Most pathologists are familiar with a pseudomembranous type of fat necrosis as a useful feature of chronic LDS. [ncbi.nlm.nih.gov]

Clinically and histologically the changes in the abdominal-wall skin resembled lipodermatosclerosis, a condition normally seen in the legs secondary to chronic venous insufficiency. [ncbi.nlm.nih.gov]

Lipodermatosclerosis Chronic Venous Insufficiency Venous Insufficiency Varicose Veins Other: Copper impregnated compression stocking Other: Normal compression stocking Not Applicable Show Detailed Description Layout table for study information Study Type [clinicaltrials.gov]

Treatment [ edit ] The management of lipodermatosclerosis may include treating venous insufficiency with leg elevation and elastic compression stockings ; in some difficult cases, the condition may be improved with the additional use of the fibrinolytic [en.wikipedia.org]

Rare presentations include ulcerated plaques, morpheaform lesions, and unilateral lower extremity edema. [ncbi.nlm.nih.gov]

Fibrotic tissue may predispose the tissue to ulceration. Recurrent ulceration and fat necrosis is associated with lipodermatosclerosis. [en.wikipedia.org]

Conclusions: We suggest that the severe morphological changes in LDS and ulcer tissue play an important role in the pathogenesis of venous ulceration. 1. Falanga, V, McKenzie, A, Eaglstein, WH. Heterogeneity in oxygen diffusion around venous ulcers. [journals.sagepub.com]

Leg Ulcers See also more specific separate article Venous Leg Ulcer. The aetiology of leg ulcers may be venous, arterial or both. It is very important to determine... [evidence.nhs.uk]

( 10959062 ) Stacey MC...Black MM 2000 50 Surgical removal of ulcer and lipodermatosclerosis followed by split-skin grafting (shave therapy) yields good long-term results in "non-healing" venous leg ulcers. ( 11028859 ) Schmeller W...Gaber Y 2000 [malacards.org]

Cutaneous reactions due to gemcitabine treatment, including alopecia and maculopapular eruption, are well known. [ncbi.nlm.nih.gov]