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Lithium

Lithobid


Presentation

  • This clinical report presents the digital workflow for the virtual design and fabrication of multiple laminate veneers in a patient for enhancing the esthetics of his maxillary anterior teeth.[ncbi.nlm.nih.gov]
Fever
  • Tell your doctor if you have been sweating excessively, or if you are sick with fever, vomiting, or diarrhea. Avoid becoming overheated or dehydrated during exercise and in hot weather.[drugs.com]
  • […] concentration Drowsiness Muscle weakness Hair loss Acne Decreased thyroid function (which can be treated with thyroid hormone) Notify your doctor if you suspect you may have persistent side effects from lithium or if you develop diarrhea, vomiting, fever[webmd.com]
  • […] creatinine clearance, or proteinuria); during lithium therapy, progressive or sudden changes in renal function, even within normal range, indicate the need for re-evaluation of treatment An encephalopathic syndrome (characterized by weakness, lethargy, fever[reference.medscape.com]
Weight Gain
  • The five single most common adverse effects leading to lithium discontinuation were diarrhoea (13%), tremor (11%), polyuria/polydipsia/diabetes insipidus (9%), creatinine increase (9%) and weight gain (7%).[ncbi.nlm.nih.gov]
  • Surprising Reasons for Weight Gain There are many reasons for sudden weight gain when there are no changes in diet or exercise. Sudden weight gain could be caused...[medicinenet.com]
  • Increased thirst Increased urination Diarrhea Vomiting Weight gain Impaired memory Poor concentration Drowsiness Muscle weakness Hair loss Acne Decreased thyroid function (which can be treated with thyroid hormone) Notify your doctor if you suspect you[webmd.com]
  • After taking lithium for some time, the following may be noticed: weight gain passing urine more often and needing to drink more than usual.[netdoctor.co.uk]
Fatigue
  • OBJECTIVE: The aim of this study was to test five types of implant restorations using titanium, zirconia and lithium disilicate abutments after being subjected to long-term fatigue loading.[ncbi.nlm.nih.gov]
  • Lithium can cause nausea, diarrhea, dizziness, muscle weakness, fatigue, and a dazed feeling. These unwanted side effects often improve with continued use. Fine tremor, frequent urination, and thirst can occur and may persist with continued use.[webmd.com]
  • Miscellaneous: Fatigue, lethargy, transient scotomata, exophthalmos, dehydration, weight loss, leukocytosis, headache, transient hyperglycemia, hypercalcemia, hyperparathyroidism, excessive weight gain, edematous swelling of ankles or wrists, metallic[rxlist.com]
Goiter
  • Children born to women taking lithium during pregnancy have an increased risk of goiter and cardiac anomalies. If possible, lithium should be withheld during the first trimester.[medicinenet.com]
  • Thyroid Abnormalities : Euthyroid goiter and/or hypothyroidism (including myxedema) accompanied by lower T3 and T4. I131 uptake may be elevated. (See PRECAUTIONS .) Paradoxically, rare cases of hyperthyroidism have been reported.[rxlist.com]
Vietnamese
  • Litiy Uzbek Other (Europe) Litioa Basque ლიტიუმი [litiumi] Georgian Afro-Asiatic ليثيوم [līthiyūm] Arabic ליתיום [lithium] Hebrew Litju[m] Maltese Sino-Tibetan Lî (鋰) Hakka リチウム [riteumu] Japanese 리튬 [lityum] Korean ลิเทียม [lithiam] Thai Lithi, Liti Vietnamese[web.archive.org]
Polyuria
  • The five single most common adverse effects leading to lithium discontinuation were diarrhoea (13%), tremor (11%), polyuria/polydipsia/diabetes insipidus (9%), creatinine increase (9%) and weight gain (7%).[ncbi.nlm.nih.gov]
  • Fine hand tremor, polyuria, and mild thirst may occur during initial therapy for the acute manic phase, and may persist throughout treatment.[rxlist.com]
Confusion
  • Lithium Batteries Lithium batteries, not to be confused with Lithium Ion batteries, which are the rechargeable form of Lithium batteries. They are about the same as the alkaline batteries in almost every way.[batteryreview.org]
  • Toxicities included fatigue, somnolence, confusion or blunted affect in 50% of the patients.[ncbi.nlm.nih.gov]
  • […] tremor, lightheadedness, lack of coordination, and weakness; to moderate manifestations like giddiness, apathy, drowsiness, hyperreflexia, muscle twitching, ataxia, blurred vision, tinnitus, and slurred speech; severe manifestations such as clonus, confusion[reference.medscape.com]
Tremor
  • Tremor is a common adverse effect associated with lithium at both therapeutic and toxic serum levels.[ncbi.nlm.nih.gov]
  • Continued Common side effects of lithium can include: Hand tremor (If tremors are particularly bothersome, dosages can sometimes be reduced, or an additional medication can help.)[webmd.com]
Seizure
  • This Phelan-McDermid syndrome (PMS), also presenting with symptoms from the autism spectrum and a higher risk of developing seizure disorders, may be caused by a deletion of chromosome 22q13 or by a mutation in the SHANK3 gene.[ncbi.nlm.nih.gov]
  • Stop using this medicine and call your doctor right away if have: muscle weakness, drowsiness, clumsiness, ringing in your ears, vomiting, diarrhea, irregular heartbeats, confusion, slurred speech, trouble breathing, or seizures.[drugs.com]
  • If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.[nlm.nih.gov]
Ataxia
  • In spinocerebellar ataxia, introduction of lithium may be of benefits in terms of improvement of cerebellar symptoms.[ncbi.nlm.nih.gov]
  • Ataxia as the Primary Symptom of Lithium Toxicity . Drug Intelligence & Clinical Pharmacy, Vol. 14, Issue. 9, p. 622.[bjp.rcpsych.org]
Hyperactivity
  • Impulsive aggressive behavior associated with attention-deficit hyperactivity disorder (ADHD). Insufficient Evidence for Alcohol dependence. Blood cell disorders. Other conditions.[webmd.com]
  • Manic meaning hyperactive, exuberant and full of energy and depressive meaning down and lethargic. In order to control these episodes they take medication in the form of lithium.[micronit.com]
  • Typical symptoms of mania include pressure of speech, motor hyperactivity, reduced need for sleep, flight of ideas, grandiosity, elation, poor judgment, aggressiveness and possibly hostility.[rxlist.com]
  • Manic symptoms include hyperactivity, rushed speech, poor judgment, reduced need for sleep, aggression, and anger. Lithium also helps to prevent or lessen the intensity of manic episodes.[drugs.com]

