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Lipid Cell Tumor of the Ovary


Presentation

  • The history and the pathological findings will be presented along with the review of the literature.[ncbi.nlm.nih.gov]
  • Current diagnostic features, preoperative and postoperative androgen determinations, and histomorphological and ultrastructural studies are presented.[ncbi.nlm.nih.gov]
  • Since the intercellular canalicular system present between the tumor cells was continuous with the "peripheral canalicular system," both systems probably have a common function related to steroid metabolism.[ncbi.nlm.nih.gov]
  • Recently, authors experienced a case of lipid cell tumor of the left ovary in a 19 year old female, who presented with amenorrhea and hirsutism for 4 years. Grossly, the ovary was well encapsulated, and measured 6.5x6x4.5 cm.[jpatholtm.org]
  • These tumors may present at any age with presentations related to the hormonal activity and virilizing properties of tumor.[cancerjournal.net]
Virilization
  • Lipid cell tumor of the ovary is among the rarest tumors belonging to the virilizing group of ovarian neoplasms. A lipid cell tumor of the ovary is described in an 18-year-old woman with secondary amenorrhea, hirsutism, and frank virilization.[ncbi.nlm.nih.gov]
  • Removal of the tumor completely reversed the virilization and the abnormal responses to ACTH and human chorionic gonadotropin.[ncbi.nlm.nih.gov]
  • . : Virilizing ovarian hilus cell hyperplasia, with special reference to hormone excretion . J. Obstet. Gynaec. Brit. Comm. 72 : 285 – 291 , 1965 . 12 Hughesdon, P. E. : Ovarian lipoid and theca cell tumors—Their origins and interrelations . Obstet.[onlinelibrary.wiley.com]
  • Keywords: Ovarian tumor, steroid cell tumor, testosterone, virilization How to cite this article: Das A, Panda S, Singh A S. Steroid cell tumor: A rare virilizing ovarian tumor.[cancerjournal.net]
  • Symptoms of virilization were present in the form of deepening of voice and thinning of scalp hair.[ijdvl.com]
Weakness
  • In 10 cases (36%), negative controls exhibited weak to moderate nonspecific cytoplasmic staining.[ncbi.nlm.nih.gov]
  • […] lipid may give a chemical shift artefact 3 T1 C (Gd) the degree of contrast enhancement varies with the amount of fibrous tissue within the tumor while theca cells in the normal ovary are highly vascularized, the fibrous tissue is known for delayed weak[radiopaedia.org]
  • Symptoms may include: A tumor, swelling, or mass that can be felt or seen Elevated levels of alpha-fetoprotein (AFP) Elevated levels of beta-human chorionic gonadotropin (ß-HCG) Constipation, incontinence, and leg weakness can occur if the tumor is in[stanfordchildrens.org]
  • Immunoreactivity was graded as weak/strong (W/S), and the proportion of strong staining cells was coded as follows: S1 50%, respectively.[thedoctorsdoctor.com]
  • Diagnosis The patient is evaluated for neurological deficits (headache, mental activity changes, behavioral changes, weakness, sensory losses, or disturbances of vision, speech, gait, or balance).[medical-dictionary.thefreedictionary.com]
Swelling
  • [L. tumor, a swelling] tumor (too'mor) [L. tumor, a swelling] 1. A swelling or enlargement; one of the four classic signs of inflammation. 2. An abnormal mass.[medical-dictionary.thefreedictionary.com]
  • Occasionally, swelling, tenderness, and discharge from the breasts are prominent. Vaginal cytology typically shows increased maturation of squamous epithelial cells.[clinicalgate.com]
  • Symptoms may include: A tumor, swelling, or mass that can be felt or seen Elevated levels of alpha-fetoprotein (AFP) Elevated levels of beta-human chorionic gonadotropin (ß-HCG) Constipation, incontinence, and leg weakness can occur if the tumor is in[stanfordchildrens.org]
  • However, 50% of these patients may have no endocrine symptomatology and instead have abdominal pain or swelling. Removal of the tumor results in a nomral menses in about 4 weeks.[thedoctorsdoctor.com]
  • When JGCT occurs after puberty, patients usually present with abdominal pain, swelling, menstrual irregularities, or amenorrhea.[emedicine.medscape.com]
Italian
  • He is member of the Italian Society of Radiology (SIRM), European Society of Radiology (ESR), Radiological Society of North America (RSNA), American Roentgen Ray Society (ARRS) and European Society of Neuroradiology (ESNR).[books.google.de]
