Leydig cell tumor is a rare neoplasm arising from the Leydig cells of the testicular interstitium that produce testosterone. It can develop in children as a benign lesion, or in adults when 10% of cases undergo malignant transformation, in which case prompt recognition is necessary. A testicular mass is almost always present, and further imaging and histopathological findings are used to identify the exact tumor type.
Leydig cell tumors belong to the group of sex cord-stromal tumors of the testes and constitute only 1-3% of all testicular neoplasms, making them a rare occurrence in clinical practice   . Leydig cells are located in the interstitium, and are responsible for the production of testosterone, but also estrogen to a lesser extent, which is why signs and symptoms are often related to the excess effects of androgen hormones caused by abnormal cellular proliferation   . The tumor is diagnosed in two age groups - in prepubertal boys, and more commonly, in adults between 30-60 years of age    . In children, excess testosterone results in the development of precocious puberty - the early growth of pubic hair, the penis and the musculoskeletal system  . On the other hand, increased estrogen production will induce feminization (gynecomastia and tenderness of the breasts, as well as feminine hair distribution) . This clinical presentation is also seen in adults, but they are accompanied by loss of libido, impotence, erectile dysfunction, infertility, and most importantly, an enlarged testicle  . Studies have confirmed the rare appearance of a bilateral testicular mass, but in the vast majority of patients, a unilateral and sometimes painful intratesticular mass is typical for Leydig cell tumors   . It is exclusively benign in infants, but the potential for malignant transformation in adults, seen in 10% of cases, implies that early recognition of the tumor is vital, as dissemination through the retroperitoneal lymph nodes into the liver, the lungs, and the skeletal system has been observed   . Thus, signs and symptoms that indicate a disbalance in androgen hormones should alert the physician to conduct a meticulous workup.
Entire Body System
- Precocious Puberty
We report two boys who developed true precocious puberty after surgical treatment of a Leydig cell tumor of the testis that presented peripheral precocious puberty. [frontiersin.org]
Clinical presentation is testicular mass, pain and hormone alteration such as precocious puberty and gynecomastia. We present one case of LCT and his conservative management after an incidental finding. Literature is reviewed. [ncbi.nlm.nih.gov]
- Recurrent Pulmonary Embolism
She had a history of recurrent pulmonary embolism and unexplained secondary erythrocytosis. Past hematological investigations had not revealed any evidence of malignancy or thrombophilia, and the JAK2 mutation was negative. [ncbi.nlm.nih.gov]
- Inguinal Mass
A 53-year-old male presented with a right inguinal mass of one-year duration. The fine needle aspiration of the inguinal mass showed a highly cellular tumor composed of sheets and isolated, large round to polygonal cells with moderate pleomorphism. [ncbi.nlm.nih.gov]
The fine needle aspiration of the inguinal mass showed a highly cellular tumor composed of sheets and isolated, large round to polygonal cells with moderate pleomorphism. Many bare nuclei were seen with occasional intranuclear inclusions. [ncbi.nlm.nih.gov]
Google Scholar Handa U, Sood T, Punia RS: Testicular Leydig cell tumor diagnosed on fine needle aspiration. Diagn Cytopathol. 2010, 38: 682-684. 10.1002/dc.21306. [bmcresnotes.biomedcentral.com]
We report a 34-year-old man visited hospital because of coughing sputum mixed with blood. His chest CT showed bilateral patch clouding opacity. He was suspected with allergic alveolitis and treated with methylprednisolone. [ncbi.nlm.nih.gov]
This case provides evidence that somatic activating gsp mutation in Leydig cells may result in tumor development, leading to overexpression of the inhibin alpha subunit and hyperactivity of the testosterone biosynthetic pathway. [ncbi.nlm.nih.gov]
