Abstract The present study was aimed to evaluate the effect of licofelone, a dual inhibitor of cycloxygenase1/2-5-lipoxygenase against indomethacin-induced gastric damage in rats and mice in order to assess the role of leukotrienes if any, in non-steroidal [ncbi.nlm.nih.gov]

We also present evidences that licofelone was able to affect the arachidonic acid cascade, as it blocked the activity of 5-LOX and COXs enzymes, and it induced, through the phosphorylation of cytoplasmic phospholipase A2, the release of unesterified arachidonic [cris.unibo.it]

Licofelone provided in the osmotic device of the present invention may be 200 mg to 800 mg or more if desired. In specific embodiments of dosage forms once daily according to the present invention. [google.com.pg]

Abstract Nowadays, no data are available concerning the potential use of dual cyclooxygenase (COX)/5-lipoxygenase (LOX) inhibitors as anticancer agents in colon cancer treatment. [ncbi.nlm.nih.gov]

The emerging clinical data for licofelone indicate that it is an effective and well-tolerated therapy that could offer safety advantages over current treatment options, and that it could be suitable for the long-term treatment of a broad spectrum of patients [dx.doi.org]

Drugs that can modify disease progression represent the ultimate goal of treatment but are not clinically available. [clinicaltrialsarena.com]

[…] are here Home Archive Volume 68, Issue 6 Protective effects of licofelone, a 5-lipoxygenase and cyclo-oxygenase inhibitor, versus naproxen on cartilage loss in knee osteoarthritis: a first multicentre clinical trial using quantitative MRI Clinical and epidemiological [ard.bmj.com]

Clinical and epidemiological research Protective effects of licofelone, a 5-lipoxygenase and cyclo-oxygenase inhibitor, versus naproxen on cartilage loss in knee osteoarthritis: a first multicentre clinical trial using quantitative MRI J-P Raynauld 1, [dx.doi.org]

Clinical and epidemiological research Relationship between bone marrow lesions, cartilage loss and pain in knee osteoarthritis: results from a randomised controlled clinical trial using MRI Lukas Martin Wildi 1, Jean-Pierre Raynauld 1, Johanne Martel-Pelletier [doi.org]

Licofelone, a LOX/COX competitive inhibitor, decreases the production ofproinflammatory leukotrienes and prostaglandins (which are involved in the pathophysiology of osteoarthritis and in gastrointestinal (GI) damage induced by NSAIDs) and has the potential [ncbi.nlm.nih.gov]

Licofelone, a LOX/COX competitive inhibitor, decreases the production of proinflammatory leukotrienes and prostaglandins (which are involved in the pathophysiology of osteoarthritis and in gastrointestinal (GI) damage induced by NSAIDs) and has the potential [dovepress.com]

Licofelone decreases the production of proinflammatory leukotrienes and prostaglandins—which are involved in the pathophysiology of OA and in gastrointestinal (GI) damage induced by NSAIDs—and has the potential to combine good analgesic and anti-inflammatory [dx.doi.org]

Failure to prevent aggregation triggered by high concentrations of collagen/adrenalin in aspirin-treated platelets supports cyclooxygenase-1 as a specific target of licofelone. [sigmaaldrich.com]

This proposed study is consistent with the scope of the NCI's Program Announcement # PAR-08-055, Cancer Prevention Research Small Grant Program (R03). [grantome.com]

Licofelone completely prevented platelet aggregation induced in platelet-rich plasma by threshold aggregating concentrations of arachidonic acid (0.87+/-0.14 mM) at threshold inhibitory concentrations of 0.75+/-0.35 microM (n=5). [ncbi.nlm.nih.gov]

Thus, in the present study we investigate possible effects of licofelone on prevention and termination of SE. We also evaluated whether the nitrergic system could participate in this effect of licofelone. [escholarship.umassmed.edu]