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Lung Transplantation

Graftings Lung


Presentation

  • We present a rare case highlighting a delayed presentation of pulmonary vein thrombosis occurring longer than 2 weeks after lung transplantation and manifesting clinically as graft failure secondary to refractory pulmonary edema.[ncbi.nlm.nih.gov]
  • He presented with dyspnea grade III according to the Medical Research Council.[ncbi.nlm.nih.gov]
  • Abstract We present a case of Candida albicans infection of a previously intact pancreas in a child with cystic fibrosis status post lung transplantation.[ncbi.nlm.nih.gov]
  • There is presently limited evidence upon which to base medical decision-making regarding lung transplantation in individuals with HIV infection.[ncbi.nlm.nih.gov]
  • Herein, we present a 48-year-old woman with a recurrence pattern 24 months after bilateral sequential lung transplantation. On thoracic computed tomography, progressive parenchyma infiltrates were present without clinical symptoms.[ncbi.nlm.nih.gov]
Lymphedema
  • CASE SUMMARY: The course of the patient's recovery from an LT for P-LAM was complicated by lymphedema in the left femoral region that was caused by two E-LAM lesions remaining in the left pelvic cavity and in the retroperitoneal area.[ncbi.nlm.nih.gov]
Gaucher Disease
  • Gaucher disease (GD), a lysosomal storage disorder, may result in end-stage lung disease.[ncbi.nlm.nih.gov]
Varicella-Zoster Virus Infection
  • Varicella zoster virus infection (VZV) is one of the most common opportunistic infections among solid organ transplantation recipients.[ncbi.nlm.nih.gov]
Infectious Mononucleosis
  • This case report is about a patient with PVOD, whose first symptoms of the disease occurred after infectious mononucleosis.[ncbi.nlm.nih.gov]
Dry Cough
  • Although the patient maintained complete remission, dry cough and back pain appeared 8 years after the chemotherapy.[ncbi.nlm.nih.gov]
Abdominal Pain
  • Twenty-eight days after transplantation, the patient developed mild abdominal pain and paralytic ileus. There was no apparent infection sign.[ncbi.nlm.nih.gov]
Jaundice
  • A 48-year-old African-American male subject presented with progressive fatigue, jaundice, and new-onset leukopenia 12 weeks after undergoing bilateral lung transplantation for advanced pulmonary sarcoidosis.[ncbi.nlm.nih.gov]

Workup

  • Both patients performed the 6MWT for a lung transplantation workup while dependent on MV.[ncbi.nlm.nih.gov]
  • Candidates over the age of 70 years are not routinely referred for workup for lung transplantation. Arbitrary restrictions exist for most programs. The conventional definition offered for “elderly” patients is older than 65 years of age (Fig. 2 ).[link.springer.com]
Pneumoperitoneum
  • Abdominal computerized tomography indicated a wall defect of the appendix with multifocal fluid collection, mesenteric leave thickening, and pneumoperitoneum.[ncbi.nlm.nih.gov]
Mycobacterium Kansasii
  • Prior to transplantation, Mycobacterium kansasii was isolated in one sputum culture and the patient was considered merely colonized as no clinical evidence of pulmonary or disseminated disease was present.[ncbi.nlm.nih.gov]

Treatment

  • This report examines the efficacy of SRL treatment for the patient with E-LAM remaining after an LT for P-LAM.[ncbi.nlm.nih.gov]
  • Antiviral treatment with CDV was individually adapted according to anti-ADV immune responses, which provides a new method for tailoring antiviral treatment in lung transplant recipients.[ncbi.nlm.nih.gov]
  • The patient tolerated the treatment well, with one episode of subacute toxicity that resolved with treatment.[ncbi.nlm.nih.gov]
  • ECP is an established "second-line" treatment for CLAD/BOS.[ncbi.nlm.nih.gov]
  • Of these, few have successfully undergone lung transplantation as a treatment of end-stage respiratory failure.[ncbi.nlm.nih.gov]

