It is characterised by recurrent crops of large, sharply demarcated, ulcerative lesions, affecting mainly the lower extremities, but may generalise and become fatal as a result of secondary bacterial infection and sepsis. [1] Lucio's phenomenon was first [en.wikipedia.org]

[…] other parts of the world. [5] [6] Genetic and regional factors and factors specific to M. leprae have been shown to alter the manifestation of Lucio's phenomenon. [5] [6] Eponym [ edit ] It is named after Rafael Lucio Nájera (1819 – 1866), a Mexican physician [en.wikipedia.org]

[…] immune-complex deposition. [1] Morphology [ edit ] Histologically, the lesions are characterised by ischemic necrosis of the epidermis and superficial dermis, heavy infestation of endothelial cells with acid-fast bacilli, and endothelial proliferation and thrombosis [en.wikipedia.org]

It is characterised by recurrent crops of large, sharply demarcated, ulcerative lesions, affecting mainly the lower extremities, but may generalise and become fatal as a result of secondary bacterial infection and sepsis. [1] Lucio's phenomenon was first [en.wikipedia.org]