Presentation
The deleted mtDNAs that are present in massive amounts in Kearns-Sayre and Pearson syndromes are also present in much smaller amounts in the normal elderly; such deletions increase exponentially in long-lived tissues, such as muscle and brain. [columbia.edu]
Pamela Weintraub’s powerful presentation at the IOM workshop last October made a notable impression on the IOM Committee. [loudounlyme.org]
At the present accelerating pace of development of what may be called mitochondrial medicine, much more is likely to be achieved within the next few years. [pnas.org]
It is now clear that mitochondrial DNA mutations underlie these conditions although there is not always a clear correlation between a particular mutation and clinical presentation. 4. [clinsci.org]
It is our ambition to present a complete survey of all medical phenomena named for a person, with a biography of that person. Disclaimer: Whonamedit? does not give medical advice. [whonamedit.com]
Treatment
Edit there is no permanent cure for this disease the only type of treatment that can be given is symptomatic treatment the vitamin therapy given is in the form of Vitamins C, K, and E a high-caloric diet and protection from heat is recommended Diagnostic [luft-disease.wikia.com]
Treatment: Diet supplementation with L-Carnitine. [specialneedshomeschooling.com]
These results appear horrific to modern eyes, but the fact that people persevered with this treatment testifies to the dreadful prognosis of juvenile diabetes at that period. [diapedia.org]
Treatment: As with all mitochondrial diseases, there is no cure for Complex I deficiency. [umdf.org]
[…] expression of mitochondrial proteins as a radical treatment for mtDNA mutation load. [en.wikipedia.org]
Prognosis
The prognosis for MELAS is poor. Typically, the age of death is between 10 to 35 years, although some patients may live longer. [umdf.org]
The prognosis for MERRF varies widely depending on age of onset, type and severity of symptoms, organs involved, and other factors. Sources: Dr. Rolf Luft; The development of mitochondrial medicine. [specialneedshomeschooling.com]
These results appear horrific to modern eyes, but the fact that people persevered with this treatment testifies to the dreadful prognosis of juvenile diabetes at that period. [diapedia.org]
Etiology
Certain differences between the "coupling" data of Luft and ours and certain aspects of the "coupling" response to chloramphenicol remain unexplained, as does the ultimate etiology of the mitochondrial disease. FULL TEXT [annals.org]
Epidemiology
Choosing a future for epidemiology: I. Eras and paradigms. American J of Public Health, 86(5), 668-673, 1996 Tesh SN. Miasma and "social factors" in disease causality: lessons from the Nineteenth Century. [ph.ucla.edu]
Clin Dysmorphol. 2006 Jul;15(3):175-7 Molecular diagnosis of retinoblastoma: molecular epidemiology and genetic counseling Alonso J, Palacios I, Gámez A, Camino I, Frayle H, Menéndez I, Kontic M, García-Miguel P, Sastre A, Abelairas J, Sarret E, Sabado [segcd.org]
Clinical practice guide- lines for Clostridium difficile infection in adults: 2010 update by the Society for Healthcare Epidemiology of America (SHEA) and the Infectious Diseases Society of America (IDSA). [revistagastrocol.com]
Researchers considered mitochondrial disorders as rare, but epidemiological studies by several groups in the early twenty-first century such as Mar Tulin's group in Sweden, David Thorburn in Australia, and Douglas Turnbull and Patrick Chinnery in the [embryo.asu.edu]
PubMed CrossRef Google Scholar Chinnery PF, Johnson MA, Wardell TM, et al (2000a) The epidemiology of pathogenic mitochondrial DNA mutations. Ann Neurol 48 : 188–193. [link.springer.com]
Pathophysiology
Emphasis has been placed on the diagnosis and management of these disorders rather than on their pathophysiology. [books.google.com]
Altered GI motility in critically ill patients: current understanding of pathophysiology, clinical impact, and diagnostic approach. Nutrition in Clinical Practice 2010;25(1):16-25. Montejo JC. [revistagastrocol.com]
"Mitochondrial modulators for bipolar disorder: A pathophysiologically informed paradigm for new drug development". Australian & New Zealand Journal of Psychiatry. 47 (1): 26–42. doi : 10.1177/0004867412449303. [en.wikipedia.org]
Abstract Over the last three decades there has been a growing interest in mitochondrial pathophysiology. [link.springer.com]
Prevention
Prevention Federal 6794725 Closed Clinical Services for World Trade Center Responders 2015-07-01T00:00:00 2016-06-30T00:00:00 Centers for Disease Control and Prevention Federal 7665671 Closed Multi-Protein Recombinant Assay for the Diagnosis of Lyme Disease [stonybrook.edu]
In the fight against Lyme disease, treatment and prevention go hand in hand as scientists look for ways to stop the slow climb of cases and prevent long-term complications. [healthline.com]
By influencing these proteins, we can prevent the onset and progression of the disease. [familjenerlingperssonsstiftelse.se]
Tips for Avoiding Lyme Disease: When you are outside, here are some recommendations to help prevent Lyme disease. Try to avoid tall grass and dense vegetation. Walk in the middle of mowed trails, if possible. [loudounlyme.org]
Luft says those active outdoors should heed advice about preventing ticks by using insect repellant with 20 percent DEET, covering up arms, legs and head, and doing full body checks for ticks after being in wooded or grassy areas. [aarp.org]