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Leptospiral Meningitis

Leptospirosis Meningeal


Presentation

  • Four patients with suspected meningitis (57%) had cerebrospinal fluid pleocytosis indicative of leptospiral meningitis and presented with headache, fever and neck stiffness.[ncbi.nlm.nih.gov]
  • Clinical presentations range from nonspecific fevers to fulminant diseases such as Weil's syndrome.[tmu.pure.elsevier.com]
  • It is uncommon for leptospirosis to present as a primary neurological disease.[pmj.bmj.com]
  • Jaundice was present in only 25 (18%) of cases with renal failure in 2 cases.[link.springer.com]
Fever
  • Four patients with suspected meningitis (57%) had cerebrospinal fluid pleocytosis indicative of leptospiral meningitis and presented with headache, fever and neck stiffness.[ncbi.nlm.nih.gov]
  • This edition includes new information on botulinum toxin as a biological weapon and a therapeutic agent, neurologic effects of viruses causing hemorrhagic fevers, and infections that have recently become more prevalent or been found in new geographic[books.google.de]
  • Brouwer Published in The Netherlands journal of medicine 2015 BACKGROUND Leptospirosis is a widespread zoonotic disease characterised by headache and fever.[semanticscholar.org]
  • NIH: National Institute of Allergy and Infectious Diseases Actinomycosis Bacterial vaginosis -- aftercare Blood culture Gram stain Gram stain of skin lesion Necrotizing soft tissue infection Q fever Serology for tularemia Shigellosis Stool Gram stain[icdlist.com]
  • , autumnal fever) 3 have been noted in this country.[jamanetwork.com]
Epilepsy
  • […] parasitic diseases Approximate Synonyms Aseptic leptospiral meningitis ICD-10-CM A27.81 is grouped within Diagnostic Related Group(s) (MS-DRG v 36.0): 023 Craniotomy with major device implant or acute complex cns pdx with mcc or chemotherapy implant or epilepsy[icd10data.com]
Chills
  • Malaria A parasitic infection spread by mosquito bites, with fever, headaches, vomiting and chills developing after 10 to 15 days. Onset is slightly slower than leptospirosis and pinprick rashes are rare.[leptospirosis.org]
Vomiting
  • Malaria A parasitic infection spread by mosquito bites, with fever, headaches, vomiting and chills developing after 10 to 15 days. Onset is slightly slower than leptospirosis and pinprick rashes are rare.[leptospirosis.org]
  • The immune phase is mediated by immune complexes and is characterised by the classical manifestation of headache, vomiting, and meningeal irritation.[pmj.bmj.com]
Nausea
  • Influenza Also shows a fever, headache, nausea and muscle pain but there is no skin rash, and inflammation of the eyes is uncommon.[leptospirosis.org]
Headache
  • Four patients with suspected meningitis (57%) had cerebrospinal fluid pleocytosis indicative of leptospiral meningitis and presented with headache, fever and neck stiffness.[ncbi.nlm.nih.gov]
  • Brouwer Published in The Netherlands journal of medicine 2015 BACKGROUND Leptospirosis is a widespread zoonotic disease characterised by headache and fever.[semanticscholar.org]
  • The cough develops more rapidly than in leptospirosis, and the headache more slowly.[leptospirosis.org]
  • Diagnostic criteria were fever, myalgia, conjunctival suffusion, Jaundice, headache, altered sensorium, seizures, bleeding manifestation and oliguria.[link.springer.com]
  • Signs and symptoms can range from none to mild such as headaches, muscle pains, and fevers; to severe with bleeding from the lungs or meningitis.[icd.codes]
Seizure
  • Altered sensorium and seizures herald a worse prognosis.[pmj.bmj.com]
  • Diagnostic criteria were fever, myalgia, conjunctival suffusion, Jaundice, headache, altered sensorium, seizures, bleeding manifestation and oliguria.[link.springer.com]
  • HSV1 and nonprimary genital infection with HSV1 or 2 rarely result in meningitis (due to herpesviruses, arboviruses, rabies virus, flaviviruses [West Nile encephalitis, Japanese encephalitis], and many others) produces disturbances of the sensorium, seizures[quizlet.com]
Neck Stiffness
  • Four patients with suspected meningitis (57%) had cerebrospinal fluid pleocytosis indicative of leptospiral meningitis and presented with headache, fever and neck stiffness.[ncbi.nlm.nih.gov]
  • stiffness and analysis of the cerebrospinal fluid (CSF) established the diagnosis of aseptic meningitis.[pmj.bmj.com]
Irritability
  • The immune phase is mediated by immune complexes and is characterised by the classical manifestation of headache, vomiting, and meningeal irritation.[pmj.bmj.com]
Confusion
  • Hepatitis Patients with severe leptospirosis often show jaundice, and can be confused with viral hepatitis – however the other symptoms of leptospirosis (hemorrhages, severe muscle pain, headaches, etc.) can be used to differentiate.[leptospirosis.org]

