Edit concept Question Editor Create issue ticket

Loose Anagen Syndrome


Presentation

  • The phenotype is heterogeneous with three distinct clinical presentations.[ncbi.nlm.nih.gov]
  • Abstract We present the case of 7-year-old African American girl with loose anagen syndrome.[ncbi.nlm.nih.gov]
  • Some presentations of alopecia areata may be confused with this condition, but the pull test analysis serves to differentiate them. A variety of theories have been postulated to explain the pathophysiology of loose anagen syndrome.[ncbi.nlm.nih.gov]
  • A 4-year-old girl presented with patches of hair loss and a clinical diagnosis of trichotillomania was made. A hair pull test extracted multiple hairs easily and painlessly. Light microscopic examination was consistent with LAS.[ncbi.nlm.nih.gov]
  • Abstract We present two cases of loose anagen syndrome associated with ocular coloboma in two siblings of unaffected parents and with no family history. We believe they represent a new familial association between these two conditions.[ncbi.nlm.nih.gov]
Coarctation of the Aorta
  • Coarctation of the aorta in Noonan-like syndrome with loose anagen hair. Am J Med Genet A. 2014 May. 164A(5):1218-21. [Medline]. Smith VV, Anderson G, Malone M, Sebire NJ.[emedicine.medscape.com]
  • Read More Download full-text PDF Source Coarctation of the aorta in Noonan-like syndrome with loose anagen hair. Am J Med Genet A 2014 May 23;164A(5):1218-21. Epub 2014 Jan 23.[pubfacts.com]
Cyanosis
  • الصفحة xvi - The Rombo syndrome: a familial disorder with vermiculate atrophoderma, milia, hypotrichosis, trichoepitheliomas, basal cell carcinomas and peripheral vasodilation with cyanosis. Acta Derm Venereol. ‏[books.google.com]
Tachycardia
  • , especially chaotic atrial rhythm/multifocal atrial tachycardia or ectopic atrial tachycardia).[rasopathiesnet.org]
Alopecia
  • Some presentations of alopecia areata may be confused with this condition, but the pull test analysis serves to differentiate them. A variety of theories have been postulated to explain the pathophysiology of loose anagen syndrome.[ncbi.nlm.nih.gov]
  • Clinical differential diagnosis of trichotillomania, alopecia areata, and telogen effluvium were made.[ijpd.in]
  • LAH can be seen in normal population and in alopecia areata. The percentage of LAH in LAS is more than 50%.[helphair.com]
  • Adult onset Loose Anagen Hair syndrome with alopecia totalis. Al Am J Med Sci. 2008; 1 :58–60. [ Google Scholar ] 29. Nunez J, Grande K, Hsu S. Alopecia areata with features of Loose Anagen Hair.[ncbi.nlm.nih.gov]
Skin Lesion
  • If you have a specific question or concern about a skin lesion or disease, please consult a dermatologist.[aocd.org]
Hyperhidrosis
  • الصفحة 151 - Follicular keratosis and verrucous lesions on the extensor surfaces of the arms and legs and on the buttocks (36%) (Figures 11.5 and 11.6) • Palmopiantar hyperhidrosis (20%) Extracutaneous lesions • Cornea! ‏[books.google.com]
Skin Edema
  • Clinical features include skin edema, hydrothorax, pericardial effusion, ascites with or without polyhydramnios, and placental edema.[pubfacts.com]
Follicular Plugging
  • Hematoxylin and eosin staining of the tissue specimen revealed evidence of trichomalacia and follicular plugging [Figure 3]. However, there was no evidence of any inflammatory infiltrate.[ijpd.in]
Learning Difficulties
  • LAS has a known association with Noonan Syndrome, a congenital syndrome that includes heart defects, short stature, learning difficulties, and other characteristics.[aocd.org]
  • Toxic ingestion in children must also be considered in the differential diagnosis, especially if hair loss is accompanied by other signs or symptoms such as abdominal pain, weight loss, irritability or learning difficulties or behavioral changes.[dermatologyadvisor.com]
  • Twenty percent of cases present learning difficulties, social cognition being the most affected field (Roberts et al 2013, Pierpont 2009). Birth size is normal (in the lower range), with important neonatal weight loss.[healthdocbox.com]
Screaming
  • The twins are obsessed with their big sissy and want to be with her or on top of her at all times so when they began taking fistfuls of her hair and ripping it out at the roots without her screaming and yelling or even flinching, we knew something was[clairelasyndrome.wordpress.com]

Workup

  • How much did that appointment to the naturopath and subsequent lab workup cost, and did insurance cover the expense? Question No. 1 seeks to reveal a history consistent with telogen effluvium.[healio.com]
  • However, the molecular genetic workup can be performed in two steps: MLPA, followed by sequencing of the coding regions and splice sites (Grimm et al 2012).[healthdocbox.com]
Pericardial Effusion
  • Clinical features include skin edema, hydrothorax, pericardial effusion, ascites with or without polyhydramnios, and placental edema.[pubfacts.com]

Treatment

  • Treatment: There is no treatment for Loose Anagen, it is offer transient and the patients hair recovers and becomes ‘normal’ after several years but proper diagnosis is required to differentiate from other disorders.[hairmedic.co.uk]
  • Treatment - Loose anagen hair syndrome The treatment or hair care secrets for this defect are to handle the hair gently. Gentle handling can decrease the shedding of fibers to a fair extent.[checkorphan.org]
  • One treatment for this condition beyond watchful waiting is to recommend biotin supplements, though no data has shown this to be a scientifically supported treatment.[aocd.org]
  • Loose Anagen Syndrome Treatment: Though, there is no medical treatment for loose anagen syndrome, the problem often improves when a child enters the teen years and adulthood.[guciimage.com]
  • Treatments or hair care secrets The treatment or hair care secrets for this defect are to handle the hair gently. Gentle handling can decrease the shedding of fibers to a fair extent.[hairdiseases.com]

