Here we present a case of hypothalamic obesity syndrome as the primary presentation of a toddler found to have CNS B-cell lymphoblastic lymphoma. Cytogenetic studies on diagnostic cerebrospinal fluid revealed MLL gene rearrangement (11q23). [ncbi.nlm.nih.gov]

• Soft Tissue Mass

  Abstract We describe a young man who presented with neurological signs and symptoms, and with a paraspinal soft tissue mass involving the vertebral body at T4. [ncbi.nlm.nih.gov]

  MRI is very helpful in evaluating the bone marrow involvement, associated soft-tissue masses and early detection of cortical erosion. [ijmpo.org]

  A CT scan of the chest performed 2 months later before the initiation of chemotherapy revealed a new soft-tissue mass in the anterior mediastinum. [jamanetwork.com]

• Death in Childhood

  CONCLUSIONS: Our first nationwide study provided about 80% cure rate with only one case of toxic death in childhood advanced LBL. However, our intensified maintenance therapy could not improve the survival outcome. [ncbi.nlm.nih.gov]

• Severe Clinical Course

  Despite the severe clinical course, the patient recovered and was discharged with only residual symptoms. 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. KEYWORDS: Cryptosporidiosis; T-lymphoblastic lymphoma; graft-versus-host disease [ncbi.nlm.nih.gov]

• Overeating

  However, no progress has been made in this outcome over the past 10 years. [ncbi.nlm.nih.gov]

  Consolidation Days 1–4: Clofarabine 40mg/m2 IV over 2 hours etoposide 100mg/m2 IV over 2 hours cyclophosphamide 440mg/m2 IV over 1 hours. Cytarabine-Containing Regimens32 Days 1–5: Cytarabine 3g/m2 IV over 3 hours Day 3: Idarubicin 40mg/m2. [cancertherapyadvisor.com]

  Following this, a few drugs are administered in infusion periodically over a few months to remove any remaining cancer cells. This is called consolidation. Maintenance involves the use of drugs usually in oral form over a few years. [verywellhealth.com]

• Diplopia

  CASE REPORT: A 12-year-old boy presented with worsening left-sided weakness, nausea, vomiting, headache, blurred vision, and diplopia. Magnetic resonance imaging revealed right parietal gyral thickening with faint meningeal contrast enhancement. [ncbi.nlm.nih.gov]

• Subcutaneous Nodule

  Subcutaneous nodules located on the head or neck of infants should raise suspicion for lymphoma and biopsy should be performed in order to rule out malignancy. A prompt diagnosis is imperative when considering the aggressive nature of LBLs. [ncbi.nlm.nih.gov]

• Eczema

  Patches are usually flat, possibly scaly, and look like a rash; plaques are thicker, raised, usually itchy lesions that are often mistaken for eczema, psoriasis, or dermatitis; and tumors are raised bumps, which may or may not ulcerate. [lymphoma.org]

METHODS: In this review, we summarize the cases discussed during the workshop, review the pertinent and most recent literature on the respective topics, and provide a few key points that may aid in the workup of patients with B-ALL/LBL. [ncbi.nlm.nih.gov]

She was given supportive care and detailed lab workup was started. [cureus.com]

• Ovarian Mass

  A 15-year-old girl presented with bilateral ovarian masses, which, on biopsy proved to be precursor B-cell lymphoblastic lymphoma. [ncbi.nlm.nih.gov]

Treatment schedule was based on the previous, LSA2-L2 derived, AIEOP LNH-92 protocol. [ncbi.nlm.nih.gov]

Attempt to make a preoperative diagnosis is crucial because ovarian NHL responds well to chemotherapy and has a good prognosis. [ncbi.nlm.nih.gov]

t(12;21)(p13;q22) TEL-AML1 (ETV6-RUNX1); blasts with hyperdiploidy (50 - 66 chromosomes with no structural alterations) Poor prognosis: t(9;22)(q34;q11.2) BCR-ABL1; t(v;11q23) MLL rearranged; blasts with hypodiploidy ( 46 chromosomes); t(1;19)(q23;p13.3 [pathologyoutlines.com]

We describe the case of an infant with primary cutaneous B-cell LBL who was initially diagnosed by a primary care physician with an infectious etiology and consequently treated with topical and oral antibiotics. [ncbi.nlm.nih.gov]

Definition / general Pre B lymphoblastic leukemia is defined as 20% or more lymphoblasts in bone marrow Terminology Disorder of immature B cells that usually affects children, and often presents with diffuse multiorgan involvement Etiology Derived from [pathologyoutlines.com]

Conversely, a diagnosis of ALL requires at least 20% lymphoblasts in marrow. [2] Etiology and Pathophysiology Lymphoblastic lymphoma is associated with exposure to radiation or pesticides and congenital or acquired immunosuppression and is more common [emedicine.medscape.com]

(Etiology) Lymphocytes are a type of white blood cells that are responsible for providing immunity in the human body. B-cells and T-cells are the two different types of lymphocytes. [dovemed.com]

PATIENTS AND METHODS: The present retrospective cohort study used the Surveillance, Epidemiology, and End Results database to identify adult patients (age, 18 years) with LL with data recorded from 2001 to 2012. [ncbi.nlm.nih.gov]

Epidemiology B-ALL is predominantly a disease of childhood (75% of cases 6 years old). B lymphoblastic lymphoma constitutes 10% of cases of lymphoblastic lymphoma and 75% of cases are less than 18 years old. [e-immunohistochemistry.info]

[…] peripheral blood and bone marrow involvement is extensive, the term acute lymphoblastic leukemia (T-ALL) is used Pathogenesis • T-cell progenitor or thymic lymphocytes are considered the normal counterparts for T-ALL and T-LBL, respectively Clinical features Epidemiology [doctorlib.info]

As a result, the true number of women with lipedema, or its epidemiology, is unknown. [lipedema.org]

Haematology (51) Internal Medicine (51) Pathology and Forensic Medicine (48) Oncology, Radiation Therapy (35) Physiology and Pathophysiology (27) Paediatrics, Neonatology (17) Medical Chemistry and Biochemistry (16) Surgery, Traumatology and Orthopaedics [portal.mefanet.cz]

Pathophysiological dilemmas of lipedema. Med Hypotheses. 2014;83:599–606. CrossrefPubMedGoogle Scholar [4] Fife CE, Maus EA, Carter MJ. Lipedema: a frequently misdiagnosed and misunderstood fatty deposition syndrome. [degruyter.com]

Conversely, a diagnosis of ALL requires at least 20% lymphoblasts in marrow. [2] Etiology and Pathophysiology Lymphoblastic lymphoma is associated with exposure to radiation or pesticides and congenital or acquired immunosuppression and is more common [emedicine.medscape.com]

The underlying pathophysiology of large fat cells and surrounding hyaluronic acid and water can also be found in diabetes, therefore studying the fat in either condition is crucial. [obesityaction.org]

Primary testicular lymphoblastic B cell lymphoma is an aggressive disease and it is necessary a multimodal therapy (surgery, chemotherapy and radiotherapy) to prevent metastasis. [ncbi.nlm.nih.gov]

CNS prophylaxis may be given to prevent lymphoma cells from spreading to the brain and spinal cord. [cancer.ca]

Some of these cells include red blood cells which carry oxygen, platelets which are used to form blood clots and prevent bleeding, and white blood cells whose function is to fight infection. [cumc.columbia.edu]

How can Lymphoblastic Lymphoma be Prevented? Presently, the cause of Lymphoblastic Lymphoma is unknown and there are no known methods to prevent its formation. Eliminating certain risk factors may help in avoiding the condition. [dovemed.com]