Hirsutism
  • A lipid cell tumor of the ovary is described in an 18-year-old woman with secondary amenorrhea, hirsutism, and frank virilization.[ncbi.nlm.nih.gov]
  • An ovarian lipid cell tumor without Reinke's crystalloids in a woman with secondary amenorrhea, minimal hirsutism, and elevated 17-ketosteroid excretion was studied by light and electron microscopy.[ncbi.nlm.nih.gov]
  • Key Words: Lipid cell tumor ; Amenorrhea ; Hirsutism[jpatholtm.org]
  • Reedy et al. reported a case of an undifferentiated NOS steroid cell tumor with hirsutism, amenorrhea, clitoromegaly, and temporal baldness. [6] In our case, hirsutism was associated with signs of virilization in the form of deepening of voice, clitoromegaly[ijdvl.com]
  • This clinical presentation differs from the usual clinical symptoms, which are virilization and signs of androgenism as hirsutism and change of body fat distribution.[omicsonline.org]
Suggestibility
  • Peripheral and ovarian vein steroid concentrations suggest that the tumor produced androgens preferentially by way of the delta 4 steroidogenesis pathway.[ncbi.nlm.nih.gov]
  • The intercellular and "peripheral" canalicular systems and cytoplasmic microfilaments found in this tumor suggest that this ovarian lipid cell tumor was derived from the ovarian stroma.[ncbi.nlm.nih.gov]
  • Peripheral and ovarian vein steroid concentrations suggest that the tumor produced androgens preferentially by way of the Δ 4 steroidogenesis pathway. 1989 S.[karger.com]
  • Evidence obtained using a biotin blocking kit, and a monoclonal antibody against biotin, suggests endogenous biotin-like reactivity as the source of the nonspecific staining.[ncbi.nlm.nih.gov]
  • Lengyel and colleagues suggest fat metabolism may also be a factor in other cancers where there is a rich source of fat cells, such as breast cancer.[medicalnewstoday.com]
Amenorrhea
  • A lipid cell tumor of the ovary is described in an 18-year-old woman with secondary amenorrhea, hirsutism, and frank virilization.[ncbi.nlm.nih.gov]
  • An ovarian lipid cell tumor without Reinke's crystalloids in a woman with secondary amenorrhea, minimal hirsutism, and elevated 17-ketosteroid excretion was studied by light and electron microscopy.[ncbi.nlm.nih.gov]
  • Key Words: Lipid cell tumor ; Amenorrhea ; Hirsutism[jpatholtm.org]
  • Definition / general Any age, usually associated with virilizing syndrome (defeminization and amenorrhea) Cells either lutein (theca / stroma), hilar (Leydig, with Reinke crystals) or adrenal cortical type If Cushing syndrome present, tumor often called[pathologyoutlines.com]
  • Gonadal dysgenesis is defined as a defect in development that causes abnormal sex steroid production and subsequent clinical manifestations such as delayed puberty or primary amenorrhea. In general, Turner syndrome (normally 45 X, or rarely ...[mhmedical.com]
Adnexal Mass
  • Página 406 - Goldstein SR, Subramanyam B, Snyder JR et al: The postmenopausal cystic adnexal mass, the potential role of ultrasound in conservative management. Obstet Gynaecol 73:8, 1989. ‎ Página 46 - Kelly, SJ (1977).[books.google.es]
  • In patients of reproductive age, the vast majority of adnexal masses are benign.[www1.cgmh.org.tw]
  • Gynecol Oncol 1996, 61:438-441 3) Gehrig PA, Fowler WC Jr, Lininger RA: Ovarian capillary hemangioma presenting as an adnexal mass with massive ascites and elevated CA-125.[turkjpath.org]
  • When seen in cases of the syndrome, the lesion is typically small, bilateral, and calcified whereas those unassociated with the syndrome form unilateral adnexal masses. Figure 19 Sex cord tumor with annular tubules.[nature.com]
Secondary Amenorrhea
  • A lipid cell tumor of the ovary is described in an 18-year-old woman with secondary amenorrhea, hirsutism, and frank virilization.[ncbi.nlm.nih.gov]
  • An ovarian lipid cell tumor without Reinke's crystalloids in a woman with secondary amenorrhea, minimal hirsutism, and elevated 17-ketosteroid excretion was studied by light and electron microscopy.[ncbi.nlm.nih.gov]
  • However, menstrual irregularities such as oligomenorrhea, menorrhagia, and secondary amenorrhea tend to be the hallmark of these tumors in women of reproductive age.[www1.cgmh.org.tw]

