Case presentation A 10 year old girl initially presented to our dermatology clinic with an 8 month history of skin lesions developing on her right upper limb. [ped-rheum.biomedcentral.com]

We present a case of a young and healthy patient that developed such lesions on her upper and lower extremities over 5 years. [ncbi.nlm.nih.gov]

We present here a peculiar case of linear atrophoderma affecting a teenager. [moh-it.pure.elsevier.com]

Diagnosing Atrophoderma of Pasini and Pierini (APP) is reasonably straightforward – it usually presents in adolescents and young adults, more often in females, with sharply defined, single or multiple round to oval, hyperpigmented, depressed lesions with [drwarrenrheymann.com]

• Inflammation

  There were no prior skin lesions or inflammation. There was no significant medical or family history. [ncbi.nlm.nih.gov]

  Typically, the lesions develop without preceding inflammation and are devoid of subsequent induration or sclerosis. [ped-rheum.biomedcentral.com]

  Role of PPARgamma in inflammation. Prospects for ... Skin inflammation was confirmed as the cause of alopecia when topical aspirin cured the inflammation and prevented the hair loss. [reizendeaardeschool.nl]

• Asymptomatic

  We present a 40-year-old woman with asymptomatic, linear, hyperpigmented atrophic plaques in a Blaschkoid distribution on the right back and right upper extremity that is consistent with a diagnosis of linear atrophoderma of Moulin. [ncbi.nlm.nih.gov]

  The lesions were asymptomatic and the child was otherwise healthy. [scinapse.io]

  CASE REPORT A 22-year-old Malay woman presented with an 11-year history of asymptomatic, unilateral brown patches affecting the right arm, right side of the trunk, and right leg. There were no prior skin lesions or inflammation. [semanticscholar.org]

  This asymptomatic spot usually fades away by school age (1). McCune-Albright syndrome: Incorrect. [revistabiomedica.org]

  It is characterized by asymptomatic hyperpigmented atrophic band-like lesions localized mostly on the trunk following the lines of Blaschko. Distribution is usually unilateral, and extensive lesions with bilateral involvement are extremely rare. [papersearch.net]

• Pain

  Lesions are not painful. [quizlet.com]

  The sclerosis can entrap superficial nerves and result in pain, tingling and sometimes mild weakness. Symptoms due to deeper tissue involvement Deep involvement over joints causes joint pain or limited joint movement (contractures). [dermnetnz.org]

  Your skin Holds body fluids in, preventing dehydration Keeps harmful microbes out, preventing infections Helps you feel things like heat, cold, and pain Keeps your body temperature even Makes vitamin D when the sun shines on it Anything that irritates [icdlist.com]

  Its hard but not painful. Can. I have a lump on my abdomen. It's hard but not painful. Can't tell the size but i'd say smaller than a fist or the size of a fist of a child's hand. Actinic cheilitis wikipedia, the free encyclopedia. [moroskyhojonet.blogspot.com]

• Swelling

  Medicine a swelling or small palpable mass. 4. A collection or totality; an. Hard lumps in stomach area? Yahoo answers. [moroskyhojonet.blogspot.com]

  […] microbes out, preventing infections Helps you feel things like heat, cold, and pain Keeps your body temperature even Makes vitamin D when the sun shines on it Anything that irritates, clogs, or inflames your skin can cause symptoms such as redness, swelling [icdlist.com]

  R hand with muscular atrophySlightly atrophic epidermis; slight perivascular infiltrate; spotted swelling of collagen fibers9 10 5 F Slightly atrophic, brown, S-shaped plaques with a sensation of tightness. [myslide.es]

• Weakness

  Subsequently, he developed visual extinction of the right eye, slight numbness, and weakness of the left extremities. Simultaneously, multiple atrophic brownish patches occurred on his side. [pubfacts.com]

  The sclerosis can entrap superficial nerves and result in pain, tingling and sometimes mild weakness. Symptoms due to deeper tissue involvement Deep involvement over joints causes joint pain or limited joint movement (contractures). [dermnetnz.org]

  Myopathic changes, atrophy and weakness of involved and adjacent muscles may occur (Uziel et al. 1994). Discrepancies of limb length are a frequent complication in children with limb involvement (Liu et al. 1994). [arthritisresearch.us]

  Benign redundant skin folds that improve with age May be associated with: Developmental delay, Facial dysmorphism osteogenesis imperfecta: mutation, key clinical features AD/AR Mutation in type I collagen (bONE) Blue sclera dentinogenesis imperfecta Weak [studyblue.com]

  Musculoskeletal: joint, muscle aches, loss of joint range of motion, carpal tunnel syndrome and muscle weakness. Genitourinary: erectile dysfunction, dyspareunia, scleroderma renal crises and kidney failure. [ipfs.io]

• Osteoporosis

  Dec 18th, 2018 - Chronic urticaria (CU) carries many risk factors for osteoporosis, but data on the relation between CU and osteoporosis are lacking. To evaluate the association between CU and osteoporosis in a large community-based study. [allmedx.com]

