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Lithium
Lithobid

Images

WIKIDATA, Public Domain
WIKIDATA, Public Domain
WIKIDATA, Public Domain
WIKIDATA, Public Domain
WIKIDATA, Public Domain

Presentation

We present a case report and review of the literature of burn injuries sustained in association with cellular phone usage. [ncbi.nlm.nih.gov]

Entire Body System

  • Weight Gain

    Q: Is the combination of Lamictal and lithium making me gain weight? How much weight should I expect to gain? A: Lithium did not appear to cause weight gain in clinical studies. [everydayhealth.com]

    The five single most common adverse effects leading to lithium discontinuation were diarrhoea (13%), tremor (11%), polyuria/polydipsia/diabetes insipidus (9%), creatinine increase (9%) and weight gain (7%). [ncbi.nlm.nih.gov]

    Increased thirst Increased urination Diarrhea Vomiting Weight gain Impaired memory Poor concentration Drowsiness Muscle weakness Hair loss Acne Decreased thyroid function (which can be treated with thyroid hormone) SOURCES: WebMD Medical Reference: "Bipolar [webmd.com]

    This condition can cause symptoms that include: depression dry skin fatigue intolerance to cold trouble thinking quickly weight gain A person who is taking lithium will need to undergo regular tests to monitor their thyroid function. [medicalnewstoday.com]

  • Fever

    Tell your doctor if you have been sweating excessively, or if you are sick with fever, vomiting, or diarrhea. Avoid becoming overheated or dehydrated during exercise and in hot weather. [drugs.com]

    Her nine month old had a cough and a fever, symptoms that many American parents would simply treat with over the counter children’s Tylenol and rest. [villagesinpartnership.org]

    Check with your doctor right away if you have anxiety, restlessness, a fast heartbeat, fever, sweating, muscle spasms, twitching, nausea, vomiting, diarrhea, or see or hear things that are not there. [mayoclinic.org]

    […] concentration Drowsiness Muscle weakness Hair loss Acne Decreased thyroid function (which can be treated with thyroid hormone) Notify your doctor if you suspect you may have persistent side effects from lithium or if you develop diarrhea, vomiting, fever [webmd.com]

  • Fatigue

    OBJECTIVE: The aim of this study was to test five types of implant restorations using titanium, zirconia and lithium disilicate abutments after being subjected to long-term fatigue loading. [ncbi.nlm.nih.gov]

    Thyroid problems Share on Pinterest A person with hypothyroidism may experience fatigue, depression, and intolerance to cold. Hypothyroidism is another concern for those taking lithium. [medicalnewstoday.com]

    Lithium can cause nausea, diarrhea, dizziness, muscle weakness, fatigue, and a dazed feeling. These unwanted side effects often improve with continued use. Fine tremor, frequent urination, and thirst can occur and may persist with continued use. [webmd.com]

  • Goiter

    These side effects are due to lithium's action on ion transport.[6] Hematologic: Leukocytosis and aplastic anemia Gastroenterologic: Diarrhea and nausea Endocrinal: Euthyroid goiter or hypothyroid goiter Other: Acne, rash, and weight gain. [ncbi.nlm.nih.gov]

    Children born to women taking lithium during pregnancy have an increased risk of goiter and cardiac anomalies. If possible, lithium should be withheld during the first trimester. [medicinenet.com]

    Thyroid Abnormalities: Euthyroid goiter and/or hypothyroidism (including myxedema) accompanied by lower T3 and T4. Iodine 131 uptake may be elevated.. Paradoxically, rare cases of hyperthyroidism have been reported. [ndrugs.com]

    Thyroid Abnormalities : Euthyroid goiter and/or hypothyroidism (including myxedema) accompanied by lower T3 and T4. I131 uptake may be elevated. (See PRECAUTIONS .) Paradoxically, rare cases of hyperthyroidism have been reported. [rxlist.com]

