She presented initially with CS and underwent right adrenalectomy; a few years later she presented with macromastia and mastodynia, possibly due to estrogen excess from her remaining left adrenocortical masses. [ncbi.nlm.nih.gov]

According to the present invention, the peptide cleavage and global deprotection reagents used in the process of the present invention is a cocktail mixture of acid, scavengers and solvents. [google.ch]

Case Report A 78 year old man with recently diagnosed prostate cancer (Gleeson 7, non-invasive) saw his urologist two days prior to presentation. [headache.imedpub.com]

• Inguinal Hernia

  hernia, Penile swelling, Post void residual, Prostatic pain, Pyuria ; Miscellaneous —Abdominal distention, Facial swelling/edema, Feet burning, Flu, Eyelid growth, Hypoproteinemia, Accidental injury, Knee effusion, Mass, Pallid, Sallow, Weakness. [rxlist.com]

  hernia, Penile swelling, Post void residual, Prostatic pain, Pyuria ; Miscellaneous- Abdominal distention, Facial swelling/edema, Feet burning, Flu, Eyelid growth, Hypoproteinemia, Accidental injury, Knee effusion, Mass, Pallid, Sallow, Weakness. [web.archive.org]

• Thyroid Nodule

  nodule ; Musculoskeletal System — Ankylosing spondylosis, Arthritis, Blurred disc margins, Bone fracture, Muscle stiffness, Muscle tenderness, Pelvic fibrosis, Spasms/cramps; Central/Peripheral Nervous System —Auditory hallucinations/ tinnitus, Decreased [rxlist.com]

  nodule; Musculoskeletal System- Ankylosing spondylosis, Arthritis, Blurred disc margins, Bone fracture, Muscle stiffness, Muscle tenderness, Pelvic fibrosis, Spasms/cramps; Central/Peripheral Nervous System- Auditory hallucinations/ tinnitus, Decreased [web.archive.org]

• Camping

  GnRHa co-administered with chemotherapy agents stimulated its receptors and raised intracellular cAMP levels. But it neither activated anti-apoptotic pathways nor prevented follicle loss, DNA damage and apoptosis induced by these drugs. [ncbi.nlm.nih.gov]

• Decreased Breath Sounds

  […] hearing, Decreased reflexes, Euphoria, Hyperreflexia, Loss of smell, Motor deficiency; Respiratory System —Chest tightness, Decreased breathing sounds, Hemoptysis, Pleuritic chest pain, Pulmonary infiltrate, Rales/rhonchi, Rhinitis, Strep throat, Wheezing [rxlist.com]

  […] hearing, Decreased reflexes, Euphoria, Hyperreflexia, Loss of smell, Motor deficiency; Respiratory System- Chest tightness, Decreased breathing sounds, Hemoptysis, Pleuritic chest pain, Pulmonary infiltrate, Rales/rhonchi, Rhinitis, Strep throat, Wheezing [web.archive.org]

• Carotid Bruit

  Cardiovascular System — Bradycardia, Carotid bruit, Extrasystole, Palpitations, Perivascular cuffing (eyes), Ruptured aortic aneurysm, Stroke, Tachycardia, Transient ischemic attack ; Gastrointestinal System — Flatus, Dryness of mouth and throat, Hepatitis [rxlist.com]

  Cardiovascular System- Bradycardia, Carotid bruit, Extrasystole, Palpitations, Perivascular cuffing (eyes), Ruptured aortic aneurysm, Stroke, Tachycardia, Transient ischemic attack ; Gastrointestinal System- Flatus, Dryness of mouth and throat, Hepatitis [web.archive.org]

• Heart Murmur

  murmur (3%), thrombophlebitis (2%), cardiac failure (1%), angina pectoris, cardiac arrhythmia, myocardial infarction, pulmonary embolism, syncope Central nervous system: Headache (7%), insomnia (7%), dizziness (5%), ostealgia (5%), anxiety, depression [drugs.com]

• Skin Lesion

  /ear, Dry skin, Ecchymosis, Hair loss, Itching, Local skin reactions, Pigmentation, Skin lesions; Urogenital System — Bladder spasms, Dysuria, Incontinence, Testicular pain, Urinary obstruction; Miscellaneous —Depression, Diabetes, Fatigue, Fever/chills [rxlist.com]

