The documents contained in this web site are presented for information purposes only. The material is in no way intended to replace professional medical care by a qualified specialist and should not be used as a basis for diagnosis or treatment. [orpha.net]

For each presented case and phenotype, a full medical report will be produced including a tailored diagnostic strategy. [centogene.com]

Funding and Disclosures Presented at the annual meeting of the Society for Gynecologic Investigation, Chicago, March 15–18, 1995. [nejm.org]

[…] transcription of the LHCGR gene caused by a mutation in exon 6A leads to Leydig cell hypoplasia type II. ( 23232123 ) Kossack N....Gromoll J. 2013 7 Leydig cell hypoplasia due to inactivating luteinizing hormone/chorionic gonadotropin receptor gene mutation presenting [malacards.org]

• Hemophilia A

  A Severe hemophilia B Sex chromosome disorder of sex development Smith-Lemli-Opitz syndrome Sudden infant death-dysgenesis of the testes syndrome Symptomatic form of hemophilia A in female carriers Symptomatic form of hemophilia B in female carriers [se-atlas.de]

• Movement Disorder

  […] of glycosylation 1k ALG1 Congenital disorder of glycosylation 1g ALG12 Congenital disorder of glycosylation 1i ALG2 Congenital disorder of glycosylation 1d ALG3 Congenital disorder of glycosylation 1c ALG6 Congenital disorder of glycosylation 1c, mild [springer.com]

• Flushing

  During this period when testosterone levels are low, the athletes may experience sexual dysfunction, hot flushes, fatigue, and depressed mood, causing some athletes to resume androgen use and thus perpetuating the cycle of abuse, withdrawal symptoms, [gynecology.blogsky.com]

• Sexual Dysfunction

  For further discussion of sexual dysfunction, disorders of the prostate, and testicular cancer, see Chaps. 49, 91, 92, respectively. [gynecology.blogsky.com]

  Androgen deprivation therapy in men with prostate cancer has been associated with increased risk of bone fractures, diabetes mellitus, cardiovascular events, fatigue, sexual dysfunction, and poor quality of life. [clinicalgate.com]

The material is in no way intended to replace professional medical care by a qualified specialist and should not be used as a basis for diagnosis or treatment. [orpha.net]

[…] of specialists often work together to identify treatment options for a person with LCH. [rarediseases.info.nih.gov]

CLOSE Medical Disclaimer The medical information on this site is provided as an information resource only, and is not to be used or relied on for any diagnostic or treatment purposes. [diseaseinfosearch.org]

Male Factor Infertility: Treatment Treatment options for male factor infertility have expanded greatly in recent years. Secondary hypogonadism is highly amenable to treatment with pulsatile GnRH or gonadotropins (see below). [gynecology.blogsky.com]

TREATMENT MALE FACTOR INFERTILITY Treatment options for male factor infertility have expanded greatly in recent years. Secondary hypogonadism is highly amenable to treatment with pulsatile GnRH or gonadotropins (see below). [clinicalgate.com]

Roughly 10% of infertility cases have a genetic etiology. Known genetic causes of infertility include chromosomal aberrations, single gene variants and phenotypes with multifactorial inheritance 3. [centogene.com]

Despite extensive evaluation, the etiology is established in fewer than one-half of patients. FIGURE 411-5 Evaluation of gynecomastia. E 2, 17β-estradiol; hCGβ, human chorionic gonadotropin β; T, testosterone. [clinicalgate.com]

In spite of extensive evaluation, the etiology is established in fewer than one-half of patients. Gynecomastia: Treatment When the primary cause can be identified and corrected, breast enlargement usually subsides over several months. [gynecology.blogsky.com]

Orphanet): - Rare developmental defect during embryogenesis - Rare endocrine disease - Rare genetic disease - Rare infertility - Rare urogenital disease Classification (ICD10): - Congenital malformations, deformations and chromosomal abnormalities - Epidemiological [csbg.cnb.csic.es]

In epidemiologic surveys, low total and bioavailable testosterone concentrations have been associated with decreased appendicular skeletal muscle mass and strength, decreased self-reported physical function, higher visceral fat mass, insulin resistance [clinicalgate.com]

In epidemiologic studies, testosterone concentrations are inversely related to waist-to-hip ratio and directly correlated with HDL cholesterol levels. [gynecology.blogsky.com]

Reproductive endocrinology: physiology, pathophysiology, and clinical management. 3rd ed. Philadelphia: W.B. Saunders, 1991:576-630. 26. Smyth CD, Miro F, Whitelaw PF, Howles CM, Hillier SG. [nejm.org]

The pathophysiology of reproductive dysfunction during acute illness is unknown but likely involves a combination of cytokine and/or glucocorticoid effects. [clinicalgate.com]

Leydig cell hypoplasia is an autosomal recessive disorder in which loss of function of the LHCGR gene in the male prevents normal sexual development. Two types of LCH have been defined (Toledo, 1992). [ncbi.nlm.nih.gov]

Leydig cell agenesis Leydig Cell Hypoplasia Get Update Overview Leydig cell hypoplasia is an autosomal recessive disorder in which loss of function of the LHCGR gene in the male prevents normal sexual development. [diseaseinfosearch.org]

Report of the Meeting on the Prevention of Infertility at the Primary Health Care Level. WHO, Geneva; 1983. WHO/MCH/1984.4. Boivin J, Bunting L, Collins JA, & Nygren KG (2007). [centogene.com]

This mutation eliminates the last five cysteine residues in the FSH β-subunit and prevents production of FSH in vitro. [nejm.org]

Mutations in the CYP19 gene, which encodes aromatase, prevent testosterone conversion to estradiol. [clinicalgate.com]