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Lymph Node Hyperplasia

Adenopathy


Presentation

  • When the overlying skin is involved, testicular carcinoma may lead to inguinal lymphadenopathy, 20 which is present in 58 percent of patients diagnosed with penile or urethral carcinoma. 21 In neither case is it the typical presenting finding.[aafp.org]
  • All patients presented with progressive cervical lymph node enlargement after median treatment duration of 20 months (range, 9 to 35 months). One patient presented additionally inguinal lymph node enlargement.[bloodjournal.org]
  • In the present case, diagnosis of solitary AFLNH was rendered by histopathologic means.[jpgmonline.com]
  • Abstract Twenty-two cases are presented of patients whose solitary painless, enlarged lymph nodes demonstrated an extreme degree of reactive hyperplasia with giant follicles which were misdiagnosed as lymphoma in 11 (50%) instances.[ncbi.nlm.nih.gov]
  • Abstract A 14-year-old boy presented with fever, anemia, hepatosplenomegaly, generalized lymphadenopathy and nephrotic syndrome.[karger.com]
Fever of Unknown Origin
  • One patient's disease had a subacute course with fevers of unknown origin, mucocutaneous candidiasis, and progressive thrombocytopenia, while the other patient's disease had a fulminant course with anemia, thrombocytopenia, and splenic lymphoma.[mayoclinic.pure.elsevier.com]
Pseudotumor
  • Abstract Four women with multicentric angiofollicular lymph node hyperplasia had a distinct clinical syndrome characterized by peripheral neuropathy, pseudotumor cerebri, IgA dysproteinemia, and thrombocytosis.[annals.org]
Disability
  • The neuropathies were severe and disabling. Clinical courses have been variable with some responses to therapy with steroids and alkylating agents. No neoplastic transformations have occurred.[annals.org]

Workup

  • An evaluation of the probability of malignant causes and the effectiveness of physicians' workup. J Fam Pract . 1988;27:373–6. 5. Kelly CS, Kelly RE Jr. Lymphadenopathy in children. Pediatr Clin North Am . 1998;45:875–88. 6.[aafp.org]
  • A complete clinical workup of the patient was done. Laboratory investigations revealed serum bilirubin (1.1 mg/dl); direct (0.6 mg/dl); alkaline phosphatase 208 IU/L; ALT 64IU/L.[cancerjournal.net]

Treatment

  • The treatment of multicentric type usually involves medications and other therapies to control the over growth of the cells. The treatment depends on the extent of the condition and whether the patient has HIV or HHV-8 or both.[gleneaglesglobalhospitals.com]
  • One of the most important decisions you will make is choosing which treatment is best for you.[medigoo.com]
  • The authors have succeeded in documenting the current diverse roles of radiati on therapy in the treatment of benign diseases. This volume represents a significant and important contribution to our armamentarium for the treatment of these diseases.[books.google.com]
  • Please find comprehensive information on Castleman Disease (CD) regarding definition, distribution, risk factors, causes, signs & symptoms, diagnosis, complications, treatment, prevention, prognosis, and additional useful information HERE .[dovemed.com]

Prognosis

  • […] extent of the disease, and an individual’s response to treatment Please find comprehensive information on Castleman Disease (CD) regarding definition, distribution, risk factors, causes, signs & symptoms, diagnosis, complications, treatment, prevention, prognosis[dovemed.com]
  • The present study, wherein the pattern of hyperplasia is correlated with NPI of the tumor, helps in predicting the prognosis of patient.[ccij-online.org]
  • Treatment and prognosis For unicentric Castleman disease treatment is surgical, with good prognosis (can be curative). Multicentric Castleman disease may be treated with any combination of surgery, chemotherapy and prednisolone 6 .[radiopaedia.org]
  • Those with multicentric disease often have a poor prognosis with a median survival time of less than 3 years. After several relapses, hospice stay may be appropriate for certain populations. F. Prognosis and Patient Counseling.[clinicaladvisor.com]

Etiology

  • EXPOSURES A complete exposure history is essential to determining the etiology of lymphadenopathy.[aafp.org]
  • No specific etiologic factors were identified. Microscopically, the enlarged giant follicles involved the entire surface area of the lymph node, frequently assuming a serpentine configuration resulting from coalescence.[ncbi.nlm.nih.gov]
  • : follicular, paracortical / diffuse, sinus and mixed Etiology Multiple etiologic factors, including: Bacteria Fungi Viruses Chemicals Environmental pollutants Drugs: phenytoin, allopurinol, atenolol, gold, penicillin, quinidine Altered tissue components[pathologyoutlines.com]
  • It is necessary to complete with exhaustive etiology investigation in front of this clinical presentation.[endocrine-abstracts.org]
  • A specific etiology cannot be determined for the large majority of cases of reactive paracortical hyperplasia.[nature.com]

Epidemiology

  • Essential features Clinically manifests as lymph node enlargement No clonal process No cytologic or architectural atypia Terminology Reactive lymphoid hyperplasia Reactive follicular hyperplasia Diffuse paracortical hyperplasia Sinus histiocytosis Epidemiology[pathologyoutlines.com]
  • […] included in the list of differential diagnosis of causes of granulomatous inflammation. [20] A comparison of our study and various other studies revealed a number of differences with respect to certain parameters which can be attributed to different epidemiological[ccij-online.org]
  • The epidemiological analysis of these cases, including the case reported here, showed that there is predilection for females, with 17 cases (77.3%) and 5 (22.7%) in males, with a ratio female: male of 3.4:1; ages ranged from 38 to 79 years, averaging[omicsonline.org]
Sex distribution
Age distribution

Pathophysiology

  • […] intrinsic or environmental antigens Most lymph node enlargements are reactive In children, most lymphadenopathies are benign; in adults, chance of malignancy increases with age Sites Any lymph node group can be affected depending on the stimulation Pathophysiology[pathologyoutlines.com]
  • The aetiology and management of Castleman disease at 50 years: translating pathophysiology to patient care. Br J Haematol. 2005;129(1):3-17. Nishimoto N, Kanakura Y, Aozasa K, et al.[rarediseases.org]
  • Associated infections include HIV and HHV-8, with HHV-8 thought to be involved in the pathophysiology of the disease in HIV infected patients. B.[clinicaladvisor.com]

Prevention

  • […] on the extent of the disease, and an individual’s response to treatment Please find comprehensive information on Castleman Disease (CD) regarding definition, distribution, risk factors, causes, signs & symptoms, diagnosis, complications, treatment, prevention[dovemed.com]
  • This article exemplifies the AAFP 2002 Annual Clinical Focus on cancer: prevention, detection, management, support, and survival .[aafp.org]
  • For example, drugs can be given before or along with chemotherapy to prevent or reduce nausea and vomiting. Most side effects are temporary and go away after treatment is finished.[medigoo.com]
  • An immune response is triggered when the body senses an invasion and lymphocytes attempt to prevent the foreign invader from traveling throughout the circulatory system.[wisegeekhealth.com]

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