They present most commonly as a testicular mass or with endocrine symptoms. We report three new cases of Leydig cell tumors that presented in different forms. The relevant literature is reviewed and the management of these tumors is discussed. [ncbi.nlm.nih.gov]

LCTs can either be benign or malignant with clinical presentation varying from testicular mass associated with endocrinal manifestations to metastatic lesions in case of malignant tumors. [sciedu.ca]

Foci of calcification and hyalinization were present. The adjacent testis showed normal spermatogenesis. This patient was doing well at 3-years' follow-up with no evidence of metastasis. [indianjurol.com]

• Virilization

  LCTs of the testis are frequently hormonally active, leading to either feminizing or virilizing syndromes. The tumor is usually benign, but malignant variants can occur. [ncbi.nlm.nih.gov]

  Virilization (including precocious puberty) may occur. Hyperestrogenism may also occur and patients may demonstrate gynaecomastia. Malignancy cannot be excluded on imaging. [radiopaedia.org]

  Virilization is often seen in children, and gynecomastia may be present in 30% of adults. Because of the rarity of these tumors, minimal endocrine data are available on these patients. [health.am]

  ORPHA:99916 Synonym(s): Androblastoma Arrhenoblastoma Ovarian Sertoli-Leydig cell cancer Ovarian malignant Sertoli-Leydig cell tumor Virilizing ovarian tumor Prevalence: - Inheritance: - Age of onset: Adult, Elderly, Childhood, Adolescent ICD-10: C56 [orpha.net]

• Asymptomatic

  Men between 30 and 60 years are asymptomatic or may present with loss of libido, erectile dysfunction, impotence, and infertility. [indianjcancer.com]

  Adults are usually asymptomatic, although gynecomastia may be present in 20-25%. Ten percent of tumors in adults are malignant. Laboratory findings include elevated serum and urinary 17-ketosteroids as well as estrogens. [health.am]

  If it is secreting androgens the tumour is usually asymptomatic, but can cause precocious puberty in pre-pubertal boys. If the tumour secretes oestrogens it can cause feminisation in young boys. [en.wikipedia.org]

  Men usually present with either an asymptomatic mass or with endocrine abnormalities such as gynecomastia (20-40%) or loss of libido. [ijpmonline.org]

  Men usually present with either an asymptomatic mass or with endocrine abnormalities such as gynaecomastia (20-40%) or loss of libido. Azoospermia is not usually reported as a symptom of this tumor. [hormones.gr]

• Fracture

  Enteropathy (Inflammatory Bowel Disease) View Article All Articles Medical Articles Cat Skin and Fur April 24, 2019 Medical Articles Yeast (Malassezia) Dermatitis April 24, 2019 Medical Articles Feline Stomatitis April 23, 2019 Medical Articles Toe Fractures [bluepearlvet.com]

• Testicular Mass

  Abstract Leydig cell tumors of the testis are rare, mostly presenting as a testicular mass or as endocrinological symptoms. [ncbi.nlm.nih.gov]

  Gross examination revealed a testicular mass measuring 9.5 cm × 7 cm × 6 cm. Cut surface was brownish with areas of hemorrhage, necrosis, and calcification [Figure 1] a. [indianjcancer.com]

  Most patients (93%) had a testicular mass. [mayoclinic.pure.elsevier.com]

Review Topic QID: 106375 5 No further workup, instruct patient to return if symptomatic M1 Select Answer to see Preferred Response PREFERRED RESPONSE 2 Sorry, this question is for PEAK Premium Subscribers only ARTICLES (4) VIDEOS (1) Topic COMMENTS (12 [medbullets.com]

Testicular Cancer Workup. Available online at http://emedicine.medscape.com/article/279007-overview. Accessed July 2014. Motzer RJ, Agarwal N, Beard C, et al. Testicular Cancer. [labtestsonline.it]

CT scanning of the abdomen and chest radiography: Indicated if malignancy is suspected See Workup for more detail. Management Radical orchiectomy was once the primary treatment for Leydig cell tumors, and it remains in use for malignant cases. [emedicine.medscape.com]

Unfortunately, the patient could not be cured with this effective treatment. [ncbi.nlm.nih.gov]

Treatment Surgical treatment of the testicular tumor Inguinal (radical) orchiectomy is often the initial treatment for larger tumors. [urology-textbook.com]

As Leydig cell tumors are rare, these treatments have not been studied as much as treatments for other, more common testicular cancers. [medlineplus.gov]