  Osteoporosis and fractures Alopecia, swollen veins Narrow chest, age spots Premature CAD Average lifespan: 12 years Werner Syndrome (adult-onset progeria) AR ; Mutation in WRN (RECQL2) – encodes DNA helicase Onset in second decade of life Sclerodermoid [studyblue.com]

  PO, IV, IM, SC, IT D (Au) Myeosuppression, pulmonary toxicity, hepatotoxicity, neurotoxicity and rarely kidney failure, hypersensitivity reactions, skin and bone necrosis and osteoporosis. [ipfs.io]

• Skin Disease

  A Case of Linear Atrophoderma of Moulin 10.1111/j.1346-8138.1996.tb02676.x Many different congenital and acquired skin diseases are seen along Blaschko's lines. [scinapse.io]

  skin disease | case report | adolescent | follow up | human | male | Related Technologies Acidity regulator (Research Taxonomy) base (1); [info.rdi.ku.ac.th]

  disease (p.11-21) Kenshi Yamasaki, Richard L Gallo Genes and skin Association of segmental neurofibromatosis 1 and oculo-auriculo-vertebral spectrum in a 24-year-old female (p.22-5) Marco Castori, Silvia Majore, Francesco Romanelli, Biagio Didona, Paola [jle.com]

  Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Pascal 002 Biological and medical sciences / 002B Medical sciences / 002B08 Dermatology / 002B08J Skin involvement in other diseases. [pascal-francis.inist.fr]

  Elsevier Health Sciences, ٣٠‏/١٠‏/٢٠٠٩ - 1052 من الصفحات Thoroughly revised and up-dated, this comprehensive, authoritative reference will help both the experienced and novice practitioner diagnose skin diseases and disorders more accurately and effectively [books.google.com]

• Ulcer

  Ohio State University Medical Center article International Scar Meeting in Tokyo 2010 International Scar Meeting v t e Cutaneous keratosis, ulcer, atrophy, and necrobiosis ( L82–L94, 700–701.5 ) Epidermal thickening keratoderma : Keratoderma climactericum [marefa.org]

  External links http://tray.dermatology.uiowa.edu/CalCut01.htm v · d · e Cutaneous keratosis, ulcer, atrophy, and necrobiosis (L82–L94, 700–701.5) Epidermal thickening keratoderma : Keratoderma climactericum • Paraneoplastic keratoderma (Acrokeratosis [en.academic.ru]

  Sclerodactyly often leads to ulceration of the skin of the distal digits and is commonly accompanied by atrophy of the underlying soft tissues. [ipfs.io]

  Medical Encyclopedia) Milia (Medical Encyclopedia) Sebaceous cyst (Medical Encyclopedia) Seborrheic keratosis (Medical Encyclopedia) Skin lesion removal (Medical Encyclopedia) Skin lesion removal-aftercare (Medical Encyclopedia) Stasis dermatitis and ulcers [icdlist.com]

• Alopecia

  The Journal of dermatology 41 (9), 830-833, 2014 9 2014 Bullous pilomatricoma Developed after the Hepatitis-A vaccination B Tas, E Tas, M Sar West Indian Medical Journal 63 (6), 2014 6 2014 Congenital temporal triangular alopecia: A typical Brauer nevus [scholar.google.com.tr]

  When associated with cardiofaciocutaneous syndrome the follicular keratosis is more e extensive with alopecia of the scalp. [quizlet.com]

  König A, Happle R, Hoffmann R: "Are TNF-a or IL-1b responsible for the therapeutic effect of contact sensitization in alopecia areata?" Arch Dermatol Res 288: 308 (1996) 7. [uni-marburg.de]

• Skin Atrophy

  |Atrophy of skin caused by systemic corticosteroid|Atrophy of skin caused by systemic corticosteroid (disorder)|Atrophy of skin caused by topical corticosteroid|Atrophy of skin caused by topical corticosteroid (disorder)|Atrophy of skin due to systemic [averbis.com]

  The swellinginitially developed after trauma 4 months before Evaluation of skin atrophy associated with linear atrophoderma of Moulin by ultrasound imaging References [dokument.tips]

  Cited by Multiple subcutaneous haematomas of the legs causing skin necrosis in an elderly patient affected by corticosteroid-induced skin atrophy: Case report and review of literature. [pubmed.ncbi.nlm.nih.gov]

  Keywords : linear atrophoderma of moulin (1 items found) | Atrophoderma of Moulin (1 items found) | review (2982 items found) | Linear dermatosiscalcipotriol | treatment response | priority journal | Blaschko's lines | histopathology | skin atrophy | [info.rdi.ku.ac.th]

  In the dermis, there was no distinct pigment incontinence, no inflammation or alteration of connective tissue texture, and the clinical impression of skin atrophy was attributed to atrophy of the subcutaneous tissue [ 1 ]. [derm101.com]

