As many of the presenting symptoms can be non-specific, there may be a delay in diagnosis. LP can, however, be diagnosed in a multitude of ways. [cancertherapyadvisor.com]

Herein we report a rare case of primary GSCC presenting as linitis plastica that was diagnosed using endoscopic ultrasound (EUS)-guided biopsy. [e-ce.org]

Methods: We present the case of a 57-year-old woman with a history of signet cell gastric adenocarcinoma (linitis plastica) and a Krukenberg tumor who presented with nausea, blurry vision, and a chronic headache of two months’ duration. [n.neurology.org]

Here we present a case of metastatic breast cancer presenting as linitis plastica, as well as the treatment algorithm for this rare clinical entity. [ncbi.nlm.nih.gov]

• Weight Loss

  Left: 76 year-old woman with several months of progressive loss of appetite, early satiety and weight loss. The walls of the stomach appeared thickened, and the stomach distended poorly. [endoatlas.com]

  A 62-yr-old woman was evaluated for a 2-wk history of regurgitation and weight loss. Radiologic studies demonstrated a stenotic region in the distal third of the esophagus. Multiple endoscopic biopsies were nondiagnostic. [ncbi.nlm.nih.gov]

• Vomiting

  Sijil kottikkal sivaraman Email: [email protected] DOI : http://dx.doi.org/10.7869/tg.274 Case report A 43-year-old lady without associated comorbidity presented with upper abdominal dull aching pain, persistent nonbilious vomiting,loss of appetite and [tropicalgastro.com]

  A 52-year-old Caucasian woman presented with progressive nausea and vomiting, weight loss, and burning epigastric and chest pain. [ncbi.nlm.nih.gov]

  Just scratching the surface: intractable nausea and vomiting. Am J Med 2015 ; 128 : e3 – 5. 3 Park MS, Ha HK, Choi BS, Kim KW, Myung SJ, Kim AY, et al. Scirrhous gastric carcinoma: endoscopy versus upper gastrointestinal radiography. [academic.oup.com]

• Dysphagia

  A 60-year-old woman had progressive lower abdominal pain, nonbloody diarrhea, and weight loss, followed by severe epigastric pain and dysphagia. [ncbi.nlm.nih.gov]

  Patients may present progressive dysphagia. Gastric LP is characterized by malignant glandular proliferation of independent cells (signet-ring cells) in the fibrous stroma leading to thickening and rigidity of the gastric wall. [orpha.net]

• Abdominal Pain

  We report a case of primary linitis plastica of the sigmoid colon in a 32-year-old Chinese woman who presented with a 7-month history of constipation and associated abdominal pain and tenesmus. [ncbi.nlm.nih.gov]

  Right: 40 year-old woman with several months of abdominal pain attributed to ulcer disease, and several weeks of diminished appetite and weight loss. The walls of the proximal stomach appeared thickened, and the proximal stomach distended poorly. [endoatlas.com]

• Nausea

  A 52-year-old Caucasian woman presented with progressive nausea and vomiting, weight loss, and burning epigastric and chest pain. [ncbi.nlm.nih.gov]

  Just scratching the surface: intractable nausea and vomiting. Am J Med 2015 ; 128 : e3 – 5. 3 Park MS, Ha HK, Choi BS, Kim KW, Myung SJ, Kim AY, et al. Scirrhous gastric carcinoma: endoscopy versus upper gastrointestinal radiography. [academic.oup.com]

  Signs and symptoms are nonspecific: satiety, nausea and vomiting, epigastric pain, and weight loss. Patients may present progressive dysphagia. [orpha.net]

• Early Satiety

  Early satiety may be more prominent in patients in LP based on the diffuse involvement of the stomach, which causes limited distensibility. [cancertherapyadvisor.com]

  Left: 76 year-old woman with several months of progressive loss of appetite, early satiety and weight loss. The walls of the stomach appeared thickened, and the stomach distended poorly. [endoatlas.com]

  Patients with LP will have more intense symptoms presented with gastric cancer in addition to early satiety and how much stomach involvement there is since it may lead to limited distensibility. Diagnosis & Staging View Full Article Related Videos [debbiesdream.org]

  The player requires Flash Player plugin Case description A 35 year-old female, who began her disease with jaundice, weight loss, early satiety, nausea and vomiting. The endoscopy was performed and all the gastric mucosa and walls were infiltrated. [medtube.net]

