In some cases, lymphadenitis remains asymptomatic. When symptomatic, the lymph node may be swollen and palpable with pain and tenderness. Neck stiffness is a common symptoms with cervical lymph node enlargement and often seen in infectious mononucleosis and cat scratch fever. Preauricular lymphadenitis is common in infections like conjunctivitis, and keratoconjunctivitis. Inflammation of the retropharyngeal node causes dysphagia and dyspnea. Patients with node enlargement in mediastinum may present with cough, stridor, pleural effusion, and dysphagia. Abdominal pain is common in cases where the intraabdominal nodes are enlarged and in iliac node enlargement. Supraclavicular lymphadenopathy has the highest risk of malignancy. Malignancy often results in hard, nontender, and firm nodes. Lymph node enlargement caused by infections is soft, tender and movable. Erythema of the skin is noted in some of the swollen nodes associated with infectious diseases. In many cases, the manifestations of the underlying disease may appear only after the initial lymph gland inflammation or enlargement.

Increased risk of lymphadenitis is seen in patients who have a clinical history of upper respiratory tract infection, conjunctivitis, persistent fever, and anorexia. Those who have a history of contact with animals or livestock also are at a high-risk of developing this condition.

• Generalized Lymphadenopathy

  The patient was an elderly man who presented with fever and generalized lymphadenopathy. [ncbi.nlm.nih.gov]

  Case presentation : A 53-year old female who presented with fever, generalized lymphadenopathy, and constitutional symptoms underwent lymph node biopsy after concern for malignant lymphoma. [oatext.com]

  […] enlarged lymph nodes R59.9 Enlarged lymph nodes, unspecified R59.- ) human immunodeficiency virus [HIV] disease resulting in generalized lymphadenopathy ( ICD-10-CM Diagnosis Code B20 Human immunodeficiency virus [HIV] disease 2016 2017 2018 2019 Billable [icd10data.com]

  Generalized lymphadenopathy is often caused by a viral infection, and less frequently by malignancies, collagen vascular diseases, and medications. Laboratory tests are not necessary in most children with cervical lymphadenopathy. [link.springer.com]

• Fever

  The differential diagnosis for fever and lymphadenopathy is diverse and encompasses a breadth of diseases with varying ranges of prognoses. [oatext.com]

  It usually runs a benign course and recurrence is rare.[ 2, 3 ] Case Report A 31-year-old female presented with a 10-day history of high-grade fever and loss of appetite and generalized weakness. [ncbi.nlm.nih.gov]

  To help with any pain, you can take standard pain relievers or fever reducers. [sharecare.com]

• Lymphadenopathy

  Fine-needle aspiration cytology is a useful method for diagnosing and differentiating toxoplasma lymphadenitis from more serious causes of lymphadenopathy, such as metastatic lymphadenopathy or lymphoma. [ncbi.nlm.nih.gov]

  KFD most commonly presents as fever and unilateral cervical lymphadenopathy in young women, however the lymphadenopathy can also be multifocal. [oatext.com]

• Inflammation

  Biopsy is suggested to check the cause of inflammation. Treatment of lymphadenitis depends on the underlying cause for inflammation. Analgesics may help in controlling pain. [symptoma.com]

  Lymphadenitis occurs when the glands become enlarged by swelling (inflammation), often in response to bacteria, viruses, or fungi. The swollen glands are usually found near the site of an infection, tumor, or inflammation. [baptistjax.com]

  Lymphadenitis can be a complication of many different infections and is usually found in the area of an infection, inflammation, or tumor. [kidshealth.org]

  Lymph node inflammation can occur for a variety of reasons. Any infection or virus, including the common cold, can cause your lymph nodes to swell. Cancer can also cause lymph node inflammation. [healthline.com]

• Asymptomatic

  METHODS: Dye test titers of patients with acute toxoplasmosis (pregnant and not pregnant) with TL (TL+) were compared with those in patients with asymptomatic acute infection (TL-). [ncbi.nlm.nih.gov]

  After appropriate treatment the swelling subsided and the patient remained asymptomatic at the 6 months follow up. The patient was on same regime for 3 more months. No further complications were noticed. [ijpmonline.org]

