Presentation
VLA15 is a protein subunit-based vaccine which targets the Outer Surface Protein A (OspA) of Borrelia, the most dominant protein expressed by the bacteria when present in a tick. [empr.com]
In this presentation, the important role that vaccination can play in maintaining canine health is discussed. [vetfolio.com]
The Centers for Disease Control and Prevention (CDC) last week released the webinar, HHS Working Group on Lyme and Other Tickborne Diseases presents: Vaccines for Lyme Disease – Past, present, and future, which looks at such issues as Why we need a vaccine [outbreaknewstoday.com]
At present two different recombinant OspA vaccine preparations (monovalent) are being evaluated in humans in large-scale phase III efficacy trials in the United States. [ncbi.nlm.nih.gov]
4/2014 vol. 95 abstract: Short communication Anna Urbanowicz, Dominik Lewandowski, Marek Figlerowicz vol. 95(4) C pp. 255-258 C 2014 Online publish date: 2015/12/21 The present invention relates to a Lyme disease vaccine, a genetic construct, recombinant [biotechnologia-journal.org]
Skin
- Ulcer
Local ulceration and drainage at the site of injection, which occurred in 50% and 83% of volunteers in the two highest dose groups, persisted for 1-70 days before the ulcers healed. [ncbi.nlm.nih.gov]
Treatment
Doctors are very confident, and hope FDA trials for the treatment will start next spring. The treatment could be available to the public in two to three years. [countryliving.com]
Post-treatment Lyme disease syndrome is simply a fabricated medical condition disguising treatment failure as we have been dealing with an antibiotic resistant superbug from day one deliberately concealed to promote vaccine development. [change.org]
Some will receive notice to get treatment right away if they portray a circular red rash on their skin in the form of a bullseye. [naturalhealth365.com]
There is currently no vaccine for the fast-growing disease in the US, & treatments cost over $1Bn every year. Valneva might have a vaccine to stem the tide. [labiotech.eu]
The existence of this post-treatment Lyme disease syndrome (PTLDS) is an important part of the picture when calculating the impact of the disease. [medcitynews.com]
Prognosis
What is the prognosis of Lyme disease? Lyme disease is usually curable with antibiotics. [medicinenet.com]
Resources ★Government and Other Resources by category: General/ Overviews Basic Science/ Research Children Clinical Trials Diagnosis Dictionaries/ Glossaries News-Focused Organizations Prevention/ Screening Treatment ★Lyme Disease: General Diagnosis Prognosis [medmk.com]
Etiology
The GLT25D1 and GLT25D2 genes now allow addressing of the biological significance of collagen glycosylation and the importance of this posttranslational modification in the etiology of connective tissue disorders. [blog.goo.ne.jp]
There was no evidence of a consistent temporal pattern supporting an etiologic relationship between vaccination and subsequent events. [academic.oup.com]
The spirochetal etiology of Lyme disease. New England Journal of Medicine. 1983; 308 :733–740. [ PubMed ] 3. Anon. Summary of notifiable diseases – United States 2002. Morbidity and Mortality Weekly Report. 2004; 51 :1–84. [ PubMed ] 4. [ncbi.nlm.nih.gov]
Epidemiology
Paul Mead, chief of epidemiology and surveillance for the CDC's Lyme disease program, told Business Insider in June. "A safe and effective vaccine could help us turn the tide." [businessinsider.com]
More than half of the cases of Lyme disease from these areas, and virtually all of the cases from nonendemic areas, can be linked epidemiologically to travel to a highly endemic area of the United States. [ncbi.nlm.nih.gov]
Descriptive epidemiology of adverse events after immunization: reports to the Vaccine Adverse Event Reporting System (VAERS), 1991-1994, J Pediatr, 1997, vol. 131 (pg. 529 - 535 ) 11. [academic.oup.com]
“Low demand for the vaccine and its subsequent withdrawal from the market represent a loss of a powerful tool for Lyme disease prevention,” a 2007 article in journal Epidemiology & Infection concluded. [healthline.com]
Prevention
Valneva offers two commercial vaccines for travelers: IXIARO®/JESPECT® indicated for the prevention of Japanese encephalitis and DUKORAL® indicated for the prevention of cholera and, in some countries, prevention of diarrhea caused by ETEC. [precisionvaccinations.com]
LYME DISEASE PREVENTION AND THE POTENTIAL UTILITY OF A SAFE AND EFFECTIVE VACCINE Lyme disease prevention has focused traditionally on reducing human exposure to the bites of infected ticks. [academic.oup.com]
Cameron, MD MPH The OspA vaccine trial was 78% effective at preventing a culture confirmed erythema migrans rash. But the vaccine was only 48% effective at preventing what the authors referred to as “possible Lyme disease.” [danielcameronmd.com]
Now, data from a European biotechnology company suggests that such case numbers could be prevented with the development of its novel vaccine candidate. [medicaldaily.com]