The history and the pathological findings will be presented along with the review of the literature. [ncbi.nlm.nih.gov]

Recently, authors experienced a case of lipid cell tumor of the left ovary in a 19 year old female, who presented with amenorrhea and hirsutism for 4 years. Grossly, the ovary was well encapsulated, and measured 6.5x6x4.5 cm. [jpatholtm.org]

• Virilization

  Lipid cell tumor of the ovary is among the rarest tumors belonging to the virilizing group of ovarian neoplasms. A lipid cell tumor of the ovary is described in an 18-year-old woman with secondary amenorrhea, hirsutism, and frank virilization. [ncbi.nlm.nih.gov]

  The tumor was a cause of virilizing symptoms and infertility in the patient. Surgical removal of the tumor reverted the symptoms of virilization, and the patient subsequently conceived. [jmedicalcasereports.biomedcentral.com]

  Symptoms of virilization were present in the form of deepening of voice and thinning of scalp hair. [ijdvl.com]

• Sweating

  and Sweat, M. L. : Enzymatic steroid conversion in a masculinovoblastoma. J. Clin. Endocr. 22 : 773 – 786, 1962. 5 Corral-Garlado, J., Acevedo, H. A., de Salazar, J. C. P., Loria, M., and Goldzieher, J. W. : The polycystic ovary—VI. [onlinelibrary.wiley.com]

  Dermoid cyst with hair follicle ( left ), sebaceous glands, and sweat glands (magnification, 80). (Serov SF, Scully RE, Sobin LJ: Histological Typing of Ovarian Tumours. Geneva, World Health Organization, 1973.) [glowm.com]

  Histology Cyst cavity is often lined with keratinized squamous epithelium and usually contains abundant sebaceous and sweat glands (Figure 6). There is usually a raised protuberance projecting into the cyst cavity known as the Rokitansky nodule. [intechopen.com]

• Suggestibility

  Peripheral and ovarian vein steroid concentrations suggest that the tumor produced androgens preferentially by way of the delta 4 steroidogenesis pathway. [ncbi.nlm.nih.gov]

  Peripheral and ovarian vein steroid concentrations suggest that the tumor produced androgens preferentially by way of the Δ 4 steroidogenesis pathway. 1989 S. [karger.com]

  Sertoli-Leydig cell tumours As the name suggests, Sertoli-Leydig cells contain both Sertoli and Leydig cells. [atlasgeneticsoncology.org]

• Adnexal Mass

  Página 406 - Goldstein SR, Subramanyam B, Snyder JR et al: The postmenopausal cystic adnexal mass, the potential role of ultrasound in conservative management. Obstet Gynaecol 73:8, 1989. ‎ Página 46 - Kelly, SJ (1977). [books.google.es]

  A CT scan confirmed a 10.4 5.9 cm solid left adnexal mass as well as another solid nodule mass measuring 4.9 4 cm in the cul-de-sac and mild ascites (Figures 1(c) and 1(d)). [hindawi.com]

• Secondary Amenorrhea

  A lipid cell tumor of the ovary is described in an 18-year-old woman with secondary amenorrhea, hirsutism, and frank virilization. [ncbi.nlm.nih.gov]

  However, menstrual irregularities such as oligomenorrhea, menorrhagia, and secondary amenorrhea tend to be the hallmark of these tumors in women of reproductive age. [www1.cgmh.org.tw]

  These tumors produce high levels of estrogen, which causes its characteristic symptoms: menometrorrhagia; endometrial hyperplasia; tender, enlarged breasts; postmenopausal bleeding; and secondary amenorrhea. [en.wikipedia.org]

• Ovarian Disorder

  Young and Scully s 1979 classification of ovarian tumors with endocrine manifestations ( Figure 1 ) includes sex-cord stromal tumors, steroid-cell tumors and other ovarian disorders with endocrine function. [omicsonline.org]

Tumor markers such as CA-125, CEA, and CA 19-9 are typically not helpful in the workup. [hindawi.com]

• Ovarian Mass

  Pathology On gross examination, the left adnexa consisted of a normal fallopian tube attached to an 11 8 4 cm solid ovarian mass with a smooth intact surface. [hindawi.com]

Prompt diagnosis and treatment are emphasized in this potentially malignant and disfiguring androgenic tumor that is readily amenable to surgery. [ncbi.nlm.nih.gov]