Prognosis

  • Prognosis - Loose anagen hair syndrome Not supplied. Treatment - Loose anagen hair syndrome The treatment or hair care secrets for this defect are to handle the hair gently. Gentle handling can decrease the shedding of fibers to a fair extent.[checkorphan.org]
  • Prognosis The diffuse hair loss that occurs in loose anagen syndrome often raises considerable concern among patients, parents, and clinicians.[emedicine.medscape.com]
  • […] gender differences, and neural dysfunction and cognitive profile. [ 1 ] When it occurs in early childhood, it can be regarded as a distinct clinical entity. [ 1 ] Because trichotillomania can present in multiple age groups, it is helpful in terms of prognosis[chatarinaberbagi.blogspot.com]
  • TREATMENT AND PROGNOSIS Most cases of LAS resolve spontaneously with age and this could be contributed to androgen that may affect the follicle indirectly through a mesenchymal–epithelial interaction.[ 11 ] Therefore some hair acquire normal anagen appearance[ncbi.nlm.nih.gov]

Etiology

  • Abstract Loose anagen syndrome, or loose anagen hair, is a recently described condition of unknown etiology that may be under-recognized. The typical patient is a child with sparse fine hair that can easily be pulled out.[ncbi.nlm.nih.gov]
  • Etiology Although its occurrence is typically sporadic, familial cases of loose anagen syndrome have been observed. Inheritance appears to be in an autosomal dominant pattern with variable penetrance.[emedicine.medscape.com]
  • Etiology The exact cause remains unknown. There is defective anchoring of anagen hairs, which causes them to be easily and painlessly extracted from the scalp.[dermatologyadvisor.com]
  • The RASopathies are a complex group of conditions regarding phenotype and genetic etiology.[pubfacts.com]
  • The precise etiology of chronic tics in childhood often remains elusive. However, abnormalities in the dopamine pathways have been supposed as possible mechanism underlying neurotransmitter alterations[ 24 ].[ijponline.biomedcentral.com]

Epidemiology

  • Main Outcome Measures Epidemiologic data for all forms of alopecia were ascertained, such as sex, age at onset, age at the time ... more Resumen .—Describimos un caso de sindrome del cabello anageno suelto en una nina de 9 anos.[scinapse.io]
  • […] distinctive facial phenotype, macrocephaly, enlarged cerebral spinal fluid spaces, a short neck with redundant skin, severe growth hormone deficiency, mild psychomotor delay with attention deficit/hyperactivity disorder, and increased skin pigmentation [11] Epidemiology[emedicine.medscape.com]
  • Classification Treatment Epidemiology History References Further reading External links Signs and symptoms edit WAS occurs most often males due its Xlinked recessive pattern inheritance affecting between per million.[add-value.be]
  • Although no broad-based population epidemiologic studies had been conducted as of 2009, the lifetime prevalence of trichotillomania is estimated to be between 0.6% (overall) and as high as 1.5% (in males) to 3.4% (in females). [ 6 ] With a 1% prevalence[chatarinaberbagi.blogspot.com]
  • ., (1966), Epidemiology of autistic conditions in young children: Some characteristics of the parents and children, Social Psychiatry, Kuehn B.M., (2007), CDC: autism spectrum disorders common, Journal of the American Medical Association, 297, CDC, (2012[healthdocbox.com]
Sex distribution
Age distribution

Pathophysiology

  • A variety of theories have been postulated to explain the pathophysiology of loose anagen syndrome. In some cases, there is an autosomal dominant pattern of inheritance. In most cases, this condition spontaneously improves with age.[ncbi.nlm.nih.gov]
  • Pathophysiology of LAHS The affected hairs in LAHS are anagen (growing) hairs that may lack an inner and outer root sheath on a pull test. The anagen bulbs are often dysmorphic and the hairs may demonstrate longitudinal grooves and ruffled cuticles.[dermnet.com]
  • Pathophysiology The precise pathogenesis of LAS is not known; however, theories postulating an abnormality in the hair’s anchoring mechanism predominate.[ncbi.nlm.nih.gov]

Prevention

  • Prevention - Loose anagen hair syndrome Not supplied. Diagnosis - Loose anagen hair syndrome Not supplied. Prognosis - Loose anagen hair syndrome Not supplied.[checkorphan.org]
  • By using a patient’s history and looking at the hair under a microscope, a dermatologist can prevent this confusion and avoid unnecessary treatments.[aocd.org]
  • Like with many undesirable hair conditions, prevention is always better than cure and trichorrhexis nodosa can be readily avoided by practicing ‘kinder’ and more gentle routines to the hair.[hairfinder.com]
  • *These statements have not been evaluated by the Food and Drug Administration.These products are not intended to diagnose, treat, cure or prevent any disease. Disclaimer Please register to get your referral link. Your Referral URL: Click to copy[belegenza.com]
  • “The basic treatment is none, other than trying to prevent trauma to the hair itself,” he says. “The least you can do to manipulate the hair, the better in terms of keeping it in place.”[metroparent.com]

Ask Question

5000 Characters left Format the text using: # Heading, **bold**, _italic_. HTML code is not allowed.
By publishing this question you agree to the TOS and Privacy policy.
• Use a precise title for your question.
• Ask a specific question and provide age, sex, symptoms, type and duration of treatment.
• Respect your own and other people's privacy, never post full names or contact information.
• Inappropriate questions will be deleted.
• In urgent cases contact a physician, visit a hospital or call an emergency service!