Presentation
For administration by inhalation, the compounds of the present invention are delivered in the form of an aerosol spray presentation from pressurized packs or nebulisers. [google.com]
We suggest that preceding administration of pranlukast aggravates clinical presentations of CSS. [ncbi.nlm.nih.gov]
Entire Body System
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Leg Edema
RESULTS: Adverse reactions appeared in 4 patients (4.9%; diarrhea, dizziness and leg edema). The mean improvement in PEFR on week 16 was 18.5 /- 2.3, 18.8 /- 3.2, and 15.2 /- 3.8% in groups I-III, respectively (p 0.01, for all groups). [ncbi.nlm.nih.gov]
Respiratoric
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Chronic Cough
BACKGROUND: Chronic cough is the only symptom of cough variant asthma (CVA) and atopic cough (AC). Cysteinyl leukotriene receptor antagonists have been shown to be effective in CVA, but there are no reports on their effectiveness in AC. [ncbi.nlm.nih.gov]
Eyes
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Photophobia
The effect of montelukast in reducing burning, photophobia, secretion, and redness persisted 15 days after discontinuation. [jamanetwork.com]
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Ptosis
Examination revealed no ptosis. [google.com]
Face, Head & Neck
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Facial Pain
Patients' symptoms were scored according to "facial pain", "headache", "nasal blockage", "nasal discharge", "sense of smell" and "daily activity", and measurements of peak inspiratory nasal flow were made, before and after the introduction of montelukast [ncbi.nlm.nih.gov]
Neurologic
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Peripheral Neuropathy
We present the case of a 26-year-old patient, who developed severe central and peripheral neuropathy after a short-term treatment with LTRA, followed by gastrointestinal perforation and bleeding. [ncbi.nlm.nih.gov]
Prescribers should be alert to the development of eosinophilia, vasculitic rash, worsening pulmonary symptoms, cardiac complications, or peripheral neuropathy [niformulary.hscni.net]
neuropathy. 52 Box 2: Safety of leukotriene receptor antagonists Generally well tolerated, side effect profile similar to placebo. [pmj.bmj.com]
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Stroke
[…] recurrent events; n 153,937 and n 132,291 for stroke and myocardial infarction, respectively). [ncbi.nlm.nih.gov]
The purpose of this study was to determine whether leukotriene receptor antagonists (LTRAs), as montelukast, used in asthma are associated with a decreased myocardial infarction (MI) and ischemic stroke (IS) risk. [erj.ersjournals.com]
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Numbness of the Hand
A 77-year-old Japanese female developed Churg-Strauss syndrome (CSS), showing fever and numbness in bilateral hands. [ncbi.nlm.nih.gov]
Urogenital
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Microscopic Hematuria
She presented fever up to 38 C with microscopic hematuria and proteinuria, serum creatinine level of 0.7 mg/dl, and C-reactive protein of 11 mg/dl. [ncbi.nlm.nih.gov]
Treatment
Therefore, it has been suggested that antileukotrienes may be beneficial in the treatment of this disease. [ncbi.nlm.nih.gov]
Prognosis
Low expression of cyslt1r and high expression of cyslt2r mediate good prognosis in colorectal cancer. Eur J Cancer 46, 826–835 (2010). 29. Magnusson, C. et al. [nature.com]
Epidemiology
Melton III, L.J. and Selwyn, B.J. (1988) The Epidemiology of Pelvic Endometriosis. Clinical Obstetrics and Gynecology, 31, 787-800. [ 2 ] Dmownski, W.P., Braum, D. and Gebel, H.M. (1990) Endometriosis: Genetics and Immunologic Aspects. [dx.doi.org]
Bozek A, Jarzab J (2013) Epidemiology of IgE-dependent allergic diseases in elderly patients in Poland. Am J Rhinol Allergy 27: e140–145. View Article Google Scholar 4. [journals.plos.org]
The paperwork is not onerous, and we will all benefit as we learn more about this syndrome, its epidemiology, and its expression. [asthma.partners.org]
Pathophysiology
The pathophysiology of allergic rhinitis and its similarities to asthma suggest that these agents could play a significant therapeutic role in managing this upper airway disorder. [ncbi.nlm.nih.gov]
Cysteinyl-LTs and CysLTRs have been implicated in the pathophysiology of other inflammatory conditions including cancer, atopic dermatitis, idiopathic chronic urticaria, and cardiovascular diseases. [eurekaselect.com]
MAIN MESSAGE Leukotrienes appear to have an important role in the pathophysiology of asthma, including airway inflammation. [cfp.ca]
Home CCC Leukotriene Receptor Antagonists by, last update April 9, 2019 CLASS Leukotriene Receptor Antagonists example is Montelukast MECHANISM OF ACTION Leukotrienes are central to the pathophysiology of acute asthma Leukotrienes are synthesized from [litfl.com]
Prevention
In addition, it has been shown that LTRAs may have a potential role in preventing atherosclerosis progression. [ncbi.nlm.nih.gov]
[…] asthma symptoms and that is being studied in the prevention of lung cancer. [fpnotebook.com]