  /ear, Dry skin, Ecchymosis, Hair loss, Itching, Local skin reactions, Pigmentation, Skin lesions; Urogenital System- Bladder spasms, Dysuria, Incontinence, Testicular pain, Urinary obstruction; Miscellaneous- Depression, Diabetes, Fatigue, Fever/chills [web.archive.org]

  SubQ: Eligard: Vary/rotate injection site; choose site with adequate subcutaneous tissue (eg, upper or mid-abdomen, upper buttocks) that does not have excessive pigment, nodules, lesions, or hair. [drugs.com]

• Keratosis

  […] deficiency; Respiratory System —Chest tightness, Decreased breathing sounds, Hemoptysis, Pleuritic chest pain, Pulmonary infiltrate, Rales/rhonchi, Rhinitis, Strep throat, Wheezing / bronchitis ; Integumentary System — Boil (pubic), Bruises, Hives, Keratosis [rxlist.com]

  Motor deficiency; Respiratory System- Chest tightness, Decreased breathing sounds, Hemoptysis, Pleuritic chest pain, Pulmonary infiltrate, Rales/rhonchi, Rhinitis, Strep throat, Wheezing / bronchitis ; Integumentary System- Boil (pubic), Bruises, Hives, Keratosis [web.archive.org]

• Knee Effusion

  effusion, Mass, Pallid, Sallow, Weakness. [rxlist.com]

• Muscle Tenderness

  […] stiffness, Muscle tenderness, Pelvic fibrosis, Spasms/cramps; Central/Peripheral Nervous System —Auditory hallucinations/ tinnitus, Decreased hearing, Decreased reflexes, Euphoria, Hyperreflexia, Loss of smell, Motor deficiency; Respiratory System —Chest [rxlist.com]

  […] stiffness, Muscle tenderness, Pelvic fibrosis, Spasms/cramps; Central/Peripheral Nervous System- Auditory hallucinations/ tinnitus, Decreased hearing, Decreased reflexes, Euphoria, Hyperreflexia, Loss of smell, Motor deficiency; Respiratory System- Chest [web.archive.org]

• Auditory Hallucination

  hallucinations/ tinnitus, Decreased hearing, Decreased reflexes, Euphoria, Hyperreflexia, Loss of smell, Motor deficiency; Respiratory System —Chest tightness, Decreased breathing sounds, Hemoptysis, Pleuritic chest pain, Pulmonary infiltrate, Rales/ [rxlist.com]

  hallucinations/ tinnitus, Decreased hearing, Decreased reflexes, Euphoria, Hyperreflexia, Loss of smell, Motor deficiency; Respiratory System- Chest tightness, Decreased breathing sounds, Hemoptysis, Pleuritic chest pain, Pulmonary infiltrate, Rales/ [web.archive.org]

• Hyporeflexia

  0-2.0 skin hypopigmentation / Delayed / 0-2.0 purpura / Delayed / 0-2.0 urticaria / Rapid / 0-0.1 photosensitivity / Delayed / 0-0.1 eructation / Early / 5.0 amenorrhea / Delayed / Incidence not known libido increase / Delayed / Incidence not known hyporeflexia [pdr.net]

• Hot Flushes

  The results of the QLQ-PR25 revealed that patients experienced an increase in hot flushes (p < 0.001) and erection problems and uncomfortable sexual intimacy among the sexual functioning items (p = 0.030 and p = 0.023, respectively), but day-time urinary [ncbi.nlm.nih.gov]

  In particular, low rates of hot flushes were reported. [bmcurol.biomedcentral.com]

  Common side effects Hot flushes and sweats Hot flushes are a common side effect of this treatment. During a flush, your neck and face may feel warm and look red. Flushes may last from a few seconds up to 10 minutes. [macmillan.org.uk]

• Amenorrhea

  A 43-year-old woman with a history of 5 years of amenorrhea sought help in achieving a pregnancy. Her gonadotropins were found to be elevated and thus she was diagnosed as having ovarian failure. [ncbi.nlm.nih.gov]

  Kaplan–Meier Estimates of Times to the Control of Bleeding and Persistent Amenorrhea. [nejm.org]

Disease is recurrent androgen receptor-positive with distant metastases Individual has a performance status of 0-3 Uterine leiomyomas (fibroid tumors) if ALL of the following: Individual is a female 18 years of age or older Diagnosis confirmed by a workup [bcbst.com]

