Presentation
The history and the pathological findings will be presented along with the review of the literature. [ncbi.nlm.nih.gov]
It presents a novel multidisciplinary approach to the subject as described by clinicians, surgeons, pathologists, basic scientists and related medical researchers. [books.google.de]
Herein, we present a case of a 28-year-old female with NOS subtype of steroid cell tumor, who presented with hirsutism, virilization, and amenorrhea and a had successful response to surgery during follow-up. [edm.bioscientifica.com]
Gastrointestinal
- Early Satiety
She had nausea and early satiety without fever, chills, or vomiting. Her last normal menstrual cycle was 3 months ago. She has since experienced daily vaginal bleeding of 6 spotted pads per day. [archivesofpathology.org]
Symptoms can include: abdominal enlargement or swelling, abdominal fullness, early satiety (feeling full early), changes in bowel or bladder habits, or clothes not fitting well. [medicinenet.com]
satiety Symptoms independently associated with the presence of ovarian cancer include pelvic and abdominal pain, increased abdominal size and bloating, and difficulty eating or feeling full. [1] Symptoms associated with later-stage disease include gastrointestinal [emedicine.medscape.com]
- Acute Abdomen
Patients commonly present with abdominal pain resembling acute abdomen. The tumor displays multiple histologic patterns. [med-ed.virginia.edu]
It can present with acute abdomen, misdiagnosed as acute appendicitis or ectopic pregnancy or with bleeding per vaginum [22]. It is difficult to diagnose ovarian malignancies from functional cysts or benign ovarian tumors. [intechopen.com]
Neurologic
- Seizure
The patient is monitored for seizures and increased ICP. Diagnostic tools include skull x-rays, brain scan, CT scan, MRI, cerebral angiography, and EEG. [medical-dictionary.thefreedictionary.com]
[…] hypersensitivity; severe heart failure, cardiomyopathy, impaired cardiac function, preexisting myelosuppression Interactions May decrease phenytoin and digoxin plasma levels; phenobarbital may decrease plasma levels of doxorubicin; cyclosporine may induce coma or seizures [www1.cgmh.org.tw]
Urogenital
- Adnexal Mass
Página 406 - Goldstein SR, Subramanyam B, Snyder JR et al: The postmenopausal cystic adnexal mass, the potential role of ultrasound in conservative management. Obstet Gynaecol 73:8, 1989. Página 46 - Kelly, SJ (1977). [books.google.es]
Clinical features These tumors may be asymptomatic, diagnosed as adnexal mass during routine antenatal ultrasound imaging. The overall estimated incidence of adnexal masses in pregnancy ranges from 2 to 10% [20]. [intechopen.com]
A CT scan confirmed a 10.4 5.9 cm solid left adnexal mass as well as another solid nodule mass measuring 4.9 × 4 cm in the cul-de-sac and mild ascites (Figures 1(c) and 1(d)). [hindawi.com]
- Salpingitis
Other histopathological findings included chronic cervicitis, an atrophic endometrium with endometritis, myometritis, and an intramural leiomyoma, salpingitis, and a simple serous cyst in the left ovary. [hindawi.com]
- Ovarian Disorder
Albert Altchek, Liane Deligdisch, Nathan Kase Elsevier, 04.09.2003 - 568 Seiten This updated second edition of Diagnosis and Management of Ovarian Disorders provides thorough, yet succinct insight into the ever-changing realm of ovarian disorders. [books.google.de]
Young and Scully´s 1979 classification of ovarian tumors with endocrine manifestations ( Figure 1 ) includes sex-cord stromal tumors, steroid-cell tumors and other ovarian disorders with endocrine function. [omicsonline.org]
Workup
Tumor markers such as CA-125, CEA, and CA 19-9 are typically not helpful in the workup. [hindawi.com]
Ultrasound
- Ovarian Mass
Imaging including CT of the adrenals and ovaries can identify an ovarian or adrenal mass. There have been reports of small aberrant masses in the parametria that can go missed on imaging. [hindawi.com]
Treatment
The breadth of information provided by this book will appeal to clinicians and researchers involved in the study and treatment of ovarian disorders. [books.google.de]
Prompt diagnosis and treatment are emphasized in this potentially malignant and disfiguring androgenic tumor that is readily amenable to surgery. [ncbi.nlm.nih.gov]