Workup

Cerebrospinal Fluid Abnormality
  • Typical cerebrospinal fluid abnormalities consisted of a mildly elevated leukocyte count (median 206 leukocytes/mm3, range 6-2072) with a lymphocytic predominance (median 95%).[ncbi.nlm.nih.gov]

Treatment

  • Antibiotics are the usual treatment. When you take antibiotics, follow the directions carefully. Each time you take antibiotics, you increase the chances that bacteria in your body will learn to resist them causing antibiotic resistance.[icdlist.com]
  • Effectively monitor the pace of drug clearing in patients undergoing pharmacogenomic treatments with a new chapter on this groundbreaking new area.[books.google.com]
  • He recovered well after an early investigation and treatment for leptospirosis based on suspected relevant risk factors and clinical manifestations.[tmu.pure.elsevier.com]
  • Links: risk factors clinical features diagnosis treatment[gpnotebook.co.uk]

Prognosis

  • PROGNOSIS Prognosis of neuroleptospirosis is generally good. Meningitis usually resolves by 3–6 weeks.[pmj.bmj.com]

Etiology

  • Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology.[icd10coded.com]
  • […] had enteroviral or leptospiral etiologies.[ncbi.nlm.nih.gov]
  • The case presented symptomatology not heretofore described in leptospirosis, and increased the number of clinical pictures that suggest the possibility of leptospiral etiology.[annals.org]
  • Since the entity known as aseptic meningitis was described by Wallgren over a quarter of a century ago, 1 considerable progress in the recognition of some of the multiple etiologic agents of this syndrome has been made.[jamanetwork.com]

Epidemiology

  • Laboratory investigations have led to the identification of new strains; epidemiologic observations have thrown light on the natural reservoirs of infection, and clinicians have described several different expressions of leptospiral infection in man.[jamanetwork.com]
  • Epidemiological Study of microscopic agglutination test in a pediatric community popultaion. Unpublished data Google Scholar 10. Guidugli F, Casto AA:antibiotics for treating Leptospirosis.[link.springer.com]
  • A sensitive, specific, and rapid method for the diagnosis of leptospirosis is important for the clinician, the patient, and effective epidemiological surveillance.[jcm.asm.org]
Sex distribution
Age distribution

Pathophysiology

  • These include the characteristic neuroimaging appearance of specific bacterial infections, the limitations of neuroimaging, the cerebrospinal fluid analysis, the pathogenesis and pathophysiology of bacterial CNS infections, the developments of specific[books.google.com]

Prevention

  • Get optimal test results with guidance on error detection, correction, and prevention as well as cost-effective test selection.[books.google.com]
  • Conclusion: To facilitate optimal use of antibiotic treatments and prevent lethal complications of leptospirosis, we report this case of leptospirosis, which highlights the importance of knowing the occupational history and environmental exposures of[tmu.pure.elsevier.com]
  • […] the initiation of infection Serum antibody blocks viremic spread to target tissue, preventing disease • Cause vesicular rash around the mouth and on the hands or soles of feet (hand-foot-and- mouth disease), and sore throat, herpes- like vesicles in[quizlet.com]

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