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Lovastatin

6 Methylcompactin


Presentation

  • The results of the present study revealed that lovastatin reduced nitric oxide production via the reduction of inducible nitric oxide synthase (iNOS) expression in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells.[ncbi.nlm.nih.gov]
Camping
  • Moreover, the phosphorylation levels of 2 crucial signal molecules for EGF-induced Cyr61 expression, the cAMP response element-binding protein (CREB) and extracellular signal-regulated kinase (ERK), were decreased in cells cotreated with troglitazone[ncbi.nlm.nih.gov]
  • Sapkota GP, Kieloch A, Lizcano JM, Lain S, Arthur JS, et al. (2001) Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433[journals.plos.org]
Progressive Dementia
  • dementia (e.g., Alzheimer’s disease) or clinically important cognitive decline. 200 Not associated with any specific statin, patient's age, statin dosage, or concomitant drug therapy. 200 FDA states that cardiovascular benefits of statins outweigh the[drugs.com]
Diarrhea
  • . • Gastrointestinal : Abdominal pain, non- fatal liver failure , constipation, diarrhea, indigestion, flatulence and nausea. • Musculoskeletal : Muscle cramps, muscle pain, Immune-Mediated Necrotizing Myopathy (IMNM). • Central Nervous System : Dizziness[medindia.net]
  • Common side effects of lovastatin include: Creatine phosphokinase (CPK) elevation Gas ( flatulence ) Abdominal / stomach pain Stomach upset Constipation Diarrhea Muscle pain/tenderness Nausea Indigestion Heartburn Weakness Blurred vision Rash Muscle cramps[rxlist.com]
  • In clinical studies, common side effects included but were not limited to: Increased liver enzymes (see Mevacor and Liver Problems ) Gas Constipation Headache Muscle pain, known medically as myalgia (see Mevacor and Muscle Pain ) Diarrhea Abdominal pain[cholesterol.emedtv.com]
  • Disorders of motion like constipation on one hand or even development of diarrhea on the other hand. To find out more about a safe and natural alternative to lower cholesterol click here.[all-about-lowering-cholesterol.com]
  • Statin medications may also cause gastrointestinal problems like gas, nausea, constipation, anorexia or diarrhea. These symptoms may be worse when you start the medication but tend to improve as your body gets used to the medicine.[livestrong.com]
Dysphagia
  • […] woman (height, 155 cm; weight, 54 kg; and body mass index, 22.5 kg/m2) presented to the outpatient neurology clinic with acute progressive quadriparesis and generalized myalgia (without focal sensory loss, numbness, dizziness, diplopia, dysarthria, dysphagia[ncbi.nlm.nih.gov]
Periodontitis
  • KEYWORDS: Chitosan; Collagen membrane; Epigallocatechin-3-gallate; Guided tissue regeneration; Lovastatin; Periodontitis[ncbi.nlm.nih.gov]
Hepatomegaly
  • All had hepatomegaly, elevated serum aminotransferase activities and hyperlipoproteinemia.[ncbi.nlm.nih.gov]
Cyanosis
  • With lovastatin therapy there was complete healing and except for transient cyanosis related to temporary cessation of therapy, there has been no recurrence for the past thirty months.[ncbi.nlm.nih.gov]
Skin Ulcer
  • ulceration, infection, bleeding) with concomitant use of niacin (1.5–2 g daily) and simvastatin (40–80 mg daily, with or without ezetimibe) 369 371 Use concomitantly with caution; weigh benefits against risks of concomitant use 118 119 Propranolol No[drugs.com]
Proximal Muscle Weakness
  • Neurologic examination revealed severe proximal muscle weakness involving both upper and lower extremities as well as proximal muscle tenderness and areflexia in the lower limbs.[ncbi.nlm.nih.gov]
  • muscle weakness and elevated CK concentrations that persist despite discontinuance of statin therapy, necrotizing myopathy without substantial inflammation, and improvement following therapy with immunosuppressive agents. 118 119 Risk of myopathy is[drugs.com]
Diplopia
  • A 59-year-old Asian woman (height, 155 cm; weight, 54 kg; and body mass index, 22.5 kg/m2) presented to the outpatient neurology clinic with acute progressive quadriparesis and generalized myalgia (without focal sensory loss, numbness, dizziness, diplopia[ncbi.nlm.nih.gov]
Incontinence
  • […] weight, 54 kg; and body mass index, 22.5 kg/m2) presented to the outpatient neurology clinic with acute progressive quadriparesis and generalized myalgia (without focal sensory loss, numbness, dizziness, diplopia, dysarthria, dysphagia, or sphincter incontinence[ncbi.nlm.nih.gov]
Areflexia
  • Neurologic examination revealed severe proximal muscle weakness involving both upper and lower extremities as well as proximal muscle tenderness and areflexia in the lower limbs.[ncbi.nlm.nih.gov]
Dysarthria
  • […] year-old Asian woman (height, 155 cm; weight, 54 kg; and body mass index, 22.5 kg/m2) presented to the outpatient neurology clinic with acute progressive quadriparesis and generalized myalgia (without focal sensory loss, numbness, dizziness, diplopia, dysarthria[ncbi.nlm.nih.gov]

