The present study aimed to identify prognostic factors for continence and need for CIC in LMM. STUDY DESIGN: The present study retrospectively identified 143 patients from the multidisciplinary clinic who underwent TCR for LMM between 1995 and 2010. [ncbi.nlm.nih.gov]

• Gangrene

  An emergent laparotomy was performed and revealed diffuse gangrenous change of both small and large bowels. A jejunostomy was done and strong antibiotics were given, but the baby died two days after the operation. [ncbi.nlm.nih.gov]

• Dysostosis

  […] infant with PELVIS (perineal hemangioma, external genital malformations, lipomyelomeningocele, vesicorenal abnormalities, imperforate anus, and skin tag) syndrome misdiagnosed as diaper rash. ( 24948350 ) Shimizu M....Yachie A. 2014 23 Spondylocostal dysostosis [malacards.org]

• Abdominal Distension

  The clinical presentations were bloody stool and abdominal distension. A plain abdominal film demonstrated pneumatosis intestinalis and air in the portal vein. [ncbi.nlm.nih.gov]

• Abdominal Mass

  The lipomyelomeningocele presented as an expanding abdominal mass. Ventriculoatrial shunting and two operations to repair the myelomeningocele were performed to control the expanding abdominal mass. [ncbi.nlm.nih.gov]

• Cutaneous Manifestation

  Patients frequently present with cutaneous manifestations, progressive neurological deterioration, bladder dysfunction, and intractable pain. Early surgical intervention with untethering is recommended for symptomatic patients. [ncbi.nlm.nih.gov]

  Manifestations Found in Patients with Lipomyelomeningocele SERIES HOFFMAN ET AL.,20 1985 (N = 97) KANEV ET AL.,22 1990 (N = 80) Soft tissue mass 97 80 Skin dimple 26 14 Hemangioma 24 9 Hypertrichosis 1 11 Skin tag/tail-like appendage 5 6 Atretic or denuded [clinicalgate.com]

• Muscular Atrophy

  Clinical examination may reveal muscular atrophy, leg length discrepancy, varus or valgus foot deformity of one or both legs, hammertoes or claw toes, scoliosis, mixed deep tendon reflexes (absent, normal, increased), mixed/patchy sensory abnormalities [clinicalgate.com]

• Motor Disturbances

  RESULTS: Preoperatively, all patients displayed severe neurological deficits such as motor disturbance, muscle atrophy, and bladder dysfunction. Several months before surgery, all showed progressive symptoms. [ncbi.nlm.nih.gov]

• Lower Motor Neurone Lesion

  One child had a lower motor neuron lesion, and 5 had a mixed upper and lower motor neuron lesion. [ncbi.nlm.nih.gov]

• Limb Weakness

  Out of these nine patients, three patients with lower limb weakness associated with urinary and fecal incontinence showed improvement in both motor and bladder/bowel functions and regained bladder/bowel control. [ncbi.nlm.nih.gov]

• Clonus

  There was no ankle clonus. There was a good urine stream, and an anal wink was present. [consultant360.com]

Initial workup included an ultrasound of the region that was concerning for spinal dysraphism, including sacral agenesis and an associated intraspinal mass. [ncbi.nlm.nih.gov]

• Occipital Encephalocele

  Encephalocele with Lipomyelomeningocele, Tetralogy of Fallot, and Situs Inversus. ( 27200165 ) Franco A....Yang C.W. 2016 16 Lack of efficacy of an intradural somatic-to-autonomic nerve anastomosis (Xiao procedure) for bladder control in children with [malacards.org]

Spine-shortening osteotomy might be a feasible mode of treatment for adult TCS caused by a spinal lipoma. [ncbi.nlm.nih.gov]

Simple cosmetic treatment does not prevent neurologic difficulties and may make later, more complete treatment difficult. [neurosurgery.ucla.edu]

Simple cosmetic treatment of the subcutaneous fat pad does NOT prevent Neurological deficit, and may make later definitive treatment more difficult. [lexilouandus.blogspot.com]

and treatment strategies for traumatic brain injury in soldiers. [books.google.com]

Prognosis for the infant with this skin-covered lesion is very good if appropriate care is provided early. [ncbi.nlm.nih.gov]

Prognosis - Lipomyelomeningocele hey are classified as dorsal, caudal and transitional varieties. Lipomas of the filum terminal form a different category. [checkorphan.org]

The early diagnosis and the operative treatment may improve the outcome and the prognosis for the patient. Keywords lipomyelomeningocele; tethered cord effect; operative technique; results [thieme-connect.com]

This case illustrates the favorable prognosis of this entity and the importance of prompt diagnosis and multidisciplinary counseling 6). References [operativeneurosurgery.com]

Aminoff MJ, Logue V (1974) The prognosis of patients with spinal vascular malformations. Brain 97:211–218 PubMed Article CAS Google Scholar 2. [link.springer.com]

Although a genetic component has been well established in the etiology of open NTDs, studies examining the genetics of closed NTDs such as lipomyelomeningocele are rare. [ncbi.nlm.nih.gov]

Open NTDs have a complex etiology, involving both genetic and environmental factors. [nature.com]

This can be caused by a variety of etiologies: myelomeningocele, lipomyelomeningocele, diastematomyelia, tight filum terminale, dermal sinus tract, tumor, and scar tissue. [medical-dictionary.thefreedictionary.com]

BACKGROUND: The epidemiology of neural tube defects (NTDs) may depend on the type of the defect and its location. There is little epidemiologic information on lipomyelomeningocele, a type of NTD. [ncbi.nlm.nih.gov]

Forrester MB, Merz RD: Descriptive epidemiology of lipomyelomeningocele, Hawaii, 1986-2001. Birth Defects Res A Clin Mol Teratol 2004;70:953-956. [karger.com]

Epidemiology and control of neural tube defects. Oxford, UK: Oxford University Press ; 1992. 12. George TM, Wolpert CM, Worley G, Mackey JF, Fuchs HE, Speer MC. Variable presentation of Neural Tube Defects in Three Families. [nature.com]

The current pathophysiological theories and surgical management are discussed. [ncbi.nlm.nih.gov]

Pathophysiologically, neuronal dysfunction in tethered cord syndrome results partly from inability for the spinal cord neurons to utilize oxygen, that is, the impaired oxidative metabolism, partly due to lack of oxygen supply (ischemic effect), and partly [rarediseases.org]

[…] common form of occult spinal dysraphism (spina bifida occulta), which are a broad collection of spinal malformations loosely grouped together by their common characteristic of being skin covered.1, 2 The suffix “oma” implies a neoplastic event in the pathophysiology [onlinelibrary.wiley.com]

This new surgical procedure can maintain a CSF bath around the lumbosacral cord, thus preventing dural adhesion. [ncbi.nlm.nih.gov]