• Pulmonary Infiltrate

  infiltrate, Rales/rhonchi, Rhinitis, Strep throat, Wheezing / bronchitis ; Integumentary System — Boil (pubic), Bruises, Hives, Keratosis, Mole, Shingles, Spiders; Urogenital System — Blisters on penis, Inguinal hernia, Penile swelling, Post void residual [rxlist.com]

  infiltrate, Rales/rhonchi, Rhinitis, Strep throat, Wheezing / bronchitis ; Integumentary System- Boil (pubic), Bruises, Hives, Keratosis, Mole, Shingles, Spiders; Urogenital System- Blisters on penis, Inguinal hernia, Penile swelling, Post void residual [web.archive.org]

  […] embolism, pulmonary infiltrates, retroperitoneal fibrosis (pelvic), seizure, skin photosensitivity, suicidal ideation (rare), tenosynovitis (symptoms), thrombocytopenia, transient ischemic attacks, urticaria Warnings/Precautions Concerns related to adverse [drugs.com]

• Calcium Increased

  BUN, Increased calcium, Increased creatinine, Infection/inflammation, Ophthalmologic disorders, Swelling ( temporal bone ). [rxlist.com]

• Blood Urea Nitrogen Increased

  blood urea nitrogen (≥5%), increased serum creatinine (≥5%), increased urine specific gravity (≥5%), polyuria (2% to 4%) Respiratory: Emphysema ( Miscellaneous: Fever ( Immediate release formulation: >10%: Cardiovascular: ECG changes (19%), peripheral [drugs.com]

• Adrenocortical Hyperplasia

  Primary bilateral macronodular adrenocortical hyperplasia (PBMAH) is an uncommon cause of adrenal Cushing syndrome (CS) in which cortisol and occasionally other steroid hormones can be secreted under the influence of aberrantly expressed G-protein coupled [ncbi.nlm.nih.gov]

• Pleural Rub

  rub, Pneumonia, Pulmonary fibrosis ; Integumentary System — Carcinoma of skin/ear, Dry skin, Ecchymosis, Hair loss, Itching, Local skin reactions, Pigmentation, Skin lesions; Urogenital System — Bladder spasms, Dysuria, Incontinence, Testicular pain, [rxlist.com]

  rub, Pneumonia, Pulmonary fibrosis ; Integumentary System- Carcinoma of skin/ear, Dry skin, Ecchymosis, Hair loss, Itching, Local skin reactions, Pigmentation, Skin lesions; Urogenital System- Bladder spasms, Dysuria, Incontinence, Testicular pain, Urinary [web.archive.org]

The use of leuprolide acetate can delay the diagnosis and treatment of leiomyosarcoma and thus may increase the risk of morbidity and affect the treatment outcome of patients with leiomyosarcoma. [ncbi.nlm.nih.gov]

Multimedia: Slideshows, Images & Quizzes Related Disease Conditions Endometriosis (Symptoms, Causes, Treatments, and Prognosis) Endometriosis implants are most commonly found on the ovaries, the Fallopian tubes, outer surfaces of the uterus or intestines [medicinenet.com]

[…] post-DL LH on 7.5 mg Greater than 2 IU/liter 6 (20) 2 IU/liter or less (proceed to lower dose) 24 (80) Study progress Dropout 3 (12) Completed three doses 21 (88) No. of subjects (%) Gender Male 6 (20) Female 24 (80) Etiology of early puberty Organic [doi.org]

Two of these AEs were considered serious, and the subjects received blood transfusions, but these events were considered not related to study drug by the investigator (alternative etiologies of suspected subacute upper gastrointestinal bleeding and metastatic [nature.com]

Large-scale, epidemiologically sound, long-term studies of the risks to women and offspring from lupron and other fertility drugs remain lacking - therefore the "informed consent process" is inherently flawed, and as such, is a misnomer. [lupronvictimshub.com]

Fertil Steril 54, 419 –427. and Warner ML ( 1997 ) Epidemiology of endometriosis. [doi.org]

The pathophysiologic mechanism by which these agents induce apoplexy remains unclear. We describe a case of pituitary apoplexy in a young woman receiving leuprolide in preparation for ovum donation. [ncbi.nlm.nih.gov]

But it neither activated anti-apoptotic pathways nor prevented follicle loss, DNA damage and apoptosis induced by these drugs. [ncbi.nlm.nih.gov]

Treatments developed for prevention will also need to have superior safety. [doi.org]

Leuprorelin also prevents stress-induced immunosuppression in animal models. Additionally, leuprorelin exhibits anticancer activity, inhibiting proliferation of prostate cancer cells in vitro. [lktlabs.com]