• Pruritus

  Genetic basis of cutaneous diseases Arne Kanig and Rudolf Happle Ichthyoses erythrokeratodermas and related disorders Keratodermas Kro Dariers disease and HaileyHailey disease Daniel Hohl Theodora Mauro and leanPhilippe Gorog Mosaicism and linear lesions Pruritus [books.google.it]

  April 01, 2016 Chronic pruritus in Turkish dermatology outpatients: prevalence, sociodemographic and clinical characteristics. April 01, 2016 Exploring mechanisms of IgE-mediated autoimmunity through the lens of bullous pemphigoid. [medscape.com]

  No clinical symptoms such as pain, pruritus or previous inflammation were present. [revistabiomedica.org]

  The patient referred a continuous lumbar discomfort, mild pruritus and moderate pain at night. There were no other clinical symptoms and the remaining physical examination was otherwise normal. [clinicaldermatology.eu]

"Scleroderma Workup". Medscape Reference. WebMD. Retrieved 6 March 2014. ↑ Jimenez, SA; Cronin, PM; Koenig, AS; O'Brien, MS; Castro, SV (15 February 2012). Varga, J; Talavera, F; Goldberg, E; Mechaber, AJ; Diamond, HS, eds. [ipfs.io]

Young children with BLT should beoffered a chance of medical treatment before extensive surgical destruction isused. ... [epidemiologie-sousse.org]

No previous reports have discussed the treatment of LAM. This case is reported to discuss the use of methotrexate as an effective treatment of this rare skin condition. [docksci.com]

Currently, there is no standard treatment regimen for LAM. [ncbi.nlm.nih.gov]

The lesions usually develop during childhood or adolescence, and the prognosis is good. The diagnosis is made clinically and histopathologically. [ncbi.nlm.nih.gov]

LAM is an etiologically unknown form of dermal atrophy. It is generally characterized by oval or round atrophic, nonsclerotic, hyperpigmented patches following Blaschko's lines. [ncbi.nlm.nih.gov]

The exact etiology of LAM is still obscure. Several treatment modalities were reported but none was consistently successful. We report a case of LAM in which a favorable outcome was obtained with topical calcipotriol. [info.rdi.ku.ac.th]

Classification of these conditions often presents many nosological challenges, since underlying etiologies and pathogenetics are often not known. [howlingpixel.com]

Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Pascal 002 Biological and medical sciences / 002B Medical sciences / 002B08 Dermatology / 002B08J Skin involvement in other diseases. [pascal-francis.inist.fr]

“The epidemiology of morphea (localized scleroderma) in Olmsted County 1960-1993”. J. Rheumatol. 24 (1): 73–80. PMID 9002014. ^ Laxer RM, Zulian F (2006). “Localized scleroderma”. [thetanningguru.com]

Juvenile localized scleroderma: clinical and epidemiological features in 750 children. An international study. Rheumatology (Oxford). [wikidoc.org]

"Epidemiology of systemic sclerosis: incidence, prevalence, survival, risk factors, malignancy, and environmental triggers.". Current Opinion in Rheumatology. 24 (2): 165–70. doi : 10.1097/BOR.0b013e32834ff2e8. [ipfs.io]

(A case report with a brief summary of the epidemiology and associated findings of UNT.) Anderton, RL, Smith, G. “Unilateral nevoid telangiectasia with gastric involvement”. Arch Dermatol. vol. 111. 1975. pp. 617-621. [dermatologyadvisor.com]

Epidemiology, clinical presentation, and pathogenesis. J Am Acad Dermatol. 2011;64:217-28. [ Links ] 39. Gaviria CM, Jiménez SB, Gutiérrez J. Morfea o esclerodermia localizada. Rev Asoc Colomb Dermatol. 2014;22:126-40. [ Links ] 40. [scielo.org.mx]

To date, the pathophysiology is unclear. Different authors hypothesize that the disease is secondary to a mosaic manifestation as a result of a post-zygotic mutational event. [ncbi.nlm.nih.gov]

Other possible factors involved in the pathophysiology include hemodynamic disturbances, neural alteration, angiogenic factors, and changes in supportive connective tissue and vasculature. [dermatologyadvisor.com]

Endothelin signalling is implicated in the pathophysiology of fibrosis. [19] Vitamin D is implicated in the pathophysiology of the disease. [ipfs.io]

Your skin Holds body fluids in, preventing dehydration Keeps harmful microbes out, preventing infections Helps you feel things like heat, cold, and pain Keeps your body temperature even Makes vitamin D when the sun shines on it Anything that irritates [icdlist.com]

The information presented here is not intended to diagnose, treat, cure or prevent any disease. Read disclaimer. [gulfdoctor.net]

Analgesia (painkillers) and anti-inflammatory drugs, including steroids, are used to suppress the symptoms, while disease-modifying antirheumatic drugs (DMARDs) are required to inhibit or halt the underlying immune process and prevent long-term damage [kriso.ee]

Skin inflammation was confirmed as the cause of alopecia when topical aspirin cured the inflammation and prevented the hair loss. [reizendeaardeschool.nl]