Leukonychia totalis was present as the most common manifestation in all affected members while knuckle pads were only present in male members. [biomedsearch.com]

This condition can be presented as an isolated condition or in association with systemic diseases. [karger.com]

If, however, only one mutant copy of the gene is inherited, the individual will be a carrier of the condition, but will not be present with any symptoms. [dovemed.com]

In this report, we present three sibs (a sister and two brothers) with isolated congenital leukonychia totalis, without any manifestation among parents and other family members. [ncbi.nlm.nih.gov]

• Dentist

  Skip to main content Check Your Symptoms Find A Doctor Find A Dentist Connect to Care Find Lowest Drug Prices Health A-Z Drugs & Supplements Living Healthy Family & Pregnancy News & Experts Mobile Apps Subscriptions Privacy and More Sign In Menu Health [webmd.com]

• Orthopnea

  She reported a four-month history of worsening dyspnea on exertion, orthopnea, and a progressive whitening of her fingernails. [nejm.org]

• Blepharitis

  She also had multiple trichilemmal cysts (see 609649) and short eyelashes that were irregular in size and in implantation and were associated with blepharitis, tearing, conjunctival irritation, and photophobia. [omim.org]

  The signs and symptoms of Leukonychia Totalis may include: Abnormal structure of the fingernails and toenails White discoloration on the nails (leukonychia) Abnormality of the eyelashes Inflammation of the eyelid (blepharitis) Sensitivity to light Additionally [dovemed.com]

  Abnormality of the toenails [ more ] 0008388 Adenoma sebaceum 0009720 Nephrolithiasis Kidney stones 0000787 30%-79% of people have these symptoms Abnormal eyelash morphology Abnormal eyelashes Abnormality of the eyelashes Eyelash abnormality [ more ] 0000499 Blepharitis [rarediseases.info.nih.gov]

• Nystagmus

  Ring J. 1998 20 Familial leukonychia totalis. ( 9833061 ) Grosshans E.M. 1998 21 A syndrome of leukonychia totalis and multiple sebaceous cysts. ( 9220192 ) Slee J.J....Goldblatt J. 1997 22 Multiple epiphyseal dysplasia with small head, congenital nystagmus [malacards.org]

The patient's laboratory workup was unremarkable and included a normal complete blood count with differential and negative arsenic and lead levels. Fig. 2 Histopathology of the nail plate with parakeratosis. [karger.com]

The patient's laboratory workup was unremarkable and included a normal complete blood count with differential and negative arsenic and lead levels. Histopathology of the nail plate with parakeratosis. [ncbi.nlm.nih.gov]

• Glycosuria

  We cannot determine whether renal glycosuria is a component of this syndrome. [unboundmedicine.com]

• Dyslipidemia

  Her medical history included hypertension and dyslipidemia. Patient’s laboratory work up revealed stage I chronic kidney disease and renal hypoplasia. [epostersonline.com]

More on Genetics of Leukonychia totalis » Treatments: Leukonychia totalis Treatment : There is no universally successful treatment for the whitening of the nails in people with leukonychia totalis. [3] However, if the condition is known to have an underlying [familydiagnosis.com]

CLOSE Medical Disclaimer The medical information on this site is provided as an information resource only, and is not to be used or relied on for any diagnostic or treatment purposes. [diseaseinfosearch.org]

and in some cases, due to treatment also. [dovemed.com]

Treating Leukonychia The treatment of leukonychia depends on the cause, and hence, the first method involved in treatment is to diagnose the cause of this condition. [healthhearty.com]

Prognosis - Leukonychia totalis Not supplied. Treatment - Leukonychia totalis Not supplied. Resources - Leukonychia totalis Not supplied. [checkorphan.org]

The overall prognosis depends on the severity of the nail condition and any associated abnormality Who gets Leukonychia Totalis? (Age and Sex Distribution) Leukonychia Totalis is a rare congenital disorder. [dovemed.com]

