The clinical presentation of cutaneous sarcoidosis is highly variable. Rare presentations include ulcerated plaques, morpheaform lesions, and unilateral lower extremity edema. [ncbi.nlm.nih.gov]

Methods: This was a retrospective study of patients presenting to Mayo Clinic between 1976 and 1998 with a diagnosis of lipodermatosclerosis. Results: Of 97 patients, 84 (87%) were women. Mean age was 62 years (range, 25-88 years). [mayoclinic.pure.elsevier.com]

• Pathologist

  Most pathologists are familiar with a pseudomembranous type of fat necrosis as a useful feature of chronic LDS. [ncbi.nlm.nih.gov]

• Venous Insufficiency of Leg

  Treatment [ edit ] The management of lipodermatosclerosis may include treating venous insufficiency with leg elevation and elastic compression stockings ; in some difficult cases, the condition may be improved with the additional use of the fibrinolytic [en.wikipedia.org]

• Ulcer

  Rare presentations include ulcerated plaques, morpheaform lesions, and unilateral lower extremity edema. [ncbi.nlm.nih.gov]

  Fibrotic tissue may predispose the tissue to ulceration. Recurrent ulceration and fat necrosis is associated with lipodermatosclerosis. [en.wikipedia.org]

  Conclusions: We suggest that the severe morphological changes in LDS and ulcer tissue play an important role in the pathogenesis of venous ulceration. 1. Falanga, V, McKenzie, A, Eaglstein, WH. Heterogeneity in oxygen diffusion around venous ulcers. [journals.sagepub.com]

  Leg Ulcers See also more specific separate article Venous Leg Ulcer. The aetiology of leg ulcers may be venous, arterial or both. It is very important to determine... [evidence.nhs.uk]

  ( 10959062 ) Stacey MC...Black MM 2000 50 Surgical removal of ulcer and lipodermatosclerosis followed by split-skin grafting (shave therapy) yields good long-term results in "non-healing" venous leg ulcers. ( 11028859 ) Schmeller W...Gaber Y 2000 [malacards.org]

• Eruptions

  Cutaneous reactions due to gemcitabine treatment, including alopecia and maculopapular eruption, are well known. [ncbi.nlm.nih.gov]

Patients attending hospital expect to receive effective evidence-based treatment that improves health and minimises the risk of harm. [ncbi.nlm.nih.gov]

Follow-up laboratory testing was done for 2 months after cessation of treatment. [mon.uvic.cat]

Etiology: Progressive venous disease Pathophysiology Knowledge is evolving, but incomplete. The problem begins with venous hypertension and extravasation of fluid from veins, and end result is skin hardening and fibrosis. [infectiousdiseaseadvisor.com]

Pathophysiology issues especially well summarized.) Copyright 2017, 2013 Decision Support in Medicine, LLC. All rights reserved. [infectiousdiseaseadvisor.com]

(Effects of compression therapy: prevention of extravasation of fluid into extravascular spaces not only as a mechanical aid, but also through decreasing vascular permeability by tightening the paracellular barrier) Campbell, L, Miller, OF. [infectiousdiseaseadvisor.com]