Typically, in a vast majority of cases, the prognosis is excellent, since it is usually a benign tumor In rare case of a malignancy, the prognosis may depend upon several factors including the stage of the tumor and health status of the individual Generally [dovemed.com]

This article provides an overview of the major pathologic manifestations of LCT of the testis; patient characteristics; clinical, radiologic, and laboratory features; prognosis; and management. [ncbi.nlm.nih.gov]

Seminoma late metastasis and excellent prognosis Embryonal worse prognosis than seminoma Choriocarcinoma worst prognosis in contrast to good prognosis in females metastasizes to lungs Please rate topic. [medbullets.com]

The overall prognosis of testicular tumors is excellent; patients can often be cured even in advanced, metastatic stages. [amboss.com]

It is recommended that all endocrine, nutritional, neoplastic, chromosomal, and drug etiologies of gynecomastia be investigated before surgical resection of the enlarged breasts. [popline.org]

(Etiology) The cause of Leydig Cell Tumor of the Testis is unknown. [dovemed.com]

Etiology Risk factors Cryptorchidism (increased risk for germ cell tumors ) [4] Contralateral testicular cancer Germ cell neoplasia in situ (GCNIS) Family history of testicular cancer Klinefelter syndrome, Down syndrome (increased risk for germ cell tumors [amboss.com]

[…] are malignant Sites Origin from testis is demonstrable in most cases Rarely originates from epididymis ( Andrologia 2013;45:430 ) Pathophysiology Produce testosterone, dehydroepiandrosterone and androstenedione, which cause symptoms described below Etiology [pathologyoutlines.com]

The etiology of Leydig cell tumors remains unknown. Unlike germ cell testicular tumors, Leydig cell neoplasms are not associated with cryptorchidism. It is thought that an endocrine role may contribute to the development of these tumors. [emedicine.medscape.com]

Leydig Cell Tumors Epidemiology & Pathology Leydig cell tumors are the most common non-germ cell tumors of the testis and account for 1-3% of all testicular tumors. [health.am]

[…] more common in Hispanics compared to Asian and black populations in the US References: [1] [2] [3] Epidemiological data refers to the US, unless otherwise specified. [amboss.com]

Epidemiology 1–3% of all testicular tumors. Most common in boys (5–10 years old) and in adults aged 30–60 years. Pathology of the Leydig cell tumor Small yellow-brown tumors, sharply circumscribed in the testicular tissue. [urology-textbook.com]

Introduction Testicular tumors can be of germ cell or non-germ cell origin germ cell origin are the majority (95%) and are more commonly malignant non-germ cell origin usually benign Epidemiology incidence most common cancer in men between 15-35 years [medbullets.com]

Testes Overview Epidemiology [ edit ] 7000 cases/yr. Most common neoplasm in men ages 15-35. [en.wikibooks.org]

^ a b "Leydig Cell Tumors: Practice Essentials, Background, Pathophysiology". 2016-10-27. ^ Biegel, L. B.; Liu, R. C.; Hurtt, M. E.; Cook, J. C. (1995). [en.wikipedia.org]

Epidemiology : usually develop after the age of 4 Pathophysiology : produces ↑↑ amounts of testosterone and a small amount of estrogen, progesterone, and corticosteroids → testosterone excess causes precocious puberty in males (and masculinization in [amboss.com]

[…] and evolution of Leydig cells Epidemiology 1 - 3% of testicular tumors No predilection based on ethnicity or race ~10% are malignant Sites Origin from testis is demonstrable in most cases Rarely originates from epididymis ( Andrologia 2013;45:430 ) Pathophysiology [pathologyoutlines.com]

Background Pathophysiology A German anatomist, Franz Leydig, first described Leydig cells in 1870. [9] Leydig cells are located within the interstitium of the testis, between the seminiferous tubules, and produce testosterone in response to luteinizing [emedicine.medscape.com]

Pathologists have to be familiar with the diagnostic histopathologic features, immunohistochemical panel of this tumor, and its principal differential diagnoses to prevent tumor misdiagnosis. [ncbi.nlm.nih.gov]

Removal of the testis Debulking surgery to reduce tumor size, followed by chemotherapy Clotting the vessels in the tumor (embolization) Chemotherapy Radiotherapy Undertaking treatment of underlying conditions How can Leydig Cell Tumor of the Testis be Prevented [dovemed.com]

Available online at https://www.cancer.org/cancer/testicular-cancer/causes-risks-prevention/risk-factors.html. Accessed on 2/13/18. (February 12, 2016) Testicular Cancer Survival Rates. American Cancer Society. [labtestsonline.it]