaris, melasma, photodamage, freckles, and lentigines. [collinsdictionary.com]

  Lentigines are brown-pigmented lesions, darker than freckles, flat or raised, seen on all parts of the skin and present in almost every child and adult. [jamanetwork.com]

  Background : The risk of post-inflammatory hyperpigmentation (PIH) is increased during freckles and lentigines treatment in Asians. [tandfonline.com]

• Hyperpigmentation

  Wausau, WI (October 8, 2018) – Solar lentigines, a form of benign epidermal hyperpigmentation, are a serious concern for aging skin in the Asian population. [aslms.org]

  You are always better served by erring on the side of caution and having areas of hyperpigmentation checked by your doctor or dermatologist if you observe: Changes in color (e.g. darkening or uneven coloring) Changes in texture (e.g. raised borders, scaly [halecosmeceuticals.com]

  Histologic Features: Increased density of basilar melanocytes compared to adjacent uninvolved skin Elongation of the rete ridges with a club-shaped appearance Hyperpigmentation of the basal epidermis, sometimes extending into the upper epidermis, often [dermpedia.org]

  The most common among them include lentigines, postinflammatory hyperpigmentation, dark eye circles, and melasma.The typical clinical presentation includes multiple lentigines and cardiac defects.Hyperpigmented spots were frequent and were noted at early [collinsdictionary.com]

  Background : The risk of post-inflammatory hyperpigmentation (PIH) is increased during freckles and lentigines treatment in Asians. [tandfonline.com]

• Skin Lesion

  All demographic data including age, gender, occupation, family history of DM, estimated average sun exposure and presence of skin lesions were collected and analyzed. [caspjim.com]

  Lentigines are benign, light or dark skin color lesions which usually occur in older people as a result of early or normal aging of the skin, due to modern lifestyle and mainly due to chronic sun exposure. [cosmeticdermamedicine.gr]

  Dermoscopy The examination of [skin lesions] with a 'dermatoscope'. [dermoscopedia.org]

  Reflectance confocal microscopy can be used to visualise dynamic skin processes, allowing non-invasive in vivo follow-up of skin lesions after treatment. [medicaljournals.se]

  Lumps and bumps can appear on your skin – seemingly out of nowhere. Before you hit the panic button, take a deep breath and remember that not all skin lesions are dangerous. [zoskinhealth.com]

• Skin Disease

  See also [ edit ] Freckle List of skin diseases Mole Skin disease Skin lesion References [ edit ] ^ Random House Webster's Unabridged Dictionary. Random House, Inc. 2001. p. 1101. [en.wikipedia.org]

  Disease Clinical apps Boards fodder archive Choosing Wisely Appropriate use Featured Clinical guidelines Review current clinical guidelines, those in development, and guidelines that the AAD has collaborated on. [aad.org]

  Copyright © 2019 Hospital for Skin Diseases (Institute of Dermatology), Chinese Academy of Medical Sciences, and Chinese Medical Association, published by Wolters Kluwer, Inc. [journals.lww.com]

  Texto completo To the Editor: Noonan syndrome with multiple lentigines (NSML), also known as LEOPARD syndrome, is a rare genetic skin disease whose acronym comes from its main clinical manifestations: lentigines (multiple), electrocardiographic conduction [actasdermo.org]

  Simultaneous use of other topical skin lightening. Patient refusal to participate in the study. [clinicaltrials.gov]

• Photosensitivity

  Their occurrence is sudden following a hormonal disorder, the use or topical application of drugs that increase photosensitivity and during pregnancy. [cosmeticdermamedicine.gr]

  Photosensitivity, photo-induced disorders and disorders by ionizing radiation. In: Fitzpatrick's Color Atlas and Synopsis of Clinical Dermatology. 8th ed. McGraw Hill; 2017. https://www.accessmedicine.mhmedical.com. Accessed Feb. 24, 2021. [mayoclinic.org]

  The exclusion criteria were as follows: pregnancy, recent sun tanning, previous laser or topical treatments, history of oral retinoid treatment with in the previous 6 months, known photosensitivity or taking photosensitizing medication and history of [e-ijd.org]

  The spots were asymptomatic and not associated with photosensitivity. She was born of a second degree consanguineous marriage and had a history of seizures. She denied any history of syncopal attacks, dyspnea, and cyanosis. [ijpd.in]

Workup Dermoscopic evaluation of a few lichenoid regressing solar lentigines showed a pattern similar to that of lichenoid regressing seborrheic keratosis. [3] Preferentially expressed antigen in melanoma immunostaining may be utilized to distinguish [emedicine.medscape.com]

In our study RCM was not only used to monitor changes in SL after laser treatment, but also to confirm the diagnosis pre-treatment. [medicaljournals.se]

[…] power was used to push the blood to the outside of laser treatment area and prevent purpura. [e-ijd.org]

PIH risk was 20% after LP Alexandrite treatment, 10% with QS Nd:YAG, and absent after LPDL and LP KTP treatment. Conclusion : A long pulse laser and small spot size appear to reduce the risks of lentigines treatment in darker skin types. [tandfonline.com]

