Symptoma

Libman-Sacks Disease

Complete catalog of autoantibodies produced * Includes an outstanding review of imaging techniques for the diagnosis of lupus and its complications for each organ system * Includes CD-ROM of images excellent for teaching purposes and downloading into presentations [books.google.com]

We present a 30-year-old man with probable primary APS (with no history of thromboses) presenting with diffuse alveolar hemorrhage, an uncommon presentation. [journals.lww.com]

A 61-year-old female with history of antiphospholipid syndrome presented in acute pulmonary edema. Echocardiography demonstrated mobile vegetations on the free margins of both the anterior and the posterior mitral valve leaflets. [mayoclinic.pure.elsevier.com]

  • Failure to Thrive

    Fred Ferri’s popular "5 books in 1" format provides quick guidance on menorrhagia, Failure to Thrive (FTT), Cogan’s syndrome, and much more. [books.google.com]

  • Heart Disease

    Valvular heart disease is relatively rising in both congenital and acquired cases, but the autoimmune endocarditis remains rare. [actamedindones.org]

    Disease Valvular heart disease is a well-recognized cardiac manifestation in APS and SLE. [phaonlineuniv.org]

    disease IV drug use immunosuppression prosthetic heart valve congenital heart disease Etiology Pathogenesis endothelial damage on the surface of the cardiac valve can cause a thrombus to form factors include turbulent blood flow that can damage endothelium [medbullets.com]

    Discussion Valvular heart diseases are the most frequent and important cardiac manifestations of systemic lupus erythematosus 4,8. [scielo.br]

    Note also the thickened, shortened, and fused chordae tendineae that represent remote rheumatic heart disease. [library.med.utah.edu]

  • Heart Murmur

    Fever and a heart murmur are sometimes present. Blood cultures Echocardiography Noninfective endocarditis should be suspected when chronically ill patients develop symptoms suggesting arterial embolism. [merckmanuals.com]

    Also I'm not sure if the heart murmur was described, but this would be another way of ruling out stenosis over regurg This is how I think of why regurg stenosis: LSE buildup of gunk on leaflets, I shouldn't take much gunk buildup to WEIGH DOWN the leaflet [forums.studentdoctor.net]

    murmur and Evidence of multiple systemic emboli Main differential diagnosis is Infective endocarditis - distinction is important Laboratory Exclude DIC: full blood count, prothrombin time, partial thromboplastin time, fibrinogen, thrombin time, D dimers [pathologyoutlines.com]

    Therefore, people with severe heart murmurs should speak to their doctor about taking an antibiotic before receiving dental work. [hopkinslupus.org]

    A previously healthy 14-year-old girl was found to have a heart murmur when examined during an episode of upper respiratory tract infection. [annalspc.com]

A hypercoagulable workup should also be obtained in each case suspected of LS endocarditis including lupus anticoagulant and antiphospholipid antibodies. However, the primary evaluation for LSE is by echocardiography. [statpearls.com]

Autoimmune workup was negative. Hematological workup showed an isolated lupus anticoagulant with normal anti-cardiolipin antibodies. Repeat lupus anticoagulant a few days later was negative. [ncbi.nlm.nih.gov]

  • Albuminuria

    The features these patients exhibited in common were an arthritis of varying duration, the subsequent development of albuminuria of rather marked degree, nephrotic edema, subsequent renal insufficiency and, finally, a fatal outcome with the pathologic [jamanetwork.com]

  • White Matter Lesions

    In a study of 14 patients, focal white matter lesions and cerebral infarcts on pre-mortem MRI correlated highly with old and acute cerebral infarcts and microthromboemboli on histopathology (10). [imaging.onlinejacc.org]

  • Gliosis

    (G and H) (H&E 40 and 100 , respectively) Old deeper (white matter) infarct with liquefactive necrosis, residual macrophages, and gliosis (arrows). (I) (H&E 100 ) Large cerebral vessel with fibrin thrombi (arrow). [imaging.onlinejacc.org]

Home Vol 49, No 2 (2017) Ginanjar Autoimmune Disease with Cardiac Valves Involvement: Libman-Sacks Endocarditis Abstract This case study aim to evaluate the response of steroid treatment for autoimmune endocarditis. [actamedindones.org]

Cardiologia 18(4): 225-233, 1951 Therapeutic value of partial substitutive transfusions in the treatment of malignant lupus erythematosus visceritis (Libman-Sacks disease). [eurekamag.com]

This edition focuses on evidence-based findings, treatment consensuses, and practical clinical information. [books.google.com]

Improvements in imaging modalities, particularly in echocardiography, have allowed better estimation of the prevalence of the disease, but further investigation is still needed into its pathogenesis, treatment, and association with APS. [ucdavis.pure.elsevier.com]

[…] contributing authors—twenty of them new to this edition—provide comprehensive coverage of every aspect of cutaneous and systemic lupus erythematosus, including definitions, pathogenesis, autoantibodies, clinical and laboratory features, management, prognosis [books.google.com]

Prognosis The prognosis of LS endocarditis has not been fully studied and there continues to be a need for further studies to better define prognosis. From clinical observations, the prognosis of LS is considered poor. [statpearls.com]

It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. [hon.ch]

* Comprehensive current coverage of basic models of etiology and pathogenesis * Complete catalog of autoantibodies produced * Includes an outstanding review of imaging techniques for the diagnosis of lupus and its complications for each organ system [books.google.com]

Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. [icd10coded.com]

Epidemiologic, twin, and human leukocyte antigen data suggest a strong genetic contribution to the etiology of SLE, but the exact cause is unknown. [pedsinreview.aappublications.org]

Epidemiology In patients with SLE, the reported prevalence of LS vegetations are 1 in 10 patients. [1] LS endocarditis most commonly affects patients between 40 to 80 years of age. [3] A significant correlation was found between LS endocarditis and SLE [statpearls.com]

[…] valve surface, rich in fibrin and platelet aggregates but devoid of inflammation or infective organisms Terminology Also called marantic endocarditis Diagrams / tables Images hosted on other servers: Differences between NBTE and infective endocarditis Epidemiology [pathologyoutlines.com]

[…] endocarditis was higher in patients with underlying malignancy compared to the general population on autopsy (1.25% versus 0.2%). [4] The highest incidence of LS endocarditis in this study was observed in patients with pancreatic adenocarcinoma. [4] Pathophysiology [statpearls.com]

[…] endocarditis Diagrams / tables Images hosted on other servers: Differences between NBTE and infective endocarditis Epidemiology NBTE is uncommon but underestimated as symptoms are often attributed to other diseases Sites Cardiac valves and endocardial surface Pathophysiology [pathologyoutlines.com]

Rapidly find the answers you need with separate sections on diseases and disorders, differential diagnosis, clinical algorithms, laboratory results, and clinical preventive services, plus an at-a-glance format that uses cross-references, outlines, bullets [books.google.com]

In case of SLE with APLS, in which anticoagulation and antiplatelet therapy is required to prevent the thromboembolic event and thrombocytopenic purpura, after valve replacement, strict management of anticoagulation plays an essential role to prevent [jstage.jst.go.jp]

Anticoagulation should be considered as secondary prevention for thromboembolic phenomena in patients who have had a thromboembolic event. [statpearls.com]