Presentation
She presented initially with CS and underwent right adrenalectomy; a few years later she presented with macromastia and mastodynia, possibly due to estrogen excess from her remaining left adrenocortical masses. [ncbi.nlm.nih.gov]
According to the present invention, the peptide cleavage and global deprotection reagents used in the process of the present invention is a cocktail mixture of acid, scavengers and solvents. [google.ch]
Case Report A 78 year old man with recently diagnosed prostate cancer (Gleeson 7, non-invasive) saw his urologist two days prior to presentation. [headache.imedpub.com]
Entire Body System
- Chills
[…] sexual interest, vaginal discomfort/dryness/itching/discharge, vaginal bleeding, swelling of the ankles/feet, increased urination at night, dizziness, breakthrough bleeding in a female child during the first 2 months of leuprolide treatment, weakness, chills [web.archive.org]
[…] sexual interest, vaginal discomfort/dryness/itching/ discharge, vaginal bleeding, swelling of the ankles/feet, increased urination at night, dizziness, breakthrough bleeding in a female child during the first 2 months of leuprolide treatment, weakness, chills [rxlist.com]
Contact your advice line or doctor straight away as this can be life threatening bruising, bleeding gums or nosebleeds eyesight changes allergic reaction high temperature (fever) or chills increased risk of getting an infection heart problems bone thinning [cancerresearchuk.org]
When to Call the Doctor Call your doctor or nurse if you have any of these symptoms and/or any new or unusual symptoms: Fever of 100.5 F (38 C) or higher Chills Headache that does not go away Feeling that your heart is beating in a fast or not normal [upmc.com]
- Burning Pain
Side Effects Mild burning/pain/bruising at the injection site, hot flashes (flushing), increased sweating, night sweats, tiredness, headache, upset stomach, breast changes, acne, joint /muscle aches, trouble sleeping, reduced sexual interest, vaginal [webmd.com]
SIDE EFFECTS: Hot flashes (flushing), increased sweating, night sweats, tiredness, swelling of the ankles/ feet, increased urination at night, dizziness, or mild burning/ pain /bruising at the injection site may occur. [medicinenet.com]
Side Effects Hot flashes (flushing), increased sweating, night sweats, tiredness, swelling of the ankles/feet, increased urination at night, dizziness, or mild burning/pain/bruising at the injection site may occur. [myhealth.alberta.ca]
Common side effects of Lupron Injection include redness/burning/stinging/pain/bruising at the injection site, hot flashes (flushing), increased sweating, night sweats, tiredness, headache, upset stomach, nausea, diarrhea, constipation, stomach pain, breast [web.archive.org]
- Arm Pain
Get medical help right away if any of these very serioussymptoms of a heart attack (such as chest/jaw/left arm pain, shortness of breath, unusual sweating ), signs of a stroke (such as weakness on one side of the body, trouble speaking, sudden vision [webmd.com]
Tell your doctor immediately if you experience any of the following serious side effects: bone pain, numbness/tingling/ weakness of the arms/legs, blood in the urine, painful/difficult urination, unusual weakness, inability to move.Tell your doctor right [medicinenet.com]
Tell your doctor right away if you have any bone pain, numbness/tingling/weakness of the arms/legs, blood in the urine, painful/difficult urination, unusual weakness, or inability to move. [myhealth.alberta.ca]
[…] spreading to the arm or shoulder, nausea, sweating, general ill feeling. [web.archive.org]
- Ecchymosis
Memory disorder, Mood swings, Nervousness, Numbness, Paresthesia, Peripheral neuropathy, Syncope /blackouts, Taste disorders; Respiratory System —Cough, Pleural rub, Pneumonia, Pulmonary fibrosis ; Integumentary System — Carcinoma of skin/ear, Dry skin, Ecchymosis [rxlist.com]
