Treatment of manifestations: Poor feeding may require nasogastric tube feedings in newborns and later placement of a gastrostomy tube. [ncbi.nlm.nih.gov]

Symptoms of the disorder may include unusual facial appearance, difficulty swallowing, failure to thrive, muscle spasms, seizures, and severe psychomotor retardation. Hands, fingers, or toes may be deformed. [ninds.nih.gov]

Children born with lissencephaly may have an unusual facial appearance, difficulty swallowing, failure to thrive, and severe psychomotor retardation. Anomalies of the hands, fingers, or toes, muscle spasms, and seizures may also occur. [medicinenet.com]

Children who are born with lissencephaly suffer from severe motor impairment, seizures, muscle spasticity, muscle hypotonia, facial abnormalities, difficulty swallowing, abnormalities of the limbs, fingers and toes and failure to thrive. [disabilitybenefitscenter.org]

Lissencephaly Symptoms Children affected by this disorder may display various symptoms like: Ataxia Seizures Microcephaly Failure to thrive Difficulty in swallowing Unusual facial appearance Hypotonia or muscle spasticity Severe psychomotor retardation [hxbenefit.com]

They usually present with seizures, muscle spasticity, low muscle tone and a number of other neurological symptoms. [disability-benefits-help.org]

Children who are born with lissencephaly suffer from severe motor impairment, seizures, muscle spasticity, muscle hypotonia, facial abnormalities, difficulty swallowing, abnormalities of the limbs, fingers and toes and failure to thrive. [disabilitybenefitscenter.org]

The fetus had normal 46, XY karyotype and similar anomalies found in the index case, with cranio-facial edema and arthrogryposis. X-ray films showed epiphyseal stippling of cervical vertebrae, feet and sacrum. [ncbi.nlm.nih.gov]

Symptoms of the disorder may include unusual facial appearance, difficulty swallowing, failure to thrive, muscle spasms, seizures, and severe psychomotor retardation. Hands, fingers, or toes may be deformed. [ninds.nih.gov]

MR imaging of a patient with epilepsy and psychomotor retardation at 5 months revealed parieto-occipital pachygyria with almost normal cortical appearance and thickness in the frontal region; this appearance evolved into diffuse pachygyria at 7 years. [ncbi.nlm.nih.gov]

Clinical description Children with lissencephaly have feeding and swallowing problems, muscle tone anomalies (early hypotonia and subsequently limb hypertonia), seizures (in particular, infantile spasms) and severe psychomotor retardation. [orpha.net]

Other symptoms associated to lissencephaly and the disorders associated to it (ILS, Miller-Dieker, Walker-Warburg) include: seizures and spasms, trouble swallowing and feeding, intellectual impairment, malformation in hands and feet and psychomotor retardation [amplexa.com]

Patients present with lissencephaly, agenesis of the corpus callosum, refractory epilepsy of neonatal onset, acquired microcephaly and male genotype with ambiguous genitalia. [ncbi.nlm.nih.gov]

Seizures may be particularly problematic but anticonvulsant medications can help. [ninds.nih.gov]

[…] muscle jerks (myoclonic seizures); and episodes of muscle rigidity, convulsions, and loss of consciousness (tonic-clonic seizures). [ghr.nlm.nih.gov]

It is to consider lissencephaly in the diagnosis of developmental delay with seizure disorder as many patients may be diagnosed as cerebral palsy. [ncbi.nlm.nih.gov]

After the first months of life, most children with ILS develop a variety of seizure types, including persisting infantile spasms, short periods of loss of consciousness (absence seizures); sudden episodes of weak muscle tone (drop attacks); rapid, uncontrolled [ghr.nlm.nih.gov]

Approximately 80% have infantile spasms, although the EEG does not always show the typical hypsarrhythmia pattern. The onset of infantile spasms may be associated with a decline in function. [ncbi.nlm.nih.gov]

Hyponatremia is the most frequent electrolyte disorder in critically ill neurological patients. [ncbi.nlm.nih.gov]