  Enlarged lymph nodes can be asymptomatic, or they can cause local pain and tenderness. Overlying skin may be unaffected or erythematous. Cervical lymphadenitis can lead to neck stiffness and torticollis. [emedicine.medscape.com]

• Hodgkin Lymphoma

  lymphoma Non-Hodgkin lymphomas Squamous cell carcinomas of nasopharyngeal or laryngeal structures Axillary lymph nodes Axillary lymph nodes receive lymphatic drainage from upper extremities and breasts. [emedicine.medscape.com]

  Enlarged lymph nodes that do not cause pain, tenderness, or redness may indicate a serious different disorder, such as lymphoma, tuberculosis, or Hodgkin lymphoma. Such lymph nodes require a doctor’s attention. [msdmanuals.com]

• Sputum

  CBNAAT detects pulmonary TB with greater efficacy than sputum microscopy (diagnosis in In the differential diagnosis, reactive hyperplasia, lymphoma, sarcoidosis, generalized, and lymphadenopathy of HIV were considered. [ijpmonline.org]

  A minimum 5.0 ml of sputum improves the sensitivity of acid-fast smear for Mycobacterium tuberculosis. Am J Respir Crit Care Med 2000;161:1559-62. 2. Mistry Y, Ninama GL, Mistry K, Rajat R, Parmar R, Godhani A. [cytojournal.com]

  The fine needle aspiration and cytology is important technique, and is useful for patient who cannot provide sputum. [omicsonline.org]

  […] first thing is eliminated (or confirmed) Quincke edema - an allergic reaction that threatens life, as well as congenital cysts and tumors in the neck region that are very similar to enlarged lymph nodes; Allergy skin tests, microscopic examination of sputum [en.medicine-worlds.com]

  A chest X-ray was normal and sputum for acid-fast bacilli (AFB) was negative. Lactate dehydrogenase level in serum was normal. [jmedicalcasereports.biomedcentral.com]

• Neck Swelling

  Some of the common symptoms of Cervical Lymphadenitis are: Swelling of the lymph nodes in neck Swelling of the lymph nodes under jaw Presence of lumps under skin Swelling in the neck Pain in the neck Facial swelling Fever and chills Persistent sore throat [epainassist.com]

  The patient first noted the neck swelling in April 1996. CT scan of the neck was obtained, revealing bilateral cervical and left submandibular lymphadenopathy. [academic.oup.com]

  A total of 140 patients with enlargement of cervical lymph node or swelling of the neck or draining sinus presenting to different specialties of our hospital were studied in detail. [ijmyco.org]

• Neck Stiffness

  Cervical lymphadenitis can lead to neck stiffness and torticollis. [emedicine.medscape.com]

  When it appears in the neck, it can cause pain, neck stiffness and redness of the skin over the lymph nodes. Lymphadenitis also commonly causes of fevers. [livestrong.com]

  stiffness Diagnosis You will be asked about your symptoms and medical history. [cancercarewny.com]

In children the cervical, inguinal and axillary lymph nodes generally show a swelling up to 12 years of age, after which it reduces in size. The first step towards diagnosis would be take a complete medical history of the patient to check for risk factors. Physical exam up to look for local infections including scalp, ears, nose, upper respiratory tract and chest would help to diagnose underlying cause, if present. A thorough systemic examination is conducted to check for symptoms of malignancy, particularly in the abdominal region. In any case, five factors are important in diagnosis [5]:

• Size
• Pain or tenderness
• Consistency
• Matting
• Location

Initial evaluation of the lymphadenitis focuses at the region of primary lymph node enlargement. The second line tests including skin testing for tuberculosis, antinuclear antibody test, hepatitis B serology tests, HIV tests and imaging and are based on specific indications. This is particularly true of persistent generalized lymphadenitis. A number of laboratory studies help in diagnosing the cause of lymphadenitis. Bacterial infections can be diagnosed with the help of Gram staining. The organism can be identified through culture of the specimen. Leukocytosis is indicative of infectious diseases that lead to lymphadenitis. Erythrocyte sedimentation rate, and CRP levels show an increase and are indicative of inflammation. 