Memory disorder, Mood swings, Nervousness, Numbness, Paresthesia, Peripheral neuropathy, Syncope /blackouts, Taste disorders; Respiratory System- Cough, Pleural rub, Pneumonia, Pulmonary fibrosis ; Integumentary System- Carcinoma of skin/ear, Dry skin, Ecchymosis [web.archive.org]
/ Incidence not known sinus tachycardia / Rapid / Incidence not known QT prolongation / Rapid / Incidence not known wheezing / Rapid / Incidence not known thrombocytopenia / Delayed / Incidence not known Mild injection site reaction / Rapid / 0-37.5 ecchymosis [pdr.net]
- El Salvador
AbbVie, Singapore; AbbVie, Turkey; AbbVie Farmacéuticos, Mexico; Medcor Pharmaceuticals, Netherlands Lucrin Depot Abbott, Bulgaria; Abbott, Costa Rica; Abbott, Guatemala; Abbott, Honduras; Abbott, Nicaragua; Abbott, Panama; Abbott, Portugal; Abbott, El [drugs.com]
Gastrointestinal
Skin
- Night Sweats
Common side effects of Lupron Injection include redness/burning/stinging/pain/bruising at the injection site, hot flashes (flushing), increased sweating, night sweats, tiredness, headache, upset stomach, nausea, diarrhea, constipation, stomach pain, breast [web.archive.org]
Side Effects Mild pain/irritation at the injection site, hot flashes (flushing), increased sweating, night sweats, tiredness, headache, breast changes, acne /seborrhea, joint /muscle aches, vaginal discomfort/dryness, vaginal bleeding /discharge, or increased [webmd.com]
Common side effects of Lupron Injection include: redness/burning/stinging/pain/bruising at the injection site, hot flashes (flushing), increased sweating, night sweats, tiredness, headache, upset stomach, nausea, diarrhea, constipation, stomach pain, [rxlist.com]
SIDE EFFECTS: Hot flashes (flushing), increased sweating, night sweats, tiredness, swelling of the ankles/ feet, increased urination at night, dizziness, or mild burning/ pain /bruising at the injection site may occur. [medicinenet.com]
- Hyperhidrosis
[…] myalgia / Early / 0-8.2 mastalgia / Delayed / 3.1-7.0 gynecomastia / Delayed / 2.2-7.0 cough / Delayed / 1.3-6.6 urinary urgency / Early / 0-6.0 increased urinary frequency / Early / 2.2-6.0 anorexia / Delayed / 0-6.0 libido decrease / Delayed / 3.3-5.4 hyperhidrosis [pdr.net]
- Eruptions
Leuprolide-induced papuloerythroderma, as well as a limited number of other disseminated cutaneous eruptions caused by this drug, is extremely rare, with only one case previously reported. [ncbi.nlm.nih.gov]
Musculoskeletal
- Fracture
Dryness of mouth and throat, Hepatitis, Hepatomegaly, Occult blood (rectal exam), Rectal fistula / erythema ; Endocrine System —Libido increase, Thyroid nodule ; Musculoskeletal System — Ankylosing spondylosis, Arthritis, Blurred disc margins, Bone fracture [rxlist.com]
Other side effects, including thinning of bones that may lead to fracture, and rare but serious problems with the pituitary gland in the brain, have been reported with ELIGARD. [eligard.com]
Other side effects, including thinning of bones thatmay lead to fracture, and rare but serious problems with the pituitary gland in the brain, have been reported with ELIGARD. See package insert for full Prescribing and Safety Information. [tolmar.com]
Hypotension, Myocardial infarction ; Endocrine System -Diabetes; Gastrointestinal System - Hepatic dysfunction; Hemic and Lymphatic System - Decreased WBC ; Integumentary System - Hair growth; Central/Peripheral Nervous System - Convulsion, Spinal fracture [web.archive.org]
- Myalgia
Anorexia 6 5 Constipation 7 9 Nausea/vomiting 5 17 Endocrine System *Decreased testicular size 7 11 *Gynecomastia/breast tenderness or pain 7 63 *Hot flashes 55 12 *Impotence 4 12 Hemic and Lymphatic System Anemia 5 5 Musculoskeletal System Bone pain 5 2 Myalgia [rxlist.com]