[…] stimulting activity polypeptide 1) - activating mutation (R201S) is seen occasionally ( J Androl 2012;33:578 ) This somatic activating gsp mutation in Leydig cells may result in tumor development, leading to overexpression of inhibin alpha subunit and hyperactivity [pathologyoutlines.com]
Some authors have reported in Leydig tumors in adult a somatic activating mutation in the guanine nucleotide-binding protein α gene, which may result in tumor development, leading to overexpression on the inhibin alpha subunit and hyperactivity of the [bmcresnotes.biomedcentral.com]
Both men suffered from severe restlessness, insomnia and irritability, which they described as intolerable and disrupting normal life activities. [ncbi.nlm.nih.gov]
- Testicular Mass
Hereby, we present the case of two brothers affected by 11-β hydroxylase deficiency and presenting with bilateral testicular masses. [ncbi.nlm.nih.gov]
- Painless Testicular Mass
Each patient had a well circumscribed, painless testicular mass, increased serum testosterone (101 and 444 ng/dl [normal 0 to 25]), normal gonadotropins and negative alpha-fetoprotein levels. [ncbi.nlm.nih.gov]
Presents a painless testicular mass. Tumor cells may produce androgen, estrogens or both and presents with gynecomastia or precocious puberty; symptoms usually regress with excision. [auanet.org]
- Testicular Pain
In the other patients diagnosis was made by ultrasound performed for testicular pain (4 patients, 16.6%) or the appearance of gynecomastia (3 patients, 12.5%). Frozen section examination was done in 20 of 24 patients (83%). [ncbi.nlm.nih.gov]
Indications for Leydig Cell Tumor of the Testis include: Loss of libido Overdevelopment of breasts in males (gynecomastia) Breast pain, especially if accompanied by enlargement Trouble breathing Headache Low blood pressure Anemia Testicular pain, lump [dovemed.com]
- Scrotal Mass
The malignant forms are generally discovered in elder men presenting a scrotal mass with no hormonal changes [1-7]. We describe a small and rare benign Leydig cell tumor found incidentally in an old man. [smirg.org]
- Testicular Disease
Schweyer, Tumoren des Gonadenstromas, Der Pathologe, 2014, 35, 3, 245 CrossRef 11 Giorgio Bozzini, Stefano Picozzi, Dario Ratti, Stefano Casellato, Luca Carmignani, Long-term follow up with sparing surgery for testicular diseases: A safe choice in benign [onlinelibrary.wiley.com]
The initial diagnosis of a testicular tumor can be rather easily made with a proper physical examination that will palpate a mass and a detailed patient history that will assess the course and progression of symptoms . However, a mass may not always be present, especially in the beginning of tumorigenesis. For this reason, a detailed laboratory workup is necessary. In all patients in whom signs of excess androgen production are present, serum values of luteinizing hormone (LH), follicle-stimulating hormone (FSH), estrogen, estradiol, progesterone, adrenocorticotropin hormone (ACTH) and cortisol should be evaluated  . Testosterone levels will almost always be raised in the setting of precocious puberty, whereas increased estrogen and estradiol are seen in patients who suffer from feminization and gynecomastia  . It should be noted that tumor markers for testicular tumors, including alpha-fetoprotein (AFP), beta-human chorionic gonadotropin (β- hCG), lactate dehydrogenase (LDH) and placental alkaline phosphatase (PALP) are negative, as they are only useful for germ cell testicular tumors    . In addition to clinical and laboratory studies, imaging procedures, such as ultrasonography (US) of the testes, is the next step in confirming the diagnosis   . A homogeneous hypoechoic appearance on US is the hallmark of a benign Leydig cell tumor, but if the lesion is heterogeneous, malignant transformation should be suspected, in which case computed tomography (CT) and magnetic resonance imaging (MRI) of the pelvis and abdomen are recommended to exclude metastatic spread     . A definite diagnosis is made after a biopsy and subsequent histopathological examination with immunohistochemistry . α-Inhibin, but also calretinin and Melan-A are reliable markers for differentiation between sex cord stromal tumors and germ cell tumors of the testes .
