Herein, we present a 31-year-old man diagnosed with uremic leontiasis ossea. [cureus.com]

[…] characteristic radiologic features of uremic leontiasis ossea. 6 Case Report We present case report of two patients (12-year-old girl and 29- year-old male) presenting with jaw masses. [slideplayer.com]

The present publication represents a study of the unusual bony lesions. It is hoped that the findings will contribute some information which will help to re-evaluate the condition described in the literature as “leontiasis ossea.” [pubs.rsna.org]

[…] are the hallmarks while on the quiescent and inactive stage there is a predominance of cortical thickening and sclerosis, and finally, it can have a mixed pattern presentation. [imagejournals.org]

The patient noted that the bulky hard mass on his palate had been present for several years and grew slowly overtime. [clinicalimagingscience.org]

• Developmental Disorder

  Although FD is linked to an activating mutation in the gene that encodes the subunit of stimulatory G protein (Gs) located at 20q13.2–13.3, it is a non-heritable congenital developmental disorder. [link.springer.com]

• Noncompliance

  Since childhood, she had been noncompliant with her diet and medication; her secondary hyperparathyroidism deteriorated over the years. [ncbi.nlm.nih.gov]

• Saddle Nose

  Physical examinations revealed: toggled speech (nasal speech), mouth breathing and facial change, saddle nose, nares widening, increased interdental space and mandibular enlargement. [journalrip.com]

• Orthopnea

  He also complained of shortness of breath with exertion, orthopnea, as well as mild chest pain. Fluid overload was suspected due to the patient's missed dialysis. [cureus.com]

• Chest Pain

  He also complained of shortness of breath with exertion, orthopnea, as well as mild chest pain. Fluid overload was suspected due to the patient's missed dialysis. [cureus.com]

• Jaw Pain

  Facial swelling and bilateral or unilateral jaw pain may be part of the initial complaints. [cureus.com]

• Nasal Speech

  Physical examinations revealed: toggled speech (nasal speech), mouth breathing and facial change, saddle nose, nares widening, increased interdental space and mandibular enlargement. [journalrip.com]

• Rugger-Jersey Spine

  When described, it is termed a rugger jersey spine given it close resemblance to the pattern seen on a rugby jersey. [clinicalimagingscience.org]

  Findings in secondary (and tertiary) hyperparathyroidism are numerous: sub periosteal bone resorption, osteopenia, osteosclerosis e.g. rugger-jersey spine, soft tissue calcification, generalized increased uptake on Tc-99m pertechnetate bone scan, superior [file.scirp.org]

It is possible that at this stage of the disease, the patient has tertiary hyperparathyroidism when treatment is rarely successful7. [ncbi.nlm.nih.gov]

HD treatment was initiated and further post-HD evaluation showed improvement of the patient's overall status. [cureus.com]

A medical practitioner should always be consulted for diagnosis and treatment of all medical conditions. [hospitalhelp.co.uk]

There is no treatment other than exposing the overgrown bone, and chipping away pieces, or excising entirely where possible. [bionity.com]

More often, most lesions can be managed through staged procedures with overall very favorable outcomes and good long term prognosis. [skullbaseinstitute.com]

Treatment usually entails parathyroidectomy with monitoring of serum calcium, phosphate, and vitamin D levels while on appropriate replacement (calcium/vitamin D) or binding (phosphate) pharmacotherapy. 4 The prognosis is usually favorable. [appliedradiology.com]

Clinical-Medical Image: Paget disease of the bone is a chronic disorder of unknown etiology that typically results in enlarged, deformed bones due to abnormal and excessive bone remodeling. [imagejournals.org]

Indian J Ophthalmol 1969;17:166-70 Introduction The term leontiasis ossea was first coined by Virchow [6] in 1896 to describe the leonine appearance of the facial deformity in this rare condition of unknown etiology. [ijo.in]

Case Presentation A 31-year-old man with a past medical history of ESRD of unknown etiology, on hemodialysis (HD) since 2004, presented to the emergency department (ED) complaining of missed dialysis. [cureus.com]

However, nutritional and secondary hyperparathyroidism due to uremia has been suggested as major etiologies for the disease [5]. After parathyroidectomy, facial changes can be stabilized or improve mildly. [file.scirp.org]

The report aims to review the pathophysiology of the condition as described in the literature, the patient presentation and imaging modalities used to investigate, and classical findings seen in patients with uremic leontiasis ossea. [cureus.com]

Pathophysiological origin of the disease is not clearly understood. However, nutritional and secondary hyperparathyroidism due to uremia has been suggested as major etiologies for the disease [5]. [file.scirp.org]

Strict medical management of metabolic derangements, prevention of secondary hyperparathyroidism and adherence to hemodialysis are the best possible options to prevent this condition. [cureus.com]

Hence, early recognition and treatment of leontiasis ossea can prevent its complications. Please cite this paper as: Raffiei Jelodar H, Yarmohamadi M, Baghai Wadji M, Babaei MR. Leontiasis ossea; a rare presentation of secondary hyperparathyroidism. [journalrip.com]

Early recognition andconfident diagnosisof ULO is essential to prevent progression to facial disfigurement andavoid invasive procedures. [posterng.netkey.at]

During hemodialysis patients often develop numerous comorbid conditions that may interfere with the existing disease and prevent further treatment, as was the reported case. [ncbi.nlm.nih.gov]