Correct measurements of the enlarged lymph node can be taken using ultrasonography. But this may not be useful in differentiating a malignant lymph node enlargement. Biopsy is suggested if the condition is not related to any local infection or if it has been there for more than four to six weeks. Biopsy is also the procedure if the affected node is supraclavicular or ulcerated. Presence of symptoms like prolonged fever and weight loss calls for a biopsy of the lymph node tissue. To obtain specimen for diagnosis, fine needle aspiration is used except when malignancy is suspected. The affected lymph node is drained after incision if abscesses are found, but this procedure is avoided in the case of lymphadenitis caused by mycobacterial infection, as it may lead to the formation of fistula.

• Neutrophilia

  […] nodes can be the cause Clinical features Enlarged painful / tender lymph nodes, redness of overlying skin, low grade fever, malaise Diagnosis Clinical examination, exclude specific causes Laboratory Depending on the cause, CBC may show leukocytosis with neutrophilia [pathologyoutlines.com]

• Chlamydia

  Additional testing for gonorrhea, chlamydia, syphilis, and human immunodeficiency virus was negative. [journals.lww.com]

Treatment of lymphadenitis mainly depends on the underlying cause for inflammation of the lymph nodes [6]. Investigation and consultation is required particularly if the inflammation persists for more than six weeks or increase in size [7]. Treatment may include analgesics, antibiotics, chemotherapy or radiation depending on the cause. If the lymph node enlargement is present for two weeks or lesser, and if the size is less than 3 cm, expectant management of the condition is the suggested treatment option. If the nodes are tender and is larger than 2-3 cm, particularly with erythema of the overlying skin, antimicrobial treatment, usually with clindamycin, is recommended [8]. Local guidelines are followed in case of tuberculosis. Chemotherapy and radiotherapy are suggested for malignancies of different types.

In some cases, incision and drainage may be required, particularly for large nodes. Incision is also required for getting aspirate for a diagnostic culture. When the etiology of lymphadenitis is confirmed, the patient may be referred to specialist based on the underlying cause. Further consultations may be with an infectious disease specialist, hematologist, dermatologist, a surgeon or a radiologist, based on the etiology. In most of the cases, the inflammation may resolve when the underlying condition is treated successfully.

Prognosis for this condition depends on the underlying condition that causes lymphadenitis. If lymph node enlargement is caused by malignancies, the condition has a poor prognosis. Other conditions like HIV infection, rheumatoid arthritis and SLE also has increased and prolonged morbidity. Further, the presence of complications like abdominal lymphadenitis may alter the prognosis of the disease condition. But in most of the cases, prognosis is good with early diagnosis and treatment. Treatment with antibiotics aids in reducing infections and improving the prognosis. Those who have elevated risk of infections may have to undergo prolonged antibiotic therapy. Many of them may show recurrence of the infection too. In some cases, the enlargement may resolve within few weeks of prompt treatment, while in some the swelling remain for months.

One of the most common causes of lymphadenitis is infections. Apart from infectious conditions, neoplasms and some vascular disorders also may lead to lymph node inflammation [1]. Infectious diseases like cat scratch fever, pharyngitis, toxoplasmosis, shingles, tuberculosis, mononucleosis and scarlet fever are known to cause enlargement of lymph glands. Sexually transmitted diseases that result in lymphadenitis include syphilis, chancroid, hepatitis B, HIV infection, and lymphogranuloma venereum. A number of neoplasms also manifest in the form of lymph node inflammation and includes metastatic melanoma, prostatic cancer, breast cancer, renal carcinoma, Kaposi’s sarcoma, neuroblastoma, and lympholytic and myelocytic leukemia. Other systemic diseases including systemic lupus erythematosus (SLE), and rheumatoid arthritis are also known to cause inflammation of the lymph nodes. Some rare causes of this condition include hyperthyroidism, Gaucher disease, and sarcoidosis.

Regional lymphadenitis often serves as an indicator for further clinical investigation of underlying diseases [2]. Inflammation of supraclavicular lymph nodes point to the presence of lung or gastrointestinal cancer. Axillary node enlargement is common in cat scratch fever, breast cancer, melanoma, brucellosis, and other infectious diseases. Epitrochlear node inflammation frequently occurs in syphilis, lymphoma and sarcoidosis. Inguinal node enlargement is indicative of lymphoma, pelvic malignancy, or sexually transmitted diseases.
In some rare cases, medications are also known to cause lymph node enlargement and include drugs like sulphonamides, atenolol, captopril, penicillin, cephalosporin and hydralazine.

