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Lung Transplantation
Grafting Lung

Images

WIKIDATA, Public Domain
WIKIDATA, CC BY-SA 3.0
WIKIDATA, CC BY-SA 3.0

Presentation

He presented with dyspnea grade III according to the Medical Research Council. [ncbi.nlm.nih.gov]

Entire Body System

  • Surgical Procedure

    Furthermore, preoperative 3D-CT simulation is useful in developing and performing a special surgical procedure, such as right-to-left inverted LDLLT. [ncbi.nlm.nih.gov]

    Lung transplants are among the most complicated surgical procedures, and these patients require lifelong care. The lung transplant team at Norton Thoracic Institute completed 114 lung transplants in 2016. [dignityhealth.org]

    Lung transplant: A lung transplant is a surgical procedure to remove a diseased lung and replace it with a healthy one from an organ donor. The surgery may be done for a single lung or for both lungs. [vanderbilthealth.com]

    A lung transplant is a surgical procedure to replace a diseased or failing lung(s) with a healthy lung(s) from a deceased donor. [transplant.bc.ca]

  • Chronic Infection

    […] of these infections. [emedicine.com]

    Poorly controlled chronic infection with highly virulent/resistant pathogens is an absolute contraindication to lung transplantation. [scielo.br]

  • Swelling

    Signs of heart rejection include fatigue, swelling of the arms or legs, weight gain, and fever. [emedicinehealth.com]

    Ex vivo lung perfusion (EVLP) is an innovative technique that is applied before transplantation, infusing nutrients into the lungs and reducing swelling, making the organ more suitable for transplant. [loyolamedicine.org]

    Call your healthcare provider if you have any of the below: Fever of 100.4°F (38°C) or higher, or as advised by your medical team Redness or swelling of the incision Blood or other fluid leaking from the incision Pain around the incision that gets worse [hopkinsmedicine.org]

  • Pathologist

    William Funkhouser (lung transplant pathologist) provides expertise in interpreting lung biopsy specimens from transplant recipients, and Dr. [med.unc.edu]

    With involvement from pulmonologists, surgeons, pathologists, nurses, pulmonary rehabilitation specialists and other medical staff, we often can help improve lung function while patients wait for transplant, enhancing recovery. [houstonmethodist.org]

Gastrointestinal

  • Nausea

    Signs of rejection: fever; flu-like symptoms, including chills, dizziness, nausea, general feeling of illness, night sweats; increased difficulty in breathing; worsening pulmonary test results; increased chest pain or tenderness; increase or decrease [en.wikipedia.org]

    Other symptoms include the following: Nausea and vomiting Weight gain Confusion Swelling of your arms and legs ( edema ) Severe fatigue and tiredness Decreased urine The main symptom for lung disease is shortness of breath. [emedicinehealth.com]

  • Vomiting

    Other symptoms include the following: Nausea and vomiting Weight gain Confusion Swelling of your arms and legs ( edema ) Severe fatigue and tiredness Decreased urine The main symptom for lung disease is shortness of breath. [emedicinehealth.com]

    […] transplantation include: Squamous cell skin carcinoma within the last 2 years Body mass index of 38 Single vessel coronary artery disease Aspergillus colonisation of the lungs Current smoker Symptoms or signs of acute rejection may include: Breathlessness Hypoxia Vomiting [breathe.ersjournals.com]

Workup

Both patients performed the 6MWT for a lung transplantation workup while dependent on MV. [ncbi.nlm.nih.gov]

Candidates over the age of 70 years are not routinely referred for workup for lung transplantation. Arbitrary restrictions exist for most programs. The conventional definition offered for “elderly” patients is older than 65 years of age (Fig. 2 ). [link.springer.com]

Treatment

Antiviral treatment with CDV was individually adapted according to anti-ADV immune responses, which provides a new method for tailoring antiviral treatment in lung transplant recipients. [ncbi.nlm.nih.gov]

Prognosis

CONCLUSION: Elevated mPAP, dPAP, and sPAP are related to worse prognosis in patients with esLD referred for lung transplantation. Copyright © 2018 Elsevier Inc. All rights reserved. [ncbi.nlm.nih.gov]

Etiology

This case report describes infection by S. prolificans, which rarely becomes an etiologic agent in lung transplant patients, and shows that endobronchial topical amphotericin B instillation is a therapeutic option when systemic antifungal treatment is [ncbi.nlm.nih.gov]

Epidemiology

This article reviews the epidemiology, pathogenesis, risk factors, prevention, and treatment of primary graft dysfunction. Copyright © 2017 Elsevier Inc. All rights reserved. [ncbi.nlm.nih.gov]

Epidemiology of aspergillosis in lung transplant recipients is fairly well-defined; the challenge remains both diagnosis and treatment of this disease. [aspergillus.org.uk]

[…] thromboembolic pulmonary hypertension ( CTEPH ) First lung-kidney transplant in Ohio (only 37 performed in the U.S. since 1995) Lung transplant research: Multidisciplinary research collaboration with Nationwide Children’s Hospital at the Center for the Epidemiological [wexnermedical.osu.edu]

Pathophysiology

Primary pulmonary hypertension: pathophysiology and therapy Stuart Rich 2. Genetics of pulmonary hypertension Richard C. Trembath and Rachel Harrison 3. Pathology of pulmonary hypertension Anne E. Bishop and Julia M. Polak 4. [cambridge.org]

Am J Respir Crit Care Med 172:379–383 CrossRef PubMed Google Scholar Verleden GM, Egan J, Israel-Biet D et al (2004) Chronic lung allograft rejection: prevalence, pathology, risk factors and pathophysiology. [link.springer.com]

[…] hypertension, CF, and COPD, each with a 6-month survival of 96%.. 64 This high early mortality seen after lung transplantation in patients with pulmonary hypertension likely reflects the ability of vasodilator therapy to prolong life despite significant pathophysiology [phaonlineuniv.org]

Prevention

Long-term toxicities attributed to tacrolimus, such as nephrotoxicity and neurotoxicity, can limit the long-term success of tacrolimus in preventing allograft rejection. [ncbi.nlm.nih.gov]

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