Presentation
A coronoid lamella was present. At the base of coronoid lamella thinned out granular layer and necrotic keratinocytes were also seen. In the dermis pigment incontinence and perivascular lymphocytic infiltrate were present. [ncbi.nlm.nih.gov]
Entire Body System
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Lymphadenopathy
Concurrent right inguinal lymphadenopathy was demonstrated on biopsy to be reactive in nature. [ncbi.nlm.nih.gov]
Immune System
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Inguinal Lymphadenopathy
Concurrent right inguinal lymphadenopathy was demonstrated on biopsy to be reactive in nature. [ncbi.nlm.nih.gov]
Skin
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Anhidrosis
The center generally is atrophic with anhidrosis and alopecia.3 Classic porokeratosis of Mibelli, disseminated superficial actinic porokeratosis, porokeratosis palmaris et plantaris disseminata, and punctate porokeratosis are characterized by autosomal [mdedge.com]
Rare case reports of porokeratotic adnexal ostial nevus (PAON) describe other findings, including psoriasis, focal anhidrosis, developmental delay, seizures, scoliosis, hemiparesis, polyneuropathy, hyperthyroidism, hearing loss, and breast hypoplasia. [emedicine.medscape.com]
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Shagreen Patch
Patch,) Lichenoid Keratosis (52 %) ( Benign Lichenoid Keratosis, Lichen Planus-like Keratosis, Solitary Lichen Planus, Solitary Lichenoid Keratosis,) Palmoplantar Keratoderma (52 %) Plaque-type Porokeratosis (52 %) ( Classic Porokeratosis, Porokeratosis [gulfdoctor.net]
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Scaly Rash
CASE REPORT A 23-year-old man with a lifelong history of a "scaly rash" had been treated by various physicians with a wide variety of treatment moralities, including cryosurgery, electrosurgery, and keratolytics, all of which yielded only temporary results [kundoc.com]
Neurologic
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Dysesthesia
[…] cutaneous diseases Arne Kanig and Rudolf Happle Ichthyoses erythrokeratodermas and related disorders Keratodermas Kro Dariers disease and HaileyHailey disease Daniel Hohl Theodora Mauro and leanPhilippe Gorog Mosaicism and linear lesions Pruritus and dysesthesia [books.google.de]
Workup
Colonoscopy
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Colitis
A case of a large, nonhealing full-thickness ulcer caused by a giant ulcerating squamous cell carcinoma occurring within lesions of long-standing linear porokeratosis is reported in a 43-year-old woman with a recent diagnosis of ulcerative colitis (UC [ncbi.nlm.nih.gov]
Her past medical history included a lifelong history of linear PK and a more recent (2 years before presentation) diagnosis of ulcerative colitis (UC). Initially believing the chronic, nonhealing wound was of benign etiology, Ms. [o-wm.com]
Treatment
The treatment of LP is contradictory and disappointing in general. [ncbi.nlm.nih.gov]
However, only time and the treatment of other individuals with porokeratoses will determine the overall effectiveness of the CO2 laser in the treatment of this unique lesion. REFERENCES 1. [kundoc.com]
No response was observed after 1 year of treatment with calcipotriol ointment. Figure 1. Reddish-brown hyperkeratotic papules and plaques linearly arranged on the back of the right lower leg before treatment. [jamanetwork.com]
Prognosis
PET scans did not show metastases, so her prognosis is good based on definitive excision of the tumor. [ncbi.nlm.nih.gov]
Prognosis - Linear porokeratosis Not supplied. Treatment - Linear porokeratosis Not supplied. Resources - Linear porokeratosis Not supplied. [checkorphan.org]
Etiology
Porokeratosis is a keratinization disorder of multiple etiologies including genetic aberrancy, trauma, and infection. [ncbi.nlm.nih.gov]
Clinical analysis and etiology of porokeratosis. Exp Ther Med. 2014;8:737–41. PubMed PubMedCentral Google Scholar 10. Schamroth JM, Zlotogorski A, Gilead L. Porokeratosis of Mibelli. Overview and review of the literature. [link.springer.com]
[…] suggests that the disease represents a focal, expanding clone of abnormal keratinocytes. [5] Although cornoid lamella may rarely be associated with some other conditions like viral warts, some ichthyoses and nevoid hyperkeratosis, [6] the clinical picture, etiology [ijdvl.com]
Epidemiology
Definition / general Rare disease, consists of an atrophic center bordered by a peripheral grooved keratotic ridge Epidemiology Six major categories: classic, localized, linear, punctuate, disseminated superficial porokeratosis and disseminated superficial [pathologyoutlines.com]
Research output : Contribution to journal › Article Method-dependent epidemiological cutoff values for detection of triazole resistance in Candida and Aspergillus species for the Sensititre Yeastone colorimetric broth and etest agar diffusion methods [moh-it.pure.elsevier.com]
Diagnosis and treatment of varicose veins, Part 1: Definition, epidemiology, etiology, classification, clinical aspects, diagnostic and indications. Chirurq 2010;81:1035-44. 16. Alley E, Green R, Schuchter L. Cutaneous toxicities of cancer therapy. [ijdvl.com]
A rare case of a hyperkeratotic variant has been described in a patient with known HIV and HCV infections and a coexisting therapy-related immunosuppressed state. [38] Epidemiology Frequency Disseminated superficial actinic porokeratosis (DSAP) and porokeratosis [emedicine.medscape.com]
Inform (US) U. of Washington: Pneumonia, PCP, with cystic lung destruction Medscape: Granulomatous Pneumocystis carinii Pneumonia Medscape: New Guidelines for PCP Prophylaxis in Children Medscape: Molecular Epidemiology of Pneumocystis carinii Pneumonia [catsclem.nl]
Pathophysiology
[…] histopathologic sampling, and the rarity of this variant could be explained by the low prevalence of this condition in the population or perhaps low biopsy rate of lesions that appear to represent a localized form of keratosis pilaris to physicians. [10] Pathophysiology [emedicine.medscape.com]
Prevention
The information presented here is not intended to diagnose, treat, cure or prevent any disease. Read disclaimer. [gulfdoctor.net]
Treatment is requested for cosmetic reasons and to prevent malignant transformation. Topical agents, such as keratolytics, 5-fluorouracil, corticosteroids, retinoids, and calcipotriol, has shown variable degrees of success. [link.springer.com]
Prevention - Linear porokeratosis Not supplied. Diagnosis - Linear porokeratosis * Classic porokeratosis (Mibelli) During childhood, a small, asymptomatic or slightly pruritic lesion develops, expanding over a period of years. [checkorphan.org]
How can Linear Porokeratosis be Prevented? Currently, there are no known methods to prevent the occurrence of Linear Porokeratosis. [dovemed.com]
It can help improve the appearance of lesions and prevents remission of the disease. Vitamin D – It is effective after three to six months of treatment. [healthfixit.com]