• Conjunctival Pallor

  Physical examination upon admission revealed no anemia (via conjunctival pallor examination), jaundice or pulmonary abnormalities. On palpation, the abdomen of the patient was soft and flat, with no areas of tenderness. [spandidos-publications.com]

Post -operative clinico-radiological workup was done to exclude secondary. [ncbi.nlm.nih.gov]

The mucosa can, however, also appear normal, which requires high clinical suspicion in further workup. The antrum and pylorus are most commonly involved in LP, while the fundus is the least involved. [cancertherapyadvisor.com]

The patient was diagnosed as Crohn’s disease and further workup revealed multiple strictures in the small bowel though large bowel was normal and subsequently managed with azathioprine and supportive medications. [tropicalgastro.com]

The patient was admitted to the hospital and underwent an additional workup, including upper endoscopy. The endoscopic examination revealed a large friable mass in the antrum. [onlinelibrary.wiley.com]

• Small Liver

  In 40 of these cases a circumscribed peritoneal carcinomatosis and in 12 patients small liver metastases could be resected. [eurjmedres.biomedcentral.com]

Management and treatment Treatment options include surgical resection (mainly total gastrectomy) for localized disease. [orpha.net]

Treatment for linitis plastica is like treatment for other types of stomach cancers. What is linitis plastica? Linitis plastica is a type of adenocarcinoma. Adenocarcinoma is the most common form of stomach cancer. [cancerresearchuk.org]

Sometimes an endoscopic ultrasound is useful to establish the diagnosis and in guiding treatment. The treatment for linitis plastica is a controversial issue. [ncbi.nlm.nih.gov]

However, the efficacy of existing treatments for non-metastasis is limited. We still need to explore more effective treatments. [atm.amegroups.com]

Of significance is the fact that it carries a prognosis that is poor compared to other types of colorectal cancers. [ncbi.nlm.nih.gov]

Prognosis Gastric LP has a very poor prognosis due to the frequent occurrence of peritoneal dissemination, lymphatic invasion and extension toward neighboring organs. The 5-year survival rate is around 10-20% in Japan and Europe. [orpha.net]

Etiology LP is generally a sporadic disease but familial cases have been described. Etiology is unknown. [orpha.net]

(A) CK7 and (B) CK19 staining of percutaneous biopsy of left psoas muscle with tumor cells, confirming metastatic CCA and ruling out alternative malignancies and etiologies. [acgcasereports.gi.org]

The term, which does not specify the etiology, was first used in 1865 by Brinton,1 who considered the lesion to be an advanced stage of gastritis, but did not exclude cancer. [jamanetwork.com]

Her scrutinizing clinical history and examination negated any systemic conditions; while the discrimination between local etiologies rested upon histopathological confirmation. [ccij-online.org]

A retrospective review of GA patients with LP from the surveillance, epidemiology, and end results database (2004-2009) was performed. 29,440 patients with GA were identified, of whom 948 (3.2%) had LP. [mayoclinic.pure.elsevier.com]

Summary Epidemiology Gastric LP accounts for about 10% of all gastric cancers but the exact prevalence in the general population is unknown. [orpha.net]

Linitis plastica Microchapters Home Patient Information Overview Historical Perspective Classification Pathophysiology Causes Differentiating Linitis plastica from Other Diseases Epidemiology and Demographics Risk Factors Screening Natural History, Complications [wikidoc.org]

A retrospective review of GA patients with LP from the surveillance, epidemiology, and end results database (2004‐2009) was performed. 29,440 patients with GA were identified, of whom 948 (3.2%) had LP. [ingentaconnect.com]

Trials.gov US National Guidelines Clearinghouse NICE Guidance FDA on Linitis plastica pathophysiology CDC on Linitis plastica pathophysiology Linitis plastica pathophysiology in the news Blogs on Linitis plastica pathophysiology Directions to Hospitals [wikidoc.org]

Continuing Education Activity This activity reviews the epidemiology, pathophysiology, genetic background, staging, histological assessment, evaluation, treatment, the prognosis of gastric linitis plastica (LP). [ncbi.nlm.nih.gov]

History and Symptoms Staging Diagnostic study of choice Physical Examination Laboratory Findings Electrocardiogram X-ray Echocardiography and Ultrasound CT MRI Other Imaging Findings Other Diagnostic Studies Treatment Medical Therapy Surgery Primary Prevention [wikidoc.org]

The doctor counseled the patient in his office and prescribed Nexium, a PPI heartburn medication that would prevent excessive acid reflux. [expertinstitute.com]