[…] partial thromboplastin time (≥5%), prolonged prothrombin time (≥5%), hepatomegaly ( Hypersensitivity: Hypersensitivity reaction ( Infection: Infection (5%) Local: Pain at injection site (2% to 5%), injection site reaction ( Neuromuscular & skeletal: Myalgia [drugs.com]
[…] fatigue / Early / 0-17.5 asthenia / Delayed / 0-12.2 skin irritation / Early / 0-12.2 infection / Delayed / 0-12.2 headache / Early / 0-10.2 arthralgia / Delayed / 0-9.3 insomnia / Early / 0-8.5 dizziness / Early / 0-8.3 paresthesias / Delayed / 0-8.2 myalgia [pdr.net]
- Arthralgia
Abdominal pain, abscess at injection site, anaphylaxis, anaphylactoid reaction, asthma, bone fracture (spine), cerebrovascular accident, convulsions, coronary artery disease, decreased white blood cell count, diabetes mellitus, fibromyalgia syndrome (arthralgia [drugs.com]
Other adverse events occurring in >5% of patients in either group during follow-up were nasopharyngitis, headache, nausea, arthralgia, intermenstrual bleeding, and pregnancy. Table III. [doi.org]
[…] injection site reaction / Rapid / 0-37.5 ecchymosis / Delayed / 0-34.6 musculoskeletal pain / Early / 0-32.7 fatigue / Early / 0-17.5 asthenia / Delayed / 0-12.2 skin irritation / Early / 0-12.2 infection / Delayed / 0-12.2 headache / Early / 0-10.2 arthralgia [pdr.net]
Neurologic
- Dizziness
However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. [web.archive.org]
However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching /swelling (especially of the face/ tongue /throat), severe dizziness, trouble breathing. [webmd.com]
This drug may make you dizzy. Alcohol or marijuana can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana. [myhealth.alberta.ca]
Signs of high blood pressure like very bad headache or dizziness, passing out, or change in eyesight. Signs of dehydration like dry skin, mouth, or eyes; thirst; fast heartbeat ; dizziness; fast breathing; or confusion. [drugs.com]
- Difficulty Concentrating
Get medical help right away if any of these very serious side effects occur: sudden severe headache, sudden severe mental/mood changes (such as severe confusion, difficulty concentrating), vision changes, severe vomiting, fainting. [webmd.com]
Get medical help right away if any of these very serious side effects occur: sudden severe headache, sudden severe mental/mood changes (e.g., severe confusion, difficulty concentrating ), vision changes, severe vomiting, fainting .A very serious allergic [medicinenet.com]
Get medical help right away if you have any very serious side effects, including: sudden severe headache sudden severe mental/mood changes (such as severe confusion, difficulty concentrating) vision changes severe vomiting A very serious allergic reaction [myhealth.alberta.ca]
Urogenital
- Vaginal Bleeding
Other adverse reactions included acne; rash with or without fever, blisters or sores, and facial swelling; and vaginitis, vaginal bleeding or vaginal discharge. [healio.com]
Three cases of heavy vaginal bleeding during leuprolide acetate therapy for leiomyomata are reported. In all cases, acute anemia developed, necessitating blood transfusions and emergency myomectomies. [ncbi.nlm.nih.gov]
Your doctor may need to change the doses of your medications or monitor you carefully for side effects. tell your doctor if you have unusual vaginal bleeding. [nlm.nih.gov]
Call the doctor if your child has vaginal bleeding after the second injection. This may indicate a dose change is needed. [cincinnatichildrens.org]
Leuprolide will also shrink tumors in the uterus, which decreases vaginal bleeding and helps prevent anemia. When given regularly to boys and girls who have early puberty, leuprolide slows the development of the genital area for both sexes. [mayoclinic.org]
- Hot Flushes
The results of the QLQ-PR25 revealed that patients experienced an increase in hot flushes (p < 0.001) and erection problems and uncomfortable sexual intimacy among the sexual functioning items (p = 0.030 and p = 0.023, respectively), but day-time urinary [ncbi.nlm.nih.gov]