  • Myxedema

    Thyroid Abnormalities : Euthyroid goiter and/or hypothyroidism (including myxedema) accompanied by lower T3 and T4. I131 uptake may be elevated. (See PRECAUTIONS .) Paradoxically, rare cases of hyperthyroidism have been reported. [rxlist.com]

    Thyroid Abnormalities: Euthyroid goiter and/or hypothyroidism (including myxedema) accompanied by lower T3 and T4. Iodine 131 uptake may be elevated.. Paradoxically, rare cases of hyperthyroidism have been reported. [ndrugs.com]

Urogenital

  • Polyuria

    When the kidneys are not able to control fluid balance you may notice: Greater than normal urine out-put (polyuria), along with greater than normal fluid intake (polydipsia) due to excessive thirst Getting up at night to urinate (nocturia) can be a sign [kidney.org]

    Renal involvement results in a reduced urinary concentrating capacity, expressed as obligate polyuria, with secondary thirst. With long-term therapy, this may result in nephrogenic diabetes insipidus. [ncbi.nlm.nih.gov]

    Fine hand tremor, polyuria, and mild thirst may occur during initial therapy for the acute manic phase, and may persist throughout treatment. [rxlist.com]

    Fine hand tremor, polyuria and mild thirst may occur during initial therapy for the acute manic phase, and may persist throughout treatment. [ndrugs.com]

  • Kidney Failure

    Lithium should not be used by patients who have or have had: acute myocardial infarction, acute kidney failure, or certain rare disorders of heart rhythm (notably, the Brugada syndrome of ventricular arrhythmia). [journalbipolardisorders.springeropen.com]

Neurologic

  • Tremor

    Tremor is a common adverse effect associated with lithium at both therapeutic and toxic serum levels. [ncbi.nlm.nih.gov]

    Common side effects of lithium include mild tremor, thirst, and mild nausea. [everydayhealth.com]

    ANSWER Common side effects of lithium can include: Hand tremor (If tremors are particularly bothersome, dosages can sometimes be reduced or an additional medication can help.) [webmd.com]

  • Confusion

    Lithium Batteries Lithium batteries, not to be confused with Lithium Ion batteries, which are the rechargeable form of Lithium batteries. They are about the same as the alkaline batteries in almost every way. [web.archive.org]

    […] tremor, lightheadedness, lack of coordination, and weakness; to moderate manifestations like giddiness, apathy, drowsiness, hyperreflexia, muscle twitching, ataxia, blurred vision, tinnitus, and slurred speech; severe manifestations such as clonus, confusion [reference.medscape.com]

  • Seizure

    This Phelan-McDermid syndrome (PMS), also presenting with symptoms from the autism spectrum and a higher risk of developing seizure disorders, may be caused by a deletion of chromosome 22q13 or by a mutation in the SHANK3 gene. [ncbi.nlm.nih.gov]

    Some of the combinations can lead to an increased risk of seizures, particularly in people with a history of a seizure disorder or who are already at risk for seizures. [everydayhealth.com]

    Stop using this medicine and call your doctor right away if have: muscle weakness, drowsiness, clumsiness, ringing in your ears, vomiting, diarrhea, irregular heartbeats, confusion, slurred speech, trouble breathing, or seizures. [drugs.com]

  • Ataxia

    In spinocerebellar ataxia, introduction of lithium may be of benefits in terms of improvement of cerebellar symptoms. [ncbi.nlm.nih.gov]

    Concurrent use of calcium channel blocking agents with lithium may increase the risk of neurotoxicity in the form of ataxia, tremors, nausea, vomiting, diarrhea, and/or tinnitus. Caution is recommended. [rxlist.com]

    Ataxia as the Primary Symptom of Lithium Toxicity. Drug Intelligence & Clinical Pharmacy, Vol. 14, Issue. 9, p. 622. [dx.doi.org]

  • Hyperactivity

    Impulsive aggressive behavior associated with attention-deficit hyperactivity disorder (ADHD). Insufficient Evidence for Alcohol dependence. Blood cell disorders. Other conditions. [webmd.com]

