We present a 30-year-old man with probable primary APS (with no history of thromboses) presenting with diffuse alveolar hemorrhage, an uncommon presentation. [journals.lww.com]

A 61-year-old female with history of antiphospholipid syndrome presented in acute pulmonary edema. Echocardiography demonstrated mobile vegetations on the free margins of both the anterior and the posterior mitral valve leaflets. [mayoclinic.pure.elsevier.com]

Systemic thromboembolism can manifest as peripheral arterial embolism presenting as cold limbs or mesenteric ischemia presenting as severe abdominal pain. [statpearls.com]

We present a rare case of a young female patient with lupus-negative Libman-Sacks endocarditis complicated by CAPS. [ncbi.nlm.nih.gov]

• Noncompliance

  Patients were excluded due to age 60 years, pregnancy, heart or brain disease unrelated to SLE, atrial fibrillation or flutter, cardiomyopathy, intracardiac thrombi, drug abuse, renal dysfunction, difficult venous access, self-withdrawal or noncompliance [imaging.onlinejacc.org]

• Chronic Fatigue Syndrome

  Kradin has a number of clinical interests including Chronic Fatigue Syndrome, Interstitial Lung Disease, Multiple Chemical Sensitivity and Pulmonary Immunology. He also holds an Associate Professor position of Pathology at Harvard Medical School. [books.google.com]

• Heart Disease

  Valvular heart disease is relatively rising in both congenital and acquired cases, but the autoimmune endocarditis remains rare. [actamedindones.org]

  Disease Valvular heart disease is a well-recognized cardiac manifestation in APS and SLE. [phaonlineuniv.org]

  Provides a clinically based approach to echocardiography, with an in-depth discussion of the main cardiac events seen in practice, including adult congenital heart disease. [books.google.com]

  Despite this, these patients have a greater incidence of stroke, peripheral embolism, heart failure, infective endocarditis, and death as compared with patients with no valvular heart disease 9. [scielo.br]

• Heart Murmur

  Fever and a heart murmur are sometimes present. Blood cultures Echocardiography Noninfective endocarditis should be suspected when chronically ill patients develop symptoms suggesting arterial embolism. [merckmanuals.com]

  The second question came down to a left-sided systolic murmur. [forums.studentdoctor.net]

  Heart Endocarditis Noninfective endocarditis Topic Completed: 1 April 2014 Revised: 4 March 2019 Copyright: 2014-2019, PathologyOutlines.com, Inc. [pathologyoutlines.com]

  Visits to the dentist offer opportunities for bacteria to sneak into the blood and land on a heart valve. Therefore, people with severe heart murmurs should speak to their doctor about taking an antibiotic before receiving dental work. [hopkinslupus.org]

  A previously healthy 14-year-old girl was found to have a heart murmur when examined during an episode of upper respiratory tract infection. [annalspc.com]

• Hemianopsia

  Online Video 1A 18 year old female with SLE and acute homonymous hemianopsia, confusional state, and cognitive dysfunction. [imaging.onlinejacc.org]

• Vaginal Bleeding

  A 37-year-old woman presented to our hospital’s gynecologic services with severe vaginal bleeding. She was considered for total abdominal hysterectomy. [cardiovascimaging.portal.tools]

• Homonymous Hemianopsia

  Online Video 1A 18 year old female with SLE and acute homonymous hemianopsia, confusional state, and cognitive dysfunction. [imaging.onlinejacc.org]

A hypercoagulable workup should also be obtained in each case suspected of LS endocarditis including lupus anticoagulant and antiphospholipid antibodies. However, the primary evaluation for LSE is by echocardiography. [statpearls.com]

• White Matter Lesions

  Gray & no veg/MES = gray matter perfusion in patients with no vegetations and no cerebromicroembolism; gray & veg/MES = gray matter perfusion in patients with vegetations and cerebromicroembolism; white & no veg/MES = white matter perfusion in patients [imaging.onlinejacc.org]

• Gliosis

  (G and H) (H&E 40× and 100×, respectively) Old deeper (white matter) infarct with liquefactive necrosis, residual macrophages, and gliosis (arrows). (I) (H&E 100×) Large cerebral vessel with fibrin thrombi (arrow). [imaging.onlinejacc.org]

Home Vol 49, No 2 (2017) Ginanjar Autoimmune Disease with Cardiac Valves Involvement: Libman-Sacks Endocarditis Abstract This case study aim to evaluate the response of steroid treatment for autoimmune endocarditis. [actamedindones.org]

Cardiologia 18(4): 225-233, 1951 Therapeutic value of partial substitutive transfusions in the treatment of malignant lupus erythematosus visceritis (Libman-Sacks disease). [eurekamag.com]

With the diagnosis of endocarditis and awaiting the haemocultures, treatment with empirical antibiotics was started with vancomycin + ceftazidime + gentamicin. [revistanefrologia.com]

Improvements in imaging modalities, particularly in echocardiography, have allowed better estimation of the prevalence of the disease, but further investigation is still needed into its pathogenesis, treatment, and association with APS. [ucdavis.pure.elsevier.com]

Treatment / Management The treatment for patients with LS endocarditis is not well established, partially due to the scarcity of information on the natural history of the disease in untreated patients. [statpearls.com]

Prognosis The prognosis of LS endocarditis has not been fully studied and there continues to be a need for further studies to better define prognosis. From clinical observations, the prognosis of LS is considered poor. [statpearls.com]

Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. [icd10coded.com]

The diagnosis of LS generally gets delayed as we look for other etiologies of patients presenting illness (thromboembolic event). [statpearls.com]

It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. [hon.ch]

Epidemiologic, twin, and human leukocyte antigen data suggest a strong genetic contribution to the etiology of SLE, but the exact cause is unknown. [pedsinreview.aappublications.org]

Epidemiology In patients with SLE, the reported prevalence of LS vegetations are 1 in 10 patients. [1] LS endocarditis most commonly affects patients between 40 to 80 years of age. [3] A significant correlation was found between LS endocarditis and SLE [statpearls.com]

[…] valve surface, rich in fibrin and platelet aggregates but devoid of inflammation or infective organisms Terminology Also called marantic endocarditis Diagrams / tables Images hosted on other servers: Differences between NBTE and infective endocarditis Epidemiology [pathologyoutlines.com]

[…] endocarditis was higher in patients with underlying malignancy compared to the general population on autopsy (1.25% versus 0.2%). [4] The highest incidence of LS endocarditis in this study was observed in patients with pancreatic adenocarcinoma. [4] Pathophysiology [statpearls.com]

[…] endocarditis Diagrams / tables Images hosted on other servers: Differences between NBTE and infective endocarditis Epidemiology NBTE is uncommon but underestimated as symptoms are often attributed to other diseases Sites Cardiac valves and endocardial surface Pathophysiology [pathologyoutlines.com]

In case of SLE with APLS, in which anticoagulation and antiplatelet therapy is required to prevent the thromboembolic event and thrombocytopenic purpura, after valve replacement, strict management of anticoagulation plays an essential role to prevent [jstage.jst.go.jp]

Rapidly find the answers you need with separate sections on diseases and disorders, differential diagnosis, clinical algorithms, laboratory results, and clinical preventive services, plus an at-a-glance format that uses cross-references, outlines, bullets [books.google.com]

Anticoagulation should be considered as secondary prevention for thromboembolic phenomena in patients who have had a thromboembolic event. [statpearls.com]