They cause syncope and sudden death in response to exercise or emotional stress, and can present with a sentinel event of sudden cardiac death in infancy. [uniprot.org]

Pertussis was circulating in the community, but not influenza. The past and family medical history showed a history of long QT syndrome that was diagnosed after the paternal grandfather had a syncopal incident. [pediatriceducation.org]

Despite the FDA’s warning, azithromycin obviously continues to have an important role in treating certain infections (especially pertussis) in the pediatric population. [uspharmacist.com]

Discussion Mycoplasma pneumoniae is a frequent cause of pharyngitis, pneumonia and acute bronchitis, but acute otitis media is uncommon. [pediatriceducation.org]

She had no rhinorrhea, fever, nausea, vomiting or shortness of breath. Overall she just didn’t feel well but was attending school and doing her sports activities. [pediatriceducation.org]

Even though the clinical diagnosis of J-LN is rather straightforward, it is important to genotype all these patients because it has been shown by Schwartz et al. [ 3 ] that the smaller group with KCNE1 mutations has a markedly less severe clinical course [ojrd.biomedcentral.com]

This subject complained of blurred vision and bilateral temporal hemianopsia for 1 month. Brain magnetic resonance image (MRI) revealed 3 cm sized suprasellar mass and TSS was performed. [abstracts.eurospe.org]

Issues in newborn screening for phenylketonuria. Am Fam Physician. 1999;60:1462-1466. 12. Leslie LK, Rodday AM, Saunders TS, et al. Cardiac screening prior to stimulant treatment of ADHD: a survey of US-based pediatricians. [uspharmacist.com]

Case report A 29 year-old Caucasian male, recently diagnosed with seizure disorder, was brought to emergency room for altered mental status with combative behavior. [jtd.amegroups.com]

Diagnosis • Personal/family Hx • LongQTS-triggered syncope/seizure/SCD • Provoke like accident/drownings/emotional/sleep/rest • ECG: QTc 450msec(M) & 460msec (F) 22. Schwartz score 3.5:high (P) 23. Bazett’s QTc QT/ RR 24. Rare variants 25. [de.slideshare.net]

[…] disorder should be suspected when the electrocardiogram shows characteristic QT abnormalities, or when there is a family history of long QT syndrome or of an event that raises suspicion of long QT syndrome, such as sudden death, syncope, or ill-defined “seizure [mdedge.com]

Interestingly an overlap between LQTS and true epileptic seizures is recognized in a small proportion of patients with long QT2. [rarediseases.org]

Case report A 29 year-old Caucasian male, recently diagnosed with seizure disorder, was brought to emergency room for altered mental status with combative behavior. [jtd.amegroups.com]

Cardiovascular monitoring and stimulant drugs for attention-deficit/hyperactivity disorder. Pediatrics. 2008;122:451-453. 14. FDA. [uspharmacist.com]

[…] could theoretically prolong the QT interval through prolonged recovery of inactivated sodium channels. 39 No matter what anesthetic technique is used, light or insufficient anesthesia, hypertension, bradycardia, tachycardia, hypoxemia, and hypocapnia or hypercapnia [anesthesiology.pubs.asahq.org]

[…] hypothermia could theoretically prolong the QT interval through prolonged recovery of inactivated sodium channels. 39 No matter what anesthetic technique is used, light or insufficient anesthesia, hypertension, bradycardia, tachycardia, hypoxemia, and hypocapnia [anesthesiology.pubs.asahq.org]

ICH E14 Step 2: The Clinical Evaluation of QT/QTc Interval Prolongation and Proarrhythmic Potential for Non-Antiarrhythmic Drugs. www.fda.gov/ohrms/dockets/dockets/04d0377/04D-0377-EC7-Attach-1.pdf. Accessed January 30, 2014. 15. [uspharmacist.com]

Hypokalemia, hypocalcemia, and use of loop diuretics are risk factors for QTc interval prolongation. [4] LQTS has been recognized as mainly Romano-Ward syndrome (ie, familial occurrence with autosomal dominant inheritance, QT prolongation, and ventricular [emedicine.medscape.com]

There is 2:1 atrioventricular block because the t wave has not even started when the next p wave appears; since ventricular repolarisation has not yet occurred, the ventricle cannot yet be depolarised again. [adc.bmj.com]

[…] strip showing 2:1 atrioventricular block secondary to prolongation of the QT interval. ( C ) A rhythm strip demonstrating polymorphic ventricular tachycardia. [pnas.org]

QTc 500 ms. 5. 2:1 atrioventricular block. 6. T wave electric alternans. 7. LQTS3 genotype. [revespcardiol.org]

Timothy syndrome may include a functional 2/1 atrioventricular block, due to an exceedingly long QT interval5,19,48. [romanianjournalcardiology.ro]

The delayed recovery predisposes individuals to the development of early afterdepolarizations and initiation of torsade de pointes arrhythmias. The torsade produces the syncope and sudden death. [journals.lww.com]

Drugs That Prolong the QT Interval and/or Induce Torsades de Pointes Table 1. Drugs That Prolong the QT Interval and/or Induce Torsades de Pointes [anesthesiology.pubs.asahq.org]

LQTS manifestations include syncope, ventricular tachyarrhythmias, torsade de pointes and also cardiac arrest or unexplained sudden death. Patients may also be identified through family history or incidental ECG findings. [pediatriceducation.org]

ICDs do not prevent the occurrence of torsade de pointes and, therefore, are used in conjunction with beta blockers and/or cardiac sympathectomy. [rarediseases.org]

Okt. 2013 The long QT syndrome (LQTS) is a rare inherited heart condition in which delayed repolarization of the heart following a heartbeat increases the risk of episodes of torsades de pointes (TDP, a form of irregular heartbeat that originates from [de.slideshare.net]

A 24-hour ambulatory ECG tracing was obtained in each individual. 5/14 patients with LQTS had pathological findings during ambulatory ECG monitoring (2 patients with episodes of torsade de pointes tachycardia, 2 patients with T-wave alternans and 1 patient [karger.com]

T wave alternans Beat-to-beat alternation of the T wave, in polarity or amplitude, may be present at rest for brief moments but most commonly appears during emotional or physical stresses and may precede TdP (Fig. 2 ). [ojrd.biomedcentral.com]

Follow-up electrocardiograms and Holter records show persistent QT prolongation, bizarre T waves, and intermittent episodes of T wave alternans. On propranolol monotherapy the boy is thriving and completely free of ventricular arrhythmias. [link.springer.com]

Another indicative finding is T-wave alternans (alternating polarity and amplitude), which may be present at rest for brief moments but most commonly appears during emotional or physical stress. [aafp.org]

B, Alternating T-wave axis and morphology (T-wave alternans) leading to an episode of torsades de pointes (TdP) triggered by a ventricular ectopic beat. [circ.ahajournals.org]

In addition to the diagnostic criteria just mentioned, T wave morphology may help differentiate LQT1–3. 27 Typically, a broad T wave is observed in LQT1 ( Figure A ), a biphasic T wave in LQT2 ( Figure B ) and a late-appearing T wave in LQT3, which has [jstage.jst.go.jp]