Workup

Liver Biopsy
  • After 12 months, liver biopsy demonstrated a significant decrease in vacuolisation of hepatocytes, with fewer and smaller droplets.[ncbi.nlm.nih.gov]

Treatment

  • Abstract The aim of this study was to prospectively assess the safety and efficacy of lovastatin in the treatment of cholesteryl ester storage disease in siblings who were ages 11.6 and 5 y at the beginning of treatment.[ncbi.nlm.nih.gov]

Prognosis

  • Keywords Ovarian Cancer Doxorubicin Statin Lovastatin Ovarian Cancer Cell Background As a malignancy with particularly poor prognosis, novel therapeutic options are urgently required for the treatment of ovarian cancer[ 1 , 2 ] In 2009, approximately[bmccancer.biomedcentral.com]

Etiology

  • Areca nut (AN) chewing is the most important etiological factor in the pathogenesis of oral cancer in India and many Southeast Asian countries. Yet, the molecular mechanisms involved in the AN-induced oral cancer remain largely unknown.[ncbi.nlm.nih.gov]
  • Keywords Atherosclerosis Hemodialysis Lipid peroxidation Anti oxidants Introduction End stage renal diseases (ESRD), despite of the different etiologies, show a common hyperatherogenic state [ 1 ].[lipidworld.biomedcentral.com]
  • […] routine monitoring of hepatic function in children and adolescents receiving statins. 357 If serious liver injury with clinical manifestations and/or hyperbilirubinemia or jaundice occurs, promptly interrupt lovastatin therapy. 118 119 If an alternate etiology[drugs.com]
  • If an alternate etiology is not found, do not restart lovastatin. Prior to initiating lovastatin therapy, secondary causes for hypercholesterolemia, such as dysproteinemias, obstructive liver disease, and alcoholism, should be excluded.[pdr.net]

Epidemiology

  • BACKGROUND AND AIMS: Epidemiological and experimental studies indicate that high cholesterol may increase susceptibility to age-associated neurodegenerative disorders, such as Alzheimer's disease (AD).[ncbi.nlm.nih.gov]
  • Skip Navigation Oxford Journals Contact Us My Basket My Account About This Journal Contact This Journal Subscriptions Current Issue Archive Search Oxford Journals Medicine American Journal of Epidemiology Volume /cgi/reprint/110/3281, Number /cgi/reprint[web.archive.org]
Sex distribution
Age distribution

Pathophysiology

  • This suggests that in view of their pleiotropic effects, it is plausible that statins may favourably augment the pathophysiological mechanisms of these two conditions.[trialsjournal.biomedcentral.com]

Prevention

  • Pretreatment of ARO cells with a p27, but not p21, antisense oligonucleotide prevented the lovastatin-induced G0/G1 arrest in ARO cells.[ncbi.nlm.nih.gov]
  • Prevention Conference V : Beyond Secondary Prevention : Identifying the High-Risk Patient for Primary Prevention : Noninvasive Tests of Atherosclerotic Burden : Writing Group III Circulation, January 4, 2000; 101 (1): e16 - e22. [Full Text] [PDF] M.[web.archive.org]
  • ., statin). 1 2 3 4 5 118 119 Uses for Lovastatin Prevention of Cardiovascular Events ACC/AHA cholesterol management guideline recommends statins as first-line therapy for prevention of atherosclerotic cardiovascular disease (ASCVD) in adults; extensive[drugs.com]

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