Nonetheless, total leukonychia due to systemic disorders appears to have reasonably good prognosis as it seems to be transient and reversible. [amhsjournal.org]

Taking hemoglobin and platelet inhibition into account might reflect the relationship between myelosuppression and prognosis more accurately. [bmccancer.biomedcentral.com]

The prognosis of leukonychia remains undetermined. Although there is no specific treatment for true leukonychia, Bettoli and Tosti [10] reported that congenital leukonychia has a possibility of gradual improvement over the lifetime of an individual. [karger.com]

The constant presence of SNHL and close overlap in associated dermatologic abnormalities also suggests a single genetic etiology. [biomedsearch.com]

M iscellaneous Etiologies of Neutropenia Selected etiologies of neutropenia are noted in Table 4. The clinician should approach leukopenia by one of the mechanisms noted in the above section. [antimicrobe.org]

The clinical features partially overlap with Vohwinkel syndrome and Keratitis-Ichthyosis-Deafness syndrome, both disorders caused by dominant mutations in the GJB2 gene encoding the gap junction protein connexin-26, suggesting an etiological relationship [scienceopen.com]

4300071,China; Prenatal Gene Diagnosis for the Duchenne Muscular Dystrophy Risk Fetus by Molecule Markers [J];Medical Journal of Wuhan University;2009-06 5 LI Xiumei,ZHOU Jinxia,TIAN Ke.Han Dan Medical College,Handan,Hebei,056029; A study of inheritance epidemiology [en.cnki.com.cn]

Schwann J: Dermatitis caused by Thaumatopoea pinivora caterpillars and their epidemiological significance. Przegl Dermatol. 1961; 48: 415-422. 14. Schwann J: Milker's nodes as an epidemiological problem in the area of Szczecin (Stettin). [odermatol.com]

GUIDED MEDLINE SEARCH FOR RECENT REVIEWS Epidemiology Clinical Manifestation Pathogenesis Therapy Prevention Guided medline search for historical aspects Leukocytosis and Leukopenia [antimicrobe.org]

Global epidemiology of hepatitis C virus infection: new estimates of age-specific antibody to HCV seroprevalence. Hepatology. 2013;57(4):1333–42. [smw.ch]

Nasopharyngeal carcinoma in Indonesia: epidemiology, incidence, signs, and symptoms at presentation. Chin J Cancer. 2012;31(4):185–96. View Article PubMed PubMed Central Google Scholar Peng G, Wang T, Yang KY, Zhang S, Zhang T, Li Q, et al. [bmccancer.biomedcentral.com]

Mechanisms of Clinical Signs is the first consolidated text of its kind; designed to help medical students and junior doctors understand the pathophysiological mechanisms behind clinical signs. [books.google.de]

One common explanation is zinc deficiency. [4] Pathophysiology Associated Conditions Kidney disease Liver disease Causes Causes In Alphabetical Order Anemia Arsenic poisoning Calcium deficiency Cardiac Diseases Cirrhosis Congenital isolated nail dysplasia [wikidoc.org]

Its pathophysiology is not well established, although it is hypothesized to be secondary to abnormal keratinization of the nail plate. [karger.com]

Defects in connexin genes have been associated with a broad scope of Mendelian disorders, and the pathophysiology of mutant connexins contributing to these disorders generally arises from three mechanisms: retention of connexin proteins in the cytoplasm [academic.oup.com]

Prevention - Leukonychia totalis Not supplied. Diagnosis - Leukonychia totalis A doctor will take a thorough medical history, and may test liver and kidney function. [checkorphan.org]

The only prevention one can take to prevent Leukonychia is to reduce possibilities of minor injury to the nails so the white marks do not occur. [handresearch.com]

How can Leukonychia Totalis be Prevented? Currently, Leukonychia Totalis may not be preventable, if it is inherited. [dovemed.com]

Prevention There are ways that a person can prevent white spots appearing again. [medicalnewstoday.com]