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Luft Disease


Presentation

  • The deleted mtDNAs that are present in massive amounts in Kearns-Sayre and Pearson syndromes are also present in much smaller amounts in the normal elderly; such deletions increase exponentially in long-lived tissues, such as muscle and brain.[columbia.edu]
  • Pamela Weintraub’s powerful presentation at the IOM workshop last October made a notable impression on the IOM Committee.[loudounlyme.org]
  • It is now clear that mitochondrial DNA mutations underlie these conditions although there is not always a clear correlation between a particular mutation and clinical presentation. 4.[clinsci.org]
  • At the present accelerating pace of development of what may be called mitochondrial medicine, much more is likely to be achieved within the next few years.[pnas.org]
Hyperthermia
  • No longer are myotonia, periodic paralysis, and malignant hyperthermia untreatable medical curiosities. No longer are cases of steroid-un responsive myositis given up as hopeless.[books.google.com]
Torticollis
  • Das Krankheitsbild erinnert an… … Deutsch Wikipedia Newcastle Disease — Torticollis bei einem Küken mit ND Die Newcastle Krankheit (engl.: Newcastle Disease oder Pseudo Fowlpest) ist eine weltweit verbreitete, außerordentlich ansteckende und anzeigepflichtige[medicine.academic.ru]
Asthenia
  • Luft disease (looft) a hypermetabolic disorder of striated muscle caused by an abnormal quantity and type of mitochondria producing excessive cellular respiration; it is characterized by profuse perspiration, asthenia, progressive weakness, and an abnormally[encyclo.co.uk]
  • Luft disease a hypermetabolic disorder of striated muscle caused by an abnormal quantity and type of mitochondria producing excessive cellular respiration; it is characterized by profuse perspiration, asthenia, progressive weakness, and an abnormally[medicine.academic.ru]

Treatment

  • Edit there is no permanent cure for this disease the only type of treatment that can be given is symptomatic treatment the vitamin therapy given is in the form of Vitamins C, K, and E a high-caloric diet and protection from heat is recommended Diagnostic[luft-disease.wikia.com]
  • Treatment of the neuromuscular diseases has also un dergone dramatic change based on new discoveries in the fields of immunology and pharmacology.[books.google.com]
  • Treatment: Diet supplementation with L-Carnitine.[specialneedshomeschooling.com]
  • These results appear horrific to modern eyes, but the fact that people persevered with this treatment testifies to the dreadful prognosis of juvenile diabetes at that period.[diapedia.org]

Prognosis

  • The prognosis for MELAS is poor. Typically, the age of death is between 10 to 35 years, although some patients may live longer.[umdf.org]
  • The prognosis for MERRF varies widely depending on age of onset, type and severity of symptoms, organs involved, and other factors. Sources: Dr. Rolf Luft; The development of mitochondrial medicine.[specialneedshomeschooling.com]
  • These results appear horrific to modern eyes, but the fact that people persevered with this treatment testifies to the dreadful prognosis of juvenile diabetes at that period.[diapedia.org]

Etiology

  • Certain differences between the "coupling" data of Luft and ours and certain aspects of the "coupling" response to chloramphenicol remain unexplained, as does the ultimate etiology of the mitochondrial disease. FULL TEXT[annals.org]

Epidemiology

  • Choosing a future for epidemiology: I. Eras and paradigms. American J of Public Health, 86(5), 668-673, 1996 Tesh SN. Miasma and "social factors" in disease causality: lessons from the Nineteenth Century.[ph.ucla.edu]
  • Researchers considered mitochondrial disorders as rare, but epidemiological studies by several groups in the early twenty-first century such as Mar Tulin's group in Sweden, David Thorburn in Australia, and Douglas Turnbull and Patrick Chinnery in the[embryo.asu.edu]
  • PubMed CrossRef Google Scholar Chinnery PF, Johnson MA, Wardell TM, et al (2000a) The epidemiology of pathogenic mitochondrial DNA mutations. Ann Neurol 48 : 188–193.[link.springer.com]
  • Epidemiology [ edit ] About 1 in 4,000 children in the United States will develop mitochondrial disease by the age of 10 years.[en.wikipedia.org]
  • The incidence is unknown, although the epidemiological studies of the MELAS-3243 mtDNA mutation have estimated the prevalence to be 1-16/100,000 in the adult population. There is no cure or specific treatment for MELAS.[umdf.org]
Sex distribution
Age distribution

Pathophysiology

  • Emphasis has been placed on the diagnosis and management of these disorders rather than on their pathophysiology.[books.google.com]
  • Abstract Over the last three decades there has been a growing interest in mitochondrial pathophysiology.[link.springer.com]
  • "Mitochondrial modulators for bipolar disorder: A pathophysiologically informed paradigm for new drug development". Australian & New Zealand Journal of Psychiatry . 47 : 26–42. doi : 10.1177/0004867412449303 .[en.wikipedia.org]

Prevention

  • The structural damage is conceived of to be caused by a genetic defect preventing proper aggregation of the enzyme molecules in the cristae.[ncbi.nlm.nih.gov]
  • Prevention Federal 6794725 Closed Clinical Services for World Trade Center Responders 2015-07-01T00:00:00 2016-06-30T00:00:00 Centers for Disease Control and Prevention Federal 7665671 Closed Multi-Protein Recombinant Assay for the Diagnosis of Lyme Disease[stonybrook.edu]
  • By influencing these proteins, we can prevent the onset and progression of the disease.[familjenerlingperssonsstiftelse.se]
  • Luft says those active outdoors should heed advice about preventing ticks by using insect repellant with 20 percent DEET, covering up arms, legs and head, and doing full body checks for ticks after being in wooded or grassy areas.[aarp.org]
  • One way to prevent defective mitochondria from transmitting from mother to offspring is to use assisted reproduction technologies.[embryo.asu.edu]

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