From cover to cover, it gives practical, timely advice on screening, diagnosis, and treatment. Ovarian cancer is the leading cause of death from gynecologic malignancies in the Western world. [books.google.de]

Non-epithelial ovarian cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow up. Ann. Oncol., 21 2010, (Supplement 5): v30 – v36 6. Geerts I, Vergote I, Neven P, Billen J. [labtestsonline.cz]

Statistics and Prognosis Granulosa cell tumors occur at the peak age of 50-55, but can occur earlier in life. They are known to reappear as much as a decade or two after one is diagnosed. [knowcancer.com]

or therapies New developments in treatment As with any cancer, prognosis and long-term survival can vary greatly from individual to individual. [stanfordchildrens.org]

The prognosis of SCT is usually good and correlates with the stage and degree of differentiation of the tumor [ 3 ]. [ispub.com]

Prognosis of these germ cell tumors is excellent. [intechopen.com]

The prognosis is similar to that of the latter tumor. [glowm.com]

Malignant lipid cell tumor of the ovary: clinical, biochemical and etiologic considerations. J Clin Endocrinol Metab. 1970 Mar;30(3):336–344. [PubMed] [Google Scholar] Taylor HB, Norris HJ. Lipid cell tumors of the ovary. [ncbi.nlm.nih.gov]

Lipsett MB, Kirschner MA, et al (1970) Malignant lipid-cell tumor of the ovary: Clinical, biochemical and etiologic considerations. J Clin Endocrinol 30:336–344 Google Scholar 11. [link.springer.com]

Etiology The exact etiology of dysgerminomas is not identified, though recent molecular studies have implicated loss of function with potential tumor suppressor gene TRC8/RNF139 as a possible etiology [48]. [intechopen.com]

Discussion In a case of rapid-onset hirsutism, virilization, and menstrual irregularity, neoplastic etiology should always be kept in mind. Therefore, comprehensive workup is required. [edm.bioscientifica.com]

Pathophysiology: Two theories exist as to the etiology of sex cord騯tromal tumors. The first proposes that these neoplasms are derived from the mesenchyme of the developing genital ridge. [www1.cgmh.org.tw]

Ovarian Cancer, a volume in the American Cancer Society Atlas of Clinical Oncology series, thoroughly discusses pathology, biology, epidemiology, genetics and screening. [books.google.de]

Sertoli–Leydig cell tumor group Epidemiology Sertoli-Leydig cell tumors are uncommon benign tumors, accounting for less than 0.5% of all ovarian tumors. [emedicine.medscape.com]

Epidemiology They are the second most common% ) hepatic adenoma, after the inf. Adenoma; Carcinoma. [kunoyofymuxy.tk]

Hepatocellular Carcinoma: Epidemiology, Risk Factors, and Screening. Medscape, from Semin Liver Dis. 2005;25(2):143-154 [On-line information]. Available online at . (2005 January 05). LBA AFP-L3. Wako [On-line package insert]. [labtestsonline.hu]

Epidemiology studies have shown a correlation between increased risk of ovarian epithelial tumours with increased number of ovulation cycles. [atlasgeneticsoncology.org]

Furuya M (2012) Ovarian cancer stroma: pathophysiology and the roles in cancer development. Cancers (Basel) 4: 701-724. Roth LM, Talerman A (2006) Recent advances in the pathology and classification of ovarian germ cell tumors. [omicsonline.org]

Pathophysiology Historically, most theories of the pathophysiology of ovarian cancer included the concept that it begins with the dedifferentiation of the cells overlying the ovary. [emedicine.medscape.com]

Pathophysiology: Two theories exist as to the etiology of sex cord騯tromal tumors. The first proposes that these neoplasms are derived from the mesenchyme of the developing genital ridge. [www1.cgmh.org.tw]

[…] though research is still ongoing in this area.[24] Higher caffeine intake and consumption of more than two cups of tea a day have both been associated with lower ovarian cancer risk.[21] Smoking tobacco is protective for sex cord-stromal tumors.[22] Pathophysiology [en.wikipedia.org]

Preventive Services Task Force Reaffirmation Recommendation Statement. USPSTF [On-line information].Available online at October 2012. [labtestsonline.it]

[…] aren’t many ways to prevent GCT, although it is possible to detect it early. [knowcancer.com]

Is it possible to prevent ovarian cancer? There is no way to truly prevent ovarian cancer. [medicinenet.com]

Mechanism of action is through binding to guanine thereby preventing DNA transcription. [www1.cgmh.org.tw]