Reliable population estimates of incidence of this condition are rare. Results of a Dutch study showed that the incidence of this condition in the generalized population is about 0.6%[3]. In this study conducted on 2,556 patients, only 1.1% had malignancy of any form. Unexplained forms of lymphadenitis are rare and found only in 1% of the population with this condition [4]. The risk of cancer is about 4% in people above 40 years with unexplained lymphadenitis. The risk of cancer decreases considerably (0.4%) in people below this age. About three fourth of the all lymphadenitis are localized in nature. In most of the cases, inflammation of the node is caused by a specific pathology in the drainage of lymph in the area. About 25% of the cases requires further investigation for underlying disease to rule out chances of diseases like HIV infection, and tuberculosis.

Under normal conditions lymph nodes show a hyperplastic response to infections as a part of the body’s defense system to prevent diseases. The inflammation may resolve on its own within few weeks once the threat is contained. But in some cases, enlargement may remain, particularly during prolonged or severe forms of infection. Lymph node enlarge in size when an infection is drained into the local lymph gland. The area of involvement of lymph node enlargement will be limited when the underlying disease is localized. In a systemic disease, on the other hand, node involvement will be generalized. Enlargement of the node ensues when lymphocytes, plasma cells or monocytes undergo multiplication within the node. Enlargement is also noted when the node is infiltrated by malignant cells or neutrophils. 

The best way to prevent lymphadenitis is prompt diagnosis and treatment of bacterial and viral infections, both of which are common causes of lymph node enlargement [9]. Maintaining good health and general health is equally important in warding off infections of any kind. Avoiding skin injury, insect bites, and scratches on the skin will go a long way in preventing infections and thus lymphadenitis. One should take care to treat skin ulcers promptly and appropriately.

Lymphadenitis refers to the inflammation of the lymph nodes resulting in swollen and tender lymph glands. Lymph nodes are an integral part of the lymphatic system and are found distributed in clusters throughout the body. These nodes help to trap and filter disease-causing organisms and other abnormal cells from the lymph, thus aiding in fighting infections.

Lymphadenitis is a common symptom in many diseases. Many infections result in localized lymph node enlargement and the common regions where lymph node enlargement is present include cervical, axillary and inguinal lymph glands. Postauricular, supraclavicular and epitrochlear lymph node enlargement is relatively uncommon. Inflammation may be localized or generalized, and affecting a single node or a group of nodes.

Lymphadenitis refers to the inflammation of the lymph nodes present along the lymphatic vessels in the body. These nodes play an important role in fighting infections by filtering disease-causing organisms and other abnormal objects from the lymph. Many bacterial and viral infections result in swelling of the lymph nodes in different parts of the body. In most of the cases, the swollen glands are present near the site of infection. Tumors and some metabolic diseases also result in swollen lymph glands. This condition is often seen after infection by bacteria such as Streptococcus or Staphylococcus.

Lymphadenitis may be seen in any age group. The most common symptom of this condition is the swelling of the lymph nodes which may be tender or hard. The skin covering the node may become tender with or without reddish streaks. Lymphadenitis may be confined to one region or scattered in different parts. If a patient has difficulty in breathing or rapid heartbeat along with swollen lymph glands, it represents a life threatening situation and should seek immediate medical care.

The doctor may start with a complete physical exam and feel the characteristics of the swelling in the lymph nodes. This will help to look out for any signs of infection or injury close to the swollen glands. Biopsy is suggested to check the cause of inflammation. Treatment of lymphadenitis depends on the underlying cause for inflammation. Analgesics may help in controlling pain. If infection is the underlying cause for the swelling, antibiotics are recommended. Swelling can be reduced by anti-inflammatory drugs. Other medications are recommended based on the specific reason that leads to swelling in nodes. If tumors are the cause for swelling, radiation therapy or chemotherapy may be opted. Surgery may be suggested to drain the abscess from the node.

In most of the cases, inflammation of the lymph glands resolve on their own. It may take a few weeks for the swelling to disappear after the treatment. Early diagnosis and treatment are very important in the success of the treatment. But in some cases the swelling may persist and lead to complications.

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