Abstract Malignant Testicular Leydig Cell tumors (leydigomas) are extremely rare to occur and mostly carry a bad prognosis. [ncbi.nlm.nih.gov]
Typically, in a vast majority of cases, the prognosis is excellent, since it is usually a benign tumor In rare case of a malignancy, the prognosis may depend upon several factors including the stage of the tumor and health status of the individual Generally [dovemed.com]
Outlook (Prognosis) Prognosis of SLCT depends on the stage and degree of differentiation of the tumor. Since these tumors are typically benign and their growth is slow, outlook is generally very positive. [knowcancer.com]
It is recommended that all endocrine, nutritional, neoplastic, chromosomal, and drug etiologies of gynecomastia be investigated before surgical resection of the enlarged breasts. [popline.org]
(Etiology) The cause of Leydig Cell Tumor of the Testis is unknown. [dovemed.com]
[…] are malignant Sites Origin from testis is demonstrable in most cases Rarely originates from epididymis ( Andrologia 2013;45:430 ) Pathophysiology Produce testosterone, dehydroepiandrosterone and androstenedione, which cause symptoms described below Etiology [pathologyoutlines.com]
Malignant transformation is rare, and given the slow growth, prognosis is generally good. 2 The etiology of LCTs remains unknown. [pediatrics.aappublications.org]
Epidemiology 1–3% of all testicular tumors. Most common in boys (5–10 years old) and in adults aged 30–60 years. Pathology of the Leydig cell tumor Small yellow-brown tumors, sharply circumscribed in the testicular tissue. [urology-textbook.com]
Leydig Cell Tumors Epidemiology & Pathology Leydig cell tumors are the most common non-germ cell tumors of the testis and account for 1-3% of all testicular tumors. [health.am]
Definition / general Most common sex cord stromal tumor; recapitulates normal development and evolution of Leydig cells Epidemiology 1 - 3% of testicular tumors No predilection based on ethnicity or race 10% are malignant Sites Origin from testis is demonstrable [pathologyoutlines.com]
Epidemiology Leydig cell tumours constitute 1-3% of all testicular tumours. Clinical features In children, they may present with isosexual pseudoprecocity. In adults, they present with a mass and/or gynaecomastia. [e-immunohistochemistry.info]
Summary Epidemiology Age related incidence rate was found to be 1 per 500,000 women. Sex cord stromal tumors constitute about 5% of ovarian malignancies. [orpha.net]
Signs and Symptoms (Pathophysiology) Symptoms can include infrequent or no menstrual periods, the development of facial hair, a hoarse voice, increased muscle mass, acne, and clitoromegaly. [knowcancer.com]
[…] development and evolution of Leydig cells Epidemiology 1 - 3% of testicular tumors No predilection based on ethnicity or race 10% are malignant Sites Origin from testis is demonstrable in most cases Rarely originates from epididymis ( Andrologia 2013;45:430 ) Pathophysiology [pathologyoutlines.com]
Background Pathophysiology A German anatomist, Franz Leydig, first described Leydig cells in 1870.  Leydig cells are located within the interstitium of the testis, between the seminiferous tubules, and produce testosterone in response to luteinizing [emedicine.medscape.com]
PMID 18382911. a b "Leydig Cell Tumors: Practice Essentials, Background, Pathophysiology". 2016-10-27. Biegel, L. B.; Liu, R. C.; Hurtt, M. E.; Cook, J. C. (1995). [en.wikipedia.org]
Pathologists have to be familiar with the diagnostic histopathologic features, immunohistochemical panel of this tumor, and its principal differential diagnoses to prevent tumor misdiagnosis. [ncbi.nlm.nih.gov]
[…] the adrenogenital syndrome (which may contain fat) and may prevent misdiagnosis of a LCT with spindle cells as a sarcoma or unclassified sex cord-stromal tumor. [journals.lww.com]
Removal of the testis Debulking surgery to reduce tumor size, followed by chemotherapy Clotting the vessels in the tumor (embolization) Chemotherapy Radiotherapy Undertaking treatment of underlying conditions How can Leydig Cell Tumor of the Testis be Prevented [dovemed.com]
- Al-Agha OM, Axiotis CA. An in-depth look at Leydig cell tumor of the testis. Arch Pathol Lab Med. 2007;131(2):311-317.
- Gheorghisan-Galateanu AA. Leydig cell tumors of the testis: a case report. BMC Res Notes. 2014;7:656.
- Suardi N, Strada E, Colombo R, et al. Leydig cell tumor of the testis: presentation, therapy, long-term follow-up and the role of organ-sparing surgery in a single-institution experience. BJU Int. 2009;103(2):197-200.
- Albers P, Albrecht W, Algaba F, et al. Guidelines on Testicular Cancer: 2015 Update. Eur Urol. 2015;68(6):1054-1068.
- Thambi R, Pothen L, Emmanuel KM, Vijayalakhmi A. Leydig cell tumor of testis with indeterminate features. Indian J Cancer. 2015;52(4):529-530.
- Sönmez N, Ton Ö, Arısan S, Kılınç F, Eken K, Güney S. Bilateral Leydig cell tumor of the testis: a case report. Contemp Oncol (Pozn). 2012;16(4):356-359.