Four weeks later, the patient presented with a 20-lb weight gain and generalized swelling. He had no new symptoms other than discomfort from fluid retention. The review of systems at the time was entirely negative. [cjasn.asnjournals.org]

Three weeks later, she developed worsening respiratory insufficiency, ARDS, sepsis, respiratory arrest, and cardiac arrest resulting in death. [neurology.org]

Lung involvement is particularly uncommon, but can sometimes dominate the clinical course of LCDD and lead to severe respiratory insufficiency 9. [erj.ersjournals.com]

Examination showed hypophonia, mild macroglossia, tongue stiffness, submandibular and submental musculature stiffness, firm sternocleidomastoids, generalized 4-extremity weakness, and bilateral thenar atrophy. [neurology.org]

Bedossa P, Fabre M, Paraf F, Martin E, Lemaigre G: Light chain deposition disease with liver dysfunction. Human Pathol, 19: 1008–1014, 1988. CrossRef Google Scholar 25. [link.springer.com]

Liver dysfunction can also occur, with progression to hepatic failure. Other symptoms of LCDD relate to congestive heart failure, peripheral neuropathy, and skin lesions secondary to the deposition of light chains. [emedicine.medscape.com]

Peripheral neuropathy with pain, loss of sensation or an inability to control muscles can develop if the nervous system is involved, and if light chains are deposited in the skin, lesions can appear. [davita.com]

Other symptoms of LCDD relate to congestive heart failure, peripheral neuropathy, and skin lesions secondary to the deposition of light chains. Weichman K, Dember LM, Prokaeva T, Wright DG, Quillen K, Rosenzweig M, et al. [emedicine.medscape.com]

No sign and symptom of liver or neurological involvement was found, none the less, maculopapular skin lesions were noted in case N02 which may be the sign of cutaneous deposits as described by some authors [ 9, 13, 14 ]. [omicsonline.org]

hematuria, and nephrotic syndrome. [emedicine.medscape.com]

Nephrotic syndrome is present in approximately 30% of cases, and microscopic hematuria is common. Hypertension occurs frequently and may be severe, as in this case. Renal failure develops in most cases over the course of weeks to years. [cjasn.asnjournals.org]

In all cases there were single or multiple pulmonary nodules, in one case associated with cysts. [jcp.bmj.com]

Kijner CM, Yousem SA: Systemic light chain deposition disease presenting as multiple pulmonary nodules. Am J Surg Pathol, 12: 405–413, 1988. PubMed CrossRef Google Scholar 20. [link.springer.com]

Systemic light chain deposition disease presenting as multiple pulmonary nodules. A case report and review of the literature. Am J Surg Pathol 1988 ; 12 : 405 –413. View Abstract [erj.ersjournals.com]

Albuminuria is not correlated with the existence of NGS, at least initially, and may occur in the absence of significant glomerular lesions by light microscopy. [jasn.asnjournals.org]

Albuminuria levels do not correlate with the presence of glomerulonephritis and can be present even without glomerulosclerosis. [10] Renal function declines rapidly as a rapidly progressive glomerulonephritis or acute tubulointerstitial nephritis. [4] [emedicine.medscape.com]

Severe albuminuria is the rule. Nephrotic syndrome is present in approximately 30% of cases, and microscopic hematuria is common. Hypertension occurs frequently and may be severe, as in this case. [cjasn.asnjournals.org]

During the investigation period the serum creatinine increased to 288 μmol/l and the creatinine clearance declined to 16 ml/min. [academic.oup.com]