RESULTS: Adverse reactions appeared in 4 patients (4.9%; diarrhea, dizziness and leg edema). The mean improvement in PEFR on week 16 was 18.5 /- 2.3, 18.8 /- 3.2, and 15.2 /- 3.8% in groups I-III, respectively (p 0.01, for all groups). [ncbi.nlm.nih.gov]

BACKGROUND: Chronic cough is the only symptom of cough variant asthma (CVA) and atopic cough (AC). Cysteinyl leukotriene receptor antagonists have been shown to be effective in CVA, but there are no reports on their effectiveness in AC. [ncbi.nlm.nih.gov]

The effect of montelukast in reducing burning, photophobia, secretion, and redness persisted 15 days after discontinuation. [jamanetwork.com]

Patients' symptoms were scored according to "facial pain", "headache", "nasal blockage", "nasal discharge", "sense of smell" and "daily activity", and measurements of peak inspiratory nasal flow were made, before and after the introduction of montelukast [ncbi.nlm.nih.gov]

We present the case of a 26-year-old patient, who developed severe central and peripheral neuropathy after a short-term treatment with LTRA, followed by gastrointestinal perforation and bleeding. [ncbi.nlm.nih.gov]

Prescribers should be alert to the development of eosinophilia, vasculitic rash, worsening pulmonary symptoms, cardiac complications, or peripheral neuropathy [niformulary.hscni.net]

neuropathy. 52 Box 2: Safety of leukotriene receptor antagonists Generally well tolerated, side effect profile similar to placebo. [pmj.bmj.com]

[…] recurrent events; n 153,937 and n 132,291 for stroke and myocardial infarction, respectively). [ncbi.nlm.nih.gov]

The purpose of this study was to determine whether leukotriene receptor antagonists (LTRAs), as montelukast, used in asthma are associated with a decreased myocardial infarction (MI) and ischemic stroke (IS) risk. [erj.ersjournals.com]

A 77-year-old Japanese female developed Churg-Strauss syndrome (CSS), showing fever and numbness in bilateral hands. [ncbi.nlm.nih.gov]

She presented fever up to 38 C with microscopic hematuria and proteinuria, serum creatinine level of 0.7 mg/dl, and C-reactive protein of 11 mg/dl. [ncbi.nlm.nih.gov]