Treatment

  • Thyroxine treatment was prescribed to 8 (32%) lithium-treated patients.[ncbi.nlm.nih.gov]

Prognosis

  • A long duration of neurotoxicity associated with lithium treatment does not necessarily indicate an irreversible prognosis.[ncbi.nlm.nih.gov]
  • Noncontiguous Stage II Grade 2 Follicular Lymphoma / Noncontiguous Stage II Grade 3 Follicular Lymphoma / Noncontiguous Stage II Mantle Cell Lymphoma / Noncontiguous Stage II Marginal Zone Lymphoma / Noncontiguous Stage II Small Lymphocytic Lymphoma / Poor Prognosis[drugbank.ca]

Etiology

  • Articles were reviewed for etiology, location, severity and treatment. We also present a case of a burn to the upper thigh resulting from cellular phone battery malfunction.[ncbi.nlm.nih.gov]

Epidemiology

  • BACKGROUND: Several epidemiological studies have shown the inverse association of lithium levels in drinking water and suicide rates; however, it is necessary to perform a clinical study dealing with individual patients.[ncbi.nlm.nih.gov]
  • A recent review of epidemiological studies of lithium in drinking water reported that 9 out of 11 studies found an association between higher levels of lithium in local water and “beneficial clinical, behavioral, legal and medical outcomes.”[nytimes.com]
  • From Biological Activity and Epidemiological Observation to Food Fortification . Biological Trace Element Research, CrossRef Google Scholar Kavanagh, Laurence Keohane, Jerome Garcia Cabellos, Guiomar Lloyd, Andrew and Cleary, John 2018.[bjp.rcpsych.org]
Sex distribution
Age distribution

Pathophysiology

  • The cytokine hypothesis of depression postulates that cytokines play a key role in the pathophysiology of depression. Concordantly, it has been shown that proinflammatory cytokine serum levels decrease during antidepressant treatment.[ncbi.nlm.nih.gov]

Prevention

  • INTRODUCTION: Lithium is a medication used to treat bipolar disorder and may also prevent cognitive decline and suicide.[ncbi.nlm.nih.gov]

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