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Acronym LIH Synonyms Leucine-sensitive hypoglycemia of infancy Disclaimer Any medical or genetic information present in this entry is provided for research, educational and informational purposes only.[uniprot.org]
The present report describes a mother and 2 children with leucine-induced hypoglycemia (LIH). Hypoglycemic episodes following high-protein meals first appeared at age 4-7 months.[ncbi.nlm.nih.gov]
Abstract The clinical and electroencephalographic signs of leucine-induced hypoglycemia in the infant can be alleviated with oral or intravenousadministration of sodium glutamate.[pediatrics.aappublications.org]
Profound hypoglycemia or a very rapid fall in blood sugar causes convulsions and final coma. hunting dog hypoglycemia a stress-related syndrome seen in dogs that are fasted before a hunt, later experiencing exhaustion and hypoglycemic seizures. juvenile[medical-dictionary.thefreedictionary.com]
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Studies have shown that most people suffering from its symptoms test normal for blood sugar, leading many doctors to suggest that actual cases of reactive hypoglycemia are quite rare.[checkorphan.org]
A reason that this investigation did not occur years ago, is partly because older works suggested that high levels of L-Leucine are correlated with increased seizures frequency and acute exposure with hypoglycemia.[icaas-org.com]
Animal pancreatic cancer models suggest that it may also increase growth of pancreatic tumors (34).[mskcc.org]
Some studies on appetite suppressing effects suggest higher doses of 300mg/kg body weight. Most information suggests a 3:1:1 ratio of leucine to valine to isoleucine.[metaboliceffect.com]
The classic form presents as a neonate, with the ingestion of dietary protein, with a maple syrup-like odor of cerumen, sweat and urine, irritability, poor feeding, vomiting, lethargy and a progressive encephalopathy that may result in coma with respiratory[genedx.com]
The various signs and symptoms exhibited by the sufferers of reactive hypoglycemia include: Coma Fatigue Nausea Rhinitis Anxiety Tremors Flushing Dizziness Vomiting Sweating Irritability Confusion Numbness Headaches Depression Nervousness Panic attacks[hxbenefit.com]
Profound hypoglycemia or a very rapid fall in blood sugar causes convulsions and final coma. hunting dog hypoglycemia a stress-related syndrome seen in dogs that are fasted before a hunt, later experiencing exhaustion and hypoglycemic seizures. juvenile[medical-dictionary.thefreedictionary.com]
[…] short-term maintenance of blood glucose but do play a role in long-term management of glucose metabolism. 3.8 mmol/L - glucagon/adrenaline released 3.2 mmol/L - symptoms begin 2.8 mmol/L - cognitive problems 1.5 mmol/L - reduced level of consciousness, convulsions[sharinginhealth.ca]
Often precipitated by excitement, anorexia, hypothermia or gastrointestinal disorders. The cause is unclear, but believed to be incomplete development of metabolic pathways for glucose production.[medical-dictionary.thefreedictionary.com]
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To evaluate the therapeutic effects and to study the mechanism of hyperinsulinism in LIH, the leucine test was repeated under treatment with diphenylhydantoin, oxprenolol (a beta-blocker), and diazoxide.[ncbi.nlm.nih.gov]
It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice .[uniprot.org]
Treatment - Hypoglycemia- leucine-induced Treatment of the immediate symptoms of hypoglycemia can include eating sugar. For example, a patient can eat a piece of candy, drink milk, or drink fruit juice.[checkorphan.org]
Prognosis - Hypoglycemia- leucine-induced Like diabetes, there is no cure for reactive hypoglycemia, only ways to control it.[checkorphan.org]
Reactive Hypoglycemia Prognosis Although there are no permanent cures for Reactive hypoglycemia, maintaining a strict diet plan and regularly coordinating with the physician will allow an individual to manage the symptoms associated with this condition[hxbenefit.com]
Etiology Glutamate dehydrogenase (GDH) is a mitochondrial matrix enzyme that catalyzes the oxidative deamination of glutamate, yielding alpha-ketoglutarate and an ammonia by-product.[orpha.net]
Patients who use insulin as a part of intensive therapy are at increased risk of hypoglycemia several hours after drinking alcohol. return to top Pathophysiology Glucagon and epinephrine are the most important immediate responders to hypoglycemia.[sharinginhealth.ca]
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Prevention - Hypoglycemia- leucine-induced Drug-induced hypoglycemia Preventing hypoglycemic insulin reactions in diabetics requires taking glucose readings through frequent blood sampling. Insulin then can be regulated based on those readings.[checkorphan.org]
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[…] an excessive/ uncontrolled insulin secretion (inappropriate for the level of glycemia), asymptomatic hyperammonemia and recurrent episodes of profound hypoglycemia induced by fasting and protein rich meals, requiring rapid and intensive treatment to prevent[orpha.net]
[…] creatinine [51] (half-life of creatinine is 3.85 hours in healthy subjects [52] ) Absorbed reactive AGEs such as Pentosidine may swiftly be cleared from the blood, only to get reabsorbed and/or rapidly bind to tissue proteins to a major extend [53], preventing[waiwiki.org]