A variant form of cystatin C, Leu68Glu, is associated with cerebral hemorrhage in Icelandic families. 23 Amyloid deposits have been demonstrated in cerebral blood vessels. [jamanetwork.com]

He also complained of diplopia and numbness in his left foot. His CSF protein level was slightly high (53 mg/dl) without pleocytosis. Cranial CT and MRI showed no abnormalities. [jnnp.bmj.com]

We would also expect that slowly progressive symptoms might suggest bilateral disease, and rapid onset symptoms might suggest a unilateral damage, difficult to distinguish from the combination of another disorder (such as sudden hearing loss, or vestibular [dizziness-and-balance.com]

Two months later, he developed progressive confusion, fatigue, erectile difficulties, urinary urgency and incontinence. In March 2012, he suffered from recurrent episodes of slurred speech and right-sided weakness, lasting 30 min. [link.springer.com]

Other neurologic signs included bilateral sensorineural hearing loss and cerebellar ataxia. Autonomic dysfunction was not identified and there was no visceral organ involvement. At age 52 years, he was admitted because of a new-onset seizure. [n.neurology.org]

Examination of the limbs revealed increased tone and brisk reflexes in the upper and lower limbs and mild bilateral heel-shin ataxia. [link.springer.com]

Both patients revealed pyramidal tract signs and cerebellar ataxia. Audiometric studies showed bilateral, mild sensorineural hearing loss in the patients whose cerebrospinal fluid (CSF) protein levels increased. [jnnp.bmj.com]

Protein accumulation in this tissue can cause stroke and cerebral hemorrhage, hydrocephalus, ataxia, rigidity and spastic paralysis, seizures, and dementia. Similar to form neuropathic eye problems may also occur. [ivami.com]

She was the daughter of a patient with an Ala36Pro TTR mutation, who died at 43 years old due to a stroke caused by leptomeningeal vascular amyloidosis. [fapnewstoday.com]

Clinical features Seizures, stroke-like episodes, dementia, psychomotor deterioration, variable amyloid deposition in the vitreous humour. [medical-dictionary.thefreedictionary.com]

[…] amyloidosis throughout the natural course of the disease. 2 This CNS ATTR is mainly related to the production of TTR variants by the choroid plexus and manifests with TIA-like episodes, aura-like episodes, ischemic or hemorrhagic brain or spinal cord strokes [ingentaconnect.com]

Protein accumulation in this tissue can cause stroke and cerebral hemorrhage, hydrocephalus, ataxia, rigidity and spastic paralysis, seizures, and dementia. Similar to form neuropathic eye problems may also occur. [ivami.com]

Clinical features include seizures, stroke-like episodes, dementia, psychomotor deterioration, variable amyloid deposition in the vitreous humor. [malacards.org]

At age 52 years, he was admitted because of a new-onset seizure. Gadolinium-enhanced T1-weighted brain MRI showed striking leptomeningeal enhancement (figure, A). [n.neurology.org]

Clinical features Seizures, stroke-like episodes, dementia, psychomotor deterioration, variable amyloid deposition in the vitreous humour. [medical-dictionary.thefreedictionary.com]

[…] throughout the natural course of the disease. 2 This CNS ATTR is mainly related to the production of TTR variants by the choroid plexus and manifests with TIA-like episodes, aura-like episodes, ischemic or hemorrhagic brain or spinal cord strokes, epileptic seizures [ingentaconnect.com]

Protein accumulation in this tissue can cause stroke and cerebral hemorrhage, hydrocephalus, ataxia, rigidity and spastic paralysis, seizures, and dementia. Similar to form neuropathic eye problems may also occur. [ivami.com]

Clinical features include seizures, stroke-like episodes, dementia, psychomotor deterioration, variable amyloid deposition in the vitreous humor. [malacards.org]

He subsequently died of multiple intracranial hemorrhages with local extension into the subarachnoid space (figure, C). [n.neurology.org]

A point mutation in the TTR gene resulting in Gly-for-Val amino acid substitution at codon 30 was associated with the condition. 13 In another report, a patient with intracranial hemorrhage due to extensive meningeal amyloidosis has been described as [jamanetwork.com]

Individuals with leptomeningeal amyloidosis show CNS signs and symptoms including: dementia, psychosis, visual impairment, headache, seizures, motor paresis, ataxia, myelopathy, hydrocephalus, or intracranial hemorrhage. [pharmaceuticalintelligence.com]

Protein accumulation in this tissue can cause stroke and cerebral hemorrhage, hydrocephalus, ataxia, rigidity and spastic paralysis, seizures, and dementia. Similar to form neuropathic eye problems may also occur. [ivami.com]

Typical clinical central nervous system manifestations include cerebral infarction and hemorrhage, hydrocephalus, ataxia, spastic paralysis, convulsion, and dementia. [ojrd.biomedcentral.com]

The CSF study revealed hyperproteinaemia (177 mg/dL) and xanthochromia. The electromyography study ruled out peripheral neuropathy. [elsevier.es]

The CSF protein level was 1,099 mg/dL with xanthochromia. He subsequently died of multiple intracranial hemorrhages with local extension into the subarachnoid space (figure, C). [n.neurology.org]

A CSF examination on 11 June revealed xanthochromia and showed that the protein level had increased to 145 mg/dl with mild lymphocytic pleocytosis (27/mm 3 ). [jnnp.bmj.com]

As described in the previous report by Uitti et al, 5 leptomeninges of patients in this kindred were markedly thickened with amyloid deposits and their spinal cords were severely atrophic with gliosis, which was presumed to be the cause of paraplegia. [jamanetwork.com]