Salvage therapy Patients with failed primary treatment are offered salvage treatment protocols (e.g. TIP, GPT) and in some cases high dose intensity multi drug treatment. Salvage treatment is with curative intent. [bccancer.bc.ca]
Prognosis
Statistics and Prognosis Granulosa cell tumors occur at the peak age of 50-55, but can occur earlier in life. They are known to reappear as much as a decade or two after one is diagnosed. [knowcancer.com]
or therapies New developments in treatment As with any cancer, prognosis and long-term survival can vary greatly from individual to individual. [stanfordchildrens.org]
Prognosis of these germ cell tumors is excellent. [intechopen.com]
The prognosis is similar to that of the latter tumor. Strumal Carcinoid Tumor. [glowm.com]
The prognosis of SCT is usually good and correlates with the stage and degree of differentiation of the tumor [ 3 ]. [ispub.com]
Etiology
Register Malignant Lipid Cell Tumor of the Ovary: Clinical, Biochemical and Etiologic Considerations - 24 Hours access EUR €36.00 GBP £28.00 USD $45.00 Rental This article is also available for rental through DeepDyve. [academic.oup.com]
Malignant lipid cell tumor of the ovary: clinical, biochemical and etiologic considerations. J Clin Endocrinol Metab. 1970 Mar;30(3):336–344. [PubMed] [Google Scholar] Taylor HB, Norris HJ. Lipid cell tumors of the ovary. [ncbi.nlm.nih.gov]
Lipsett MB, Kirschner MA, et al (1970) Malignant lipid-cell tumor of the ovary: Clinical, biochemical and etiologic considerations. J Clin Endocrinol 30:336–344 Google Scholar 11. [link.springer.com]
Etiology The exact etiology of dysgerminomas is not identified, though recent molecular studies have implicated loss of function with potential tumor suppressor gene TRC8/RNF139 as a possible etiology [48]. [intechopen.com]
Discussion In a case of rapid-onset hirsutism, virilization, and menstrual irregularity, neoplastic etiology should always be kept in mind. Therefore, comprehensive workup is required. [edm.bioscientifica.com]
Epidemiology
Ovarian Cancer, a volume in the American Cancer Society Atlas of Clinical Oncology series, thoroughly discusses pathology, biology, epidemiology, genetics and screening. [books.google.de]
Epidemiology They are the second most common% ) hepatic adenoma, after the inf. Adenoma; Carcinoma. [kunoyofymuxy.tk]
Sertoli–Leydig cell tumor group Epidemiology Sertoli-Leydig cell tumors are uncommon benign tumors, accounting for less than 0.5% of all ovarian tumors. [emedicine.medscape.com]
Hepatocellular Carcinoma: Epidemiology, Risk Factors, and Screening. Medscape, from Semin Liver Dis. 2005;25(2):143-154 [On-line information]. Available online at http://www.medscape.com/viewarticle/506830. (2005 January 05). LBA AFP-L3. [labtestsonline.hu]
Epidemiology studies have shown a correlation between increased risk of ovarian epithelial tumours with increased number of ovulation cycles. [atlasgeneticsoncology.org]
Pathophysiology
Pathophysiology Historically, most theories of the pathophysiology of ovarian cancer included the concept that it begins with the dedifferentiation of the cells overlying the ovary. [emedicine.medscape.com]
Furuya M (2012) Ovarian cancer stroma: pathophysiology and the roles in cancer development. Cancers (Basel) 4: 701-724. Roth LM, Talerman A (2006) Recent advances in the pathology and classification of ovarian germ cell tumors. [omicsonline.org]
Pathophysiology: Two theories exist as to the etiology of sex cord騯tromal tumors. The first proposes that these neoplasms are derived from the mesenchyme of the developing genital ridge. [www1.cgmh.org.tw]
[…] though research is still ongoing in this area.[24] Higher caffeine intake and consumption of more than two cups of tea a day have both been associated with lower ovarian cancer risk.[21] Smoking tobacco is protective for sex cord-stromal tumors.[22] Pathophysiology [en.wikipedia.org]
Prevention
[…] aren’t many ways to prevent GCT, although it is possible to detect it early. [knowcancer.com]
Preventive Services Task Force Reaffirmation Recommendation Statement. USPSTF [On-line information].Available online at http://www.uspreventiveservicestaskforce.org/uspstf12/ovarian/ovarartaddend.htm.Accessed October 2012. [labtestsonline.it]
Is it possible to prevent ovarian cancer? There is no way to truly prevent ovarian cancer. [medicinenet.com]
Mechanism of action is through binding to guanine thereby preventing DNA transcription. [www1.cgmh.org.tw]