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Lymphoblastic Lymphoma


Presentation

  • Here we present a case of hypothalamic obesity syndrome as the primary presentation of a toddler found to have CNS B-cell lymphoblastic lymphoma. Cytogenetic studies on diagnostic cerebrospinal fluid revealed MLL gene rearrangement (11q23).[ncbi.nlm.nih.gov]
Fishing
  • We reported a 27-year-old man with primary testicular Ph-positive B lymphoblastic lymphoma, for which fluorescent in-situ hybridization (FISH) for the Philadelphia chromosome was not performed at the initial hospitalization.[ncbi.nlm.nih.gov]
Ascitic Fluid
  • Cytologic examination of the ascitic fluid showed two distinct populations of neoplastic lymphoid cells, a predominant population of larger cells with fine powdery ("blastic") chromatin, visible to prominent nucleoli and occasional small cytoplasmic vacuoles[ncbi.nlm.nih.gov]
Soft Tissue Mass
  • Abstract We describe a young man who presented with neurological signs and symptoms, and with a paraspinal soft tissue mass involving the vertebral body at T4.[ncbi.nlm.nih.gov]
Death in Childhood
  • CONCLUSIONS: Our first nationwide study provided about 80% cure rate with only one case of toxic death in childhood advanced LBL. However, our intensified maintenance therapy could not improve the survival outcome.[ncbi.nlm.nih.gov]
Severe Clinical Course
  • Despite the severe clinical course, the patient recovered and was discharged with only residual symptoms. 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. KEYWORDS: Cryptosporidiosis; T-lymphoblastic lymphoma; graft-versus-host disease[ncbi.nlm.nih.gov]
Overeating
  • However, no progress has been made in this outcome over the past 10 years.[ncbi.nlm.nih.gov]
  • Over the past several decades, there have been strides to increase the efficacy of treatment regimens, resulting in increased survival rates.[en.wikipedia.org]
Diplopia
  • CASE REPORT: A 12-year-old boy presented with worsening left-sided weakness, nausea, vomiting, headache, blurred vision, and diplopia. Magnetic resonance imaging revealed right parietal gyral thickening with faint meningeal contrast enhancement.[ncbi.nlm.nih.gov]
Subcutaneous Nodule
  • Subcutaneous nodules located on the head or neck of infants should raise suspicion for lymphoma and biopsy should be performed in order to rule out malignancy. A prompt diagnosis is imperative when considering the aggressive nature of LBLs.[ncbi.nlm.nih.gov]

Workup

  • METHODS: In this review, we summarize the cases discussed during the workshop, review the pertinent and most recent literature on the respective topics, and provide a few key points that may aid in the workup of patients with B-ALL/LBL.[ncbi.nlm.nih.gov]
Ovarian Mass
  • A 15-year-old girl presented with bilateral ovarian masses, which, on biopsy proved to be precursor B-cell lymphoblastic lymphoma.[ncbi.nlm.nih.gov]

Treatment

  • Treatment schedule was based on the previous, LSA2-L2 derived, AIEOP LNH-92 protocol.[ncbi.nlm.nih.gov]

Prognosis

  • Attempt to make a preoperative diagnosis is crucial because ovarian NHL responds well to chemotherapy and has a good prognosis.[ncbi.nlm.nih.gov]

Etiology

  • We describe the case of an infant with primary cutaneous B-cell LBL who was initially diagnosed by a primary care physician with an infectious etiology and consequently treated with topical and oral antibiotics.[ncbi.nlm.nih.gov]
  • Etiology and Pathophysiology Like all non-Hodgkin lymphomas (NHLs), lymphoblastic lymphoma is associated with exposure to radiation or pesticides and congenital or acquired immunosuppression.[emedicine.medscape.com]

Epidemiology

  • PATIENTS AND METHODS: The present retrospective cohort study used the Surveillance, Epidemiology, and End Results database to identify adult patients (age, 18 years) with LL with data recorded from 2001 to 2012.[ncbi.nlm.nih.gov]
  • Molecular array studies have identified subtypes of the above noted abnormalities that may have distinct prognoses. [4, 5] Epidemiology In the United States, lymphoblastic lymphoma is relatively rare, comprising only 2% of all non-Hodgkin lymphomas (NHLs[emedicine.medscape.com]
  • Surveillance Epidemiology and End Results (SEER). Bethesda, MD: National Cancer Institute. Archived from the original on 26 September 2009. Retrieved 3 November 2009. Table 1.4: Age-Adjusted SEER Incidence and U.S.[en.wikipedia.org]
Sex distribution
Age distribution

Pathophysiology

  • Etiology and Pathophysiology Like all non-Hodgkin lymphomas (NHLs), lymphoblastic lymphoma is associated with exposure to radiation or pesticides and congenital or acquired immunosuppression.[emedicine.medscape.com]

Prevention

  • Primary testicular lymphoblastic B cell lymphoma is an aggressive disease and it is necessary a multimodal therapy (surgery, chemotherapy and radiotherapy) to prevent metastasis.[ncbi.nlm.nih.gov]
  • A treatment strong enough to kill the majority of malignant cells would also cause serious harm to the patient and likely prevent recovery afterwards. That’s one reason why follicular lymphoma remains incurable.[lymphomasurvival.com]
  • In the past, physicians commonly utilized radiation in the form of whole-brain radiation for central nervous system prophylaxis, to prevent occurrence and/or recurrence of leukemia in the brain.[en.wikipedia.org]

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