Presentation
Similar lesions were present on the ears, although in much smaller numbers (Fig. 1A). Cases 1 and 3 presented with intense hand and foot edema and necrotic toes (Fig. 1C). [ijl.ilsl.br]
Entire Body System
- Sepsis
It is characterised by recurrent crops of large, sharply demarcated, ulcerative lesions, affecting mainly the lower extremities, but may generalise and become fatal as a result of secondary bacterial infection and sepsis. [1] Lucio's phenomenon was first [en.wikipedia.org]
The progression of the former vasculitis lesions, extensive and deep necrotic areas, the association of staphylococcal and opportunistic fungal infection, sepsis and DIC led to a fatal outcome. [ijl.ilsl.br]
Cardiovascular
- Thrombosis
[…] immune-complex deposition. [1] Morphology [ edit ] Histologically, the lesions are characterised by ischemic necrosis of the epidermis and superficial dermis, heavy infestation of endothelial cells with acid-fast bacilli, and endothelial proliferation and thrombosis [en.wikipedia.org]
We observed signs of ischemia, fibrinous vasculitis, and thrombosis of small arteries with a focal deposit of fibrinoid material on the wall (Figs. 2A and 2B). [ijl.ilsl.br]
Skin
- Ulcer
Ofloxacin (800 mg/day) was similarly used in Cases 1 and 3 after collection of exudate from the ulcers. [ijl.ilsl.br]
It is characterised by recurrent crops of large, sharply demarcated, ulcerative lesions, affecting mainly the lower extremities, but may generalise and become fatal as a result of secondary bacterial infection and sepsis. [1] Lucio's phenomenon was first [en.wikipedia.org]
Treatment
[ edit ] Lucio's phenomenon is treated by anti-leprosy therapy (dapsone, rifampin, and clofazimine), optimal wound care, and treatment for bacteremia, including antibiotics. [en.wikipedia.org]
He lived with a brother who was under treatment for leprosy. [ijl.ilsl.br]
Epidemiology
In severe cases, exchange transfusion is helpful. [4] Epidemiology [ edit ] Lucio's phenomenon is seen mainly in the Caribbean and Mexico, and rare in other parts of the world. [5] [6] Genetic and regional factors and factors specific to M. leprae have [en.wikipedia.org]