Workup

  • Mammography The preoperative workup also should include a mammogram for women older than 35 years who have not had one in the preceding 6-12 months.[www1.cgmh.org.tw]
Ovarian Mass
  • CT Typically appear as unilateral, solid ovarian masses.[radiopaedia.org]
  • Most ovarian hemangiomas are of the cavernous type and they may present either as an isolated ovarian mass, usually discovered incidentally, or in conjunction with diffuse abdominopelvic hemangiomatosis 1 - 3.[turkjpath.org]
  • According to Outwater et al. the ovarian masses are isoechogenic (82%) or hypoechogenic (18%) and ascites is an infrequent finding (23%). Only a minority of SCT (14%) are calcified on image studies.[omicsonline.org]
  • .: Value of lipid-and water supression MR Images in distinguishing between blood and lipid within ovarian masses.[molcom.jp]
  • Female adnexal tumor of probable wolffian origin arises primarily in the broad ligament but may present as an ovarian mass. The architecture varies from cystic, to a slitlike glandular or a sievelike pattern.[emedicine.medscape.com]

Treatment

  • Prompt diagnosis and treatment are emphasized in this potentially malignant and disfiguring androgenic tumor that is readily amenable to surgery.[ncbi.nlm.nih.gov]
  • Serum Dihydrotestosterone (DHT) levels correlated with disease status during all phases of treatment, as did serum testosterone (T) to a lesser degree.[ncbi.nlm.nih.gov]
  • From cover to cover, it gives practical, timely advice on screening, diagnosis, and treatment. Ovarian cancer is the leading cause of death from gynecologic malignancies in the Western world.[books.google.de]
  • Patients are randomized to 1 of 2 treatment arms. ARM 1: Patients receive paclitaxel IV over 3 hours and carboplatin IV over 1 hour on day 1.[clinicaltrials.gov]

Prognosis

  • Statistics and Prognosis Granulosa cell tumors occur at the peak age of 50-55, but can occur earlier in life. They are known to reappear as much as a decade or two after one is diagnosed.[knowcancer.com]
  • , or therapies New developments in treatment As with any cancer, prognosis and long-term survival can vary greatly from individual to individual.[stanfordchildrens.org]
  • The prognosis of SCT is usually good and correlates with the stage and degree of differentiation of the tumor [ 3 ].[ispub.com]
  • The prognosis is similar to that of the latter tumor.[glowm.com]
  • Prognosis The prognosis of sex-cord-stromal tumours is good, as these tumours usually present when confined to a single ovary, and are responsive to chemotherapy.[atlasgeneticsoncology.org]

Etiology

  • Lipsett MB, Kirschner MA, et al (1970) Malignant lipid-cell tumor of the ovary: Clinical, biochemical and etiologic considerations. J Clin Endocrinol 30:336–344 Google Scholar 11.[link.springer.com]
  • Pathophysiology: Two theories exist as to the etiology of sex cord騯tromal tumors. The first proposes that these neoplasms are derived from the mesenchyme of the developing genital ridge.[www1.cgmh.org.tw]
  • The etiology of ovarian hemangiomas is unknown. Some state that it is a true tumor or hamartoma, or stimulated vessels.[turkjpath.org]
  • Several theories explain etiology of ovarian cancer: Incessant ovulation theory where increased activation of the ovary to form mature ova leads to haphazard multiplication and hence malignant conversion of the cells to form malignancy.[lecturio.com]
  • The neoplasm occurs mainly during the first 3 decades of life. [1] Etiology The etiology of JGCT is unknown.[emedicine.medscape.com]

Epidemiology

  • Ovarian Cancer, a volume in the American Cancer Society Atlas of Clinical Oncology series, thoroughly discusses pathology, biology, epidemiology, genetics and screening.[books.google.de]
  • Epidemiology They are the second most common% ) hepatic adenoma, after the inf. Adenoma; Carcinoma.[kunoyofymuxy.tk]
  • Sertoli–Leydig cell tumor group Epidemiology Sertoli-Leydig cell tumors are uncommon benign tumors, accounting for less than 0.5% of all ovarian tumors.[emedicine.medscape.com]
  • Hepatocellular Carcinoma: Epidemiology, Risk Factors, and Screening. Medscape, from Semin Liver Dis. 2005;25(2):143-154 [On-line information]. Available online at . (2005 January 05). LBA AFP-L3. Wako [On-line package insert].[labtestsonline.hu]
  • […] female genital tract understand the concept of borderline tumors and how to distinguish them from carcinomas be able to describe clinical features including relevant associations be able to suggest possible clinical outcomes and response to treatment Epidemiology[med-ed.virginia.edu]
Sex distribution
Age distribution

Pathophysiology

  • Furuya M (2012) Ovarian cancer stroma: pathophysiology and the roles in cancer development. Cancers (Basel) 4: 701-724. Roth LM, Talerman A (2006) Recent advances in the pathology and classification of ovarian germ cell tumors.[omicsonline.org]
  • Pathophysiology: Two theories exist as to the etiology of sex cord騯tromal tumors. The first proposes that these neoplasms are derived from the mesenchyme of the developing genital ridge.[www1.cgmh.org.tw]

Prevention

  • Preventive Services Task Force Reaffirmation Recommendation Statement. USPSTF [On-line information].Available online at October 2012.[labtestsonline.it]
  • […] aren’t many ways to prevent GCT, although it is possible to detect it early.[knowcancer.com]
  • Mechanism of action is through binding to guanine thereby preventing DNA transcription.[www1.cgmh.org.tw]
  • Breast feeding Breast feeding after delivery will prevent ovulation for a longer period and also protects against ovarian cancer.[lecturio.com]

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