(February 27, 2018) An Unusual Presentation of Primary Hepatic Diffuse Large B-cell Lymphoma of the Liver. [cureus.com]

Satellite nodules were seen at presentation in one case and developed after presentation in two others. Other features, such as enhancement after contrast administration, necrosis, and calcification, were variable. [ajronline.org]

Sub-acute liver failure is an uncommon presentation of primary hepatic lymphoma. Herein, we present a patient who presented with sub-acute liver failure and jaundice due to primary hepatic follicular lymphoma. [journals.sagepub.com]

Portal hypertension was, however, not present. Exploratory laparotomy revealed nodular regenerative hyperplasia of the liver. The nontumorous liver was normal. [keio.pure.elsevier.com]

CASE PRESENTATION A 65-year-old man presented to his primary care physician in August 2008 with a 2-month history of constipation and occasional right groin pain. His history was significant for right inguinal hernia repaired in 1970. [ncbi.nlm.nih.gov]

Table 2 Laboratory data A workup for causes of increased LFTs had been initiated on HD 1. [dovepress.com]

Figure 1 Imaging workup. [casereports.bmj.com]

This case highlights the importance of pursuing a liver biopsy early in the workup for abnormal liver tests of an unclear etiology, even in the absence of a liver lesion on imaging, as in some instances a more expedited diagnosis can improve prognosis [cureus.com]

[…] lymphomas. [4] 68 cases of primary MALTomas have been reported in literature till date. [3] Mean age of presentation is the sixth decade with slight female predilection. [2] Hepatic MALTomas are mostly incidentally detected during surgery or on imaging workup [ijpmonline.org]

A thorough workup is helpful including HBsAg, HCV antibodies, EBV IgM or PCR, and HIV serology. [ncbi.nlm.nih.gov]

Recurring tumors have worse prognosis compared to tumors that do not recur Response to treatment: Tumors that respond to treatment have better prognosis compared to tumors that do not respond to treatment Progression of the condition makes the outcome [dovemed.com]

Since chemotherapy is the treatment of first choice for lymphoma, adjuvant chemotherapy should be given to patients for optimal treatment[ 1 ]. The existing literature on PHL reveals the difficulties involved in diagnosis and treatment. [ncbi.nlm.nih.gov]

Surgery is also described as a possible treatment, but with less promising results and higher rates of recurrence. [elsevier.es]

Depending on the stage of the condition, treatment may involve chemotherapy, biopsy, radiation and medication. Alternative medicine Complementary medicine may be helpful along with conventional treatment. [liverdoctor.com]

Abstract We present a case of successful treatment of chemoresistant hepatic lymphoma using yttrium-90 micropheres. [ashpublications.org]

The prognosis for patients with PHL relates to the specific disease entity. [oapublishinglondon.com]

Freeman C, Berg JW, Cutler SJ (1972) Occurrence and prognosis of extranodal lymphomas. Cancer 29: 252-260. [omicsonline.org]

PHL is associated with a poor prognosis due to its aggressive nature and frequent severe co-morbidity. Of 72 PHL patients described in literature the median survival is only 15.3 mo. [ncbi.nlm.nih.gov]

The overall prognosis is poor, and the median overall survival for these patients has been estimated to be approximately 33 months [6]. [cureus.com]

The etiology of primary hepatic DLBCL is unknown. [cureus.com]

Etiology of MALToma is unclear. Chronic inflammation is known to be the possible trigger including chronic gastritis associated with H. pylori infection. [ijpmonline.org]

In the setting of worsening symptoms and abnormal liver enzymes of unknown etiology, clinicians should consider performing a differential liver biopsy. [wjgnet.com]

A workup for infectious etiologies was performed as summarized in Table 1. Testing for human immunodeficiency virus was negative. A bone marrow biopsy was performed on HD 4. [dovepress.com]

(Etiology) Lymphocytes are a type of white blood cells that are responsible for providing immunity in the human body. B-cells and T-cells are the two different types of lymphocytes. [dovemed.com]

Therefore, since the Birmingham (UK) group emphasized that the establishment of a histopathology data pool improves epidemiological analysis, this paper is based on such a pool used by the Igbo ethnic group [5, 6]. [symbiosisonlinepublishing.com]

To evaluate which patients with NHL are at the highest risk of developing an infection-related second cancer, the researchers reviewed 17 Surveillance, Epidemiology, and End Results (SEER) Program registries to identify 127,044 adults who received their [ashclinicalnews.org]

To date, fewer than 400 PHL cases have been reported in the worldwide literature 3, 7, 8, 18, 21, 25, 29 – 31 and large case series. 6, 9, 10, 14, 32 Methods Data source The Surveillance Epidemiology and End Results (SEER) program of the U.S National [xiahepublishing.com]

Surveillance Epidemiology and End Results (SEER). Bethesda, MD: National Cancer Institute. Archived from the original on 26 September 2009. Retrieved 3 November 2009. Table 1.4: Age-Adjusted SEER Incidence and U.S. [en.wikipedia.org]

Increasing incidence and descriptive epidemiology of extranodal non-Hodgkin lymphoma in parts of England and Wales. Hematol J. 2002;3(2):95–104. 8- Maher MM, McDermott SR, Fenlon HM, Conroy D, O’Keane JC, Carney DN, et al. [tunisiechirurgicale.com]

Bilirubin 2 mg/dL ( 34 μmol/L) before day 21 post‐HSCT and at least two of the following: • Hepatomegaly • Ascites • Weight gain 5% from baseline Summary Assessing liver dysfunction in the context of lymphoma or after HSCT requires an understanding of the pathophysiology [aasldpubs.onlinelibrary.wiley.com]

Pathophysiology Despite a well established underlying pathophysiology in the pathogenesis of other forms of lymphoma; both non-Hodgkin and Hodgkin lymphoma, the pathophysiology underlying primary hepatic lymphoma is largely underdetermined. [ncbi.nlm.nih.gov]

“It seems intuitive to eradicate HCV to prevent HCV-NHL as very few patients who attained an SVR developed such cancer,” the researchers wrote. “Our findings suggest the need for early AVT in infected patients. [healio.com]

How can Lymphoma of Liver be Prevented? Currently, it is not possible to prevent Lymphoma of Liver. However, controlling certain factors may help lower one’s risk for the condition. [dovemed.com]

A high index of suspicion and liver biopsy early in the course of liver dysfunction may establish the diagnosis and allow rapid initiation of chemotherapy to prevent a fatal outcome. [ejcrim.com]

[…] chemotherapy or radiation therapy include: Bone marrow diseases (such as leukemia) Heart disease Inability to have children ( infertility ) Lung problems Other cancers Thyroid problems Keep following up with a provider who knows about monitoring and preventing [medlineplus.gov]

Burkitt lymphoma may spread to the brain and spinal cord and treatment to prevent its spread may be given. [cancer.gov]