PIH risk was 20% after LP Alexandrite treatment, 10% with QS Nd:YAG, and absent after LPDL and LP KTP treatment. CONCLUSION: A long pulse laser and small spot size appear to reduce the risks of lentigines treatment in darker skin types. [read.qxmd.com]

Cryotherapy, bleaching, certain creams, chemical peels, and laser treatment are all available for the treatment of lentigines. [virginiamohs.com]

Outlook (Prognosis) Most patients adjust very well with proper attention to their specific problems. [nicklauschildrens.org]

When treatment is required but cannot be provided within primary care - eg, treatment with local chemical peel or lasers (Q-switched Nd:YAG or ruby) are effective when available. [ 8, 9 ] Prognosis Lentigines tend to worsen over time but do not become [patient.info]

PMID: 24684165 Prognosis Jurko T, Jurko A Jr, Krsiakova J, Jurko A, Minarik M, Mestanik M Acta Clin Belg 2019 Apr;74(2):82-85. Epub 2018 May 2 doi: 10.1080/17843286.2018.1467531. [ncbi.nlm.nih.gov]

Prognosis Lentigines are benign by nature. In patients in whom lentigines are associated with systemic abnormalities or complications, the prognosis may depend on the severity of the associated conditions. [emedicine.medscape.com]

Etiology and Pathophysiology Ephelides occur as a result of increased melanin content inside of keratinocytes, mainly seen in the basal cell layer. The number of melanocytes is normal. [unboundmedicine.com]

The etiology of ND is unknown, but it is associated with a large reduction in melanosomes with variable melanocyte morphology; these melanosomes do not transfer efficiently into keratinocytes.4 The few melanosomes that transfer into keratinocytes are [journals.lww.com]

(Adams et al., Principles of Neurology, 6th ed, p272) Etiology Acta Clin Belg 2019 Apr;74(2):82-85. Epub 2018 May 2 doi: 10.1080/17843286.2018.1467531. [ncbi.nlm.nih.gov]

Multiple clinical and etiologic varieties exist. The distinction of a lentigo from other melanocytic lesions (eg, melanocytic nevi, melanoma) and its role as a marker for ultraviolet damage and systemic syndromes is of major significance. [emedicine.medscape.com]

Terminology Also called solar lentigines, age spots Epidemiology Sun exposed skin of elderly (90% of whites age 60+); also truck drivers on sun exposed face ( J Dermatol 2008;35:146 ) Multiple large solar lentigos on upper back and shoulders suggest prior [pathologyoutlines.com]

Articles from The Pan African Medical Journal are provided here courtesy of African Field Epidemiology Network [ncbi.nlm.nih.gov]

Melasma: Epidemiology, pathogenesis, clinical presentation, and diagnosis. https://www.uptodate.com/contents/search. Accessed Nov. 24, 2020. Wolff K, et al. Photosensitivity, photo-induced disorders and disorders by ionizing radiation. [mayoclinic.org]

Epidemiology Incidence The incidence of ephelides, solar lentigines, and simple lentigines is currently unknown, with limited information on these benign entities reported in the literature. [unboundmedicine.com]

(A classical review of LS with emphasis on clinical presentation and insightful epidemiology relations.) Voron, DA, Hatfield, HH, Kalkhoff, RK. “Multiple lentigines syndrome. Case report and review of the literature”. [dermatologyadvisor.com]

Etiology and Pathophysiology Ephelides occur as a result of increased melanin content inside of keratinocytes, mainly seen in the basal cell layer. The number of melanocytes is normal. [unboundmedicine.com]

Darker skin patients such as Asians have higher epidermal melanin content and are more likely to develop erythema and PIH, which can be considered as a default pathophysiologic response to cutaneous injury in these patients. [e-ijd.org]

Pathophysiology Long-term exposure to ultraviolet radiation and pollution as one ages may induce the common solar lentigo. [5] Depending on the type of lentigo present, a solitary lesion or multiple lesions can occur anywhere on the body. [emedicine.medscape.com]

Sun Avoidance Practice sun protection to prevent new lentigines from appearing and prevent further darkening or growth of the existing spots. This includes the use of broad-spectrum sunscreens and limiting exposure to sunlight. [pooledermatology.com]

Prevention The only way to prevent lentigines is to properly care for your skin and protect it from the sun. [virginiamohs.com]

However, use of sunscreen may prevent new lesions from forming and existing lesions from becoming darker in the case of solar lentinges. [ozarkderm.com]

Solar lentigines are best prevented by minimizing sun exposure. They are not typically cancerous, although a check by a dermatologist is recommended. There are various treatments we have available to decrease or remove lentigines. [singerskin.com]

How can lentigines be prevented Lentigines associated with exposure ultraviolet radiation can be prevented by very careful sun protection. Clothing is more successful at preventing new lentigines than are sunscreens. [myskindoctor.co.uk]