    Manic meaning hyperactive, exuberant and full of energy and depressive meaning down and lethargic. In order to control these episodes they take medication in the form of lithium. [micronit.com]

    Typical symptoms of mania include pressure of speech, motor hyperactivity, reduced need for sleep, flight of ideas, grandiosity, elation, poor judgment, aggressiveness and possibly hostility. [rxlist.com]

    Typical symptoms of a manic episode include excessive speech, hyperactivity, reduced need for sleep, flight of ideas, grandiosity, elation, poor judgment, aggressiveness, or hostility. [everydayhealth.com]

Workup

Serum

  • Hyponatremia

    Dehydration, severe or Heart or blood vessel disease or Hyponatremia (low sodium in the blood) or Kidney disease, severe or Muscle weakness, severe or Weakened physical condition—Should not be used in patients with these conditions. [mayoclinic.org]

Treatment

A long duration of neurotoxicity associated with lithium treatment does not necessarily indicate an irreversible prognosis. [ncbi.nlm.nih.gov]

Prognosis

A long duration of neurotoxicity associated with lithium treatment does not necessarily indicate an irreversible prognosis. [ncbi.nlm.nih.gov]

[…] chronic [1] Causes Excessive intake, decreased excretion [1] Risk factors Dehydration, low sodium diet, kidney problems [1] Diagnostic method Based on symptoms and a lithium level [1] [2] Treatment Gastric lavage, whole bowel irrigation, hemodialysis [1] Prognosis [en.wikipedia.org]

Etiology

Articles were reviewed for etiology, location, severity and treatment. We also present a case of a burn to the upper thigh resulting from cellular phone battery malfunction. [ncbi.nlm.nih.gov]

Epidemiology

BACKGROUND: Several epidemiological studies have shown the inverse association of lithium levels in drinking water and suicide rates; however, it is necessary to perform a clinical study dealing with individual patients. [ncbi.nlm.nih.gov]

A recent review of epidemiological studies of lithium in drinking water reported that 9 out of 11 studies found an association between higher levels of lithium in local water and “beneficial clinical, behavioral, legal and medical outcomes.” [nytimes.com]

From Biological Activity and Epidemiological Observation to Food Fortification. Biological Trace Element Research, CrossRef Google Scholar Kavanagh, Laurence Keohane, Jerome Garcia Cabellos, Guiomar Lloyd, Andrew and Cleary, John 2018. [bjp.rcpsych.org]

Epidemiological research point to a possibility of diminished risk of dementia connected with lithium use, both in the general population and in patients with bipolar disorders. [frontiersin.org]

Cutaneous adverse eVects of lithium: epidemiology and management. ^ Ann Med Intern 1984; 13:637–638. Drug eruptions caused by lithium salts. [zh.wikipedia.org]

Pathophysiology

The cytokine hypothesis of depression postulates that cytokines play a key role in the pathophysiology of depression. Concordantly, it has been shown that proinflammatory cytokine serum levels decrease during antidepressant treatment. [ncbi.nlm.nih.gov]

For a diagnosis, the syndrome requires the absence of prior symptoms and persistence of symptoms for greater than 2 months after cessation of lithium. [12] Pathophysiology [ edit ] Lithium is readily absorbed from the gastrointestinal tract. [13] It is [en.wikipedia.org]

In bipolar disorder, the thyroid function should be examined in the context of a role of the thyroid gland and the hypothalamic-pituitary-thyroid axis in the pathophysiology of this illness. [frontiersin.org]

Prevention

They exhibit low self-discharge, and like lead acid cells, must be float charged as they approach a full state, though in this case, it is to prevent plating out metallic lithium. [energyaccess.com]

Isolating terminals prevents short-circuiting. Take steps to prevent crushing, puncturing, or putting a high degree of pressure on the battery, as this can cause an internal short-circuit, resulting in overheating. [web.archive.org]

INTRODUCTION: Lithium is a medication used to treat bipolar disorder and may also prevent cognitive decline and suicide. [ncbi.nlm.nih.gov]

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