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Ludiomil


Presentation

  • A controlled, double-blind comparison of maprotiline and imipramine in a group of 71 female outpatients with primary depression is presented.[ncbi.nlm.nih.gov]
  • At this dose the drug was well tolerated, and troublesome side-effects presented in only a small percentage of patients. Drowsiness was the most commonly reported side-effect, and the main reason for stopping treatment.[ncbi.nlm.nih.gov]
  • However, in some of these patients other confounding factors such as concomitant medications known to lower seizure threshold were also present.[rxmed.com]
  • […] occurred in patients with no previous history of seizures, but risk factors (e.g., concurrent use of drugs known to lower seizure threshold, rapid escalation of maprotiline dosage, administration of higher than recommended maprotiline dosages) were present[drugs.com]
Fever
  • […] swelling of testicles yellow eyes or skin Symptoms of overdose Convulsions (seizures) dizziness (severe) drowsiness (severe) fast or irregular heartbeat fever muscle stiffness or weakness (severe) restlessness or agitation trouble in breathing vomiting[drugs.com]
  • Overdose symptoms may include extreme drowsiness or weakness, loss of balance , agitation , fast or irregular heart rate, vomiting , fever, stiff muscles, blue lips or fingernails, fainting, and seizure (convulsions).[drugs.com]
  • Overdose symptoms may include extreme drowsiness or weakness, loss of balance, agitation, fast or irregular heart rate, vomiting, fever, stiff muscles, blue lips or fingernails, fainting, and seizure ( convulsions ).[emedicinehealth.com]
  • Overdose symptoms may include extreme drowsiness or weakness, loss of balance, agitation, fast or irregular heart rate, vomiting , fever, stiff muscles, blue lips or fingernails, fainting , and seizure ( convulsions ).[emedicinehealth.com]
Aspiration
  • Gastric lavage or aspiration should be performed promptly and is recommended up to 12 hours or even more after the overdose, since the anticholinergic effect of the drug may delay gastric emptying.[rxmed.com]
Dry Eyes
  • People who wear contact lenses should be aware that this medicine can cause dry eyes, and that wearing contact lenses during treatment may therefore irritate the surface of the eye. If you experience this, consult your doctor.[netdoctor.co.uk]

Treatment

  • Drowsiness was the most commonly reported side-effect, and the main reason for stopping treatment. The drug was acceptable to most physicians, and in this study was used in a wide age range of patients and over a broad spectrum of depressive illness.[ncbi.nlm.nih.gov]
  • […] summary, the efficacy of once daily dosage, the good response in differing types of depressive illness, the early onset of effectiveness without serious side-effects in a wide age range of patients suggests that this drug will be a useful addition for the treatment[ncbi.nlm.nih.gov]
  • Detailed Info on Signs, Symptoms, Causes, Treatments of Depression Detailed Info on Signs, Symptoms, Causes, Treatments of Bipolar Disorder The information in this monograph is not intended to cover all possible uses, directions, precautions, drug interactions[healthyplace.com]
  • Treatment: Patients in whom overdosage is suspected should be admitted to hospital without delay. No specific antidote is available and treatment is essentially symptomatic and supportive.[rxmed.com]

Etiology

  • ., brain damage of varying etiology, concomitant use of neuroleptics, alcoholism and withdrawal from alcohol, and concomitant use with other drugs that lower the seizure threshold. It appears that the occurrence of seizures is dose dependent.[rxmed.com]

Epidemiology

  • Epidemiology 3: 434–440. View Article Google Scholar 56. Lanevskij K, Japertas P, Didziapetris R, Petrauskas A (2009) Ionization-specific prediction of blood-brain permeability. J Pharm Sci 98: 122–134. View Article Google Scholar 57.[doi.org]
Sex distribution
Age distribution

Pathophysiology

  • Gulbins E, Li PL (2006) Physiological and pathophysiological aspects of ceramide. Am J Physiol Regul Integr Comp Physiol 290: R11–R26. View Article Google Scholar 34.[doi.org]

Prevention

  • 25 Oct Ludiomil Posted at 19:36h in Headache Fact Sheets Ludiomil is a preventive for certain kinds of tension-type and vascular headaches. It works on the pain center in the brain, similar to the tricyclic antidepressants.[headaches.org]
  • Ajovy fremanezumab-vfrm A calcitonin gene-related peptide receptor antagonist to prevent migraine. MORE MED UPDATES[pharmacistsletter.therapeuticresearch.com]
  • These medications can help prevent suicidal thoughts /attempts and provide other important benefits.[medicinenet.com]

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