[…] analogs are ineffective as primary therapy in the treatment of GnRH-independent † (peripheral; gonadal steroid secretion is independent of gonadotropin secretion) precocious puberty, including familial male precocious puberty (testotoxicosis), congenital virilizing [drugs.com]

GnRHa co-administered with chemotherapy agents stimulated its receptors and raised intracellular cAMP levels. But it neither activated anti-apoptotic pathways nor prevented follicle loss, DNA damage and apoptosis induced by these drugs. [ncbi.nlm.nih.gov]

Pelvic examination and ultrasonography revealed the presence of a large irregular pelvic mass. At laparotomy, uterine and bilateral adnexal masses were noted extending up to the pelvic inlet and into the broad and infundibulopelvic ligaments. [ncbi.nlm.nih.gov]

He developed headache and neck pain within a few hours of treatment followed by nausea, vomiting, ptosis and diplopia. Pituitary apoplexy is a potentially life threatening medical emergency. [ncbi.nlm.nih.gov]

We report a unique case of a disseminated papular rash following leuprolide acetate injections in a 65-year-old man that shares clinical and histopathological features of papuloerythroderma of Ofuji. [ncbi.nlm.nih.gov]

The results of the QLQ-PR25 revealed that patients experienced an increase in hot flushes (p 0.001) and erection problems and uncomfortable sexual intimacy among the sexual functioning items (p 0.030 and p 0.023, respectively), but day-time urinary frequency [ncbi.nlm.nih.gov]

The median average daily number of hot flushes (calculated by dividing the total number of hot flushes in the reference month by the number of days with data recorded in that month) was significantly lower ( P 0.001) in the DMPA-SC 104 group than in the [doi.org]

A 43-year-old woman with a history of 5 years of amenorrhea sought help in achieving a pregnancy. Her gonadotropins were found to be elevated and thus she was diagnosed as having ovarian failure. [ncbi.nlm.nih.gov]

Kaplan–Meier Estimates of Times to the Control of Bleeding and Persistent Amenorrhea. [nejm.org]

Endpoints included patient response to treatment in five signs/symptoms (dysmenorrhoea, dyspareunia, pelvic pain, pelvic tenderness, induration) and changes in bone mineral density (BMD) and productivity at 6 and 18 months. [ncbi.nlm.nih.gov]

Improvement of endometriosis-associated dyspareunia was also observed in both treatment groups, although the results did not meet statistical equivalence ( P 0.049). Figure 2. [doi.org]

Primary bilateral macronodular adrenocortical hyperplasia (PBMAH) is an uncommon cause of adrenal Cushing syndrome (CS) in which cortisol and occasionally other steroid hormones can be secreted under the influence of aberrantly expressed G-protein coupled [ncbi.nlm.nih.gov]