She presented initially with CS and underwent right adrenalectomy; a few years later she presented with macromastia and mastodynia, possibly due to estrogen excess from her remaining left adrenocortical masses. [ncbi.nlm.nih.gov]

According to the present invention, the peptide cleavage and global deprotection reagents used in the process of the present invention is a cocktail mixture of acid, scavengers and solvents. [google.ch]

• Virilization

  […] analogs are ineffective as primary therapy in the treatment of GnRH-independent † (peripheral; gonadal steroid secretion is independent of gonadotropin secretion) precocious puberty, including familial male precocious puberty (testotoxicosis), congenital virilizing [drugs.com]

• Camping

  GnRHa co-administered with chemotherapy agents stimulated its receptors and raised intracellular cAMP levels. But it neither activated anti-apoptotic pathways nor prevented follicle loss, DNA damage and apoptosis induced by these drugs. [ncbi.nlm.nih.gov]

• Tall Stature

  A 4-10/12 year-old boy presented with tall stature and advanced secondary sexual characteristics. His bone age was 13 years giving him a height prediction of 147 cm. [ncbi.nlm.nih.gov]

• Pelvic Mass

  Pelvic examination and ultrasonography revealed the presence of a large irregular pelvic mass. At laparotomy, uterine and bilateral adnexal masses were noted extending up to the pelvic inlet and into the broad and infundibulopelvic ligaments. [ncbi.nlm.nih.gov]

• Neck Pain

  He developed headache and neck pain within a few hours of treatment followed by nausea, vomiting, ptosis and diplopia. Pituitary apoplexy is a potentially life threatening medical emergency. [ncbi.nlm.nih.gov]

• Hot Flushes

  The results of the QLQ-PR25 revealed that patients experienced an increase in hot flushes (p 0.001) and erection problems and uncomfortable sexual intimacy among the sexual functioning items (p 0.030 and p 0.023, respectively), but day-time urinary frequency [ncbi.nlm.nih.gov]

  The median average daily number of hot flushes (calculated by dividing the total number of hot flushes in the reference month by the number of days with data recorded in that month) was significantly lower ( P 0.001) in the DMPA-SC 104 group than in the [doi.org]

• Amenorrhea

  A 43-year-old woman with a history of 5 years of amenorrhea sought help in achieving a pregnancy. Her gonadotropins were found to be elevated and thus she was diagnosed as having ovarian failure. [ncbi.nlm.nih.gov]

  Kaplan–Meier Estimates of Times to the Control of Bleeding and Persistent Amenorrhea. [nejm.org]

• Dyspareunia

  Endpoints included patient response to treatment in five signs/symptoms (dysmenorrhoea, dyspareunia, pelvic pain, pelvic tenderness, induration) and changes in bone mineral density (BMD) and productivity at 6 and 18 months. [ncbi.nlm.nih.gov]

  Improvement of endometriosis-associated dyspareunia was also observed in both treatment groups, although the results did not meet statistical equivalence ( P 0.049). Figure 2. [doi.org]

Disease is recurrent androgen receptor-positive with distant metastases Individual has a performance status of 0-3 Uterine leiomyomas (fibroid tumors) if ALL of the following: Individual is a female 18 years of age or older Diagnosis confirmed by a workup [bcbst.com]

• Adrenocortical Hyperplasia

  Primary bilateral macronodular adrenocortical hyperplasia (PBMAH) is an uncommon cause of adrenal Cushing syndrome (CS) in which cortisol and occasionally other steroid hormones can be secreted under the influence of aberrantly expressed G-protein coupled [ncbi.nlm.nih.gov]

The use of leuprolide acetate can delay the diagnosis and treatment of leiomyosarcoma and thus may increase the risk of morbidity and affect the treatment outcome of patients with leiomyosarcoma. [ncbi.nlm.nih.gov]

Multimedia: Slideshows, Images & Quizzes Related Disease Conditions Endometriosis (Symptoms, Causes, Treatments, and Prognosis) Endometriosis implants are most commonly found on the ovaries, the Fallopian tubes, outer surfaces of the uterus or intestines [medicinenet.com]

LH on 7.5 mg Greater than 2 IU/liter 6 (20) 2 IU/liter or less (proceed to lower dose) 24 (80) Study progress Dropout 3 (12) Completed three doses 21 (88) No. of subjects (%) Gender Male 6 (20) Female 24 (80) Etiology of early puberty Organic 14 (47) [doi.org]

Two of these AEs were considered serious, and the subjects received blood transfusions, but these events were considered not related to study drug by the investigator (alternative etiologies of suspected subacute upper gastrointestinal bleeding and metastatic [nature.com]

Abnormal vaginal bleeding of unknown etiology. 116 191 Breast-feeding. 116 191 Warnings/Precautions Warnings Fetal/Neonatal Morbidity and Mortality Expected hormonal changes increase the risk for pregnancy loss and fetal harm when administered to a pregnant [drugs.com]

Fertil Steril 54, 419 –427. and Warner ML ( 1997 ) Epidemiology of endometriosis. [doi.org]

Large-scale, epidemiologically sound, long-term studies of the risks to women and offspring from lupron and other fertility drugs remain lacking - therefore the "informed consent process" is inherently flawed, and as such, is a misnomer. [lupronvictimshub.com]

The pathophysiologic mechanism by which these agents induce apoplexy remains unclear. We describe a case of pituitary apoplexy in a young woman receiving leuprolide in preparation for ovum donation. [ncbi.nlm.nih.gov]

Pathophysiology and treatment of sexual precocity. J Clin Endocrinol Metab. 1990; 71:785-9. 158. Stein DT. Southwestern Internal Medicine Conference: new developments in the diagnosis and treatment of sexual precocity. [drugs.com]

Pathophysiology and treatment of sexual precocity. J Clin Endocrinol Metab. 1990; 71:785-9. [IDIS 273003] [PubMed 2205623] 158. Stein DT. Southwestern Internal Medicine Conference: new developments in the diagnosis and treatment of sexual precocity. [web.archive.org]

But it neither activated anti-apoptotic pathways nor prevented follicle loss, DNA damage and apoptosis induced by these drugs. [ncbi.nlm.nih.gov]

Leuprorelin also prevents stress-induced immunosuppression in animal models. Additionally, leuprorelin exhibits anticancer activity, inhibiting proliferation of prostate cancer cells in vitro. [lktlabs.com]

Although this medication works by preventing ovulation (stops you from making eggs), there is a rare chance that you could become pregnant if you have unprotected sex. [youngwomenshealth.org]

Treatments developed for prevention will also need to have superior safety. [doi.org]