Based on the clinical presentation and radiographic findings, and recent advances in the understanding of human embryogenesis, we formulate a hypothesis that such a presentation is the result of failure of normal gastrulation. [ncbi.nlm.nih.gov]

The present study aimed to identify prognostic factors for continence and need for CIC in LMM. Study design The present study retrospectively identified 143 patients from the multidisciplinary clinic who underwent TCR for LMM between 1995 and 2010. [scholars.northwestern.edu]

• Soft Tissue Mass

  The clinical presentation may be soft tissue mass, sensorial-motor loss and/or bladder dysfunction. Case presentation Here we presented a 10-month-old girl patient harboring lipomyelomeningocele in left lateral side of the lower thoracal region. [casesjournal.biomedcentral.com]

  This mass is not tender and appears to be in continuity with the normal subcutaneous tissues. [clinicalgate.com]

• Gangrene

  An emergent laparotomy was performed and revealed diffuse gangrenous change of both small and large bowels. A jejunostomy was done and strong antibiotics were given, but the baby died two days after the operation. [ncbi.nlm.nih.gov]

• Turkish

  Case presentation The Turkish 10-month-year old girl who born with normal spontaneous vaginal delivery admitted to our out-patient clinic for progressively swelling mass. [casesjournal.biomedcentral.com]

• Dysostosis

  […] infant with PELVIS (perineal hemangioma, external genital malformations, lipomyelomeningocele, vesicorenal abnormalities, imperforate anus, and skin tag) syndrome misdiagnosed as diaper rash. ( 24948350 ) Shimizu M....Yachie A. 2014 23 Spondylocostal dysostosis [malacards.org]

• Muscular Atrophy

  Clinical examination may reveal muscular atrophy, leg length discrepancy, varus or valgus foot deformity of one or both legs, hammertoes or claw toes, scoliosis, mixed deep tendon reflexes (absent, normal, increased), mixed/patchy sensory abnormalities [clinicalgate.com]

• Urinary Urgency

  Urinary dysfunction can be due to detrusor paresis, external sphincter dysfunction, or most commonly, detrusorsphincter dyssynergy.15 Urinary dysfunction may cause symptoms such as urinary incontinence, frequent urinary tract infections, urinary urgency [thejns.org]

• Urinary Dribbling

  Results Immediate postoperative complications Four (23.5%) patients of lumbosacral LMM and 1 (5.8%) patient of sacral LMM had transient altered bladder and bowel function after operative procedure in the form of frequent urinary dribbling and tendency [ncbi.nlm.nih.gov]

• Limb Weakness

  Neurological deficits included weakness of lower limbs, sensory impairment, and bladder and bowel dysfunction, either alone or in different combinations. Forty-five patients had weakness as the sole neurological manifestation. [ncbi.nlm.nih.gov]

• Motor Disturbances

  RESULTS: Preoperatively, all patients displayed severe neurological deficits such as motor disturbance, muscle atrophy, and bladder dysfunction. Several months before surgery, all showed progressive symptoms. [ncbi.nlm.nih.gov]

• Lower Motor Neurone Lesion

  One child had a lower motor neuron lesion, and 5 had a mixed upper and lower motor neuron lesion. [ncbi.nlm.nih.gov]

• Clonus

  There was no ankle clonus. There was a good urine stream, and an anal wink was present. [consultant360.com]

Initial workup included an ultrasound of the region that was concerning for spinal dysraphism, including sacral agenesis and an associated intraspinal mass. [ncbi.nlm.nih.gov]

Spine-shortening osteotomy might be a feasible mode of treatment for adult TCS caused by a spinal lipoma. [ncbi.nlm.nih.gov]

[…] can demonstrate its safety and effectiveness as a primary treatment option. [surgicalneurologyint.com]

Aim To share our operative experience, to summarize known-to-date solutions, and to analyze the treatment of this pathology for the past 10 years. [thieme-connect.com]

Simple cosmetic treatment of the subcutaneous fat pad does NOT prevent Neurological deficit, and may make later definitive treatment more difficult. [lexilouandus.blogspot.com]

Prognosis for the infant with this skin-covered lesion is very good if appropriate care is provided early. [ncbi.nlm.nih.gov]

The early diagnosis and the operative treatment may improve the outcome and the prognosis for the patient. Keywords lipomyelomeningocele; tethered cord effect; operative technique; results [thieme-connect.com]

Prognosis - Lipomyelomeningocele hey are classified as dorsal, caudal and transitional varieties. Lipomas of the filum terminal form a different category. [checkorphan.org]

This case illustrates the favorable prognosis of this entity and the importance of prompt diagnosis and multidisciplinary counseling 6). References [operativeneurosurgery.com]

Aminoff MJ, Logue V (1974) The prognosis of patients with spinal vascular malformations. Brain 97:211–218 PubMed Article CAS Google Scholar 2. [link.springer.com]

Although a genetic component has been well established in the etiology of open NTDs, studies examining the genetics of closed NTDs such as lipomyelomeningocele are rare. [ncbi.nlm.nih.gov]

Open NTDs have a complex etiology, involving both genetic and environmental factors. [nature.com]

BACKGROUND: The epidemiology of neural tube defects (NTDs) may depend on the type of the defect and its location. There is little epidemiologic information on lipomyelomeningocele, a type of NTD. [ncbi.nlm.nih.gov]

Forrester MB, Merz RD: Descriptive epidemiology of lipomyelomeningocele, Hawaii, 1986-2001. Birth Defects Res A Clin Mol Teratol 2004;70:953-956. [karger.com]

Descriptive epidemiology of lipomyelomeningocele, Hawaii, 1986-2001. Birth Defects Res A Clin Mol Teratol. 2004;70:953–956. Google Scholar | Crossref | Medline 8. Copp, AJ, Greene, NDE. Genetics and development of neural tube defects. [journals.sagepub.com]

The current pathophysiological theories and surgical management are discussed. [ncbi.nlm.nih.gov]

Pathophysiologically, neuronal dysfunction in tethered cord syndrome results partly from inability for the spinal cord neurons to utilize oxygen, that is, the impaired oxidative metabolism, partly due to lack of oxygen supply (ischemic effect), and partly [rarediseases.org]

[…] common form of occult spinal dysraphism (spina bifida occulta), which are a broad collection of spinal malformations loosely grouped together by their common characteristic of being skin covered.1, 2 The suffix “oma” implies a neoplastic event in the pathophysiology [onlinelibrary.wiley.com]

To date, no type of graft material has been shown to entirely prevent this problem. Close long-term surveillance of such patients is required to allow detection and treatment of symptomatic retethering. [ncbi.nlm.nih.gov]

Pial closure will be done with 8' 0" non absorbable suture to burry or to invert raw dorsal surface of spinal and to prevent re-tethering [Figure 13]. [pediatricneurosciences.com]