Common side effects Hot flushes and sweats Hot flushes are a common side effect of this treatment. During a flush, your neck and face may feel warm and look red. Flushes may last from a few seconds up to 10 minutes. [macmillan.org.uk]
Hot flushes and sweating We have some tips for coping with hot flushes and the possible treatments for men and women. Talk to your doctor if your hot flushes are hard to cope with. They might be able to prescribe you some medicines. [cancerresearchuk.org]
- Hematuria
bladder outlet obstruction, and neuropathy in prostate cancer patients reported during first few weeks of therapy Closely observe patients for urinary tract obstruction and hematuria in first few weeks of therapy Orchiectomy or luteinizing hormone agonists [reference.medscape.com]
Adverse Reactions: Hot flashes/sweats, inj site reaction, initial worsening of signs/symptoms (eg, bone pain, urinary tract obstruction, hematuria), edema, GI upset, pain, cardiovascular events, CNS and antiandrogenic effects, asthenia, spinal cord compression [cancertherapyadvisor.com]
In a few cases a temporary worsening of existing hematuria and urinary tract obstruction occurred during the first week. Temporary weakness and paresthesia of the lower limbs have been reported in a few cases. [rxlist.com]
- Amenorrhea
[…] and subnormal plasma estradiol levels, or lack of cornification of the vaginal mucosa without an elevation in gonadotropin levels OR Hypothalamic amenorrhea in normally estrogenized women with amenorrhea or oligomenorrhea and normal plasma free testosterone [clinicaltrials.gov]
A 43-year-old woman with a history of 5 years of amenorrhea sought help in achieving a pregnancy. Her gonadotropins were found to be elevated and thus she was diagnosed as having ovarian failure. [ncbi.nlm.nih.gov]
Kaplan–Meier Estimates of Times to the Control of Bleeding and Persistent Amenorrhea. [nejm.org]
- Vaginal Dryness
Her only symptoms were minimal hot flashes and vaginal dryness. Leuprolide acetate may be active in the treatment of ovarian tumors of low malignant potential. It should be considered frontline systemic therapy for this disease. [ncbi.nlm.nih.gov]
These side effects may include: hot flashes, vaginal dryness, decreased interest in sex, moodiness, headaches, spotting, and change in bone density. [youngwomenshealth.org]
Vaginal bleeding or dryness This treatment can cause vaginal changes. You may have bleeding when you start this treatment, or if you change to it from another treatment. If bleeding continues for more than a few days, tell your doctor or nurse. [macmillan.org.uk]
Such therapy does not compromise the efficacy of leuprolide in relieving endometriosis symptoms and may also reduce vasomotor symptoms and vaginal dryness associated with hypoestrogenism. [pdr.net]
Workup
Disease is recurrent androgen receptor-positive with distant metastases Individual has a performance status of 0-3 Uterine leiomyomas (fibroid tumors) if ALL of the following: Individual is a female 18 years of age or older Diagnosis confirmed by a workup [bcbst.com]
Serum
- Hypercholesterolemia
Despite control for possible systemic hypertension (126/90 mm Hg) and mild hypercholesterolemia (total cholesterol level =246 mg/dL [range: 16 to 200 mg/dL], high-density lipoprotein level =67 mg/dL [range: 40 to 59 mg/dL], and low-density lipoprotein [ncbi.nlm.nih.gov]
Ten subjects experienced serious cardiac AEs, all of whom had medical histories with significant risk factors (for example, hypertension, coronary artery disease and hypercholesterolemia). [nature.com]
[…] system: Nervousness (≤8%), paresthesia (≤8%), anxiety (≤6%), agitation ( Dermatologic: Acne vulgaris (≤10%), alopecia (≤5%), diaphoresis (≤5%), cellulitis ( Endocrine & metabolic: Dehydration (≤8%), gynecomastia (≤7%), decreased serum bicarbonate (≥5%), hypercholesterolemia [drugs.com]