Prognosis

  • We aimed to evaluate the incidence and prognosis of cancer following LTx for COPD.[ncbi.nlm.nih.gov]
  • CONCLUSION: Elevated mPAP, dPAP, and sPAP are related to worse prognosis in patients with esLD referred for lung transplantation. Copyright 2018 Elsevier Inc. All rights reserved.[ncbi.nlm.nih.gov]
  • This case highlights that the extremely favorable prognosis of advanced testicular germ cell tumors after systemic chemotherapy ( 90% cure rate) should not preclude lung transplant consideration in all cases, despite current guidance that considers an[ncbi.nlm.nih.gov]
  • While the multisystem-LCH course varies from spontaneous remission to rapid deterioration with lethal outcome, single system involvement is generally associated with favorable prognosis.[ncbi.nlm.nih.gov]
  • Regardless of the mode of entry, lung cancer affects the prognosis in these patients and diligence is required. Copyright 2017 Elsevier Inc. All rights reserved. KEYWORDS: Immunosuppression; Lung transplantation; Malignancy[ncbi.nlm.nih.gov]

Etiology

  • This case report describes infection by S. prolificans, which rarely becomes an etiologic agent in lung transplant patients, and shows that endobronchial topical amphotericin B instillation is a therapeutic option when systemic antifungal treatment is[ncbi.nlm.nih.gov]
  • We present a case of a 64-year-old lung transplant recipient who presented with CMV pneumonitis that was diagnosed based on the association of viral inclusion in the BAL sample, rapid response to ganciclovir, and absence of other infectious etiology.[ncbi.nlm.nih.gov]

Epidemiology

  • This article reviews the epidemiology, pathogenesis, risk factors, prevention, and treatment of primary graft dysfunction. Copyright 2017 Elsevier Inc. All rights reserved.[ncbi.nlm.nih.gov]
  • Psychiatric diagnoses of anxiety and depression and Center for Epidemiological Studies - Depression (CES-D) scores collected after hospital discharge were examined as predictors of post-surgery pain.[ncbi.nlm.nih.gov]
  • The epidemiology and risk factors for cancer were retrospectively analyzed in LT recipients from 2 cities in Spain, Madrid and Barcelona. Of the 1353 LT patients initially included in the study, 125 (9.2%) developed cancer after a mean of 3.7 years.[ncbi.nlm.nih.gov]
  • […] thromboembolic pulmonary hypertension ( CTEPH ) First lung-kidney transplant in Ohio (only 37 performed in the U.S. since 1995) Lung transplant research: Multidisciplinary research collaboration with Nationwide Children’s Hospital at the Center for the Epidemiological[wexnermedical.osu.edu]
Sex distribution
Age distribution

Pathophysiology

  • Primary pulmonary hypertension: pathophysiology and therapy Stuart Rich 2. Genetics of pulmonary hypertension Richard C. Trembath and Rachel Harrison 3. Pathology of pulmonary hypertension Anne E. Bishop and Julia M. Polak 4.[cambridge.org]

Prevention

  • Long-term toxicities attributed to tacrolimus, such as nephrotoxicity and neurotoxicity, can limit the long-term success of tacrolimus in preventing allograft rejection.[ncbi.nlm.nih.gov]
  • Infections are associated with high mortality, and prevention of transmission requires stringent infection control measures, making C. auris a potential barrier to transplantation.[ncbi.nlm.nih.gov]
  • Immunosuppressive therapy is needed to prevent episodes of graft rejection and thus subsequently reduce morbidity and mortality in this population.[ncbi.nlm.nih.gov]
  • Optimal prevention strategies require additional study. 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.[ncbi.nlm.nih.gov]
  • This article reviews the epidemiology, pathogenesis, risk factors, prevention, and treatment of primary graft dysfunction. Copyright 2017 Elsevier Inc. All rights reserved.[ncbi.nlm.nih.gov]

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