The risk of myocardial infarction, sudden cardiac death, and stroke appears low but needs to be evaluated carefully along with cardiovascular risk factors like cardiac disease, tobacco smoking, hypertension, hypercholesterolemia, and obesity. [pdr.net]
- Testosterone Increased
None of the escapes from testosterone suppression were associated with increases in PSA. [nature.com]
Treatment
Two strengths of leuprolide acetate for depot suspension in a 3-month formulation have been approved by the FDA for treatment of central precocious puberty. [healio.com]
Medical necessity criteria According to the AmeriHealth definition of medical necessity, a service cannot be more costly than an alternative service that is at least as likely to produce equivalent therapeutic or diagnostic results for the treatment of [provcomm.amerihealth.com]
The use of leuprolide acetate can delay the diagnosis and treatment of leiomyosarcoma and thus may increase the risk of morbidity and affect the treatment outcome of patients with leiomyosarcoma. [ncbi.nlm.nih.gov]
Prognosis
Multimedia: Slideshows, Images & Quizzes Related Disease Conditions Endometriosis (Symptoms, Causes, Treatments, and Prognosis) Endometriosis implants are most commonly found on the ovaries, the Fallopian tubes, outer surfaces of the uterus or intestines [medicinenet.com]
Etiology
[…] post-DL LH on 7.5 mg Greater than 2 IU/liter 6 (20) 2 IU/liter or less (proceed to lower dose) 24 (80) Study progress Dropout 3 (12) Completed three doses 21 (88) No. of subjects (%) Gender Male 6 (20) Female 24 (80) Etiology of early puberty Organic [doi.org]
Two of these AEs were considered serious, and the subjects received blood transfusions, but these events were considered not related to study drug by the investigator (alternative etiologies of suspected subacute upper gastrointestinal bleeding and metastatic [nature.com]
Abnormal vaginal bleeding of unknown etiology. 116 191 Breast-feeding. 116 191 Warnings/Precautions Warnings Fetal/Neonatal Morbidity and Mortality Expected hormonal changes increase the risk for pregnancy loss and fetal harm when administered to a pregnant [web.archive.org]
Epidemiology
Large-scale, epidemiologically sound, long-term studies of the risks to women and offspring from lupron and other fertility drugs remain lacking - therefore the "informed consent process" is inherently flawed, and as such, is a misnomer. [lupronvictimshub.com]
Fertil Steril 54, 419 –427. and Warner ML ( 1997 ) Epidemiology of endometriosis. [doi.org]
Pathophysiology
The pathophysiologic mechanism by which these agents induce apoplexy remains unclear. We describe a case of pituitary apoplexy in a young woman receiving leuprolide in preparation for ovum donation. [ncbi.nlm.nih.gov]
Pathophysiology and treatment of sexual precocity. J Clin Endocrinol Metab. 1990; 71:785-9. http://www.ncbi.nlm.nih.gov/pubmed/2205623?dopt=AbstractPlus 158. Stein DT. [drugs.com]
Pathophysiology and treatment of sexual precocity. J Clin Endocrinol Metab. 1990; 71:785-9. [IDIS 273003] [PubMed 2205623] 158. Stein DT. Southwestern Internal Medicine Conference: new developments in the diagnosis and treatment of sexual precocity. [web.archive.org]
Prevention
But it neither activated anti-apoptotic pathways nor prevented follicle loss, DNA damage and apoptosis induced by these drugs. [ncbi.nlm.nih.gov]
Treatments developed for prevention will also need to have superior safety. [doi.org]
Please prevent freeze-thaw cycles. Purity Greater than 98.0% as determined by RP-HPLC. Amino acid sequence pGlu-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEt. Safety Data Sheet Usage Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. [prospecbio.com]